Viruses, Vol. 16, Pages 627: Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients
Viruses, Vol. 16, Pages 627: Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients
Viruses doi: 10.3390/v16040627
Authors:
Xiaoqin Le
Xueqin Qian
Li Liu
Jianjun Sun
Wei Song
Tangkai Qi
Zhenyan Wang
Yang Tang
Shuibao Xu
Junyang Yang
Jiangrong Wang
Jun Chen
Renfang Zhang
Zhaoqin Zhu
Yinzhong Shen
Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shanghai Public Health Clinical Center between 2010 and 2022 were collected. The diagnosis of tuberculosis was confirmed by solid or liquid culture. The phenotypic drug susceptibility test was carried out via the proportional method, and the resistance to first-line and second-line drugs was analyzed. Logistic regression analysis was performed to identify associated risk factors for drug resistance in M. tuberculosis. Of the 304 patients with a M. tuberculosis-positive culture and first-line drug susceptibility test results, 114 (37.5%) were resistant to at least one first-line anti-tuberculosis drug. Of the 93 patients with first-line and second-line drug susceptibility test results, 40 (43%) were resistant to at least one anti-tuberculosis drug, and 20 (21.5%), 27 (29.0%), 19 (20.4%), 16 (17.2%), and 14 (15.1%) were resistant to rifamp...
Source: Viruses - Category: Virology Authors: Xiaoqin Le Xueqin Qian Li Liu Jianjun Sun Wei Song Tangkai Qi Zhenyan Wang Yang Tang Shuibao Xu Junyang Yang Jiangrong Wang Jun Chen Renfang Zhang Zhaoqin Zhu Yinzhong Shen Tags: Article Source Type: research
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