Molecules, Vol. 25, Pages 1450: Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells
This study was further aimed to evaluate the effects of honokiol on human drug-resistant glioblastoma cells and the possible mechanisms. The results by data mining in the cancer genome atlas (TCGA) database and immunohistochemistry displayed that expression of caspase-9 mRNA and protein in human glioblastomas was induced. Human TMZ-resistant U87-MG-R9 glioblastoma cells were selected and prepared from human drug-sensitive U87-MG cells. Compared to human drug-sensitive U87-MG cells, TMZ did not affect viability of U87-MG-R9 glioblastoma cells. Interestingly, treatment with honokiol suppressed proliferation and survival of h...
Source: Molecules - March 23, 2020 Category: Chemistry Authors: Gong-Jhe Wu Sun-Ta Yang Ruei-Ming Chen Tags: Article Source Type: research

Magnolia officinalis reduces inflammation and damage induced by recurrent status epilepticus in immature rats.
CONCLUSION: The results indicating that Magnolia officinalis is an alternative preventive treatment for early stages of epileptogenesis are encouraging. PMID: 32196444 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2020 Category: Drugs & Pharmacology Authors: Orozco-Suarez S, Vega-García A, Rocha L, Guevara-Guzmán R, Guerra-Araiza C, Feria-Romero I, Gallardo JM, Neri-Gomez T, Suárez-Santiago JE Tags: Curr Pharm Des Source Type: research

Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis.
This study indicates that these honokiol derivatives could be used as leads for the further derivation and development of the potential pesticide candidates for crop protection. PMID: 32165043 [PubMed - as supplied by publisher] (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - March 5, 2020 Category: Chemistry Authors: Zhi XY, Jiang LY, Li T, Song LL, Wang Y, Cao H, Yang C Tags: Bioorg Med Chem Lett Source Type: research

[ASAP] Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: < italic toggle="yes" > Magnolia officinalis < /italic > Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00610 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - February 21, 2020 Category: Neuroscience Authors: Jing Li †, Danie¨lle Copmans†, Miche`le Partoens†, Borba´la Hunyadi‡, Walter Luyten§, and Peter de Witte*† Source Type: research

Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
Cancer chemotherapy induces sarcopenia, which is a rapid loss of muscle mass that directly restricts daily activities and leads to poor quality of life and increased mortality. Although hormone-related therapies have been used to improve appetite and nutritional status, current treatments are considered palliative. Thus, the protection of skeletal muscle loss without adverse effects is essential to allow the maintenance of chemotherapy in cancer patients. Magnolol from Magnolia officinalis has several pharmacological effects including anti-cancer and anti-inflammatory activities, but the protection from muscle atrophy is n...
Source: Frontiers in Immunology - February 7, 2020 Category: Allergy & Immunology Source Type: research

Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF- β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.
This study has been conducted in TGF-β1 induced in vitro model and 21 day in vivo murine model of Bleomycin induced PF. The findings of our study suggest that HNK was able to inhibit fundamental pathways of epithelial to mesenchymal transition (EMT) and TGF-β/Smad signaling both in vitro and in vivo. Additionally, HNK also attenuated collagen deposition and inflammation associated with fibrosis. We also hypothesized that HNK interfered with IL-6/CD44/STAT3 axis. As hypothesized, HNK significantly mitigated IL-6/CD44/STAT3 axis both in vitro and in vivo as evident from outcomes of various protein expression stud...
Source: Toxicology and Applied Pharmacology - February 4, 2020 Category: Toxicology Authors: Pulivendala G, Bale S, Godugu C Tags: Toxicol Appl Pharmacol Source Type: research

CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis.
Abstract Magnolol, a major bioactive component found in Magnolia officinalis with anti-inflammation and anti-oxidation activities as well as minimized cytotoxic effects. Although magnolol has a wide range of clinical applications, the anti-tumor activity of magnolol is not efficient. Herein, we reported the synthesis and anti-cancer activities of three novel magnolol analogues CT2-1, CT2-2, CT2-3, among which CT2-3 revealed more efficient anti-non-small cell lung cancer (NSCLC) activity than magnolol. Our data showed that CT2-3 could significantly inhibit the proliferation of human NSCLC cells in a dose-dependent ...
Source: Bioorganic and Medicinal Chemistry - February 3, 2020 Category: Chemistry Authors: Chen J, Tao C, Huang X, Chen Z, Wang L, Li X, Ma M, Wu Z Tags: Bioorg Med Chem Source Type: research

