Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study
Comp Immunol Microbiol Infect Dis. 2024 Apr 17;109:102185. doi: 10.1016/j.cimid.2024.102185. Online ahead of print.ABSTRACTTo evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test method...
Source: Comparative immunology, microbiology and infectious diseases. - April 25, 2024 Category: Allergy & Immunology Authors: Anna-Rita Attili Francesca Paola Nocera Martina Sisto Martina Linardi Francesca Gigli Victor Ngu Ngwa Filomena Fiorito Claudia Cerracchio Marina C T Meligrana Eleonora Bonacucina Vincenzo Cuteri Luisa De Martino Source Type: research
Broad-Spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria and Fungi
Eur J Pharm Sci. 2024 Apr 23:106776. doi: 10.1016/j.ejps.2024.106776. Online ahead of print.ABSTRACTThe emergence of multidrug-resistant (MDR) strains causes severe problems in the treatment of microbial infections owing to limited treatment options. Antimicrobial peptides (AMPs) are drawing considerable attention as promising antibiotic alternative candidates to combat MDR bacterial and fungal infections. Herein, we present a series of small amphiphilic membrane-active cyclic peptides composed, in part, of various nongenetically encoded hydrophilic and hydrophobic amino acids. Notably, lead cyclic peptides 3b and 4b showe...
Source: European Journal of Pharmaceutical Sciences - April 25, 2024 Category: Drugs & Pharmacology Authors: Sandeep Lohan Anastasia G Konshina Rakesh K Tiwari Roman G Efremov Innokentiy Maslennikov Keykavous Parang Source Type: research
Exploring the modulatory influence on the antimalarial activity of amodiaquine using scaffold hybridisation with ferrocene integration
Eur J Med Chem. 2024 Apr 16;271:116429. doi: 10.1016/j.ejmech.2024.116429. Online ahead of print.ABSTRACTAmodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising emergence of resistant malaria parasites, some of which have been reported for ACT, the usefulness of AQ as an efficacious therapeutic drug is threatened. Employing the organometallic hybridisation approach, which has been shown to restore the antimalarial activity of chloroquine in the form of an organometallic hybrid clinical candidate fe...
Source: European Journal of Medicinal Chemistry - April 25, 2024 Category: Chemistry Authors: Mziyanda Mbaba Taryn M Golding Reinner O Omondi Roxanne Mohunlal Timothy J Egan Janette Reader Lyn-Marie Birkholtz Gregory S Smith Source Type: research
Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors
Chemosphere. 2024 Apr 23:142122. doi: 10.1016/j.chemosphere.2024.142122. Online ahead of print.ABSTRACTSuccinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these environmental chemicals, the interactions of 15 SDHIs with activities of main human drug transporters implicated in pharmacokinetics were investigated in vitro. 5/15 SDHIs, i.e., benzovindiflupyr, bixafen, fluxapyroxad, pydiflumetofen and sedaxane, were found to strongly reduce activity of the renal organic anion transp...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Marie Kerhoas Marc Le V ée Jennifer Carteret Elodie Jouan Valentin Tastet Arnaud Bruy ère Laurence Huc Olivier Fardel Source Type: research
NhaA: A promising adjuvant target for colistin against resistant Escherichia coli
Int J Biol Macromol. 2024 Apr 23:131833. doi: 10.1016/j.ijbiomac.2024.131833. Online ahead of print.ABSTRACTThe emergence and widespread of multidrug-resistant Gram-negative bacteria have posed a severe threat to human health and environmental safety, escalating into a global medical crisis. Utilization of antibiotic adjuvants is a rapid approach to combat bacterial resistance effectively since the development of new antimicrobial agents is a formidable challenge. NhaA, driven by proton motive force, is a crucial secondary transporter on the cytoplasmic membrane of Escherichia coli. We found that 2-Aminoperimidine (2-AP), ...
