Carbohydrates in Vaccine Development.
Abstract This review summarizes advancement in the development of new carbohydrate-based vaccines. Different contributions of carbohydrates for the development of vaccines are described, including carbohydrates acting as antigens, carriers or targeting moieties. Carbohydrate-based vaccines against infectious diseases, such as group A streptococcus, meningococcal meningitis and human immunodeficiency virus, are discussed. PMID: 31267872 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 2, 2019 Category: Drugs & Pharmacology Authors: Aljohani S, Hussein WM, Toth I, Simerska P Tags: Curr Drug Deliv Source Type: research

Efficient delivery of antisense Oligonucleotides by an amphipathic cell penetrating peptide in Acinetobacter baumannii.
In conclusion, our research is the first to demonstrate that CADY can deliver ASOs into bacteria and provide a novel strategy for the treatment of MDR-A. baumannii. PMID: 31244437 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - June 27, 2019 Category: Drugs & Pharmacology Authors: Chen Z, Nie D, Hu Y, Li M, Hou Z, Mao X, Luo X, Xue X Tags: Curr Drug Deliv Source Type: research

In vitro and in vivo evaluation of Olmesartan Medoxomil microcrystals and nanocrystals: Preparation, characterization, and pharmacokinetic comparison in Beagle Dogs.
Conclusion´╝ÜParticles size reduction to nano-scale by means of nanocrystals technology significantly increased in vitro dissolution rate and in vivo oral bioavailability of OLM. PMID: 31244438 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - June 27, 2019 Category: Drugs & Pharmacology Authors: Chai R, Gao H, Ma Z, Guo M, Fu Q, Liu H, He Z Tags: Curr Drug Deliv Source Type: research

Monocytes as Carriers of Magnetic Nanoparticles for Tracking Inflammation in the Epileptic Rat Brain.
Abstract BACKGROUND: Inflammation is a hallmark of epileptogenic brain tissue. Previously, we have shown that inflammation in epilepsy can be delineated using systemically-injected fluorescent and magnetite-laden nanoparticles. Suggested mechanisms included distribution of free nanoparticles across a compromised blood-brain barrier or their transfer by monocytes that infiltrate the epileptic brain. OBJECTIVE: In the current study we evaluated monocytes as vehicles that deliver nanoparticles into the epileptic brain. We also assessed the effect of epilepsy on the systemic distribution of nanoparticle-loaded mo...
Source: Current Drug Delivery - June 19, 2019 Category: Drugs & Pharmacology Authors: Han H, Eyal S, Portnoy E, Mann A, Shmuel M, Benifla M, Ekstein D, Polyak B Tags: Curr Drug Deliv Source Type: research

Dimethyloxallyl glycine-incorporated borosilicate bioactive glass scaffolds for improving angiogenesis and osteogenesis in critical-sized calvarial defects.
In this study, we fabricated bioactive glass scaffolds composed of borosilicate 2B6Sr using the Template-Method and incorporated Dimethyloxalylglycine (DMOG), a small-molecule angiogenic drug possessing good angiogenic ability, to improve bone regeneration. The in-vitro studies showed that porous borosilicate bioactive glass scaffolds releases a slow, steady amount of DMOG and stimulated the proliferation and osteogenic differentiation of human bone marrow stromal cells hBMSCs. In-vivo studies showed that the borosilicate bioactive glass scaffolds could significantly promote new bone formation and neovascularization in rat...
Source: Current Drug Delivery - June 10, 2019 Category: Drugs & Pharmacology Authors: Jin X, Han D, Tao J, Huang Y, Zhou Z, Zhang Z, Qi X, Jia W Tags: Curr Drug Deliv Source Type: research

Simvastatin Loaded Nano Hydroxyapatite in Bone Regeneration: A Study in the Rabbit Femoral Condyle.
CONCLUSION: Based on the results it can be concluded that local delivery of simvastatin enhanced the bone regeneration in rabbit femoral condyle. Simvastatin could be used as an activator to enhance bone regeneration in bone defects along with hydroxyapatite ceramics. PMID: 31187712 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - June 10, 2019 Category: Drugs & Pharmacology Authors: Chalisserry EP, Nam SY, Anil S Tags: Curr Drug Deliv Source Type: research

