Self-assembled nanoparticles of natural phytochemicals (berberine and 3,4,5-methoxycinnamic acid) originated from traditional Chinese medicine for inhibiting multidrug-resistant Staphylococcus aureus.
We reported the formation of phytochemical nanoparticles (NPs) by the self-assembly of berberine (BBR) and 3,4,5-methoxycinnamic acid (3,4,5-TCA) from Chinese herb medicine, which had good antibacterial activity against MRSA. METHOD AND RESULTS: We found that NPs had good antibacterial activity against MRSA; especially, its antibacterial activity was better than first-line amoxicillin, norfloxacin and its self-assembling precursors on MRSA. When the concentration reached 0.1 µmol/mL, the inhibition rate of NPs reached 94.62%, which was higher than that of BBR and the other two antibiotics (p
Source: Current Drug Delivery - November 24, 2020 Category: Drugs & Pharmacology Authors: Han N, Huang X, Tian X, Li T, Liu X, Li W, Huo S, Wu Q, Gu Y, Dai Z, Xu B, Wang P, Lei H Tags: Curr Drug Deliv Source Type: research

Circulatory Cells as Tumortropic Carrier for Targetability Improvement.
CONCLUSION: Despite of new challenges, cell-driven drug delivery system generally brought great benefits to and shed a light on for cancer therapy and diagnosis. PMID: 33234105 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 24, 2020 Category: Drugs & Pharmacology Authors: Zou D, Weng Y, Yang P Tags: Curr Drug Deliv Source Type: research

The Potential Migrated Mechanism of Water-Soluble Components in Pellets Prepared by Wet Extrusion/Spheronization: Effect of Drying Rate.
CONCLUSION: In conclusion, the faster drying rate was, the more tartrazine migrated to the exterior of pellets. Adjusting drying temperature and relative humidity appropriately could inhibit the migration of water-soluble components within wet extrusion/spheronization pellets. PMID: 33234103 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 23, 2020 Category: Drugs & Pharmacology Authors: Wang B, Liu J, Li Z, Xia Y, Zhang S, Li Z Tags: Curr Drug Deliv Source Type: research

Development and biocompatibility analysis of NBD peptide sustained-release microsphere scaffold nanoparticle SP-Sr-CaS/NBD.
In this study, the small molecule NBD polypeptide and bone conduction matrix Sr-CaS are microsphere-formed to prepare Sr-CaS, NBD drug-loaded sustained-release micro-spheres, in order to achieve a Sr-CaS/NBD peptide drug-loaded sustained release microsphere scaffold material (SP-Sr-CaS/NBD). We prepared the microspheres and optimized the production process to obtain particles with stable morphologi-cal properties and sustained release properties. In vitro experiments demonstrated that SP-Sr-CaS/NBD can reduce TNF-α-induced cell growth inhibition, caspase-3 activity and NF-κB transcriptional activation as the fu...
Source: Current Drug Delivery - November 16, 2020 Category: Drugs & Pharmacology Authors: Li X, Wang L, Wang C, Tan C, Liu X, Zhu Y Tags: Curr Drug Deliv Source Type: research

Comparative Evaluation of the Transdermal Permeation Effectiveness of Fu's cupping therapy on eight different types of model drugs.
CONCLUSION: FCT may be used as a novel method for enhancing the physical penetration and thus effectively promoting the transdermal absorption of drugs and might lay a foundation for future research on drug transdermal technology. PMID: 33200698 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 16, 2020 Category: Drugs & Pharmacology Authors: Miao Y, Xu J, Liu Y, Yang F, Zheng X, Xie W, Zhang Y Tags: Curr Drug Deliv Source Type: research

Application of 3D Printing Technology in Bone Tissue Engineering: A Review.
Abstract Clinically, the treatment of bone defects remains a significant challenge, as it requires autogenous bone grafts or bone graft substitutes. However, the existing biomaterials often fail to meet the clinical requirements in terms of structural support, bone induction and controllable biodegradability. In the treatment of bone defects, 3D porous scaffolds have at-tracted much attention in the orthopedic field. In terms of appearance and microstructure, complex bone scaffolds created by 3D printing technology are similar to human bone. On this basis, the combination of active substances including cells and g...
Source: Current Drug Delivery - November 12, 2020 Category: Drugs & Pharmacology Authors: Feng Y, Zhu S, Mei D, Li J, Zhang J, Yang S, Guan S Tags: Curr Drug Deliv Source Type: research

