Development and in vitro and in vivo evaluations of a microemulsion formulation for the oral delivery of oxaprozin
CONCLUSION: The obtained data revealed satisfactory results for this novel microemulsion of oxaprozin, which is very meaningful for clinical trials.PMID:34521326 | DOI:10.2174/1567201818666210914092745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 15, 2021 Category: Drugs & Pharmacology Authors: Fangming Yin Shu Meng Xin Zhao Huining Wang Yingkai Ning Yangdulin Li Zaixing Chen Source Type: research

Development and in vitro and in vivo evaluations of a microemulsion formulation for the oral delivery of oxaprozin
CONCLUSION: The obtained data revealed satisfactory results for this novel microemulsion of oxaprozin, which is very meaningful for clinical trials.PMID:34521326 | DOI:10.2174/1567201818666210914092745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 15, 2021 Category: Drugs & Pharmacology Authors: Fangming Yin Shu Meng Xin Zhao Huining Wang Yingkai Ning Yangdulin Li Zaixing Chen Source Type: research

Development and in vitro and in vivo evaluations of a microemulsion formulation for the oral delivery of oxaprozin
CONCLUSION: The obtained data revealed satisfactory results for this novel microemulsion of oxaprozin, which is very meaningful for clinical trials.PMID:34521326 | DOI:10.2174/1567201818666210914092745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 15, 2021 Category: Drugs & Pharmacology Authors: Fangming Yin Shu Meng Xin Zhao Huining Wang Yingkai Ning Yangdulin Li Zaixing Chen Source Type: research

Development and in vitro and in vivo evaluations of a microemulsion formulation for the oral delivery of oxaprozin
CONCLUSION: The obtained data revealed satisfactory results for this novel microemulsion of oxaprozin, which is very meaningful for clinical trials.PMID:34521326 | DOI:10.2174/1567201818666210914092745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 15, 2021 Category: Drugs & Pharmacology Authors: Fangming Yin Shu Meng Xin Zhao Huining Wang Yingkai Ning Yangdulin Li Zaixing Chen Source Type: research

Nanotherapeutics for Alzheimer's Disease with Preclinical Evaluation and Clinical Trials: Challenges, Promises and Limitations
Curr Drug Deliv. 2021 Sep 10. doi: 10.2174/1567201818666210910162750. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a progressive and irreversible neurodegenerative disorder, is the most common form of dementia worldwide. Currently, there is no disease-modifying AD drug, and the development of effective treatments is made even harder by the highly selective nature of the blood-brain barrier (BBB) that allows the passage only of molecules with specific chemical-physical properties. In this context, nanomedicine and its nanoparticles (NPs) offer potential solutions to the challenge of AD therapy, in particular, the...
Source: Current Drug Delivery - September 13, 2021 Category: Drugs & Pharmacology Authors: Syed Nasir Abbas Bukhari Source Type: research

Nanotherapeutics for Alzheimer's Disease with Preclinical Evaluation and Clinical Trials: Challenges, Promises and Limitations
Curr Drug Deliv. 2021 Sep 10. doi: 10.2174/1567201818666210910162750. Online ahead of print.ABSTRACTAlzheimer's disease (AD), a progressive and irreversible neurodegenerative disorder, is the most common form of dementia worldwide. Currently, there is no disease-modifying AD drug, and the development of effective treatments is made even harder by the highly selective nature of the blood-brain barrier (BBB) that allows the passage only of molecules with specific chemical-physical properties. In this context, nanomedicine and its nanoparticles (NPs) offer potential solutions to the challenge of AD therapy, in particular, the...
Source: Current Drug Delivery - September 13, 2021 Category: Drugs & Pharmacology Authors: Syed Nasir Abbas Bukhari Source Type: research

Preparation and evaluation of valnemulin hydrochloride taste-masking granules
CONCLUSION: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.PMID:34477518 | DOI:10.2174/1567201818666210903151658 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Yongjie Liang Danlei Hu Yuanyuan Yan Dongmei Chen Shuyu Xie Source Type: research