Advances in targeted gene delivery.
Abstract Gene therapy has the potential to treat both acquired and inherited genetic diseases. Generally, two types of gene delivery vectors are used - viral vectors and non-viral vectors. Non-viral gene delivery systems have attracted significant interest due to their lower toxicity, lack of immunogenicity and ease of production compared to viral vectors. To achieve the goal of maximal therapeutic efficacy with minimal adverse effects, the cell-specific targeting of non-viral gene delivery systems has attracted research interest. Targeting through cell surface receptors; the enhanced permeability and retention ef...
Source: Current Drug Delivery - May 28, 2019 Category: Drugs & Pharmacology Authors: Ara Beguma A, Toth I, Hussein WM, Moyle PM Tags: Curr Drug Deliv Source Type: research

Development and evaluation of ropivacaine loaded poly(lactic-co-glycolic acid) microspheres with low burst release.
In conclusion, the ropivacine microspheres prepared in this paper have great potential for clinical use. PMID: 31132975 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - May 28, 2019 Category: Drugs & Pharmacology Authors: Zhao X, Gao Y, Tang X, Lei W, Yang Y, Yu F, Liu Y, Yang M, Wang Y, Gong W, Li Z, Gao CS, Mei X Tags: Curr Drug Deliv Source Type: research

Talazoparib Loaded Solid Lipid Nanoparticles: Preparation, Characterization and Evaluation the Therapeutic Efficacy In Vitro.
Abstract In the present work, we report for the first time the therapeutic potential of talazoparib (BMN 673)-SLNs for the treatment of BRCA1 deficient triple negative breast cancer (TNBC). BMN 673-SLNs were produced by hot-homogenization technique then characterized. The cytotoxic and apoptotic effects of BMN 673-SLNs compared with BMN 673 were determined on HCC1937BRCA1-/-, HCC1937-R resistant TNBC and MCF-10A control cell lines. BMN 673-SLNs were found to be a reduced particle size (219.5 ± 1.45 nm) and thus more stable (-28.4 ± 2.52 mV) than BMN 673 (1652 ± 2.46 nm and -18.6 ± 0.45 ...
Source: Current Drug Delivery - May 14, 2019 Category: Drugs & Pharmacology Authors: Eskilera GG, Cecener G, Dikmen G, Egeli U, Tunca B Tags: Curr Drug Deliv Source Type: research

Drug release from pharmaceutical co-crystals: are therapeutic and safety properties of active pharmaceutical substances retained?
PMID: 31084593 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - May 13, 2019 Category: Drugs & Pharmacology Authors: Dalpiaz A, Ferretti V, Botti G, Pavan B Tags: Curr Drug Deliv Source Type: research

Preparation, Characterization and Prevention of Auto-oxidation of Amorphous Sirolimus by Encapsulation in Polymeric Films using Hot Melt Extrusion.
CONCLUSION: The film formulations showed a significant improvement in the storage stability of the amorphous form of SIR and the solubility advantage of the amorphous form was evident in the dissolution testing. The oral films can potentially improve the bioavailability of SIR by absorption through the buccal mucosa. PMID: 31038065 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 16, 2019 Category: Drugs & Pharmacology Authors: Kanaujia P, Poovizhi P, Ng WK, Tan RBH Tags: Curr Drug Deliv Source Type: research

Bioactive medications for the delivery of platelet derivatives to skin wounds.
Abstract Chronic wounds are the result of alterations in the complex series of events of physiological wound healing. In particular, the prolonged inflammation results in increased protease activity, in the degradation of extracellular matrix (ECM) and of growth factors (GFs). The relevance of platelet GFs in maintaining and restoring the complex equilibrium of different moments in wound healing is well recognized. Moreover, the observed decrease of their levels in chronic wounds suggested a possible therapeutic role of the external application to the wounds. It has been also pointed out that tissue regeneration c...
Source: Current Drug Delivery - March 20, 2019 Category: Drugs & Pharmacology Authors: Bonferoni MC, Rossi S, Sandri G, Caramella C, Del Fante C, Perotti C, Miele D, Vigani B, Ferrari F Tags: Curr Drug Deliv Source Type: research

Molecular Dynamics Simulations of Glycyrrhizic Acid Aggregates as Drug-Carriers for Paclitaxel.
CONCLUSION: GA aggregation occurs around PTX molecules in solution, forming co-joined GA-PTX cluster units at a ratio of 3:1. These clusters remain stable for the remainder of the 100ns simulation and serve to isolate and protect PTX from the aqueous environment. PMID: 30868954 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 13, 2019 Category: Drugs & Pharmacology Authors: Hussain M Tags: Curr Drug Deliv Source Type: research