Hot Melt Extrusion and its Application in 3D Printing of Pharmaceuticals.
Abstract Hot melt extrusion (HME) is a continuous pharmaceutical manufacturing process that has been extensively inves-tigated for solubility improvement and taste masking of active pharmaceutical ingredients. Recently, it is being explored for its application in 3D printing. 3D printing of pharmaceuticals allows flexibility of dosage form design, customization of dosage form for personalized therapy and the possibility of complex designs with the inclusion of multiple actives in a sin-gle unit dosage form. Fused deposition modeling (FDM) is a 3D printing technique with a variety of applications in pharma-ceutical...
Source: Current Drug Delivery - November 10, 2020 Category: Drugs & Pharmacology Authors: Deshkar S, Rathi M, Zambad S, Gandhi K Tags: Curr Drug Deliv Source Type: research

Recent Advances in Liposomal Drug Delivery System for Drug Targeting.
PMID: 33148150 [PubMed - in process] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 7, 2020 Category: Drugs & Pharmacology Authors: Shakeel F Tags: Curr Drug Deliv Source Type: research

Chlorambucil-Chitosan Nano-conjugate: An efficient Agent against Breast Cancer Targeted Therapy.
CONCLUSION: This study has created a prospective pathway for targeting cancer cells using chitosan. PMID: 33109048 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 27, 2020 Category: Drugs & Pharmacology Authors: Shayegh A, Khalatbari F, Zonoubi N, Zarazvand F, Monavvari F, Hejazinia H, Ebrahimi SES, Hamedani MP, Ali V, Hadadian S, Farzaneh J, Seyedhamzeh M, Ardestani MS Tags: Curr Drug Deliv Source Type: research

Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
CONCLUSION: Our results suggest that CVC3 and CVC8 could be suitable candidates for further investigation to develop new strategies for the prevention and/or treatment of GBM. PMID: 33109049 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 27, 2020 Category: Drugs & Pharmacology Authors: Yazici A, Marinelli L, Cacciatore I, Emsen B, Eusepi P, Di Biase G, Di Stefano A, Mardinoğlu A, Türkez H Tags: Curr Drug Deliv Source Type: research

Enhanced oral bioavailability of Etodolac by liquisolid compact technique: optimisation, in-vitro and in-vivo evaluation.
CONCLUSION: The results indicated liquisolid compact technique to be a promising strategy to enhance the bioavailability of Etodolac. PMID: 33106143 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 26, 2020 Category: Drugs & Pharmacology Authors: Pathak BK, Raghav M, Thakkar AR, Vyas BA, Shah PJ Tags: Curr Drug Deliv Source Type: research

Repaglinide and metformin loaded amberlite resin based floating microspheres for the effective management of type 2 diabetes.
Abstract BACKGROUND: Low bioavailability of anti-diabetic drugs results in the partial absorption of the drug as they are mainly absorbed from the stomach and the lower part of the GIT. Drug bioavailability of anti-diabetic drugs can be significantly increased by prolonging gastric retention time through gastro-retentive dosage form such as floating microspheres. OBJECTIVE: To develop and characterize resin based floating microspheres of Repaglinide and Metformin for superior and prolonged maintenance of normoglycaemia in type-2 Diabetes Mellitus. METHODS: Repaglinide and Metformin were complexed with Am...
Source: Current Drug Delivery - October 25, 2020 Category: Drugs & Pharmacology Authors: Jain AK, Sahu P, Mishra K, Jain SK Tags: Curr Drug Deliv Source Type: research

It is Possible to Achieve Tablets with Good Tabletability from Solid Dispersions - the Case of the High Dose Drug Gemfibrozil.
CONCLUSION: SDs proved to be effective for simultaneously improving tabletability and dissolution profile of gemfibrozil. Tablets containing gemfibrozil-HPMC-SD and croscarmellose sodium as disintegrating agent showed improved drug release and good mechanical strength, demonstrating the potential of HPMC-based SDs to simultaneously overcome the poor dissolution and tabletability properties of this drug. PMID: 33100203 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 23, 2020 Category: Drugs & Pharmacology Authors: Bigogno ER, Soares L, Mews MHR, Zétola M, Bazzo GC, Stulzer HK, Pezzini BR Tags: Curr Drug Deliv Source Type: research

