Molecules, Vol. 26, Pages 7390: Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration
In conclusion, both MN and HK decreased the function and expression of BCRP via EGFR/PI3K signaling pathway. Therefore, both compounds were promising candidates for reversing the MDR of chemotherapy. (Source: Molecules)
Source: Molecules - December 6, 2021 Category: Chemistry Authors: Chung-Ping Yu Pei-Ying Li Szu-Yu Chen Shiuan-Pey Lin Yu-Chi Hou Tags: Article Source Type: research

Molecules, Vol. 26, Pages 6899: Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
ana Scrobotă Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in...
Source: Molecules - November 16, 2021 Category: Chemistry Authors: Georgiana Cical ău Petru Babes Horia Calniceanu Adelina Popa Gabriela Ciavoi Gilda Iova Mariana Ganea Ioana Scrobot ă Tags: Review Source Type: research

Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology
This study preliminarily revealed that CR and MOR play a key role in the treatment of CG. Animal experiments also showed that CR and MOR could significantly improve CG by inhibiting MKK6/p38 and RIP/p38 pathway.PMID:34745289 | PMC:PMC8570864 | DOI:10.1155/2021/5518750 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2021 Category: Complementary Medicine Authors: Shuhan Zhou Xiaohui Xu Jiangqin Zeng Zhiyi Liu Miao Wang Wenliang Lv Source Type: research

Magnolol Attenuates Right Ventricular Hypertrophy and Fibrosis in Hypoxia-Induced Pulmonary Arterial Hypertensive Rats Through Inhibition of the JAK2/STAT3 Signaling Pathway
This study aims to evaluate the effects and underlying mechanisms of magnolol on RV remodeling in hypoxia-induced PAH. In vivo, male Sprague Dawley rats were exposed to 10% O2 for 4 weeks to establish an RV remodeling model, which showed hypertrophic and fibrotic features (increases of Fulton index, cellular size, hypertrophic and fibrotic marker expression), accompanied by an elevation in phosphorylation levels of JAK2 and STAT3; these changes were attenuated by treating with magnolol. In vitro, the cultured H9c2 cells or cardiac fibroblasts were exposed to 3% O2 for 48 h to induce hypertrophy or fibrosis, which...
Source: Frontiers in Pharmacology - October 26, 2021 Category: Drugs & Pharmacology Source Type: research

New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba
Publication date: July 2021Source: Chinese Journal of Natural Medicines, Volume 19, Issue 7Author(s): Van-Tuan VU, Xiao-Juan XU, Kang CHEN, Manh-Tuyen NGUYEN, Bich-Ngoc NGUYEN, Giang-Nam PHAM, Ling-Yi KONG, Jian-Guang LUO (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - July 9, 2021 Category: Complementary Medicine Source Type: research

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats
Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.PMID:34159200 | PMC:PMC8187047 | DOI:10.1155/2021/6688414 (Source: Biomed Res)
Source: Biomed Res - June 23, 2021 Category: Research Authors: Xiao Wang Shu Fu Chen Zhang Xin Nie Wan Liao Ming Zhao Fang Liu Source Type: research

Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats
Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.PMID:34159200 | PMC:PMC8187047 | DOI:10.1155/2021/6688414 (Source: Biomed Res)
Source: Biomed Res - June 23, 2021 Category: Research Authors: Xiao Wang Shu Fu Chen Zhang Xin Nie Wan Liao Ming Zhao Fang Liu Source Type: research

Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research

Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research

Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research

Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research

Corrigendum to “Effects and mechanism of total phenols of Magnolia officinalis combined with Maijunan Tablets on blood pressure of spontaneous hypertensive rats” [Chinese Herbal Medicines 11 (2019) 177–184]
Publication date: April 2021Source: Chinese Herbal Medicines, Volume 13, Issue 2Author(s): Ming-li Zhu, Wei Wang, Feng Qin, Yong Chen (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - April 30, 2021 Category: Complementary Medicine Source Type: research