Electrospun Transdermal Patch for Contraceptive Hormone Delivery.
CONCLUSION: The LNG-loaded patches demonstrated steady delivery of LNG across skin for up to 5 days in vitro. With additional development, LNG-loaded electrospun PCL patches could be used for long-acting contraception. PMID: 30848203 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 7, 2019 Category: Drugs & Pharmacology Authors: Mofidfar M, Prausnitz MR Tags: Curr Drug Deliv Source Type: research

Nanomedicines as Drug Delivery Carriers of Anti-Tubercular Drugs: From Pathogenesis to Infection Control.
Abstract In spite of advances in tuberculosis (TB) chemotherapy, TB is still air-born deadly disorder as major issue of health concern worldwide today. Extensive researches have been focused to develop novel drug delivery systems to shorten the lengthy therapy approaches, prevention of relapses, reducing dose related toxicities and to rectify technological related drawbacks of anti-tubercular drugs. Moreover, rapid emergence of drug resistance, poor patient compliance due to negative therapeutic outcomes and intracellular survival of Mycobacterium highlighted to develop carrier with optimum effectiveness of the an...
Source: Current Drug Delivery - February 1, 2019 Category: Drugs & Pharmacology Authors: Hussain A, Singh S, Das SS, Anjireddy K, Karpagam S, Shakeel F Tags: Curr Drug Deliv Source Type: research

Topical and transdermal drug delivery: from simple potions to smart technologies.
Abstract This overview on skin delivery considers the evolution of the principles of percutaneous absorption and skin products from ancient times to today. Over the ages, it has been recognised that products may be applied to the skin for either local or systemic effects. Major changes have occurred in our understanding of the skin and the sophistication in our technology to effectively and quantitatively deliver solutes across this barrier to specific target sites in the skin and beyond. We focus on these technologies and their role in skin delivery now and in the future. PMID: 30714524 [PubMed - as supplied...
Source: Current Drug Delivery - February 1, 2019 Category: Drugs & Pharmacology Authors: Benson HAE, Grice JE, Mohammed Y, Namjoshi S, Roberts MS Tags: Curr Drug Deliv Source Type: research

An Overview of Chitosan Nanofibers and their Applications in Drug Delivery Process.
Abstract Chitosan is a polycationic natural polymer which is abundant in nature. Chitosan has gained much attention as natural polymer in the biomedical field. The up to date drug delivery as well as the nanotechnology in controlled release of drugs from chitosan nanofibers are focused in this review. Electrospinning is one of the most established and widely used techniques for preparing nanofibers. This method is versatile and efficient for the production of continuous nanofibers. The chitosan-based nanofibers are emerging materials in the arena of biomaterials. Recent studies revealed that various drugs such as ...
Source: Current Drug Delivery - January 23, 2019 Category: Drugs & Pharmacology Authors: Al-Jbour ND, Beg MD, Gumbung J, Alam AKMM Tags: Curr Drug Deliv Source Type: research

Indinavir-Loaded Nanostructured Lipid Carriers to Brain Drug Delivery: Optimization, Characterization and Neuropharmacokinetic Evaluation.
Abstract As an anti-retroviral protease inhibitor (PI), indinavir (IDV) is part of the regimen known as Highly Active Anti-Retroviral Therapy (HAART) widely used for Human Immunodeficiency Virus (HIV) infection. The drug efficiency in treatment of the brain manifestations of HIV is, however, limited which is mainly due to the efflux by P-glycoprotein (P-gp) expressed at the Blood-Brain Barrier (BBB). To overcome the BBB obstacle, NLCs was attempted in this study as carriers for IDV, which was optimized through two steps: a "one-factor-at-a-time" screening followed by a systematic multi-objective optimiza...
Source: Current Drug Delivery - January 23, 2019 Category: Drugs & Pharmacology Authors: Nasiri M, Azadi A, Zanjani MRS, Hamidi M Tags: Curr Drug Deliv Source Type: research

Stimulus sensitive smart nano platforms: an emerging paradigm for the treatment of skin diseases.
CONCLUSION: Various stimuli explored lately for such nano platforms are pH, temperature, light and magnet. Although, the scientists have actively taken up this research topic but there are still certain lacunaes associated which have been discussed in this review. Further, an interdisciplinary collaboration between the healthcare providers and pharmacists is a pivotal requirement for such systems to be available for patients. PMID: 30674258 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 23, 2019 Category: Drugs & Pharmacology Authors: Thakur D, Kaur G Tags: Curr Drug Deliv Source Type: research