Potential application of a synthetic organo-funtionalized high load expandable mica as drug carrier for controlled release.
CONCLUSION: A successful development of a functionalized mica has been made with a promising potential application as a carrier to the drug. PMID: 33092507 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 22, 2020 Category: Drugs & Pharmacology Authors: Orta MM, Maisanaba S, Medina-Carrasco S, Jos A Tags: Curr Drug Deliv Source Type: research

Iontophoretic mediated Intraarticular delivery of Deformable Liposomes of Diclofenac sodium.
CONCLUSIONS: Results obtained indicate that iontophoretic mediated transport of deformable liposomes could improve the regional bioavailability of diclofenac sodium to the synovial joints, an efficient mode for treating MSD in elderly. PMID: 33059549 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 14, 2020 Category: Drugs & Pharmacology Authors: Kenchappa V, Salwa, Murthy SN, Shivakumar Hn Tags: Curr Drug Deliv Source Type: research

Epidemiological Situation and Efficacy of Dexamethasone for the treatment planning of COVID-19: A perspective review.
Abstract The current COVID-19 pandemic has prompted the urgent requirement for searching effective treatments since the implications are so huge globally as compared to the earlier pandemics. Momentarily, there has been no effective medicine for SARS-CoV-2 infection, and supportive care tends to be the most effective approach to treat COVID-19 patients. The rapidly growing awareness of SARS-CoV-2 virology offers a large number of possible drug targets. The World Health Organisation (WHO) is steadily updating the treatment protocol for COVID-19 based on the recent clinical trials. In the present review, we have sum...
Source: Current Drug Delivery - October 6, 2020 Category: Drugs & Pharmacology Authors: Wahab S, Ahmad I, Usmani S, Ahmad MP Tags: Curr Drug Deliv Source Type: research

New heterocyclic compounds: synthesis, antioxidant activity and computational insights of nano-antioxidant as ascorbate peroxidase inhibitor by various cyclodextrin as drug delivery systems.
CONCLUSION: For the drug delivery study, The ACD is best system for all the compounds due to the smallest cavity size which makes the binding affinities favorable and possible to prepare prospective nano-antioxidants. PMID: 33023446 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 1, 2020 Category: Drugs & Pharmacology Authors: Kaddouri Y, Abrigach F, Yousfi EB, Hammouti B, El Kodadi M, Alsalme A, Al-Zaqri N, Warad I, Touzani R Tags: Curr Drug Deliv Source Type: research

Progress of Stimuli-Responsive Nanoscale Metal Organic Frameworks as Controlled Drug Delivery Systems.
DISCUSSION: We first introduce the two main strategies associated with nanoscale metal organic frameworks used in drug loading: direct assembly and post-encapsulation. We next focus on the latest discoveries of nanoscale metal organic framework-based stimulus response systems for drug delivery, including pH, magnetics, light, ion, temperature, and other stimuli, as well as multiple stimulus-responsive drug delivery systems. Finally, we discuss the challenges and future development directions of nanoscale metal organic framework-based controlled drug release. PMID: 32940178 [PubMed - as supplied by publisher] (Source: ...
Source: Current Drug Delivery - September 16, 2020 Category: Drugs & Pharmacology Authors: Feng A, Wang Y, Ding J, Xu R, Li X Tags: Curr Drug Deliv Source Type: research

Improved drug delivery system for cancer treatment by D-glucose conjugation with eugenol from natural product.
CONCLUSION: These findings strongly indicate that K7M2 cells would be affected by toxicity of D-glucose-eugenol. Therefore, the present study suggests that D-glucose-eugenol has high potential to act as an anti-proliferative agent who may promise a new modality or approach as the drug delivery treatment for cancer or chemotherapeutic agent. PMID: 32940179 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 16, 2020 Category: Drugs & Pharmacology Authors: Razak MAIA, Hamid HA, Othman RNIR, Moktar SAM, Miskon A Tags: Curr Drug Deliv Source Type: research

