Combating multidrug-resistance in < em > S. pneumoniae < /em > : a G-quadruplex binding inhibitor of efflux pump and its bio-orthogonal assembly

This study presents a pioneering strategy to combat antibiotic resistance by genetically reducing drug efflux pump expression through G-quadruplex stabilization, offering promising avenues for addressing antibiotic resistance.PMID:38694210 | PMC:PMC11059089 | DOI:10.1093/narmme/ugae005

Source: Molecular Medicine - May 2, 2024 Category: Molecular Biology Authors: Ritapa Chaudhuri Thumpati Prasanth Debasmita Biswas Subhranshu Mandal Jyotirmayee Dash Source Type: research