Fenofibrate Solid Dispersion Processed by Hot-melt Extrusion: Elevated Bioavailability and Its Cell Transport Mechanism.
CONCLUSION: In conclusion, PVP VA64 can be regarded as a promising polymer to enhance the bioavailability of poorly water-soluble drugs such as FNB processed by hot-melt extrusion. Besides, investigations on the mechanism of the enhanced penetration are expected to lay a foundation for the subsequent development of effective and practical solid dispersion. PMID: 30674259 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 22, 2019 Category: Drugs & Pharmacology Authors: Wen T, Niu B, Wu Q, Zhou Y, Pan X, Quan G, Wu C Tags: Curr Drug Deliv Source Type: research

Advanced of Lipid based Nanocarriers and Combination Application with Physical Penetration Technique.
Abstract On account of the advantages of transdermal delivery and the application situation of transcutaneous technology in transdermal delivery, the article critically comments nanosystems as permeation enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This review focuses on recent advances in lipid based nanocarriers, including liposome, transfersomes, ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination application of the lipid based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis in the field for...
Source: Current Drug Delivery - January 18, 2019 Category: Drugs & Pharmacology Authors: Yang M, Gu Y, Tang X, Wang T, Liu J Tags: Curr Drug Deliv Source Type: research

Medicated foams and film forming dosage forms as tools to improve the thermodynamic activity of drugs to be administered through the skin.
Abstract Medicated foams and film forming systems are dosage forms formulated to undergo to a controlled metamorphosis when applied on the skin. Indeed, due to the presence of propellant or a particular air-spray foam pump, a liquid can generate a foam when applied on the stratum corneum, or a liquid or conventional dosage form can form on the skin a continuous film as a consequence of the solvent evaporation. Thanks to these controlled modifications, the drug thermodynamic activity increases favoring the skin penetration and, therefore, the bioavailability with respect to conventional semi-solid and liquid dosage...
Source: Current Drug Delivery - January 18, 2019 Category: Drugs & Pharmacology Authors: Gennari CGM, Selmin F, Minghetti P, Cilurzo F Tags: Curr Drug Deliv Source Type: research

The Effect of Focused Ultrasound on Magnetic Polyelectrolyte Capsules Loaded with Dye When Suspended in Tissue-Mimicking Gel.
Abstract Capsules containing a dye were prepared by the LbL method with iron oxide nanoparticles (50 nm) in different layers of the shell. The capsules were dispersed in a gel and subjected to focused ultrasonic irradiation at three different powers and exposure times. It was found that the inclusion of iron oxide magnetic nanoparticles in any of the polyelectrolyte shells (4, 6, 8 and 10) strengthened the capsules with respect to capsules without nanoparticles. Incorporation of nanoparticles in shell 8 provided the most resistance to fragmentation under focused ultrasonic irradiation. The relative degree of capsu...
Source: Current Drug Delivery - January 3, 2019 Category: Drugs & Pharmacology Authors: Stavarache C, Vinatoru M, Mason T Tags: Curr Drug Deliv Source Type: research

Preface.
Abstract PMID: 30523766 [PubMed - in process] (Source: Current Drug Delivery)
Source: Current Drug Delivery - December 15, 2018 Category: Drugs & Pharmacology Authors: Liang XJ Tags: Curr Drug Deliv Source Type: research

Commentary: Lectins and Nanostructured Drug Delivery Systems.
Abstract The advances and the impact of nanostructured systems on therapeutics constitute a constantly evolving reality. New strategies have been developed for drug delivery control and for directing these systems to the targeted site improving the therapy. In this commentary, the lectins are briefly reviewed; their fundamentals and the proposed applications as ligands in nanostructured drug delivery systems are discussed. PMID: 30465501 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 21, 2018 Category: Drugs & Pharmacology Authors: Bruschi ML Tags: Curr Drug Deliv Source Type: research

Formulation and characterization of Genistein-loaded nanostructured lipid carriers: Pharmacokinetic, Biodistribution and In vitro cytotoxicity studies.
CONCLUSION: In a nutshell, GenNLC seems to be a superior alternative carrier system for the formulation industry to obtain the higher entrapment with excellent stability of the formulation. PMID: 30465502 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - November 20, 2018 Category: Drugs & Pharmacology Authors: MIttal P, Vrdhan H, Ajmal G, Bonde G, Kapoor R, Mishra B Tags: Curr Drug Deliv Source Type: research