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: Xuelin Wang Yong Cui Zhaohui Wang Huilin Jiang Lei Ma Wenwen Li Xinyi Yang Jinghai Zhang Yongshan Zhao Guoqing Li Source Type: research
Inhibition of human drug transporter activities by succinate dehydrogenase inhibitors
Chemosphere. 2024 Apr 23:142122. doi: 10.1016/j.chemosphere.2024.142122. Online ahead of print.ABSTRACTSuccinate dehydrogenase inhibitors (SDHIs) are widely-used fungicides, to which humans are exposed and for which putative health risks are of concern. In order to identify human molecular targets for these environmental chemicals, the interactions of 15 SDHIs with activities of main human drug transporters implicated in pharmacokinetics were investigated in vitro. 5/15 SDHIs, i.e., benzovindiflupyr, bixafen, fluxapyroxad, pydiflumetofen and sedaxane, were found to strongly reduce activity of the renal organic anion transp...
Source: Chemosphere - April 25, 2024 Category: Chemistry Authors: Marie Kerhoas Marc Le V ée Jennifer Carteret Elodie Jouan Valentin Tastet Arnaud Bruy ère Laurence Huc Olivier Fardel Source Type: research
Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Biotechnol Lett. 2024 Apr 25. doi: 10.1007/s10529-024-03480-5. Online ahead of print.ABSTRACTDye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health. In the quest for bioremediation of these hazardous dyes, biological resources such as biodegradation bacteria and enzymes have been investigated in severely polluted environments. In this context, the triphenylmethane transporter gene (tmt) was identified in six distinct clones from a metagenomic library of the printing and dyeing wastewater treatment system. Escherichia coli expressi...
Source: Biotechnology Letters - April 25, 2024 Category: Biotechnology Authors: Zhou Wang Haoqiang Zhou Yilan Cheng Lijin An Dazhong Yan Hongjun Chao Jing Wu Source Type: research
Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study
Comp Immunol Microbiol Infect Dis. 2024 Apr 17;109:102185. doi: 10.1016/j.cimid.2024.102185. Online ahead of print.ABSTRACTTo evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test method...
Source: Comparative immunology, microbiology and infectious diseases. - April 25, 2024 Category: Allergy & Immunology Authors: Anna-Rita Attili Francesca Paola Nocera Martina Sisto Martina Linardi Francesca Gigli Victor Ngu Ngwa Filomena Fiorito Claudia Cerracchio Marina C T Meligrana Eleonora Bonacucina Vincenzo Cuteri Luisa De Martino Source Type: research
Broad-Spectrum Activity of Membranolytic Cationic Macrocyclic Peptides Against Multi-Drug Resistant Bacteria and Fungi
Eur J Pharm Sci. 2024 Apr 23:106776. doi: 10.1016/j.ejps.2024.106776. Online ahead of print.ABSTRACTThe emergence of multidrug-resistant (MDR) strains causes severe problems in the treatment of microbial infections owing to limited treatment options. Antimicrobial peptides (AMPs) are drawing considerable attention as promising antibiotic alternative candidates to combat MDR bacterial and fungal infections. Herein, we present a series of small amphiphilic membrane-active cyclic peptides composed, in part, of various nongenetically encoded hydrophilic and hydrophobic amino acids. Notably, lead cyclic peptides 3b and 4b showe...
Source: European Journal of Pharmaceutical Sciences - April 25, 2024 Category: Drugs & Pharmacology Authors: Sandeep Lohan Anastasia G Konshina Rakesh K Tiwari Roman G Efremov Innokentiy Maslennikov Keykavous Parang Source Type: research
Novel small multidrug resistance protein Tmt endows the Escherichia coli with triphenylmethane dyes bioremediation capability
Biotechnol Lett. 2024 Apr 25. doi: 10.1007/s10529-024-03480-5. Online ahead of print.ABSTRACTDye contamination in printing and dyeing wastewater has long been a major concern due to its serious impact on both the environment and human health. In the quest for bioremediation of these hazardous dyes, biological resources such as biodegradation bacteria and enzymes have been investigated in severely polluted environments. In this context, the triphenylmethane transporter gene (tmt) was identified in six distinct clones from a metagenomic library of the printing and dyeing wastewater treatment system. Escherichia coli expressi...