Enhanced Mefenamic Acid Release from Poloxamer-Silicon Dioxide Gel Filled in Hard Gelatin Capsules - An application of Liquid Semisolid Matrix Technology for Insoluble Drug
CONCLUSION: No chemical drug-polymer interactions were found in FTIR. The release of practically insoluble mefenamic acid could be enhanced from gel formulated with L64 and SiO2.PMID:34477519 | DOI:10.2174/1567201818666210903152618 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Misbah Sultana Safia Sultana Khalid Hussain Tariq Saeed Mobashar Ahmad Butt Syed Atif Raza Rizwan Mahmood Saeed Hassan Ubaid Ullah Anwer Nadeem Irfan Bukhari Source Type: research

Preparation and evaluation of valnemulin hydrochloride taste-masking granules
CONCLUSION: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.PMID:34477518 | DOI:10.2174/1567201818666210903151658 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Yongjie Liang Danlei Hu Yuanyuan Yan Dongmei Chen Shuyu Xie Source Type: research

Enhanced Mefenamic Acid Release from Poloxamer-Silicon Dioxide Gel Filled in Hard Gelatin Capsules - An application of Liquid Semisolid Matrix Technology for Insoluble Drug
CONCLUSION: No chemical drug-polymer interactions were found in FTIR. The release of practically insoluble mefenamic acid could be enhanced from gel formulated with L64 and SiO2.PMID:34477519 | DOI:10.2174/1567201818666210903152618 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Misbah Sultana Safia Sultana Khalid Hussain Tariq Saeed Mobashar Ahmad Butt Syed Atif Raza Rizwan Mahmood Saeed Hassan Ubaid Ullah Anwer Nadeem Irfan Bukhari Source Type: research

Preparation and evaluation of valnemulin hydrochloride taste-masking granules
CONCLUSION: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.PMID:34477518 | DOI:10.2174/1567201818666210903151658 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Yongjie Liang Danlei Hu Yuanyuan Yan Dongmei Chen Shuyu Xie Source Type: research

Enhanced Mefenamic Acid Release from Poloxamer-Silicon Dioxide Gel Filled in Hard Gelatin Capsules - An application of Liquid Semisolid Matrix Technology for Insoluble Drug
CONCLUSION: No chemical drug-polymer interactions were found in FTIR. The release of practically insoluble mefenamic acid could be enhanced from gel formulated with L64 and SiO2.PMID:34477519 | DOI:10.2174/1567201818666210903152618 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Misbah Sultana Safia Sultana Khalid Hussain Tariq Saeed Mobashar Ahmad Butt Syed Atif Raza Rizwan Mahmood Saeed Hassan Ubaid Ullah Anwer Nadeem Irfan Bukhari Source Type: research

Preparation and evaluation of valnemulin hydrochloride taste-masking granules
CONCLUSION: The granules developed in this study could obviously improve the palatability and sustained release of valnemulin hydrochloride. The producing method of granules by combining solid dispersion powder with wet granulation can provide ideas for other drugs with poor palatability and a short half-life.PMID:34477518 | DOI:10.2174/1567201818666210903151658 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Yongjie Liang Danlei Hu Yuanyuan Yan Dongmei Chen Shuyu Xie Source Type: research

Enhanced Mefenamic Acid Release from Poloxamer-Silicon Dioxide Gel Filled in Hard Gelatin Capsules - An application of Liquid Semisolid Matrix Technology for Insoluble Drug
CONCLUSION: No chemical drug-polymer interactions were found in FTIR. The release of practically insoluble mefenamic acid could be enhanced from gel formulated with L64 and SiO2.PMID:34477519 | DOI:10.2174/1567201818666210903152618 (Source: Current Drug Delivery)
Source: Current Drug Delivery - September 3, 2021 Category: Drugs & Pharmacology Authors: Misbah Sultana Safia Sultana Khalid Hussain Tariq Saeed Mobashar Ahmad Butt Syed Atif Raza Rizwan Mahmood Saeed Hassan Ubaid Ullah Anwer Nadeem Irfan Bukhari Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Release kinetics of hydroxypropyl methylcellulose governing drug release and hydrodynamic changes of matrix tablet
CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release-modulating mechanism in the hydrophilic matrix system.PMID:34420504 | DOI:10.2174/1567201818666210820101549 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 23, 2021 Category: Drugs & Pharmacology Authors: Chulhun Park Jong Hoon Lee Gang Jin Hai Van Ngo Jun-Bom Park Thao T D Tran Phuong H L Tran Beom-Jin Lee Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Anticancer Effect of Alginate-Chitosan Hydrogel Loaded with Curcumin and Chrysin on Lung and Breast Cancer Cell Lines
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813142007. Online ahead of print.ABSTRACTOBJECTIVE: We conducted the present study to investigate the anticancer effects of curcumin and chrysin loaded in the alginate-chitosan hydrogel on breast cancer (T47D) and lung cancer (A549).BACKGROUND: Cancer, which is defined as abnormal cell growth, is one of the biggest public health problems in the world. Natural compounds, such as polyphenols, are used as chemo-preventive and chemotherapeutic agents in different types of cancer owing to their antioxidant, antineoplastic, and cytotoxic properties. To improve their bioa...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Farhad Abbasalizadeh Effat Alizadeh Seyyed Mohammad Bagher Fazljou Mohammadali Torbati Abolfazl Akbarzadeh Source Type: research

