Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Cyclodextrin based nanosponges: A multidimensional drug delivery system and its biomedical applications
Curr Drug Deliv. 2021 Apr 22. doi: 10.2174/1567201818666210423091250. Online ahead of print.ABSTRACTCyclodextrin based nanosponges are the designed nanocarriers for projected delivery of complex drugs. They are multifunctional hypercrosslinked cyclodextrin polymers connected in a three dimensional, mesh like network. Their functional characteristics can be fabricated by using different crosslinkers or their different rations with polymer. They can encapsulate various hydrophilic, lipophilic, small sized or large sized drug molecules. They offer formulation flexibility and are primarily used for solubility, bioavailability ...
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Preeti Tanaji Mane Balaji Sopanrao Wakure Pravin Shridhar Wakte Source Type: research

Optimization of Nanostructured Lipid Carriers of Fenofibrate Using a Box-Behnken Design for Oral Bioavailability Enhancement
CONCLUSION: A Box-Behnken design was successfully applied to optimize FNB-NLC formulation for the enhancement of the dissolution and bioavailability of FNB, a poorly water-soluble drug.PMID:33902411 | DOI:10.2174/1567201818666210423110745 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 27, 2021 Category: Drugs & Pharmacology Authors: Huijuan Wang Wei Hong Xiangyu Li Qian Jin Weifeng Yea Yumiao Feng Biyao Huang Zhongjia Tai Lu Chen Zhiping Li Yuli Wang Yang Yang Chunsheng Gao Wei Gong Meiyan Yang Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Physical characterisation and stability study of formulated Chromolaena odorata gel
CONCLUSION: C. odorata gel has shown to be stable, reflecting the combination of materials used in the formulation, which did not degrade throughout the study. This work suggests the potential of this gel as a vehicle to deliver the active ingredients of C. odorata to the skin, which can be further explored as a topical application in antimicrobial wound management or other skin diseases study.PMID:33874872 | DOI:10.2174/1567201818666210419114809 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 20, 2021 Category: Drugs & Pharmacology Authors: Qurratul Ain Zakirah Mohd Zamram Hannis Fadzillah Mohsin Mashani Mohamad Mohamad Nurul Aqmar Mohamad Nor Hazalin Khuriah Abdul Hamid Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery
CONCLUSION: FA-F87-PLGA/TPGS mixed NPs are potential candidates for targeted drug delivery systems.PMID:33845742 | DOI:10.2174/1567201818666210412123210 (Source: Current Drug Delivery)
Source: Current Drug Delivery - April 13, 2021 Category: Drugs & Pharmacology Authors: Tianyi Wu Yanchun Gong Ziling Li Yuping Li Xiangyuan Xiong Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research

Green synthesized Silver Nanoparticles as Silver Lining in Antimicrobial Resistance: A Review
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331123022. Online ahead of print.ABSTRACTUnprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Sonia Parashar Manish Kumar Sharma Chanchal Garg Munish Garg Source Type: research

Magnesium aluminium silicate-metformin hydrochloride complexes - The use of isothermal calorimetry in probing the understanding of clay and drug nanocomplexations
This study reports the use of Isothermal Calorimetry (ITC) in understanding the complexation process occurring between Magnesium Aluminium Silicate (MAS) and metformin hydrochloride (MET), as a potential controlled release drug delivery system. The calorimetric results confirmed the binding between MET and MAS at various pHs (5, 7 and 9) and temperatures (25 ºC and 37 ºC). The overall change in enthalpy was found to be exothermic with a comparatively small entropic contribution to the total change in Gibbs free energy, implying that the binding was an enthalpically driven process. These findings suggest that the ...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Ana-Maria Totea Irina Dorin Peter R Laity Barbara R Conway Laura Waters Kofi Asare-Addo Source Type: research

Novel Pulmonary Delivery of Antiviral Drugs for Treating COVID-19 in Patients with Parkinson's Disease
Curr Drug Deliv. 2021 Mar 31. doi: 10.2174/1567201818666210331121803. Online ahead of print.ABSTRACTThe COVID-19 pandemic has caused a significant burden on public health worldwide. Currently, there are limited medications for the treatment of COVID-19 in patients with Parkinson's disorder (PD). Several antiviral drugs and other pharmacotherapies have shown promise and are used by various delivery methods. Among the antiviral drugs, amantadine alone was reported to provide therapeutic benefit against COVID-19 in patients with PD. Here we propose novel strategies for pulmonary drug delivery technology of antiviral drug aman...
Source: Current Drug Delivery - April 2, 2021 Category: Drugs & Pharmacology Authors: Nazrul Islam Shafiqur Rahman Source Type: research