Magnolol inhibits cancer stemness and IL-6/Stat3 signaling in oral carcinomas.
CONCLUSION: Our data suggest that magnolol is able to target CSCs and suppress the cancer stemness properties, at least in part, via IL-6/Stat3 signaling. Besides, a dietary supplement of magnolol may function as an adjunct to cisplatin treatment. PMID: 33551310 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 4, 2021 Category: General Medicine Authors: Peng CY, Yu CC, Huang CC, Liao YW, Hsieh PL, Chu PM, Yu CH, Lin SS Tags: J Formos Med Assoc Source Type: research

Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF- β/Smad Signaling
Magnolol, a hydroxylated biphenyl extracted from Magnolia officinalis, has recently drawn attention due to its anticancer potential. The present study was aimed to explore the effects of Magnolol on restraining the proliferation, migration and invasion of pancreatic cancer in vivo and in vitro. Magnolol showed significant anti-growth effect in an orthotopic xenograft nude mouse model, and immunohistochemical staining of the xenografts revealed that Magnolol suppressed vimentin expression and facilitated E-cadherin expression. The cytoactive detection using CCK-8 assay showed Magnolol inhibited PANC-1 and AsPC-1 concentrati...
Source: Frontiers in Oncology - December 2, 2020 Category: Cancer & Oncology Source Type: research

The effect of honokiol on ergosterol biosynthesis and vacuole function in Candida albicans.
Abstract Ergosterol, an essential constituent of membrane lipids of yeast, is distributed in both the cell membrane and the intracellular endomembrane system such as vacuoles. Honokiol, a major polyphenol isolated from Magnolia officinalis, has been shown to inhibit the growth of Candida albicans. Here, we assessed the effect of honokiol on ergosterol biosynthesis and vacuole function in C. albicans. Honokiol could decrease the ergosterol content and upregulate the expression of genes related with the ergosterol biosynthesis pathway. The exogenous supply of ergosterol attenuated the toxicity of honokiol against C....
Source: Journal of Microbiology and Biotechnology - November 27, 2020 Category: Biotechnology Authors: Sun L, Liao K Tags: J Microbiol Biotechnol Source Type: research

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.
Abstract Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines. Among the isolated compounds, nine compounds (3, 5, 7, 8, 12, 14, 20, 22, and 24) showed moderate cytotoxicities, and compound 23 showed the best cytotoxicity with IC50 value lower than 10 μM. PMID: 33152462 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - November 2, 2020 Category: Biochemistry Authors: Ni HF, Cai X, Qiu X, Liu L, Ma X, Wan L, Ye H, Chen L Tags: Fitoterapia Source Type: research

Magnolol inhibits sodium currents in freshly isolated mouse dorsal root ganglion neurons.
Abstract The voltage gated sodium channel (VGSC) currents in dorsal root ganglion (DRG) neurons contain mainly TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) Na+ currents. Magnolol (Mag), a hydroxylated biphenyl compound isolated from the bark of Magnolia officinalis, has been well documented to exhibit analgesic effects, but its mechanism is not yet fully understood. The aim of the present study was to investigate whether the antinociceptive effects of Mag is through inhibition of Na+ currents. Na+ currents in freshly isolated mouse DRG neurons were recorded with the whole-cell patch clamp technique. Results sho...
Source: Clinical and Experimental Pharmacology and Physiology - October 16, 2020 Category: Drugs & Pharmacology Authors: Qiu J, Zhang L, Hong J, Ni X, Li J, Li G, Zhang G Tags: Clin Exp Pharmacol Physiol Source Type: research

Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy.
Abstract Magnolol and honokiol are the two major active ingredients with similar structure and anticancer activity from traditional Chinese medicine Magnolia officinalis, and honokiol is now in a phase I clinical trial (CTR20170822) for advanced non-small cell lung cancer (NSCLC). In search of potent lead compounds with better activity, our previous study has demonstrated that magnolol derivative C2, 3-(4-aminopiperidin-1-yl)methyl magnolol, has better activity than honokiol. Here, based on the core of 3-(4-aminopiperidin-1-yl)methyl magnolol, we synthesized fifty-one magnolol derivatives. Among them, compound 30 ...
Source: European Journal of Medicinal Chemistry - October 10, 2020 Category: Chemistry Authors: Zhao M, Zheng YH, Zhao QY, Zheng W, Yang JH, Pei HY, Liu L, Liu KJ, Xue LL, Deng DX, Wang L, Ma X, Fu SH, Peng AH, Tang MH, Luo YZ, Ye HY, Chen LJ Tags: Eur J Med Chem Source Type: research

Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.
Abstract Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal axis and improve depression-like behavior caused by hypothalamus-pituitary-adrenal axis hyperactivity. The current study investigated the specific mechanism of action of this effect. A depression model was established by repeated injections of corticosterone to study the antidepressant-like effect of honokiol and its potential mechanism. Honokiol prevented ...
Source: Journal of Integrative Neuroscience - September 30, 2020 Category: Neuroscience Authors: Zhang B, Li Y, Liu M, Duan XH, Hu KL, Li LN, Yu X, Chang HS Tags: J Integr Neurosci Source Type: research

Novel oligomeric neolignans with PTP1B inhibitory activity from the bark of Magnolia officinalis var. biloba.
In this study, phytochemical investigation of M. officinalis var. biloba bark extract afforded five pairs of novel enantiomeric oligomeric neolignans, (±)-mooligomers A-E (1-5). (±)-1 and (±)-2 were two diastereomeric pairs of enantiomers with six C6-C3 subunits, and (±)-4 was a pair of previously unreported tetrameric neolignans bearing eight C6-C3 subunits. (±)-5 is the first example of a naturally occurring trilignan featuring an eight-membered ring with a magnolol moiety. The absolute configurations of (±)-1-(±)-5 were elucidated on the basis of HRESIMS, 1D and 2D NMR sp...
Source: Bioorganic Chemistry - September 24, 2020 Category: Chemistry Authors: Li C, Li CJ, Xu KL, Ma J, Huang JW, Ye F, Zang YD, Zhang DM Tags: Bioorg Chem Source Type: research

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
ConclusionsOur work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical discussion about their potential use as adjuvants in the treatment of early/mild common flu in otherwise healthy adults within the context of COVID-19. While these herbal medicines will not cure or prevent the flu, they may both improve general patient well-being and offer them an opportunity to personalize the therapeutic approaches. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 22, 2020 Category: Drugs & Pharmacology Source Type: research

Bioassay-guided isolation of two antifungal compounds from Magnolia officinalis, and the mechanism of action of honokiol
Publication date: Available online 15 September 2020Source: Pesticide Biochemistry and PhysiologyAuthor(s): Yin-Fang Yan, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Ying-Qian Liu, Rui Zhou, Hua Liu, Tian-Lin Wu, Wen-Bin Zhao, Yu-Ling Wang, Guan-Fang Hu, Fang Qin, Ying-Hui He, Hai-Xin Li, Sha-Sha Du (Source: Pesticide Biochemistry and Physiology)
Source: Pesticide Biochemistry and Physiology - September 16, 2020 Category: Biochemistry Source Type: research

Magnolia officinalis and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates
Foodborne Pathogens and Disease, Ahead of Print. (Source: Foodborne Pathogens and Disease)
Source: Foodborne Pathogens and Disease - July 22, 2020 Category: Food Science Authors: Hyojin Kim Chae Yeon Lim Mi Sook Chung Source Type: research

Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus ®-Poloxamer 188.
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188. Drug Deliv. 2020 Dec;27(1):1010-1017 Authors: Li G, Lu Y, Fan Y, Ning Q, Li W Abstract Magnolol, known to have extensive biological activities, is the major bioactive ingredient isolated from the root and stem bark of Magnolia officinalis. However, the clinical application of magnolol is limited by poor aqueous solubility and absorption. The aim of this study is to develop novel mixed micelles and nanosuspensions composed of two biocompatible copolymers, Soluplus® and Poloxamer 188...
Source: Drug Delivery - July 8, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice.
In this study, we explored the effects of M. officinalis extraction on intestinal flora to reveal its mechanism. Thirty SPF mice were divided into five groups: C (control), M (M. officinalis), A (antibiotics: cefradine and gentamicin sulfate), A&M (antibiotics + M. officinalis) and A&N (antibiotics + natural recovery). Faecal samples of all groups were collected and the taxonomic composition and diversity of bacteria was characterized using the 16S rRNA gene (16S). Alpha diversity showed gut bacteria diversity significantly decreased in the A group of mice but increased markedly after ad...
Source: Current Microbiology - June 18, 2020 Category: Microbiology Authors: Tian H, Zhao L, Zhang Q, Zhang Y, Mao X, Wang J, Li T, Li J, You Z, Ruan Q, Jiang L Tags: Curr Microbiol Source Type: research