The Use of cyclodextrin or its complexes as a potential treatment against the 2019 novel coronavirus. A mini-review.
Abstract Severe acute respiratory syndrome coronavirus 2 has spread rapidly since its discovery in December 2019 in the Chinese province of Hubei, reaching this day, all the continents. This scourge is, unfortunately, in lineage with various dangerous outbreaks such as Ebola, Cholera, Spanish flu, American seasonal flu. Until today, the best solution for the moment remains prevention (Social distancing, hand disinfection, use of masks, partial or total sanitary containment, etc.), there is also the emergence of drug treatment (research and development, clinical trials, use on patients). Recent reviews emphasized t...
Source: Current Drug Delivery - September 16, 2020 Category: Drugs & Pharmacology Authors: Sofiane F, Lamia T, Mohamed S, Mokrane IO Tags: Curr Drug Deliv Source Type: research

Study on the Slow-release Mometasone Furoate Injection of PLGA for the Treatment of Knee Arthritis.
CONCLUSION: This study shows that the microspheres prepared in this study have sufficient ability of stable drug release at least 35 days, with good efficacy and high safety. In addition, mometasone furoate can be used as a potential candidate drug for 35 day long-term injection. PMID: 32940181 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 16, 2020 Category: Drugs & Pharmacology Authors: Liang Y, Zhang J, Zhao X, Wang M, Ding S, Wang Y, Chen Y, Liu J Tags: Curr Drug Deliv Source Type: research

Role of novel drug delivery systems in coronavirus disease-2019 (covid-19): time to act now.
Abstract The corona virus disease 2019 (COVID-19) has found its roots from Wuhan (China). COVID-19 is caused by a novel corona virus SARS-CoV2, previously named as 2019-nCoV. COVID-19 has spread across the globe and declared as pandemic by World health organization (WHO) on 11th March, 2020. Currently, there is no standard drug or vaccine available for the treatment, so repurposing of existing drugs is the only solution. Novel drug delivery systems (NDDS) will be boon for the repurposing of drugs. The role of various NDDS in repurposing of existing drugs for treatment of various viral diseases and their relevance ...
Source: Current Drug Delivery - September 14, 2020 Category: Drugs & Pharmacology Authors: Mittal N, Garg V, Bhadada SK, Katare OP Tags: Curr Drug Deliv Source Type: research

Mesoporous bioactive glass scaffold delivers salvianolic acid B to promote bone regeneration in a rat cranial defect model.
CONCLUSION: It's concluded that the use of MBG scffolds delivering SB is an effective strategy for the treatment of bone defects. PMID: 32938350 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 14, 2020 Category: Drugs & Pharmacology Authors: Wu L, Wei Z, He S, Bi Y, Cao Y, Wang W Tags: Curr Drug Deliv Source Type: research

Osteomyelitis: Focus on Conventional Treatments and Innovative Drug Delivery Systems.
Abstract Osteomyelitis is a bone marrow infection which generally involves cortical plates and which may occur after bone trauma, orthopedic/maxillofacial surgery or after vascular insufficiency episodes. It mostly affects people from the Third World Countries, elderly and patients affected by systemic diseases e.g. autoimmune disorders, AIDS, osteoporosis and microvascular disease. The highest percentage of osteomyelitis cases (almost 75%) is caused by Staphylococcus spp., and in particular by Staphylococcus aureus (more than 50%). The ideal classification and the diagnosis of osteomyelitis are two important tool...
Source: Current Drug Delivery - September 13, 2020 Category: Drugs & Pharmacology Authors: Gallarate M, Chirio D, Chindamo G, Peira E, Sapino S Tags: Curr Drug Deliv Source Type: research

Madhuca longifolia embedded silver nanoparticles attenuates diethylnitrosamine (DEN) -induced renal cancer via regulating oxidative stress.
CONCLUSION: Our outcomes implicates that biofabricated MLAgNPs exhibited a chemoprotective potential in the prevention and intervention of RCC. PMID: 32914714 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 9, 2020 Category: Drugs & Pharmacology Authors: Singh D, Yadav E, Kumar V, Verma A Tags: Curr Drug Deliv Source Type: research