A brief review of the essential role of nanovehicles for improving the therapeutic efficacy of pharmacological agents against tumours
Curr Drug Deliv. 2021 Aug 13. doi: 10.2174/1567201818666210813144105. Online ahead of print.ABSTRACTCancer is the leading cause of death globally. There are several differences between cancer cells and normal cells. From all the therapies, chemotherapy is the most prominent therapy to treat cancer. However, the conventional drug delivery that is used to deliver poorly aqueous soluble chemotherapeutic agents has several obstacles such as whole-body distribution, rapid excretion, degradation before reaching the infected site, side effects, etc. Nanoformulation of these aqueous insoluble agents is the emerging delivery system...
Source: Current Drug Delivery - August 15, 2021 Category: Drugs & Pharmacology Authors: Nitin Gupta Virendra Yadav Rakesh Patel Source Type: research

Physical characterization and In Vitro evaluation of dissolution rate from Cefpodoxime proxetil loaded Self solidifying Solid SNEDDS
This study investigated the challenges of developing ternary components based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying behaviour.METHOD: Tween 80, Transcutol and PEG6000 were employed as surfactant, solvent & solidifying a base of ternary components to develop self-solidifying solid SNEDDS, respectively. Ternary phase diagrams were used to characterize solidifying behaviour of ternary components in different proportions. S-SNEDDS formulations were drawn on the solidification areas available in the phase diagram and characterized for IR, XRD, DSC and in-vitro drug release in ...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Pankaj Kumar Sharma Vikesh Kumar Shukla Anoop Kumar Source Type: research

Enhancement of the solubility of asenapine maleate through the preparation of co-crystals
CONCLUSION: co-crystals were prepared successfully by improving the solubility/dissolution rate of asenapine maleate, and were expected to enhance the bioavailability of the drug.PMID:34353260 | DOI:10.2174/1567201818666210805154345 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Suhair S Al-Nimry Mai S Khanfar Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research

Abuse Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth
CONCLUSION: Many challenges are faced throughout the development of abuse deterrent formulations. These formulations displayed substantial drop in abuse incidences but it may lead to other modes of abuse which may prove more harmful for the users.PMID:34353262 | DOI:10.2174/1567201818666210805145819 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Parmita Phaugat Suchitra Nishal Rakhi Dhiman Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Physical characterization and In Vitro evaluation of dissolution rate from Cefpodoxime proxetil loaded Self solidifying Solid SNEDDS
This study investigated the challenges of developing ternary components based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying behaviour.METHOD: Tween 80, Transcutol and PEG6000 were employed as surfactant, solvent & solidifying a base of ternary components to develop self-solidifying solid SNEDDS, respectively. Ternary phase diagrams were used to characterize solidifying behaviour of ternary components in different proportions. S-SNEDDS formulations were drawn on the solidification areas available in the phase diagram and characterized for IR, XRD, DSC and in-vitro drug release in ...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Pankaj Kumar Sharma Vikesh Kumar Shukla Anoop Kumar Source Type: research

Enhancement of the solubility of asenapine maleate through the preparation of co-crystals
CONCLUSION: co-crystals were prepared successfully by improving the solubility/dissolution rate of asenapine maleate, and were expected to enhance the bioavailability of the drug.PMID:34353260 | DOI:10.2174/1567201818666210805154345 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Suhair S Al-Nimry Mai S Khanfar Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research