Honokiol suppresses mycelial growth and reduces virulence of Botrytis cinerea by inducing autophagic activities and apoptosis.
Abstract Fungal pathogens lead to severe quality deterioration and yield loss, making it urgent to explore efficient measures to control fungal diseases at the preharvest and postharvest stages of plants. Therefore, studies on natural substances targeting alternative antimicrobial targets have become hot spots of research. Here, we show that honokiol, a polyphenolic compound obtained from Magnolia officinalis, significantly suppressed mycelial growth and reduced virulence of B. cinerea on harvested fruit by inducing autophagic activities and apoptosis. Moreover, honokiol was capable of abolishing the mitochondrial...
Source: Food Microbiology - February 1, 2020 Category: Food Science Authors: Ma D, Cui X, Zhang Z, Li B, Xu Y, Tian S, Chen T Tags: Food Microbiol Source Type: research

New obovatol trimeric neolignans with NO inhibitory activity from the leaves of Magnolia officinalis var. biloba.
Abstract Six new obovatol trimeric neolignans, houpulignans A-F (1-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined on the basis of the interpretation of HRESIMS, NMR data, and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of neolignans derived from three units of obovatol bearing a rare 1,4-benzodioxepane moiety. Compound 3 possesses a benzodihydropyran ring, meanwhile three units of obovatol in 4-6 are connected by an alkyl chain. Compounds 1-3 inhibited NO production in LPS-stimulated RAW264.7 cells with IC50 valu...
Source: Bioorganic Chemistry - January 16, 2020 Category: Chemistry Authors: Vu VT, Liu XQ, Nguyen MT, Lin YL, Kong LY, Luo JG Tags: Bioorg Chem Source Type: research

Cancers, Vol. 12, Pages 87: Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
In this study, we indicated that magnolol significantly enhanced sorafenib-diminished tumor cell growth, expression of anti-apoptotic proteins, and migration/invasion ability compared to sorafenib alone. Magnolol significantly boosted sorafenib-induced extrinsic/intrinsic dependent apoptosis pathways in HCC. Notably sorafenib could not reduce protein level of AKT (Ser473), but expression of AKT (Ser473) was significantly decreased by magnolol or magnolol combined with sorafenib. LY294002 as specific AKT inhibitor was used to confirm that AKT inactivation may promote anticancer effect of sorafenib. Taken together, AKT inhib...
Source: Cancers - December 30, 2019 Category: Cancer & Oncology Authors: Jiann-Hwa Chen I-Tsang Chiang Fei-Ting Hsu Tags: Article Source Type: research

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPAR γ and Inhibiting NLRP3 Signaling Pathway
In this study, we firstly evaluated the protective effects of magnolol on ALD, and then tried to clarify the mechanism underlying the pharmacological activities. AST, ALT, GSH-Px, and SOD were detected by respective kits. Histopathological changes of liver tissue were analyzed by H&E staining. The activities of PI3K, Nrf2, and NLRP3 signaling pathways activation were detected by western blotting analysis. It was showed that alcohol-induced ALT and AST levels were significantly reduced by magnolol, but the antioxidant enzymes of GSH-Px and SOD levels were significantly increased. Magnolol attenuated alcohol-induced path...
Source: Frontiers in Pharmacology - December 5, 2019 Category: Drugs & Pharmacology Source Type: research

Variation in the microbial community contributes to the improvement of the main active compounds of Magnolia officinalis Rehd. et Wils in the process of sweating
Magnolia officinalis Rehd. et Wils, commonly called Houpo, has been used for thousands of years in China as a traditional herbal medicine. The primary processing of Houpo requires sweating treatment, which is a s... (Source: Chinese Medicine)
Source: Chinese Medicine - October 22, 2019 Category: Complementary Medicine Authors: Qinahua Wu, Dan Wei, Linlin Dong, Yuping Liu, Chaoxiang Ren, Qianqian Liu, Cuiping Chen, Jiang Chen and Jin Pei Tags: Research Source Type: research

Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba
Publication date: Available online 4 October 2019Source: Chinese Chemical LettersAuthor(s): Chuan Li, Kailing Xu, Chuangjun Li, Jie Ma, Xiaoliang Wang, Dongming ZhangAbstract(±)-Magoilgomer A [(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (−)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and ...
Source: Chinese Chemical Letters - October 5, 2019 Category: Chemistry Source Type: research

Rapid Characterization of Compounds in Fupo Ganmao Granules by High-performance Liquid Chromatography Tandem Mass Spectrometry
In this study, the components of FP were profiled and characterized using HPLC-ESI-MS2. A total of 58 compounds were identified according to their fragmentation features in IT-TOF-MS and IT-MS2, including 13 phenolic acids, 17 flavonoids, 21 lignans, 2 alkaloids, and 5 other compounds. Among them, the identities of 8 compounds were explicitly confirmed by comparing them with standard compounds, and their contents were determined. Our study provided a comprehensive understanding of the diverse chemical profile in FP, and the approach we developed is useful for the analysis of other TCM formulas. (Source: Journal of Pharmace...
Source: Journal of Pharmaceutical and Biomedical Analysis - August 19, 2019 Category: Drugs & Pharmacology Source Type: research

Formylated honokiol analogs showed antitumor activity against lung carcinoma
Honokiol, a biphenolic neolignan with inappreciable toxicity isolated from Magnolia officinalis, has been reported to have antiangiogenic and antitumor properties in several tumor cell lines and tumor xenograft models. In our previous study, structural modification by chemical synthesis has been carried out to develop novel honokiol derivatives to improve antitumor activity and clarify the structure–activity relationship. Honokiol analogs, especially 3,5′-diformylated honokiol HK-(CHO)2, have been found to moderately block the newly grown segmental vessels from the dorsal aorta in the transgenic zebrafish-based...
Source: Anti-Cancer Drugs - August 17, 2019 Category: Cancer & Oncology Tags: Preclinical Papers Source Type: research

Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns.
CONCLUSION: The present findings suggested that honokiol was able to enhance the immunogenicity of cholangiocarcinoma cells associated with increased effectiveness of DC-based vaccine formulation. Treatment of tumour cells with honokiol offers a promising approach as an ex vivo DC-based anticancer vaccine. PMID: 31413529 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 7, 2019 Category: Gastroenterology Authors: Jiraviriyakul A, Songjang W, Kaewthet P, Tanawatkitichai P, Bayan P, Pongcharoen S Tags: World J Gastroenterol Source Type: research

Gold nano particles synthesized from Magnolia officinalis and anticancer activity in A549 lung cancer cells.
Authors: Zheng Y, Zhang J, Zhang R, Luo Z, Wang C, Shi S Abstract Nanotechnology is creating a bang in each and every field of life science. Scientists are mounting their interest of research towards gold nanoparticles as they are capable with bigger and advanced properties.Traditionally nanoparticles have been manufactured by various chemical and physical methods but have negative impact on the environment and are also highly toxic. Synthesis of nanoparticles by using plant extracts is substituting the conventional methods and it is eco-friendly too. In the current study, we prepared gold nanoparticles (AuNPs) fro...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 27, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Gold nano particles synthesized from Magnolia officinalis and anticancer activity in A549 lung cancer cells
Volume 47, Issue 1, December 2019, Page 3101-3109 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - July 25, 2019 Category: Biotechnology Authors: Yuanyuan Zheng Jianwu Zhang Rui Zhang Zhuang Luo Chu Wang Shaoqing Shi Source Type: research

Synthesis of either C2- or C4'-alkylated derivatives of honokiol and their biological evaluation for anti-inflammatory activity.
In this study, we examined the reaction condition for regioselective O-alkylation, in which C2 and C4'-alkylated analogs of honokiol were synthesized and evaluated for inhibitory activity on nitric oxide production and cyclooxygenase-2 expression. Furthermore, we successfully synthesized a potential photoaffinity probe consisting of biotin and benzophenone based on a C4'-alkylated derivative. PMID: 31257308 [PubMed - as supplied by publisher] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - June 28, 2019 Category: Drugs & Pharmacology Authors: Lee SH, Fei X, Lee C, Do HTT, Rhee I, Seo SY Tags: Chem Pharm Bull (Tokyo) Source Type: research

Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation.
In conclusion, HNK inhibits EMT in the breast cancer cells by downregulating Snail and Slug protein expression at the mRNA translation level. HNK has potential as an integrative medicine for combating breast cancer by targeting EMT. PMID: 31235819 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - June 24, 2019 Category: Drugs & Pharmacology Authors: Wang WD, Shang Y, Li Y, Chen SZ Tags: Acta Pharmacol Sin Source Type: research

Positional Isomerization of Phenylethanoid Glycosides from Magnolia officinalis.
Authors: Xue Z, Li H, Yang B Abstract Positional isomerization, an inducement leading to instability of phenylethanoid glycosides (PhGs) containing the caffeoyl moiety linked to C-3/4 of the central saccharide, is reported. Magnolosides M, A and F from Magnolia officinalis were found to be transformed into their isomers magnolosides A, D, M and B, respectively, which indicated that PhGs containing the caffeoyl moiety linking to C-3/4 of the central saccharide were unstable, and the caffeoyl group could be transferred to either C-4/3 or C-6 of the central saccharide. In addition, among the factors of temperature, so...
Source: Natural Product Communications - June 15, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research

Molecules, Vol. 24, Pages 2140: Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot
In this study, two phenol compounds, magnolol and honokiol, were extracted from Magnolia officinalis and identified by LC-MS, 1H- and 13C-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including Alternaria alternata (Fr.) Keissl, Penicillium expansum (Link) Thom, Alternaria dauci f.sp. solani, Fusarium moniliforme J. Sheld, Fusarium oxysporum Schltdl., Valsa mali Miyabe &amp;amp; G. Yamada, and Rhizoctonia solani J.G. K&amp;uuml;hn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and hono...
Source: Molecules - June 6, 2019 Category: Chemistry Authors: Ya-Han Chen Mei-Huan Lu Dong-Sheng Guo Ying-Yan Zhai Dan Miao Jian-Ying Yue Chen-Hong Yuan Ming-Min Zhao De-Rong An Tags: Article Source Type: research

Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism
In this study, the inhibitory effects and inhibition mechanism of magnolol on human carboxylesterases (hCEs), the key enzymes responsible for the hydrolytic metabolism of a variety of endogenous esters as well as ester-bearing drugs, have been well-investigated. The results demonstrate that magnolol strongly inhibits hCE1-mediated hydrolysis of various substrates, whereas the inhibition of hCE2 by magnolol is substrate-dependent, ranging from strong to moderate. Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intr...
Source: Chemico Biological Interactions - June 5, 2019 Category: Biochemistry Source Type: research

Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism.
In this study, the inhibitory effects and inhibition mechanism of magnolol on human carboxylesterases (hCEs), the key enzymes responsible for the hydrolytic metabolism of a variety of endogenous esters as well as ester-bearing drugs, have been well-investigated. The results demonstrate that magnolol strongly inhibits hCE1-mediated hydrolysis of various substrates, whereas the inhibition of hCE2 by magnolol is substrate-dependent, ranging from strong to moderate. Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intr...
Source: Chemico-Biological Interactions - June 3, 2019 Category: Molecular Biology Authors: Song YQ, Weng ZM, Dou TY, Finel M, Wang YQ, Ding LL, Jin Q, Wang DD, Fang SQ, Cao YF, Hou J, Ge GB Tags: Chem Biol Interact Source Type: research

Molecules, Vol. 24, Pages 2035: Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model
In this study, the lipopolysaccharide (LPS) mouse model was used to study the effect of honokiol on depression-like behavior induced by LPS in mice and its potential mechanism. A single administration of LPS (1 mg/kg, intraperitoneal injection) increased the immobility time in the forced swimming test (FST) and tail suspension test (TST), without affecting autonomous activity. Pretreatment with honokiol (10 mg/kg, oral administration) for 11 consecutive days significantly improved the immobility time of depressed mice in the FST and TST experiments. Moreover, honokiol ameliorated LPS-induced NF-&amp;kappa;B activation ...
Source: Molecules - May 28, 2019 Category: Chemistry Authors: Bo Zhang Ping-Ping Wang Kai-Li Hu Li-Na Li Xue Yu Yi Lu Hong-Sheng Chang Tags: Article Source Type: research

Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver
Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Feng-Ling Yu, Jun-Wen Wu, He ZhuAbstractAimAcetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.Main methodsFour groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. The morphological and biochemical assessments were used to ...
Source: Life Sciences - May 25, 2019 Category: Biology Source Type: research

A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin
Planta Med DOI: 10.1055/a-0921-7602A fluorometric imaging plate reader (FLIPR) assay utilizing Chinese hamster ovary (CHO) cells stably transfected with GABAA receptors of α 1 β 2 γ 2 subunit composition was evaluated and validated for rapid screening of plant extract libraries and efficient localization of active compounds in extracts. Validation was performed with pure compounds and extracts known to contain allosteric GABAA receptor modulators. Plants extracts that had been previously reported as active in an assay using Xenopus laevis oocytes transiently expressing GABAA receptors of &al...
Source: Planta Medica - May 24, 2019 Category: Drugs & Pharmacology Authors: Faleschini, Maria Teresa Maier, Anne Fankhauser, Sarah Thasis, Katharina Hebeisen, Simon Hamburger, Matthias Butterweck, Veronika Tags: Original Papers Source Type: research

Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
Abstract Eight new meroterpenoids with different types of monoterpene units, namely, magmenthanes A-H (1-8), were identified from the bark of Magnolia officinalis var. biloba. Magmenthane A (1) possesses a 1,3-dioxabicyclo [4.3.01,5] nonane skeleton, 1-5 possess five pairs of enantiomers and 6 possesses a 1,1'-diallyl-biphenyl fragment. The structures of 1-8 were elucidated on the basis of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) calculations. Compounds 5 and 8 displayed significant PTP1B inhibitory activities with IC50 values of 4.38 and 3.88 μM, respectively. PMID: 31054429 [PubMe...
Source: Bioorganic Chemistry - April 27, 2019 Category: Chemistry Authors: Li C, Li CJ, Ma J, Huang JW, Wang XY, Wang XL, Ye F, Zhang DM Tags: Bioorg Chem Source Type: research

Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish.
Abstract Honokiol, the main bioactive component of Magnolia officinalis, has a variety of pharmacological actions. However, its toxicity has rarely been reported. According to previous studies performed in our laboratory, honokiol microemulsion has embryo developmental toxicity. For further exploration, Zebrafish embryos were exposed to different doses of honokiol microemulsion to record the rates of mortality, malformation, and hatching. We found that high doses of honokiol microemulsion (0.6 and 0.9 μg/mL) increased mortality, inhibited hatching, caused malformation and reduced swimming activities. The low-...
Source: Toxicology and Applied Pharmacology - April 22, 2019 Category: Toxicology Authors: Li H, Zhang Q, Li W, Li H, Bao J, Yang C, Wang A, Wei J, Chen S, Jin H Tags: Toxicol Appl Pharmacol Source Type: research

The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies
Zhi-Chao Hu1,2,3†, Zu-Cheng Luo1,2,3†, Bing-Jie Jiang1,2,3†, Xin Fu1,2,3, Jiang-Wei Xuan1,2,3, Xiao-Bin Li1,2,3, Yu-Jie Bian1,2,3, Wen-Fei Ni1,2,3* and Ji-Xin Xue1,2,3* 1Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, China 2The Second School of Medicine, Wenzhou Medical University, Wenzhou, China 3Bone Research Institute, The Key Orthopaedic Laboratory of Zhejiang Province, Wenzhou, China Osteoarthritis (OA), defined as a long-term progressive joint disease, is characterized by cartilage impairment and ...
Source: Frontiers in Pharmacology - April 16, 2019 Category: Drugs & Pharmacology Source Type: research

Reynoutria japonica from Traditional Chinese Medicine: A source of Competitive Adenosine Deaminase Inhibitors for Anticancer.
CONCLUSION: Emodin may represent a good candidate anti-cancer therapy and adenosine protective agent. PMID: 30987561 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 14, 2019 Category: Chemistry Authors: Zhang XG, Ma GY, Kou F, Liu WJ, Sun QY, Guo GJ, Ma XD, Guo SJ, Jian-Ning Z Tags: Comb Chem High Throughput Screen Source Type: research

Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.
o-Suárez S Abstract During critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a preexisting neuroinflammatory condition can trigger, promote and prolong epileptiform activity and facilitate the development of epilepsy. The goal of the present study was to evaluate the long-term neuroprotective effects Magnolia officinalis extract, on a model of recurrent status epilepticus (SE) in immature rats. Sprague-Dawley rats were treated with kainic acid (KA) (3 mg/kg, dissolved in saline solution) be...
Source: Brain Research Bulletin - April 9, 2019 Category: Neurology Authors: Vega-García A, Santana-Gómez CE, Rocha L, Magdaleno-Madrigal VM, Morales-Otal A, Buzoianu-Anguiano V, Feria-Romero I, Orozco-Suárez S Tags: Brain Res Bull Source Type: research

Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Sidra Khalid, Adnan Khan, Bushra Shal, Hussain Ali, Yeong Shik Kim, Salman KhanAbstractBurn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide. The management of pain made significant progress; however, more research is needed for burn pain. In the present study, the antinociceptive effect of honokiol extracted from Magnolia officinalis was assessed for 3 consecutive days. The third-degree burns were induced by the hot water method. The honokiol both by intraperitoneal (i.p) and i...
Source: Biomedicine and Pharmacotherapy - March 28, 2019 Category: Drugs & Pharmacology Source Type: research

Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators.
Abstract Burn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide. The management of pain made significant progress; however, more research is needed for burn pain. In the present study, the antinociceptive effect of honokiol extracted from Magnolia officinalis was assessed for 3 consecutive days. The third-degree burns were induced by the hot water method. The honokiol both by intraperitoneal (i.p) and intra plantar (i.pl) route and in combination with tramadol (i.p) was found to be effective in significantly reducing the mechanical allodynia, hyperalgesia, the...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 26, 2019 Category: Drugs & Pharmacology Authors: Khalid S, Khan A, Shal B, Ali H, Kim YS, Khan S Tags: Biomed Pharmacother Source Type: research

Identification of minor lignans, alkaloids, and phenylpropanoid glycosides in Magnolia officinalis by HPLC‒DAD‒QTOF-MS/MS
Publication date: Available online 19 March 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Keke Guo, Chaoying Tong, Qiachi Fu, Jinju Xu, Shuyun Shi, Yecheng XiaoABSTRACTAn effective strategy based on high-speed counter-current chromatography (HSCCC) knockout combination with HPLC–DAD–QTOF-MS/MS analysis were developed to identify minor lignans, alkaloids, and phenylpropanoid glycosides in M. officinalis. Petroleum ether/ethyl acetate/methanol/water (8:4:7:5, v/v/v/v) as solvent system was firstly selected to separate the crude extract of M. officinalis. Two major lignans, honokiol and m...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 20, 2019 Category: Drugs & Pharmacology Source Type: research

Effects and mechanism of total phenols of Magnolia officinalis combined with Maijunan Tablets on blood pressure of spontaneous hypertensive rats
ConclusionThese results indicated that M-MJA could regulate the renin-angiotensin-aldosterone system, improve endothelial function, and inhibit CYP4A activity to reduce the production of 20-HETE, alleviate the oxidative stress disorder of the visceral organs, and eventually exert antihypertensive effect. Additionally, the anti-oxidant ability, regulating the renin-angiotensin-aldosterone system and improving endothelial function of M-MJA are more powerful than that of MJA, suggesting that M-MJA may have a better anti-hypertensive effect than MJA. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - March 10, 2019 Category: Complementary Medicine Source Type: research

A review of the phytochemistry and pharmacological activities of Magnoliae Officinalis Cortex
ConclusionsMagnoliae Officinalis Cortex is an essential traditional Chinese medicine with pharmacological activities that mainly affect the digestive system, nervous system and cardiovascular and cerebrovascular systems. This review summarises its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. These informations suggest that we should focus on the development of new drugs related to Magnoliae Officinalis Cortex, including specific constituents, so that Magnoliae Officinalis Cortex can exert greater therapeutic potential. Meanwhile, it is important to pay attention to the rational use of Magnolia re...
Source: Journal of Ethnopharmacology - February 26, 2019 Category: Drugs & Pharmacology Source Type: research

