Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3β and β-catenin signaling pathway in PC12 cells
Publication date: July 2016 Source:Neurochemistry International, Volume 97 Author(s): Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zhi-Xiu Lin Beta-amyloid (Aβ) accumulation, one of the most important pathogenic traits of Alzheimer's disease (AD), has been reported to induce neurotoxicity in vitro as well as in vivo. Honokiol, isolated from the bark of Magnolia officinalis, has neuroprotective effects in different models of AD in vivo and in vitro. However, the exact mechanism for its neuroprotective effect is not well understood. The present study aimed to investigate the molecular mechanisms underlying the pr...
Source: Neurochemistry International - June 15, 2016 Category: Neuroscience Source Type: research
Potential lipase inhibitors from Chinese medicinal herbs.
CONCLUSION: 20(S)-ginsenoside Rg3 and honokiol might be suitable candidates for the treatment of obesity.
PMID: 27267857 [PubMed - as supplied by publisher] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - June 11, 2016 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer
In this study, the epigenetic effects of magnolol and PM in NSCLC were examined in vitro and in vivo. Results revealed that magnolol and PM significantly suppressed the expression levels and function of class I histone deacetylases (HDACs). In A549 and H1299 cells, magnolol and PM remarkably induced cell apoptosis by arresting the cell cycle in the G0/G1 phase while simultaneously activating various pro-apoptotic signals, including TRAIL-R2 (DR5), Bax, caspase 3, cleaved caspase 3, and cleaved PARP. However, these apoptosis-promoting effects could be attenuated by TSA, which is a specific class I HDACs inhibitor. ChIP assa...
Source: Pharmacological Research - June 3, 2016 Category: Drugs & Pharmacology Source Type: research
Honokiol induces autophagic cell death in malignant glioma through reactive oxygen species-mediated regulation of the p53/PI3K/Akt/mTOR signaling pathway.
Abstract
Honokiol, an active constituent extracted from the bark of Magnolia officinalis, possesses anticancer effects. Apoptosis is classified as type I programmed cell death, while autophagy is type II programmed cell death. We previously proved that honokiol induces cell cycle arrest and apoptosis of U87 MG glioma cells. Subsequently in this study, we evaluated the effect of honokiol on autophagy of glioma cells and examined the molecular mechanisms. Administration of honokiol to mice with an intracranial glioma increased expressions of cleaved caspase 3 and light chain 3 (LC3)-II. Exposure of U87 MG ce...
Source: Toxicology and Applied Pharmacology - May 24, 2016 Category: Toxicology Authors: Lin CJ, Chen TL, Tseng YY, Wu GJ, Hsieh MH, Lin YW, Chen RM Tags: Toxicol Appl Pharmacol Source Type: research
Combined effect of honokiol and rosiglitazone on cell growth inhibition through enhanced G0/G1 phase arrest in hepatoma cells
Conclusion Honokiol combined with rosiglitazone showed more effective growth inhibition in hepatoma cells mediated through the regulation of G0/G1 phase-related proteins p21, cyclin D1, cyclin E1, and Rb and cell cycle progression. (Source: Journal of the Chinese Medical Association)
Source: Journal of the Chinese Medical Association - April 16, 2016 Category: Journals (General) Source Type: research
Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas.
In conclusion, the Hono-Mag exerts a synergistic anti-tumor effect by inhibiting cell proliferation and inducing autophagy and apoptosis in human GBM cells. The Hono-Mag may be applied as an adjuvant therapy to improve the therapeutic efficacy of GBM treatment.
PMID: 27074557 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - April 15, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Phenylethanoid glycosides and phenolic glycosides from stem bark of Magnolia officinalis
Publication date: Available online 13 April 2016 Source:Phytochemistry Author(s): Zhenzhen Xue, Renyi Yan, Bin Yang An investigation of the hydrophilic constituents of the stem bark of Magnolia officinalis was performed and which led to isolation and identification of twenty-one previously unreported glycosides. These included eleven phenylethanoid glycosides, magnolosides F–P, and ten phenolic glycosides, magnolosides Q–Z, along with eight known compounds. Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical hydrolysis methods, as well as by comparison with literatur...
Source: Phytochemistry - April 13, 2016 Category: Chemistry Source Type: research
Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages.
Authors: Jeong SJ, Kim OS, Yoo SR, Seo CS, Kim Y, Shin HK
Abstract
Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional Korean medicine. In the present study, the anti‑inflammatory and antioxidant effects of GHJGS were inve...
