Oleanolic acid: an antimycobacterial component of < em > Syzygium aromaticum < /em > L. and inhibitor of efflux mediated drug resistance

Nat Prod Res. 2024 Apr 18:1-7. doi: 10.1080/14786419.2024.2343916. Online ahead of print.ABSTRACTOleanolic acid (OA) was isolated from Syzygium aromaticum L. buds, and structurally characterised using different spectroscopic techniques; MS, IR,1H/13C-NMR and 2D NMR experiments. The antimycobacterial activity according to a resazurin microtiter assay (REMA) showed important inhibitory effect of OA on the virulent H37Rv strain, with the lowest minimum concentration of 50 µg/mL, compared to other fractions. Molecular docking of OA with BacA drug efflux pump resulted in good binding affinity of hydrophobic interaction type. Therefore, OA could contribute to the antimycobacterial action of clove buds, and has potential as an efflux pump inhibitor. Further studies are required on its use to combat multidrug resistant strains.PMID:38635391 | DOI:10.1080/14786419.2024.2343916
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research