Label Free Ultrasmall Fluoromagnetic Ferrite-clusters for Targeted Cancer Imaging and Drug Delivery.
Abstract The label free ultrasmall fluorescent ferrite clusters have been engineered in a controlled fashion which was stabilized by serum protein and functionalized by folic acid for the application of targeted multimodal optical and magnetic resonance (MR) cancer imaging. The ultra-small manganese ferrite nanoclusters (PMNCs) with a diameter of 4 nm has commendable effect on the longitudinal (T1) and transverse (T2) relaxation in MR imaging that was evident from the phantom and animal MRI. The calculated longitudinal molar relaxivity of nanoclusters was found to be 6.9 ± 0.10 mM-1 S-1 which was exactly 2....
Source: Current Drug Delivery - November 18, 2018 Category: Drugs & Pharmacology Authors: Haribabu V, Sharmiladevi P, Akhtar N, Farook AS, Girigoswami K, Girigoswami A Tags: Curr Drug Deliv Source Type: research

Sucrose acetate isobutyrate as an in situ-forming implant for sustained release of local anesthetics.
In this study, an injectable sucrose acetate isobutyrate (SAIB) drug delivery system (SADS) was designed and fabricated for the sustained release of ropivacaine (RP) to prolong the duration local anesthesia. By mixing SAIB, RP, and N-methyl-2-pyrrolidone, the SADS was prepared in a sol state with low viscosity before injection. After subcutaneous injection, the pre-gel solution underwent gelation in situ to form a drug-released depot. The in vitro release profiles and in vivo pharmacokinetic analysis indicated that RP-SADS had suitable controlled release properties. Particularly, the RP-SADS significantly reduced the initi...
Source: Current Drug Delivery - November 18, 2018 Category: Drugs & Pharmacology Authors: Li H, Xu Y, Tong Y, Dan Y, Zhou T, He J, Liu S, Zhu Y Tags: Curr Drug Deliv Source Type: research

Preparation, characterization, and in vitro pH-sensitivity evaluation of superparamagnetic iron oxide nanoparticle-misonidazole pH-sensitive liposomes.
Abstract BACKGROUND: The use of misonidazole (MISO), the first and a potential hypoxic tumor cell radiosensitizer, has been limited by peripheral neurotoxicity, thus discouraging phase III clinical trials. OBJECTIVE: To develop a targeted drug delivery and tracing system with pH-sensitive liposomes (SpHLs) and superparamagnetic iron oxide nanoparticles (SPIONs) to counter MISO-related adverse effects and to enable tracing under magnetic resonance. METHODS: SPION-MISO-SpHLs were prepared by a reverse evaporation and freeze-thawing method. HPLC and phenanthroline spectrophotometry were established for MISO...
Source: Current Drug Delivery - November 14, 2018 Category: Drugs & Pharmacology Authors: Li B, Li B, He D, Feng C, Luo Z, He M Tags: Curr Drug Deliv Source Type: research

Graphene Family of Nanomaterials: Reviewing Advanced Applications in Drug delivery and Medicine.
Abstract Graphene in nano form has proved to be one of the most remarkable materials. It has a single atom thick molecular structure and it possesses exceptional physical strength, electrical and electronic properties. Applications of the Graphene family of nanomaterials(GFNs) in different fields of therapy have emerged, including for targeted drug delivery in cancer, gene delivery, antimicrobial therapy, tissue engineering and more recently in more diseases including HIV. This review seeks to analyze current advances of potential applications of graphene and its family of nano-materials for drug delivery and othe...
Source: Current Drug Delivery - October 31, 2018 Category: Drugs & Pharmacology Authors: Joshi K, Mazumder B, Chattopadhyay P, Bora NS, Goyary D, Karmakar S Tags: Curr Drug Deliv Source Type: research

Humanin Nanoparticles for Reducing Pathological Factors Characteristic of Age-Related Macular Degeneration.
CONCLUSIONS: The ability of this drug delivery system to reduce retinal apoptosis with desirable pharmacokinetic and biocompatible properties makes this a promising therapeutic option for AMD. PMID: 30381074 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 31, 2018 Category: Drugs & Pharmacology Authors: Solanki A, Smalling R, Parola AH, Nathan I, Kasher R, Pathak Y, Sutariya V Tags: Curr Drug Deliv Source Type: research