Magnolol induces human Ewing sarcoma SK-ES-1 cell apoptosis via the mitochondrial and death receptor pathways.
We examined the effect of magnolol on ES cell proliferation and apoptosis in vitro as well as the mechanism of its anticancer effect. The results demonstrated that magnolol inhibited the proliferation of ES and induced ES cell apoptosis through the mitochondrial and death receptor pathways. Magnolol reduced MEK1/2, ERK1/2, and STAT3 phosphorylation in ES cells, suggesting that the MAPK/ERK and JAK/STAT3 signal transduction pathways are involved in the inhibition of ES cell growth by magnolol. In short, magnolol is a potential anti-ES drug. PMID: 32509168 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 10, 2020 Category: Research Tags: Am J Transl Res Source Type: research

[ASAP] Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement < italic toggle="yes" > Magnolia officinalis < /italic > Extract for Prevention against Oral Carcinoma
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c01475 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - June 4, 2020 Category: Food Science Authors: Dinh Bui †, Li Li†, Taijun Yin†, Xinli Wang†‡, Song Gao§, Ming You?, Rashim Singh*†, and Ming Hu*† Source Type: research

Honokiol inhibits carotid artery atherosclerotic plaque formation by suppressing inflammation and oxidative stress.
In this study, the role of honokiol in the development of carotid artery atherosclerotic lesions was evaluated in an ApoE-/- mouse model fed with a normal diet (ND) or a Western-type diet (WD) for ten weeks. After first two weeks, a perivascular collar was surgically placed on the right common carotid arteries of the mice. Then, WD-fed mice were intraperitoneally injected with honokiol (10 or 20 mg/kg) or administrated with 10 mg/kg atorvastatin calcium by gavage once a day for eight weeks. After that, the right common carotid arteries were excised for further experiments. The result showed that honokiol substantially inhi...
Source: Aging - May 3, 2020 Category: Biomedical Science Authors: Liu Y, Cheng P, Wu AH Tags: Aging (Albany NY) Source Type: research

Molecules, Vol. 25, Pages 1450: Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells
This study was further aimed to evaluate the effects of honokiol on human drug-resistant glioblastoma cells and the possible mechanisms. The results by data mining in the cancer genome atlas (TCGA) database and immunohistochemistry displayed that expression of caspase-9 mRNA and protein in human glioblastomas was induced. Human TMZ-resistant U87-MG-R9 glioblastoma cells were selected and prepared from human drug-sensitive U87-MG cells. Compared to human drug-sensitive U87-MG cells, TMZ did not affect viability of U87-MG-R9 glioblastoma cells. Interestingly, treatment with honokiol suppressed proliferation and survival of h...
Source: Molecules - March 22, 2020 Category: Chemistry Authors: Gong-Jhe Wu Sun-Ta Yang Ruei-Ming Chen Tags: Article Source Type: research

Magnolia officinalis reduces inflammation and damage induced by recurrent status epilepticus in immature rats.
CONCLUSION: The results indicating that Magnolia officinalis is an alternative preventive treatment for early stages of epileptogenesis are encouraging. PMID: 32196444 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 19, 2020 Category: Drugs & Pharmacology Authors: Orozco-Suarez S, Vega-García A, Rocha L, Guevara-Guzmán R, Guerra-Araiza C, Feria-Romero I, Gallardo JM, Neri-Gomez T, Suárez-Santiago JE Tags: Curr Pharm Des Source Type: research

Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis.
This study indicates that these honokiol derivatives could be used as leads for the further derivation and development of the potential pesticide candidates for crop protection. PMID: 32165043 [PubMed - as supplied by publisher] (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - March 4, 2020 Category: Chemistry Authors: Zhi XY, Jiang LY, Li T, Song LL, Wang Y, Cao H, Yang C Tags: Bioorg Med Chem Lett Source Type: research

[ASAP] Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: < italic toggle="yes" > Magnolia officinalis < /italic > Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00610 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - February 21, 2020 Category: Neuroscience Authors: Jing Li †, Danie¨lle Copmans†, Miche`le Partoens†, Borba´la Hunyadi‡, Walter Luyten§, and Peter de Witte*† Source Type: research

Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
Cancer chemotherapy induces sarcopenia, which is a rapid loss of muscle mass that directly restricts daily activities and leads to poor quality of life and increased mortality. Although hormone-related therapies have been used to improve appetite and nutritional status, current treatments are considered palliative. Thus, the protection of skeletal muscle loss without adverse effects is essential to allow the maintenance of chemotherapy in cancer patients. Magnolol from Magnolia officinalis has several pharmacological effects including anti-cancer and anti-inflammatory activities, but the protection from muscle atrophy is n...
Source: Frontiers in Immunology - February 6, 2020 Category: Allergy & Immunology Source Type: research

Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF- β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.
This study has been conducted in TGF-β1 induced in vitro model and 21 day in vivo murine model of Bleomycin induced PF. The findings of our study suggest that HNK was able to inhibit fundamental pathways of epithelial to mesenchymal transition (EMT) and TGF-β/Smad signaling both in vitro and in vivo. Additionally, HNK also attenuated collagen deposition and inflammation associated with fibrosis. We also hypothesized that HNK interfered with IL-6/CD44/STAT3 axis. As hypothesized, HNK significantly mitigated IL-6/CD44/STAT3 axis both in vitro and in vivo as evident from outcomes of various protein expression stud...
Source: Toxicology and Applied Pharmacology - February 3, 2020 Category: Toxicology Authors: Pulivendala G, Bale S, Godugu C Tags: Toxicol Appl Pharmacol Source Type: research

CT2-3, a novel magnolol analogue suppresses NSCLC cells through triggering cell cycle arrest and apoptosis.
Abstract Magnolol, a major bioactive component found in Magnolia officinalis with anti-inflammation and anti-oxidation activities as well as minimized cytotoxic effects. Although magnolol has a wide range of clinical applications, the anti-tumor activity of magnolol is not efficient. Herein, we reported the synthesis and anti-cancer activities of three novel magnolol analogues CT2-1, CT2-2, CT2-3, among which CT2-3 revealed more efficient anti-non-small cell lung cancer (NSCLC) activity than magnolol. Our data showed that CT2-3 could significantly inhibit the proliferation of human NSCLC cells in a dose-dependent ...
Source: Bioorganic and Medicinal Chemistry - February 2, 2020 Category: Chemistry Authors: Chen J, Tao C, Huang X, Chen Z, Wang L, Li X, Ma M, Wu Z Tags: Bioorg Med Chem Source Type: research

Honokiol suppresses mycelial growth and reduces virulence of Botrytis cinerea by inducing autophagic activities and apoptosis.
Abstract Fungal pathogens lead to severe quality deterioration and yield loss, making it urgent to explore efficient measures to control fungal diseases at the preharvest and postharvest stages of plants. Therefore, studies on natural substances targeting alternative antimicrobial targets have become hot spots of research. Here, we show that honokiol, a polyphenolic compound obtained from Magnolia officinalis, significantly suppressed mycelial growth and reduced virulence of B. cinerea on harvested fruit by inducing autophagic activities and apoptosis. Moreover, honokiol was capable of abolishing the mitochondrial...
Source: Food Microbiology - February 1, 2020 Category: Food Science Authors: Ma D, Cui X, Zhang Z, Li B, Xu Y, Tian S, Chen T Tags: Food Microbiol Source Type: research