Source: Biotechnology Letters - April 25, 2024 Category: Biotechnology Authors: Zhou Wang Haoqiang Zhou Yilan Cheng Lijin An Dazhong Yan Hongjun Chao Jing Wu Source Type: research
Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study
Comp Immunol Microbiol Infect Dis. 2024 Apr 17;109:102185. doi: 10.1016/j.cimid.2024.102185. Online ahead of print.ABSTRACTTo evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test method...
Source: Comparative immunology, microbiology and infectious diseases. - April 25, 2024 Category: Allergy & Immunology Authors: Anna-Rita Attili Francesca Paola Nocera Martina Sisto Martina Linardi Francesca Gigli Victor Ngu Ngwa Filomena Fiorito Claudia Cerracchio Marina C T Meligrana Eleonora Bonacucina Vincenzo Cuteri Luisa De Martino Source Type: research
Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study
Comp Immunol Microbiol Infect Dis. 2024 Apr 17;109:102185. doi: 10.1016/j.cimid.2024.102185. Online ahead of print.ABSTRACTTo evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test method...
Source: Comparative immunology, microbiology and infectious diseases. - April 25, 2024 Category: Allergy & Immunology Authors: Anna-Rita Attili Francesca Paola Nocera Martina Sisto Martina Linardi Francesca Gigli Victor Ngu Ngwa Filomena Fiorito Claudia Cerracchio Marina C T Meligrana Eleonora Bonacucina Vincenzo Cuteri Luisa De Martino Source Type: research
Evidence and antibiotic resistance profiles of clinical Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) and non-ACB complex members in companion animals: A 2020-2022 retrospective study
Comp Immunol Microbiol Infect Dis. 2024 Apr 17;109:102185. doi: 10.1016/j.cimid.2024.102185. Online ahead of print.ABSTRACTTo evaluate the frequency of Acinetobacter spp., belonging to both Acinetobacter calcoaceticus-baumannii (ACB) and non-ACB complex, and their antibiotic resistance profiles in veterinary medicine, a three-year (2020-2022) retrospective study was carried out on sick companion animals. Epidemiological data from different clinical canine, feline, and equine samples, were acquired. For each strain, MALDI-TOF MS identification and susceptibility to a panel of 11 antibiotics, by Kirby-Bauer and E-test method...
Source: Comparative immunology, microbiology and infectious diseases. - April 25, 2024 Category: Allergy & Immunology Authors: Anna-Rita Attili Francesca Paola Nocera Martina Sisto Martina Linardi Francesca Gigli Victor Ngu Ngwa Filomena Fiorito Claudia Cerracchio Marina C T Meligrana Eleonora Bonacucina Vincenzo Cuteri Luisa De Martino Source Type: research
Availability of drugs for the treatment of multidrug-resistant/rifampicin-resistant tuberculosis in the World Health Organization European Region, October 2023
The BPaLM regimen (bedaquiline, pretomanid, linezolid and moxifloxacin) recently recommended by the World Health Organization offers short, safe, and effective treatment for multidrug-resistant/rifampicin-resistant tuberculosis (TB). In a survey with national TB focal points in 18 central and western European countries to explore barriers for the implementation of BPaLM, only three reported full availability of pretomanid, a necessary component of this regimen. Implementation barriers included financing and procurement. Solutions on national and supranational level are needed to guarantee universal access. (Source: Eurosurveillance)
Source: Eurosurveillance - April 25, 2024 Category: Infectious Diseases Authors: Ralf Otto-Knapp, Suzanne Edwards, Giorgi Kuchukhidze, Stefan Kr öger, Brit Häcker, Stela Bivol and Askar Yedilbayev Source Type: research
Exploring the resistome, virulome, and mobilome of multidrug-resistant Klebsiella pneumoniae isolates: deciphering the molecular basis of carbapenem resistance
Klebsiella pneumoniae, a notorious pathogen for causing nosocomial infections has become a major cause of neonatal septicemia, leading to high morbidity and mortality worldwide. This opportunistic bacterium has ... (Source: BMC Genomics)
Source: BMC Genomics - April 25, 2024 Category: Genetics & Stem Cells Authors: Sidra Rahmat Ullah, Sidra Irum, Iqra Mahnoor, Humaira Ismatullah, Mariam Mumtaz, Saadia Andleeb, Abdur Rahman and Muhsin Jamal Tags: Research Source Type: research