Current updates on bone grafting biomaterials and recombinant human growth factors implanted biotherapy for spinal fusion: A review of human clinical studies.
CONCLUSION: Selection of a particular bone grafting biotherapy can be rationalized based on level of spine fusion, clinical experience and preference of orthopaedic surgeon, and prevalence of donor-site morbidities. PMID: 30360738 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 24, 2018 Category: Drugs & Pharmacology Authors: Li G, Li P, Chen Q, Thu HE, Hussain Z Tags: Curr Drug Deliv Source Type: research

Delivery of dry powders to the lungs: Influence of particle attributes from a biological and technological point of view.
Abstract Dry powder inhalers are medical devices used to deliver powder formulations of active pharmaceutical ingredients via oral inhalation to the lungs. Drug particles, from a biological perspective, should reach the targeted site, dissolve and permeate through the epithelial cell layer in order to deliver a therapeutic effect. However, drug particle attributes that lead to a biological activity are not always consistent with the technical requirements necessary for formulation design. For example, small cohesive drug particles may interact with neighbouring particles, resulting in large aggregates or even aggl...
Source: Current Drug Delivery - October 24, 2018 Category: Drugs & Pharmacology Authors: Zellnitz S, Roblegg E, Pinto J, Frohlich E Tags: Curr Drug Deliv Source Type: research

Gemcitabine-loaded Folic acid Tagged Liposomes: Improved Pharmacokinetic and Biodistribution Profile.
CONCLUSION: In conclusion, the developed GEM-loaded folic acid receptor targeted liposomal formulation could be a promising and potential alternative formulation for further development. PMID: 30360740 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 24, 2018 Category: Drugs & Pharmacology Authors: Sambamoorthy U, Venkataraju MP, Manjappa AS, Rao MEB Tags: Curr Drug Deliv Source Type: research

Permeation Efficacy of a Transdermal Vehicle with Steroidal Hormones and Nonsteroidal Anti-inflammatory Agents as Model Drugs.
CONCLUSION: Thus, the vehicle demonstrated a high performance and the possibility of it being used for drugs that present difficulties in regards to administration by the transdermal route. PMID: 30360741 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 24, 2018 Category: Drugs & Pharmacology Authors: Junqueira LA, Polonini H, Loures S, Raposo NRB, Ferreira AO, Brandaob MAF Tags: Curr Drug Deliv Source Type: research

Facile synthesis of chitosan based-(AMPS-co-AA) semi-IPNs as a potential drug carrier: enzymatic degradation, cytotoxicity, and preliminary safety evaluation.
CONCLUSION: It was confirmed that the hydrogels were degraded more by specific enzyme lysozyme as compare to the non-specific enzyme collagenase. In-vitro cytotoxicity suggested that the unloaded hydrogels were non-cytotoxic while crude drug and drug-loaded hydrogel exhibited dose-dependent cytotoxicity against HCT-116 and MCF-7. Results of acute oral toxicity on rabbits demonstrated that the hydrogels are non-toxic up to 3900 mg/kg after oral administration, as no toxicity or histopathological changes were observed in comparison to control rabbits. These pH-sensitive hydrogels appear to provide ideal basis as a safe carri...
Source: Current Drug Delivery - October 24, 2018 Category: Drugs & Pharmacology Authors: Ullah K, Sohail M, Mannan A, Rashid H, Shah A, Murtaza G, Khan SA Tags: Curr Drug Deliv Source Type: research

Continuous Vector-free Gene Transfer with a Novel Microfluidic Chip and Nanoneedle Array.
In this study, we proposed and established a carrier-free gene delivery platform utilizing staggered herringbone channel and silicon nanoneedle array, to achieve high-throughput in vitro gene transfection. With this microchip, fluidic microvortices could be induced by the staggered-herringbone-shaped grooves within the channel, which increased the contact frequency of the cells with the channel substrate. Transient disruptions on the cell membrane were well established by the nanoneedle array on the substrate. Compared to conventional nanoneedle-based delivery system, proposed microfluidic chip achieved flow-through treatm...
Source: Current Drug Delivery - October 16, 2018 Category: Drugs & Pharmacology Authors: Huang D, Zhao D, Li J, Wu Y, Du L, Xia XH, Li X, Deng Y, Li Z, Huang Y Tags: Curr Drug Deliv Source Type: research