New obovatol trimeric neolignans with NO inhibitory activity from the leaves of Magnolia officinalis var. biloba.
Abstract Six new obovatol trimeric neolignans, houpulignans A-F (1-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined on the basis of the interpretation of HRESIMS, NMR data, and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 are the first examples of neolignans derived from three units of obovatol bearing a rare 1,4-benzodioxepane moiety. Compound 3 possesses a benzodihydropyran ring, meanwhile three units of obovatol in 4-6 are connected by an alkyl chain. Compounds 1-3 inhibited NO production in LPS-stimulated RAW264.7 cells with IC50 valu...
Source: Bioorganic Chemistry - January 15, 2020 Category: Chemistry Authors: Vu VT, Liu XQ, Nguyen MT, Lin YL, Kong LY, Luo JG Tags: Bioorg Chem Source Type: research

Cancers, Vol. 12, Pages 87: Protein Kinase B Inactivation Is Associated with Magnolol-Enhanced Therapeutic Efficacy of Sorafenib in Hepatocellular Carcinoma In Vitro and In Vivo
In this study, we indicated that magnolol significantly enhanced sorafenib-diminished tumor cell growth, expression of anti-apoptotic proteins, and migration/invasion ability compared to sorafenib alone. Magnolol significantly boosted sorafenib-induced extrinsic/intrinsic dependent apoptosis pathways in HCC. Notably sorafenib could not reduce protein level of AKT (Ser473), but expression of AKT (Ser473) was significantly decreased by magnolol or magnolol combined with sorafenib. LY294002 as specific AKT inhibitor was used to confirm that AKT inactivation may promote anticancer effect of sorafenib. Taken together, AKT inhib...
Source: Cancers - December 29, 2019 Category: Cancer & Oncology Authors: Jiann-Hwa Chen I-Tsang Chiang Fei-Ting Hsu Tags: Article Source Type: research

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPAR γ and Inhibiting NLRP3 Signaling Pathway
In this study, we firstly evaluated the protective effects of magnolol on ALD, and then tried to clarify the mechanism underlying the pharmacological activities. AST, ALT, GSH-Px, and SOD were detected by respective kits. Histopathological changes of liver tissue were analyzed by H&E staining. The activities of PI3K, Nrf2, and NLRP3 signaling pathways activation were detected by western blotting analysis. It was showed that alcohol-induced ALT and AST levels were significantly reduced by magnolol, but the antioxidant enzymes of GSH-Px and SOD levels were significantly increased. Magnolol attenuated alcohol-induced path...
Source: Frontiers in Pharmacology - December 4, 2019 Category: Drugs & Pharmacology Source Type: research

Variation in the microbial community contributes to the improvement of the main active compounds of Magnolia officinalis Rehd. et Wils in the process of sweating
Magnolia officinalis Rehd. et Wils, commonly called Houpo, has been used for thousands of years in China as a traditional herbal medicine. The primary processing of Houpo requires sweating treatment, which is a s... (Source: Chinese Medicine)
Source: Chinese Medicine - October 22, 2019 Category: Complementary Medicine Authors: Qinahua Wu, Dan Wei, Linlin Dong, Yuping Liu, Chaoxiang Ren, Qianqian Liu, Cuiping Chen, Jiang Chen and Jin Pei Tags: Research Source Type: research

Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba
Publication date: Available online 4 October 2019Source: Chinese Chemical LettersAuthor(s): Chuan Li, Kailing Xu, Chuangjun Li, Jie Ma, Xiaoliang Wang, Dongming ZhangAbstract(±)-Magoilgomer A [(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (−)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and ...
Source: Chinese Chemical Letters - October 5, 2019 Category: Chemistry Source Type: research

Rapid Characterization of Compounds in Fupo Ganmao Granules by High-performance Liquid Chromatography Tandem Mass Spectrometry
In this study, the components of FP were profiled and characterized using HPLC-ESI-MS2. A total of 58 compounds were identified according to their fragmentation features in IT-TOF-MS and IT-MS2, including 13 phenolic acids, 17 flavonoids, 21 lignans, 2 alkaloids, and 5 other compounds. Among them, the identities of 8 compounds were explicitly confirmed by comparing them with standard compounds, and their contents were determined. Our study provided a comprehensive understanding of the diverse chemical profile in FP, and the approach we developed is useful for the analysis of other TCM formulas. (Source: Journal of Pharmace...
Source: Journal of Pharmaceutical and Biomedical Analysis - August 19, 2019 Category: Drugs & Pharmacology Source Type: research