Solid self-emulsifying drug delivery system (Solid SEDDS) for testosterone undecanoate: in vitro and in vivo evaluation.
CONCLUSION: According to the results of this research, oral solid TU-SEDDS is expected to be another alternative delivery system for the late-onset hypogonadism. This is beneficial to the transformation of existing drug delivery systems into preclinical and clinical studies. PMID: 32887542 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2020 Category: Drugs & Pharmacology Authors: Liang X, Hua Y, Liu Q, Li Z, Yu F, Gao J, Zhang H, Zheng A Tags: Curr Drug Deliv Source Type: research

Formulation, characterization and pharmacokinetics of long-acting ceftiofur hydrochloride suspension.
Conclusion: The results suggested that the suspension had excellent sustained-release and will make ceftiofur hydrochloride more effective and convenient to use. PMID: 32885750 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 2, 2020 Category: Drugs & Pharmacology Authors: Xie S, Zhang X, Luo W, Meng K, Chen D, Pan Y, Tao Y, Huang L, Liu Z, Wang Y, Yuan Z Tags: Curr Drug Deliv Source Type: research

Mannose Conjugated Starch Nanoparticles for Preferential Targeting of Liver Cancer.
Conclusion: In vivo, bio-distribution and plasma profile studies resulted in significantly higher concentration of 5- Fluorouracil liver suggesting that these carriers are efficient, viable, and targeted carrier of 5-FU treatment of liver cancer. PMID: 32885751 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 2, 2020 Category: Drugs & Pharmacology Authors: Jain AK, Sahu H, Mishra K, Thareja S Tags: Curr Drug Deliv Source Type: research

Nanocarriers in the delivery of hydroxychloroquine to the respiratory system: An alternative to COVID-19?
ogueira MC Abstract In response to the global outbreak caused by SARS-CoV-2, this article aims to propose the development of nanosystems for the delivery of hydroxychloroquine in the respiratory system to the treatment of COVID-19. Performed a descriptive literature review, using the descriptors 'COVID-19', 'Nanotechnology', 'Respiratory Syndrome' and 'Hydroxychloroquine', in the PubMed, ScienceDirect and SciElo databases. After analyzing the articles according to the inclusion and exclusion criteria, they were divided into 3 sessions: Coronavirus: definitions, classifications and epidemiology, pharmacological asp...
Source: Current Drug Delivery - August 26, 2020 Category: Drugs & Pharmacology Authors: Cavalcanti IDL, de Fátima Ramos Dos Santos Medeiros SM, Dos Santos Macêdo DC, Ferro Cavalcanti IM, de Britto Lira Nogueira MC Tags: Curr Drug Deliv Source Type: research

Recent developments in the principles, modification and application prospects of functionalized ethosomes for topical delivery.
Abstract Transdermal drug delivery helps to circumvent the first-pass effect of drugs and to avoid drug-induced gastrointestinal tract irritation, compared with oral administration. With the extensive application of ethosomes in transdermal delivery, the shortages of them have been noticed continuously. Due to the high concentration of volatile ethanol in ethosomes, there are problems of drug leakage, system instability, and ethosome-induced skin irritation. Thus, there is a growing interest in the development of new generations of ethosomal systems. Functionalized ethosomes have the advantages of increased stabil...
Source: Current Drug Delivery - August 24, 2020 Category: Drugs & Pharmacology Authors: Lu J, Guo T, Fan Y, Li Z, He Z, Yin S, Feng N Tags: Curr Drug Deliv Source Type: research

Factors Affecting the Penetration of Niosome into the Skin, Their Laboratory Measurements and Dependency to the Niosome Composition: A Review.
Abstract Skin, the most significant protective organ in the body, may face serious problems, including cancer, infectious diseases, etc., requiring different drugs for the treatment. However, most of these drugs have poor chemical and physical stability, and insufficient penetration through the skin layers. In recent years, with the development of nanotechnology, it has been possible to load a variety of drugs into nanocarriers, to effectively targeted drug delivery. The unique structure of niosome, presents an effective novel drug delivery system with the ability to load both hydrophilic and lipophilic drugs, hav...
Source: Current Drug Delivery - August 19, 2020 Category: Drugs & Pharmacology Authors: Khailnezhad B, Hadjizadeh A Tags: Curr Drug Deliv Source Type: research

Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy.
Abstract Mesenchymal stem cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively homing to inflammation and tumor sites. Thisreview aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy. PMID: 32819256 [PubMed - as supplied by publisher] (Source:...
Source: Current Drug Delivery - August 18, 2020 Category: Drugs & Pharmacology Authors: Xie M, Tao L, Zhang Z, Wang W Tags: Curr Drug Deliv Source Type: research

Hyaluronic acid/parecoxib-loaded PLGA microspheres for therapy of temporomandibular disorders.
CONCLUSION: The study presented new and potential insights into treatments of TMD using PLGA microspheres loaded with HA and parecoxib as a successful drug delivery system. PMID: 32811397 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Zhu D, Bai H, Xu W, Lai W, Song L, Deng J Tags: Curr Drug Deliv Source Type: research

Application of Hot Melt Extrusion Technology in the Development of Abuse Deterrent Formulations: An Overview.
Abstract The misuse, abuse, and illicit use of prescription opioid analgesics is a global public health concern. However, there are many viable therapeutic options for the treatment of patients with chronic pain. Both intact and manipulated opioid drug products are abused by various routes such as oral, nasal, and injection which may lead to overdose, drug addiction, and even death. To combat the abuse of these medications, regulatory agencies and pharmaceutical companies are switching their interest towards developing Abuse deterrent formulations (ADFs), with the intent to deter the abuse of opioid products to a ...
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Butreddy A, Nyavanandi D, Narala S, Austin F, Bandari S Tags: Curr Drug Deliv Source Type: research

The Application of Chemometrics for Efficiency Enhancement and Toxicity Reduction in Cancer Treatment with Combined Therapy.
Abstract Chemometrics is an important emerging discipline with unique charm formed by the intersection of mathematics, statistics, chemistry and computer science. The application of chemometrics in the field of pharmacy has injected fresh blood into the scientific research and clinical practice of medicine, and has provided sufficient scientific basis for drug analysis and content determination to solve the problem of cancer treatment with combined therapy in different ranges. This paper introduces the basic principles, advantages and disadvantages of several commonly used pattern recognition and multidimensional ...
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Qian K, Yan B, Xiong Y Tags: Curr Drug Deliv Source Type: research

Betulinic acid nanogels: rheological, micro structural characterization and evaluation of their anti-inflammatory activity.
CONCLUSION: The NG of BA showed to be good vehicles to treat skin inflammation. PMID: 32811400 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Sosa-Gutierrez D, Toro-Vazquez J, Cano-Sarmiento C, Grube-Pagola P, Aparicio-Saguilan A, Torres-Palacios C, Acosta-Osorio A, Garcia H Tags: Curr Drug Deliv Source Type: research

The Potential of Milk-derived Exosomes for Drug Delivery.
CONCLUSION: The emergence of milk-derived exosomes is expected to break through the limitations of exosomes as therapeutic carriers of drugs. We hope to raise awareness of the therapeutic potential of milk-derived exosomes as a new drug delivery system. PMID: 32807052 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Li S, Tang Y, Dou Y Tags: Curr Drug Deliv Source Type: research

Novel Aceclofenac cocrystals with l-Cystine: Virtual coformer screening, mechanochemical synthesis, and physicochemical investigations.
CONCLUSION: The cocrystallization technique was successfully utilized to increase the solubility and dissolution rate of aceclofenac. PMID: 32807053 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 16, 2020 Category: Drugs & Pharmacology Authors: Kumar S, Gupta A, Prasad R, Singh S Tags: Curr Drug Deliv Source Type: research

Alginate as Promising Natural Biodegradable Polymer for Pharmaceutical, Food, and Biomedical Applications.
Abstract Alginates are biopolymers usually obtained from brown seaweed, brown algae (Ochrophyta, Phaeophyceae), and bacteria (Azatobacter vineland and Pseudomonas species) belonging to the family of polycationic copolymers. They are biocompatible, biodegradable, non-antigenic, and non-toxic biopolymer with molecular mass ranges from 32,000-40,000 g/mol in commercial grades. These can be used as edible films or coatings in food industries and also some natural or chemical additives could be incorporated into them to modify their functional, mechanical, nutritional as well as organoleptic properties. Due to their hi...
Source: Current Drug Delivery - August 8, 2020 Category: Drugs & Pharmacology Authors: Kothale D, Verma U, Dewangan N, Jana P, Jain A, Jain D Tags: Curr Drug Deliv Source Type: research

