Multidrug Resistance Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Antimicrobial resistance profile in Salmonella enterica serovar Choleraesuis isolates from diseased pigs in Taiwan
This study investigated antimicrobial resistance in Salmonella enterica serovar Choleraesuis (S. Choleraesuis) isolates from diseased pigs in Taiwan (2015-2020). Among 272 isolates, florfenicol (96.7%), enrofloxacin (96.3%), doxycycline (91.2%), gentamicin (84.6%), and tiamulin (80.5%) exhibited high resistance. 99.3% of the isolates were resistant to at least one antibiotic, and 97.8% of the isolates were multidrug resistant. This study illustrated that S. Choleraesuis isolates exhibited high resistance to antimicrobials currently used in the Taiwanese swine industry.PMID:38670815 | DOI:10.1016/j.jmii.2024.04.005 (Source:...
Source: Journal of Microbiology, Immunology, and Infection - April 26, 2024 Category: Microbiology Authors: Anh Le Xuan Feng-Yang Hsu Po-Ren Hsueh Wei-Hao Lin Hung-Han Chen Ming-Tang Chiou Chao-Nan Lin Source Type: research

Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
Euro Surveill. 2024 Apr;29(17). doi: 10.2807/1560-7917.ES.2024.29.17.2400211.ABSTRACTThe BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on nation...
Source: Euro Surveill - April 26, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp Suzanne Edwards Giorgi Kuchukhidze Stefan Kr öger Brit H äcker Stela Bivol Askar Yedilbayev Source Type: research

Synthesis of Deuterated Endochin ‐Like Quinolones
A prodrug of antimalarial drug candidateELQ-300 is currently in preclinical development, requiring the availability of isotopically labeled analogs. A suitable method for isotopic labeling of these compounds has not yet been reported. Here, we describe a method for the deuteration ofELQ-300 and its prodrug using deuterated acetic acid. ABSTRACTMalaria continues to be a serious and debilitating disease. The emergence and spread of high-level resistance to multiple antimalarial drugs byPlasmodium falciparum has brought about an urgent need for new treatments that will be active against multidrug resistant malaria infections....
Source: Journal of Labelled Compounds and Radiopharmaceuticals - April 26, 2024 Category: Biochemistry Authors: Sovitj Pou, Rolf W. Winter, Katherine M. Liebman, Rosie A. Dodean, Aaron Nilsen, Andrea DeBarber, J. Stone Doggett, Michael K. Riscoe Tags: RESEARCH ARTICLE Source Type: research

Disrupting the interaction between a p53 gain ‐of‐function mutant and the transcriptional co‐activator PC4 reverses drug resistance in cancer cells
In a tumor cell harboring the gain-of-function mutant R273Hp53, the mutant p53 protein is recruited to the promoters of theMDR1 andUBE2C multidrug resistance-associated genes, assisted by the chromatin-associated protein PC4. This recruitment upregulates both genes. A peptide designed to disrupt the R273Hp53 –PC4 interaction, downregulatesMDR1 andUBE2C expression, sensitizing the cells to doxorubicin. This suggests that the PC4 –R273Hp53 interaction is a promising target for reducing drug resistance. PC4 is a chromatin-associated protein and transcriptional coactivator whose role in gene regulation by wild-type p53 is ...
Source: FEBS Letters - April 26, 2024 Category: Biochemistry Authors: Priya Mondal, Kumar Singha Roy, Supriya Varsha Bhagat, Siddharth Singh, Anupa Chattopadhyay, Damayanti Das Ghosh, Tapas K. Kundu, Susanta Roychoudhury, Siddhartha Roy Tags: Research Article Source Type: research

NhaA: A promising adjuvant target for colistin against resistant Escherichia coli
Int J Biol Macromol. 2024 Apr 23:131833. doi: 10.1016/j.ijbiomac.2024.131833. Online ahead of print.ABSTRACTThe emergence and widespread of multidrug-resistant Gram-negative bacteria have posed a severe threat to human health and environmental safety, escalating into a global medical crisis. Utilization of antibiotic adjuvants is a rapid approach to combat bacterial resistance effectively since the development of new antimicrobial agents is a formidable challenge. NhaA, driven by proton motive force, is a crucial secondary transporter on the cytoplasmic membrane of Escherichia coli. We found that 2-Aminoperimidine (2-AP), ...
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: Xuelin Wang Yong Cui Zhaohui Wang Huilin Jiang Lei Ma Wenwen Li Xinyi Yang Jinghai Zhang Yongshan Zhao Guoqing Li Source Type: research

Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors
Chemosphere. 2024 Apr 23:142122. doi: 10.1016/j.chemosphere.2024.142122. Online ahead of print.ABSTRACTSuccinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these environmental chemicals, the interactions of 15 SDHIs with activities of main human drug transporters implicated in pharmacokinetics were investigated in vitro. 5/15 SDHIs, i.e., benzovindiflupyr, bixafen, fluxapyroxad, pydiflumetofen and sedaxane, were found to strongly reduce activity of the renal organic anion transp...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Marie Kerhoas Marc Le V ée Jennifer Carteret Elodie Jouan Valentin Tastet Arnaud Bruy ère Laurence Huc Olivier Fardel Source Type: research

Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Biotechnol Lett. 2024 Apr 25. doi: 10.1007/s10529-024-03480-5. Online ahead of print.ABSTRACTDye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health. In the quest for bioremediation of these hazardous dyes, biological resources such as biodegradation bacteria and enzymes have been investigated in severely polluted environments. In this context, the triphenylmethane transporter gene (tmt) was identified in six distinct clones from a metagenomic library of the printing and dyeing wastewater treatment system. Escherichia coli expressi...
Source: Biotechnology Letters - April 25, 2024 Category: Biotechnology Authors: Zhou Wang Haoqiang Zhou Yilan Cheng Lijin An Dazhong Yan Hongjun Chao Jing Wu Source Type: research