The Superior Antitumor Effect of Self-Assembled Paclitaxel Nano-filaments for Lung Cancer Cells.
CONCLUSION: The current work demonstrated that P-NFs nano-filaments showed superior cytotoxicity of lung cancer cells, highlighting a novel profile of nano-filaments delivery systems as potential strategies for facilitating the therapeutic efficacy of Ptx in lung cancer treatment. PMID: 30332958 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 16, 2018 Category: Drugs & Pharmacology Authors: He M, Zhu J, Yu N, Kong H, Zeng X, Xie W, Xu H Tags: Curr Drug Deliv Source Type: research

Utilization of Apatinib-Loaded Nanoparticles for the Treatment of Ocular Neovascularization.
Abstract The current treatment of ocular neovascularization requires frequent intravitreal injections of anti- vascular endothelial growth factor (VEGF) agents that cause severe side effects. The purpose of this study is to prepare and characterize a novel nanoscale delivery system of apatinib for ocular neovascularization. The optimized formulation showed a particle size of 135.04 nm, polydispersity index (PDI) of 0.28 ± 0.07, encapsulation efficiency (EE) of 65.92%, zeta potential (ZP) of -23.70 ± 8.69 mV, and pH of 6.49 ± 0.20. In vitro release was carried out to demonstrate a 3.13-fold inc...
Source: Current Drug Delivery - October 16, 2018 Category: Drugs & Pharmacology Authors: Halasz K, Kelly SJ, Iqbal MT, Pathak Y, Sutariya V Tags: Curr Drug Deliv Source Type: research

Formulation and evaluation of neuroactive drug loaded chitosan nanoparticle for nose to brain delivery: In-vitro characterization and In-vivo behavior study.
Abstract The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nano particle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via nasal route. The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study. The developed RIS-CH-LNPs showed nanometric size range with high...
Source: Current Drug Delivery - October 11, 2018 Category: Drugs & Pharmacology Authors: Qureshi M, Aqil M, Imam SS, Ahad A, Sultana Y Tags: Curr Drug Deliv Source Type: research

Solid Lipid Nanoparticles and Chitosan-coated Solid Lipid Nanoparticles as Promising Tool for Silybin Delivery: Formulation, Characterization, and In Vitro Evaluation.
CONCLUSIONS: Together with the excellent stability, strong mucoadhesive property, and slow release, chitosan coated SLNs demonstrated promising potential to enhance absorption of hydrophobic Sb after oral administration. PMID: 30306869 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - October 8, 2018 Category: Drugs & Pharmacology Authors: Piazzini V, Cinci L, D'Ambrosio M, Luceri C, Bilia AR, Bergonzi MC Tags: Curr Drug Deliv Source Type: research

Nose to brain delivery of galantamine loaded nanoparticles: In-vivo pharmacodynamic and biochemical study in mice.
Abstract BACKGROUND: Presence of blood brain barrier is one of the major hurdle in drug delivery to brain for the treatment of neurological diseases. Alternative and more effective drug delivery approaches have been investigated for the drug targeting to brain in therapeutic range. OBJECTIVE: The present investigation was carried out to improve the galantamine bioavailability in brain by intranasal drug delivery through thiolated chitosan nanoparticles and compared to nasal and oral delivery of its solution using pharmacodynamic activity as well as biochemical estimation. METHOD: Thiolated chitosan (modi...
Source: Current Drug Delivery - October 3, 2018 Category: Drugs & Pharmacology Authors: Jha S, Singh SK, Mishra DN Tags: Curr Drug Deliv Source Type: research

Development of Biodegradable injectable in situ forming implants for sustained release of Lornoxicam.
CONCLUSION: Lornoxicam can be successfully formulated as in situ injectable implant that provides long term management of inflammatory disorders with improved patient compliance. PMID: 30264681 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 27, 2018 Category: Drugs & Pharmacology Authors: Christian R, Thakkar V, Patel T, Gohel M, Baldaniya L, Shah P, Pandya T, Gandhi T Tags: Curr Drug Deliv Source Type: research

A new therapeutic approach for brain delivery of Epigallocatechin gallate: Development and characterization studies.
CONCLUSION: The results indicate that the EGCG loaded SLNs provide a potential drug delivery system for improved delivery of EGCG to the brain, hence, enhancing its brain bioavailability. PMID: 30255756 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 26, 2018 Category: Drugs & Pharmacology Authors: Kaur H, Kumar B, Chakrabarti A, Medhi B, Modi M, Radotra BD, Aggarwal R, Sinha VR Tags: Curr Drug Deliv Source Type: research