Self-assemble Amphiphilic PEO-PPO-PEO Tri-block Co-polymeric Methotrexate Nanomicelles to Combat Against MCF7 Cancer Cells.
CONCLUSION: Finally concluded that MTX loaded PF127/SDS micelles act as a potential anticancer delivery system in comparison to PF127/PC and PF127 to combat against tumor cells by enhancing its cellular uptake targeting with sustained release pattern and reducing the thermodynamic instability. Thus, PF127/SDS micellar formulation can provide a useful alternative dosage form for intravenous administration of MTX. PMID: 32778025 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 8, 2020 Category: Drugs & Pharmacology Authors: Mishra MK, Gupta J, Gupta R Tags: Curr Drug Deliv Source Type: research

Pharmacokinetic and Pharmacodynamic Studies of Nifedipine Loaded Microspheres for the Treatment of Hypertension.
Abstract PURPOSE: The purpose of this research work to evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and the distribution pattern of mucoadhesive microspheres of nifedipine. METHODS: Firstly, the emulsion solvent evaporation technique was used to prepare the mucoadhesive microspheres. The microspheres were characterized by Fourier transform infrared spectroscopy (FT-IR) and in vivo studies were carried on Wistar rats. RESULTS: Blood samples of rats were withdrawal at 2, 4, and 8 h time interval, after the administration of mucoadhesive microspheres of nifedipine (Mm-N) and the saline solution ...
Source: Current Drug Delivery - August 8, 2020 Category: Drugs & Pharmacology Authors: Lal C, Garg R, Gupta GD Tags: Curr Drug Deliv Source Type: research

The impact of natural and synthetic polymers in formulating micro and nanoparticles for antidiabetic drugs.
Abstract Diabetes mellitus is one of the long known chronic diseases, today over 400 million people are diagnosed with diabetes. Yet curing diabetes is a challenge. Over the decades, the approaches of treating diabetes mellitus have evolved and polymeric materials have played an integral part in developing and manufacturing anti-diabetic medications. However, injection of insulin remains the conventional therapy for the treatment of diabetes. Oral administration is generally the most preferred route; yet, physiological barriers lead to a challenge for the formulation development for oral delivery of antidiabetic p...
Source: Current Drug Delivery - August 8, 2020 Category: Drugs & Pharmacology Authors: Al-Hashimi N, Babenko M, Saaed M, Kargar N, ElShaer A Tags: Curr Drug Deliv Source Type: research

Engineering of nanospheres dispersed microneedle system for antihypertensive action.
Abstract A combinational therapy is mostly preferred in hypertension treatment because of low-dose and less side effects like pretibial edema, gastrointestinal bleeding etc. So the objective of the present work was to formulate an advanced drug delivery system in the form of bio-responsive microneedles by incorporating nifedipine, a cardiodepressant and diltiazem, a vasodilator for effective synergism in the treatment of hypertension. The pH-responsive PLGA nanospheres of diltiazem were formulated using water-in-oil-in-water (W/O/W) double emulsion and solvent-diffusion-evaporation technique. These nanospheres wer...
Source: Current Drug Delivery - August 2, 2020 Category: Drugs & Pharmacology Authors: Sardesai M, Shende P Tags: Curr Drug Deliv Source Type: research

Assessment of Effects of Solvents on Cocrystallization by Computational Simulation Approach.
CONCLUSION: So, the present research concluded that prepared telmisartan-oxalic acid cocrystal is a successful application of crystal engineering approach to improve the physicochemical properties as well as to enhance the solubility and dissolution of telmisartan. PMID: 32753012 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 2, 2020 Category: Drugs & Pharmacology Authors: Chakraborty S, Dhibar M, Basak S Tags: Curr Drug Deliv Source Type: research