Abuse Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth
CONCLUSION: Many challenges are faced throughout the development of abuse deterrent formulations. These formulations displayed substantial drop in abuse incidences but it may lead to other modes of abuse which may prove more harmful for the users.PMID:34353262 | DOI:10.2174/1567201818666210805145819 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Parmita Phaugat Suchitra Nishal Rakhi Dhiman Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Physical characterization and In Vitro evaluation of dissolution rate from Cefpodoxime proxetil loaded Self solidifying Solid SNEDDS
This study investigated the challenges of developing ternary components based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying behaviour.METHOD: Tween 80, Transcutol and PEG6000 were employed as surfactant, solvent & solidifying a base of ternary components to develop self-solidifying solid SNEDDS, respectively. Ternary phase diagrams were used to characterize solidifying behaviour of ternary components in different proportions. S-SNEDDS formulations were drawn on the solidification areas available in the phase diagram and characterized for IR, XRD, DSC and in-vitro drug release in ...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Pankaj Kumar Sharma Vikesh Kumar Shukla Anoop Kumar Source Type: research

Enhancement of the solubility of asenapine maleate through the preparation of co-crystals
CONCLUSION: co-crystals were prepared successfully by improving the solubility/dissolution rate of asenapine maleate, and were expected to enhance the bioavailability of the drug.PMID:34353260 | DOI:10.2174/1567201818666210805154345 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Suhair S Al-Nimry Mai S Khanfar Source Type: research

siRNA as a potential therapy for COVID-19
Curr Drug Deliv. 2021 Aug 5. doi: 10.2174/1567201818666210805145320. Online ahead of print.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) is a highly contagious virus causing COVID-19 disease that severely impacted the world health, education, and economy systems in 2020. The numbers of infection cases and reported deaths are still increasing with no specific treatment identified yet to halt this pandemic. Currently, several proposed treatments are under preclinical and clinical investigations now, alongside the race to vaccinate to as much individuals as possible. The genome of SARS-CoV2 share similar...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Ahmad Aljaberi Eman M Migdadi Khalid M Abu Khadra Mahmoud Abu Samak Iman A Basheti Nizar Al-Zoubi Source Type: research

Abuse Deterrent Formulations in Constraining the Abuse Potential of Prescription Medicines: A Myth or Truth
CONCLUSION: Many challenges are faced throughout the development of abuse deterrent formulations. These formulations displayed substantial drop in abuse incidences but it may lead to other modes of abuse which may prove more harmful for the users.PMID:34353262 | DOI:10.2174/1567201818666210805145819 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Parmita Phaugat Suchitra Nishal Rakhi Dhiman Source Type: research

Formulation and evaluation of hydroxypropylmethylcellulose-dicyclomine microsponges for colon targeted drug delivery: In vitro and in vivo evaluation
CONCLUSION: The current study shows a new approach for colon specific delivery of DCH based on microsponges.PMID:34353263 | DOI:10.2174/1567201818666210805153347 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Muhammad Sher Rai Muhammad Sarfaraz Sadia Iqbal Muhammad Ajaz Hussain Muhammad Naeem-Ul-Hassan Faiza Hassan Syed Nasir Abbas Bukhari Source Type: research

Physical characterization and In Vitro evaluation of dissolution rate from Cefpodoxime proxetil loaded Self solidifying Solid SNEDDS
This study investigated the challenges of developing ternary components based on solid SNEDDS of CPD for in vitro dissolution rate enhancement and self-solidifying behaviour.METHOD: Tween 80, Transcutol and PEG6000 were employed as surfactant, solvent & solidifying a base of ternary components to develop self-solidifying solid SNEDDS, respectively. Ternary phase diagrams were used to characterize solidifying behaviour of ternary components in different proportions. S-SNEDDS formulations were drawn on the solidification areas available in the phase diagram and characterized for IR, XRD, DSC and in-vitro drug release in ...
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Pankaj Kumar Sharma Vikesh Kumar Shukla Anoop Kumar Source Type: research

Enhancement of the solubility of asenapine maleate through the preparation of co-crystals
CONCLUSION: co-crystals were prepared successfully by improving the solubility/dissolution rate of asenapine maleate, and were expected to enhance the bioavailability of the drug.PMID:34353260 | DOI:10.2174/1567201818666210805154345 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 6, 2021 Category: Drugs & Pharmacology Authors: Suhair S Al-Nimry Mai S Khanfar Source Type: research