Controlled release of doxycycline by magnetized microporous MIL53(Fe); focus on magnetization and drug loading.
Abstract In this research, MIL-53(Fe) was magnetized and the performance of the magnetized material as a drug delivery system for doxycycline was studied. The experiments were designed to load the magnetic delivery compounds with different amount of the drug. The In vitro release rate of doxycycline from magnetic MIL-53(Fe) with different drug content into saline buffered fluid (SBF, pH=7.4) and phosphate buffered saline (PBS, pH=3) was then studied. The results showed that the releasing process of the drug in PBS media achieve to the equilibration within 48h with 98% of releasing efficiency, while the releasing p...
Source: Current Drug Delivery - September 26, 2018 Category: Drugs & Pharmacology Authors: Naeimi S, Faghihian H Tags: Curr Drug Deliv Source Type: research

Improved in vivo effect of chrysin as an absorption enhancer via the preparation of solid dispersion with Brij ®L4 and aminoclay.
CONCLUSION: The SD formulation of chrysin with Brij®L4 and aminoclay appeared to be promising in improving the dissolution of chrysin and enhancing its in vivo effect as an absorption enhancer. PMID: 30246640 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 24, 2018 Category: Drugs & Pharmacology Authors: Hoon Lee S, Lee YS, Song JG, Han HK Tags: Curr Drug Deliv Source Type: research

Aspects of nanomaterials in wound healing.
Abstract Wound infections impose a remarkable clinical challenge that has a considerable influence on morbidity and mortality of patients, resulting in huge impact on economy. The unprecedented advancements in molecular biology have come up with new molecular and cellular targets that can be successfully applied to develop smarter therapeutics against diversified categories of wounds. In the recent years, nanotechnology has achieved a new horizon in the arena of wound care due to its ability to deliver plethora of therapeutics into the target site. In addition, nanomaterials being a controlled-release formulation ...
Source: Current Drug Delivery - September 18, 2018 Category: Drugs & Pharmacology Authors: Chakrabarti S, Chattopadhyay P, Islam J, Ray S, Raju PS, Mazumder B Tags: Curr Drug Deliv Source Type: research

Breaking the barrier of cancer through liposome loaded with phytochemicals.
Abstract Currently the most important cause of death is cancer. To treat the cancer there are a number of drugs existing in the market but no drug is found to be completely safe and effective. The toxicity of the drugs is the key problem in the cancer chemotherapy. However, plants and plant derived bioactive molecule have proved safe and effective in the treatment of cancers. Phytochemicals that are found in fruits, vegetables, herbs, and plant extract have been usually used for treating cancer. It has been established that several herbal drug have a strong anticancer activity. However, their poor bioavailability,...
Source: Current Drug Delivery - September 18, 2018 Category: Drugs & Pharmacology Authors: Giri TK Tags: Curr Drug Deliv Source Type: research

Fabrication and Characterization of Electrospun Nanofibers for the Modified Release of the Chronobiotic Hormone Melatonin.
Abstract Aiming at the modified release of melatonin (MLT), electrospun-MLT loaded nanofibers, filled into hard gelatin and DRcapsTM capsules, were used as formulants. Cellulose acetate, polyvinylpyrrolidinone and hydroxypropylmethylcellusose (HPMC 2910) were used for the preparation of the fiber matrices through electrospinning. The in vitro modified release profile of MLT from the fabricated matrices in gastrointestinal-like fluids was studied. At pH 1.2, the formulations CA1, CA2, PV1, HP1, HP2 and the composite formulations CAPV1-CAPV5 in hard gelatin capsules exhibited fast MLT release. In general, the same t...
Source: Current Drug Delivery - September 13, 2018 Category: Drugs & Pharmacology Authors: Vlachou M, Kikionis S, Siamidi A, Tragou K, Kapoti S, Ioannou E, Roussis V, Tsotinis A Tags: Curr Drug Deliv Source Type: research

Insights on the use of nanocarriers for acne alleviation.
Abstract Among the common myths in the cosmetics industry is the perception that acne only happens to teenagers, and specifically to females. However, acne is not limited to a specific age, neither to a certain gender, and it creates a stressful problem for many people. Many chemical treatments for acne were proven to be successful, but when administered as such they showed many adverse effects, starting from itching to skin dryness and inflammation. Natural remedies have also been explored for acne treatment, and despite their safety, they suffered many stability problems attributed to their physicochemical prope...
Source: Current Drug Delivery - September 13, 2018 Category: Drugs & Pharmacology Authors: Amer SS, Nasr M, Mamdouh W, Sammour O Tags: Curr Drug Deliv Source Type: research