Development of Thymol microsponges loaded In situ gel for the treatment of Periodontitis.
Abstract OBJECTIVE: Periodontitis is an oral disease categorized by disturbance of periodontal tissue and creation of periodontal pockets. Thymol (TH) loaded microsponge in situ gelling system was formulated for local action in the periodontal cavity for the management of periodontitis. METHOD: Solvent evaporation technique was utilized for preparation of microsponges. A Fractional factorial design (FFD) was used to screen the high risk variables impacting the characteristics of the (TH) microsponges and further optimized using Box-Behnken design. The optimized microsponges were then characterized by DSC, SEM...
Source: Current Drug Delivery - August 2, 2020 Category: Drugs & Pharmacology Authors: Patole VC, Chaudhari SP Tags: Curr Drug Deliv Source Type: research

Chloroquine assisted delivery of microRNA Mimic let-7b to NSCLC cell line by PAMAM (G5) - HA nano-carrier.
CONCLUSION: All factors considered, the results declare that application of let-7b-loaded PAMAM-HA NPs in combination with chloroquine can be a promising therapeutic option in cancer cells inhibition, the fact which has frequently been highlighted by many re-searchers upon the potentials of micro RNA delivery in cancer cells. PMID: 32753014 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 2, 2020 Category: Drugs & Pharmacology Authors: Maghsoudnia N, Eftekhari RB, Sohi AN, Dorkoosh FA Tags: Curr Drug Deliv Source Type: research

Transfersomes: the ultra-deformable carrier system for non-invasive delivery of drug.
Abstract Vesicular systems have many advantages like prolong the existence of the drug in the systemic circulation, minimizes the undesirable side-effects, reaches the active moieties to its target sites using the carriers. But the main drawback related to transdermal delivery is to cross stratum corneum which can be overcome by the utilization of novel carrier systems e.g. transfersomes which are ultra-deformable carrier system composed of phospholipid (phosphatidylcholine) and edge activators (surfactants). Edge activators are responsible for the flexibility of the bilayer membranes of transfersomes. Different e...
Source: Current Drug Delivery - August 2, 2020 Category: Drugs & Pharmacology Authors: Gupta R, Kumar A Tags: Curr Drug Deliv Source Type: research

A phospholipase-A activity in soluble Leishmania antigens causes instability of liposomes.
This study aimed to investigate the existence of phospholipase-A (PLA) activity in soluble L.major antigens (SLA) because of no reports for it so far. Liposomes were used as sensors to evaluate PLA activity. Liposomal SLA consisting of Egg phosphatidylcholine (EPC) or Sphingomyelin (SM) were prepared by two different methods in different pH or temperatures and characterized by dynamic light scattering (DLS) and thin layer chromatography (TLC). Lipid hydrolysis led to the disruption of EPC liposomal SLA in both methods but the film method (FM) produced more stable liposomes than the detergent removal method (DRM). The prepa...
Source: Current Drug Delivery - July 30, 2020 Category: Drugs & Pharmacology Authors: Chavoshian O, Arabsalmani M, Jaafari MR, Khamesipour A, Abbasi A, Saberi Z, Badiee A Tags: Curr Drug Deliv Source Type: research

Release characteristics of an essential oil component encapsulated with cyclodextrin shell matrices.
CONCLUSION: The encapsulation of myrcene was profoundly affected by the type of CDs, and the stability could be improved by complexation with suitable CDs. The binding behavior between guest and CD molecules, and the release profile of the guest molecules could be effectively explained by the kinetics parameters and molecular modelling. This study can provide an effective basis and guide for screening suitable shell matrices. PMID: 32735520 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 30, 2020 Category: Drugs & Pharmacology Authors: Li Z, Wen W, Chen X, Zhu L, Cheng G, Liao Z, Huang H, Ming L Tags: Curr Drug Deliv Source Type: research

Polymeric Precipitation Inhibitor Assisted Supersaturable SMEDDS of Efavirenz Based on Experimental Observations and Molecular Mechanics.
CONCLUSION: The designed delivery system indicated promising results in developing an effectual EFV formulation for HIV treatment. PMID: 32735521 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 30, 2020 Category: Drugs & Pharmacology Authors: Singh M, Singh D, Mahajan S, Sheikh BA, Bedi N Tags: Curr Drug Deliv Source Type: research