Source: Molecular Medicine Reports - April 9, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Honokiol inhibits sphere formation and xenograft growth of oral cancer side population cells accompanied with JAK/STAT signaling pathway suppression and apoptosis induction
Eliminating cancer stem cells (CSCs) has been suggested for prevention of tumor recurrence and metastasis. Honokiol, an active compound of Magnolia officinalis, had been proposed to be a potential candidate drug ... (Source: BMC Cancer)
Source: BMC Cancer - March 24, 2016 Category: Cancer & Oncology Authors: Jhy-Shrian Huang, Chih-Jung Yao, Shuang-En Chuang, Chi-Tai Yeh, Liang-Ming Lee, Ruei-Ming Chen, Wan-Ju Chao, Jacqueline Whang-Peng and Gi-Ming Lai Source Type: research
Protective effects of honokiol against methylglyoxal-induced osteoblast damage
Publication date: Available online 24 December 2015 Source:Chemico-Biological Interactions Author(s): Kwang Sik Suh, Suk Chon, Eun Mi Choi Honokiol is an active compound isolated from Magnolia officinalis that has been used without notable side effects in traditional medicine. We investigated the effects of honokiol against methylglyoxal (MG)-induced cytotoxicity in MC3T3-E1 osteoblast cells and the possible molecular mechanism(s) involved. The results showed that honokiol alleviated MG-induced cell death and the production of intracellular ROS, mitochondrial superoxide, cardiolipin peroxidation, and inflammatory...
Source: Chemico Biological Interactions - December 25, 2015 Category: Biochemistry Source Type: research
Protective effects of honokiol against methylglyoxal-induced osteoblast damage.
Abstract
Honokiol is an active compound isolated from Magnolia officinalis that has been used without notable side effects in traditional medicine. We investigated the effects of honokiol against methylglyoxal (MG)-induced cytotoxicity in MC3T3-E1 osteoblast cells and the possible molecular mechanism(s) involved. The results showed that honokiol alleviated MG-induced cell death and the production of intracellular ROS, mitochondrial superoxide, cardiolipin peroxidation, and inflammatory cytokines. MG induction of the soluble receptor for advanced glycation end product (AGE) was reduced by pretreatment with ...
Source: Chemico-Biological Interactions - December 24, 2015 Category: Molecular Biology Authors: Suh KS, Chon S, Choi EM Tags: Chem Biol Interact Source Type: research
Cloning, Prokaryotic Expression and Functional Analysis of Squalene Synthase (SQS) in Magnolia officinalis
In this study, a full-length cDNA of squalene synthase was cloned from M. officinalis and designated MoSQS (GenBank accession no.KT223496). The gene contains a 1240-bp open reading frame and it encodes a protein with 409 amino acids. Bioinformatic and phylogenetic analysis clearly suggested that MoSQS shared high similarity with squalene synthases among other plants. Prokaryotic expression showed that a transmembrane domain-deleted (385–409 aa) MoSQS mutant (MoSQSΔTM) could be expressed in its soluble form in Escherichia coli Transetta (DE3). GC-MS analysis showed that squalene was detected in an in vitro reaction mixtu...
Source: Protein Expression and Purification - December 13, 2015 Category: Biochemistry Source Type: research
New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity.
Abstract
Aristolochic acids (AA) are nephrotoxic agents found in Aristolochia species whose consumption leads to the onset of a progressive tubulointerstitial fibrosis. This AA-nephropathy was first reported during the Belgian outbreak of the 1990's in which more than a hundred patients consumed slimming pills containing an Aristolochia species and Magnolia officinalis. The patients developed an end-stage kidney disease requiring dialysis or transplantation. Magnolol and honokiol are bioactive compounds from M. officinalis known for their potent antioxidant activity. As they can alleviate oxidative stress,...
Source: Food and Chemical Toxicology - November 26, 2015 Category: Food Science Authors: Bunel V, Antoine MH, Stévigny C, Nortier J, Duez P Tags: Food Chem Toxicol Source Type: research
Advances on Semisynthesis, Total Synthesis, and Structure-Activity Relationships of Honokiol and Magnolol derivatives.
Abstract
Honokiol and magnolol (an isomer of honokiol) are small-molecule polyphenols isolated from the barks of Magnolia officinalis, which have been widely used in traditional Chinese and Japanese medicines. In the last decade, a variety of biological properties of honokiol and magnolol (e.g., anti-oxidativity, antitumor activity, anti-depressant activity, anti-inflammatory activity, neuroprotective activity, anti-diabetic activity, antiviral activity, and antimicrobial activity) have been reported. Meanwhile, certain mechanisms of action of some biological activities were also investigated. Moreover, ma...
Source: Mini Reviews in Medicinal Chemistry - November 19, 2015 Category: Chemistry Authors: Yang C, Zhi X, Lv M, Xu H Tags: Mini Rev Med Chem Source Type: research
Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway
In conclusion, our study is the first to report that magnolol has an inhibitory effect on the growth of GBC cells and that this compound may have potential as a novel therapeutic agent for the treatment of GBC.
This study investigated the effects of magnolol on the growth of GBC cells. The results indicated that magnolol inhibited GBC cell growth in vitro and in vivo via the p53 pathway. This work provided a rationale for Magnolol as a novel therapeutic agent for GBC. (Source: Cancer Science)
Source: Cancer Science - October 26, 2015 Category: Cancer & Oncology Authors: Maolan Li, Fei Zhang, Xu'an Wang, Xiangsong Wu, Bingtai Zhang, Ning Zhang, Wenguang Wu, Zheng Wang, Hao Weng, Shibo Liu, Guofeng Gao, Jiasheng Mu, Yijun Shu, Runfa Bao, Yang Cao, Jianhua Lu, Jun Gu, Jian Zhu, Yingbin Liu Tags: Original Article Source Type: research