Integrated Therapy Decreases the Mortality of Patients with Polymyositis and Dermatomyositis: A Taiwan-wide Population-Based Retrospective Study
In this study, we investigated the effect of integrated therapy on mortality in a retrospective PM/DM cohort in the Taiwan National Health Insurance Research Database (NHIRD).Materials and MethodsPatients with PM/DM were retrospectively enrolled from the PM/DM Registry of Catastrophic Illnesses cohort in the Taiwan NHIRD between 1997 and 2011. The patients were divided into an integrated medicine (IM) group that received CM and HM and a non-IM group that received CM alone. The Cox proportional hazards regression model and Kaplan-Meier method were used to evaluate the hazard ratio (HR) for mortality.ResultsThree hundred and...
Source: Journal of Ethnopharmacology - February 26, 2019 Category: Drugs & Pharmacology Source Type: research

Magnolol prevents ovariectomy ‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways.
Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways. Int J Mol Med. 2019 Feb 18;: Authors: Fei WY, Huo Q, Zhao PQ, Qin LJ, Li T Abstract Magnolol is the active component of the traditional Chinese medicine Magnolia officinalis, and has antioxidant, anti‑inflammatory and anticancer activities, as well as an effect on bone metabolism in vitro. In the present study, it is reported that magnolol suppresses osteoclastogenesis in vivo and in vitro. Magnolol prevented ovariectomy...
Source: International Journal of Molecular Medicine - February 18, 2019 Category: Molecular Biology Authors: Fei WY, Huo Q, Zhao PQ, Qin LJ, Li T Tags: Int J Mol Med Source Type: research

Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ding Lin, Zhongzhong Yan, Yangjie Yi, Kangming Li, Jiao Ye, Aixi Hu, Chuyun Long, Aiping LiuAbstractAs shown in a number of previous researches, the extracts of Magnolia officinalis exhibited broad-spectrum fungicidal and insecticidal activity. In our preliminary study, 5-arylbenzofuran neolignans, the secondary metabolite of Magnolia officinalis, was found to inherit the activity of Magnolia officinalis. For developing novel agrochemicals, natural 5-arylbenzofuran neolignan was selected as lead compound. After structural optimization, the fung...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research

Four new honokiol derivatives from the stem bark of Magnolia officinalis and their anticholinesterase activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Baobao Zhang, Haitao Yu, Wei Lu, Bo Yu, Lei Liu, Weijuan Jia, Zongtao Lin, Hong Wang, Shizhong ChenAbstractFour new honokiol derivatives, namely 8′,9′-dihydroxymagnaldehyde E (1), 8′,9′-dihydroxyhonokiol (2), erythro-7-O-methylhonokitriol (3), and threo-7-O-methylhonokitriol (4), together with seven known compounds, erythro-honokitriol (5), threo-honokitriol (6), magnaldehyde E (7), magnotriol B (8), magnaldehyde B (9), honokiol (10), and magnolol (11), were isolated from the stem bark of Magnolia officinalis. Their s...
Source: Phytochemistry Letters - December 19, 2018 Category: Chemistry Source Type: research

Isolation of anti-Saprolegnia lignans from Magnolia officinalis and SAR evaluation of honokiol/magnolol analogs.
Abstract To control the fish fungal pathogen Saprolegnia, the effects of the petroleum ether extracts of Magnolia officinalis were evaluated by a rapeseed (Brassicanapus) microplate method in vitro. By loading on an open silica gel column and eluting with petroleum ether-ethyl acetate-methanol, honokiol (C18H18O2) and magnolol (C18H18O2) were isolated from Magnolia officinalis. Saprolegnia parasitica growth was inhibited significantly when honokiol concentration was>8.0 mg/L, and magnolol concentration was>9.0 mg/L, with EC50 values of 4.38 and 4.92 mg/L, respectively. Six honokiol and magnolol derivat...
Source: Bioorganic and Medicinal Chemistry Letters - December 17, 2018 Category: Chemistry Authors: Hu Y, Shen Y, Tu X, Wu X, Wang GX, Ling F Tags: Bioorg Med Chem Lett Source Type: research

Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells.
Abstract Magnolol (Mag), an effective natural compound isolated from the stem bark of Magnolia officinalis, was found to have the potential for antitumor activity by inducing apoptosis in tumor cells. However, the effect of Mag on renal carcinoma cells and its molecular mechanism are unexplored. Our study provided evidence that Mag induced apoptosis in 786-O and OS-RC-2 cell lines via the mitochondrial pathway and cell cycle arrest. In this work, we found that Mag induced morphological changes and inhibited the proliferation of 786-O and OS-RC-2 cells in a dose- and time-dependent manner but exerted no notable...
Source: Biochemical and Biophysical Research communications - December 17, 2018 Category: Biochemistry Authors: Wen H, Zhou S, Song J Tags: Biochem Biophys Res Commun Source Type: research

Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension in rats through inhibition of angiotensin II and endothelin-1 expression
ConclusionWe demonstrated that treatment with magnolol reduces the development of PAH induced by pneumonectomy and monocrotaline in rats, and suppressing Ang II and ET-1-mediated processes may contribute to its protective effects. These findings suggest that magnolol may be a potential agent for PAH therapy.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 5, 2018 Category: Drugs & Pharmacology Source Type: research

Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis
Publication date: Available online 29 August 2018Source: Life SciencesAuthor(s): Lan Chen, Wen Li, Di Qi, Ling Lu, Zhengwei Zhang, Daoxin WangAbstractAimsAcute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inflammation and oxidative stress. However, whether HKL has protective effects against the dysfunction of pulmonary microvascular endothelial barrier and the potent...
Source: Life Sciences - August 30, 2018 Category: Biology Source Type: research

Protective effects of honokiol against oxidative stress-induced apoptotic signaling in mouse podocytes treated with H2O2.
In conclusion, HNK largely eliminated the role of promoting podocyte apoptosis in an oxidative stress environment, which was a protective factor on podocytes cultured with H2O2. The anti-oxidative stress mechanisms of HNK are partly due to suppressing the expression of caspase-3 and caspase-9 and upregulating phosphorylated-Akt and -Erk 1/2. PMID: 30116378 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer.
In this study, twenty honokiol and magnolol derivatives were isolated from the EtOH extract of Magnolia officinalis and the antiproliferative activity was evaluated on HCC827 (19del EGFR mutation), H1975 (L858 R/T790 M EGFR mutation), and H460 (KRAS mutation) cell lines. Among the isolated compounds, piperitylmagnolol (a 3-substituted magnolol derivative) showed the best antiproliferative activity against those three cell lines with the IC50 values of 15.85, 15.60 and 18.60 μM, respectively, which provided a direction for the structural modification of magnolol. Further structural modification led to the synthesis...
Source: European Journal of Medicinal Chemistry - June 27, 2018 Category: Chemistry Authors: Tang H, Zhang Y, Li D, Fu S, Tang M, Wan L, Chen K, Liu Z, Xue L, Peng A, Ye H, Chen L Tags: Eur J Med Chem Source Type: research

Safety and Toxicology of Magnolol and Honokiol
In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Planta Medica)
Source: Planta Medica - June 20, 2018 Category: Drugs & Pharmacology Authors: Sarrica, Andrea Kirika, Natalja Romeo, Margherita Salmona, Mario Diomede, Luisa Tags: Reviews Source Type: research

Molecules, Vol. 23, Pages 1470: Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo
k In-Soo Yoon Honokiol (2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol) and magnolol (4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol) are the major active polyphenol constituents of Magnolia officinalis (Magnoliaceae) bark, which has been widely used in traditional Chinese medicine (Houpu Tang) for the treatment of various diseases, including anxiety, stress, gastrointestinal disorders, infection, and asthma. The aim of this study was to investigate the direct effects of honokiol and magnolol on hepatic CYP1A and 2C-mediated metabolism in vitro using rat liver microsomes and in vivo using the Sprague-Dawley rat ...
Source: Molecules - June 17, 2018 Category: Chemistry Authors: Sang-Bum Kim Kyu-Sang Kim Heon-Min Ryu Seong-Ho Hong Bo-Kyoung Kim Dae-Duk Kim Jin Woo Park In-Soo Yoon Tags: Article Source Type: research