Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer
In conclusion, this study has demonstrated that honokiol can inhibit the growth of lung cancer by targeting tumor cell PD-L1, suppressing PD-L1 expression, blocking the PD-1/PD-L1 pathway, and enhancing anti-tumor immunity.PMID:38626551 | DOI:10.1016/j.intimp.2024.112098 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 16, 2024 Category: Allergy & Immunology Authors: Lianxiang Luo Tong Wu Miaorong Ji Jing Xiang Youwen Zou Yinglin Liao Source Type: research
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPAR α/γ activity
In this study, our objective was to examine the effects of phenolic extracts derived from Magnolia officinalis on the regulation of NAFLD. Specifically, we investigated the impact of Magnolol or Honokiol treatment on high-fat diet (HFD)-induced obese C57BL6/J male mice. Firstly, we monitored energy metabolism, dissected tissues, and analyzed tissue sections. Additionally, we conducted experiments on HepG2 and primary adipocytes to gain insights into the roles of Magnolol or Honokiol. To further understand the effects of these compounds on related signaling pathways and marker genes, we performed molecular docking, dual-luc...
Source: European Journal of Pharmacology - February 25, 2024 Category: Drugs & Pharmacology Authors: Yi Chu Sisi Gui Yazhen Zheng Jingwu Zhao Yaxiang Zhao Yingying Li Xiaodong Chen Source Type: research
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPAR α/γ activity
In this study, our objective was to examine the effects of phenolic extracts derived from Magnolia officinalis on the regulation of NAFLD. Specifically, we investigated the impact of Magnolol or Honokiol treatment on high-fat diet (HFD)-induced obese C57BL6/J male mice. Firstly, we monitored energy metabolism, dissected tissues, and analyzed tissue sections. Additionally, we conducted experiments on HepG2 and primary adipocytes to gain insights into the roles of Magnolol or Honokiol. To further understand the effects of these compounds on related signaling pathways and marker genes, we performed molecular docking, dual-luc...
Source: European Journal of Pharmacology - February 25, 2024 Category: Drugs & Pharmacology Authors: Yi Chu Sisi Gui Yazhen Zheng Jingwu Zhao Yaxiang Zhao Yingying Li Xiaodong Chen Source Type: research
Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons
CONCLUSION: AD iPSC-derived neurons had a high viability rate when cultured in the presence of honokiol. These results have shown that AD iPSC-derived neurons can be an excellent model for screening neurotrophic agents and improving the conditions for long-term cultures of human iPSC-derived neurons. Honokiol proves to be a potential candidate for cellular therapeutics against neurodegenerative disorders.PMID:38327632 | PMC:PMC10844589 | DOI:10.34172/bi.2023.27652 (Source: BioImpacts)
Source: BioImpacts - February 8, 2024 Category: Research Authors: Duong Thi Thuy Le Cuong Manh Vu Thuy Thi Bich Ly Nam Trung Nguyen Phuong Thi Mai Nguyen Ha Hoang Chu Source Type: research