Formylated honokiol analogs showed antitumor activity against lung carcinoma
Honokiol, a biphenolic neolignan with inappreciable toxicity isolated from Magnolia officinalis, has been reported to have antiangiogenic and antitumor properties in several tumor cell lines and tumor xenograft models. In our previous study, structural modification by chemical synthesis has been carried out to develop novel honokiol derivatives to improve antitumor activity and clarify the structure–activity relationship. Honokiol analogs, especially 3,5′-diformylated honokiol HK-(CHO)2, have been found to moderately block the newly grown segmental vessels from the dorsal aorta in the transgenic zebrafish-based...
Source: Anti-Cancer Drugs - August 17, 2019 Category: Cancer & Oncology Tags: Preclinical Papers Source Type: research

Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns.
CONCLUSION: The present findings suggested that honokiol was able to enhance the immunogenicity of cholangiocarcinoma cells associated with increased effectiveness of DC-based vaccine formulation. Treatment of tumour cells with honokiol offers a promising approach as an ex vivo DC-based anticancer vaccine. PMID: 31413529 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 6, 2019 Category: Gastroenterology Authors: Jiraviriyakul A, Songjang W, Kaewthet P, Tanawatkitichai P, Bayan P, Pongcharoen S Tags: World J Gastroenterol Source Type: research

Gold nano particles synthesized from Magnolia officinalis and anticancer activity in A549 lung cancer cells.
Authors: Zheng Y, Zhang J, Zhang R, Luo Z, Wang C, Shi S Abstract Nanotechnology is creating a bang in each and every field of life science. Scientists are mounting their interest of research towards gold nanoparticles as they are capable with bigger and advanced properties.Traditionally nanoparticles have been manufactured by various chemical and physical methods but have negative impact on the environment and are also highly toxic. Synthesis of nanoparticles by using plant extracts is substituting the conventional methods and it is eco-friendly too. In the current study, we prepared gold nanoparticles (AuNPs) fro...
Source: Artificial Cells, Nanomedicine and Biotechnology - July 27, 2019 Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research

Gold nano particles synthesized from Magnolia officinalis and anticancer activity in A549 lung cancer cells
Volume 47, Issue 1, December 2019, Page 3101-3109 . (Source: Artificial Cells, Blood Substitutes, and Biotechnology)
Source: Artificial Cells, Blood Substitutes, and Biotechnology - July 24, 2019 Category: Biotechnology Authors: Yuanyuan Zheng Jianwu Zhang Rui Zhang Zhuang Luo Chu Wang Shaoqing Shi Source Type: research

Synthesis of either C2- or C4'-alkylated derivatives of honokiol and their biological evaluation for anti-inflammatory activity.
In this study, we examined the reaction condition for regioselective O-alkylation, in which C2 and C4'-alkylated analogs of honokiol were synthesized and evaluated for inhibitory activity on nitric oxide production and cyclooxygenase-2 expression. Furthermore, we successfully synthesized a potential photoaffinity probe consisting of biotin and benzophenone based on a C4'-alkylated derivative. PMID: 31257308 [PubMed - as supplied by publisher] (Source: Chemical and Pharmaceutical Bulletin)
Source: Chemical and Pharmaceutical Bulletin - June 27, 2019 Category: Drugs & Pharmacology Authors: Lee SH, Fei X, Lee C, Do HTT, Rhee I, Seo SY Tags: Chem Pharm Bull (Tokyo) Source Type: research

Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation.
In conclusion, HNK inhibits EMT in the breast cancer cells by downregulating Snail and Slug protein expression at the mRNA translation level. HNK has potential as an integrative medicine for combating breast cancer by targeting EMT. PMID: 31235819 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - June 23, 2019 Category: Drugs & Pharmacology Authors: Wang WD, Shang Y, Li Y, Chen SZ Tags: Acta Pharmacol Sin Source Type: research