Honokiol Exerts Antidepressant Effects in Rats Exposed to Chronic Unpredictable Mild Stress by Regulating Brain Derived Neurotrophic Factor Level and Hypothalamus-Pituitary-Adrenal Axis Activity.
Abstract
Honokiol (HNK), the main active component of Magnolia officinalis, has shown a variety of pharmacological activities. In the present study, we measured the antidepressant-like effects of HNK in a rat model of chronic unpredictable mild stress (CUMS) and explored its possible mechanisms. The antidepressant-like effects of HNK were assessed in rats by an open field test (OFT), sucrose preference test (SPT) and forced swimming test (FST). Then, serum levels of corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) and hippocampal brain-derived neurotrophi...
Source: Neurochemical Research - May 31, 2018 Category: Neuroscience Authors: Wang C, Gan D, Wu J, Liao M, Liao X, Ai W Tags: Neurochem Res Source Type: research
Magnolol and Honokiol Attenuate Apoptosis of Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelium by Maintaining Secretion and Absorption Homeostasis and Protecting Mucosal Integrity.
CONCLUSIONS The current results indicate that magnolol and honokiol enhance the intestinal anti-inflammatory capacities, elongate the villus height and crypt depth, and reduce goblet cell numbers to inhibit the intestinal epithelium apoptosis and effectively protect the intestinal mucosa. These results show that magnolol and honokiol protect the intestinal mucosal integrity and regulate gastrointestinal dysfunction.
PMID: 29782483 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 23, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Magnolol abrogates chronic mild stress-induced depressive-like behaviors by inhibiting neuroinflammation and oxidative stress in the prefrontal cortex of mice.
Abstract
Magnolol, the main constituent of Magnolia officinalis, has been shown to produce antidepressant-like effect in rodents. Growing evidence shows that neuroinflammation, oxidative stress and neuroendocrine contribute to the pathogenesis of major depression. Here, the aim of this present study was to determine whether magnolol affected these systems in mice exposed to chronic mild stress (CMS). The ameliorative effect of magnolol on depressive-like symptoms was investigated through behavioral tests, including the classical sucrose preference and forced swimming tests. The behavioral evaluation showed...
Source: International Immunopharmacology - April 5, 2018 Category: Allergy & Immunology Authors: Cheng J, Dong S, Yi L, Geng D, Liu Q Tags: Int Immunopharmacol Source Type: research
Magnoliae Cortex and maize modulate Porphyromonas gingivalis-induced inflammatory reactions.
Conclusions: Both Magnoliae Cortex and maize exerted an anti-inflammatory effect on P. gingivalis-stimulated RAW 264.7 cells, and this effect was more pronounced when the extracts were combined. These findings show that these extracts may be beneficial for slowing the progression of periodontal disease.
PMID: 29770236 [PubMed] (Source: Journal of Periodontal and Implant Science)
Source: Journal of Periodontal and Implant Science - April 1, 2018 Category: Dentistry Authors: Kim JY, Kim KH, Kwag EH, Seol YJ, Lee YM, Ku Y, Rhyu IC Tags: J Periodontal Implant Sci Source Type: research
Antidepressant effects of magnolol in a mouse model of depression induced by chronic corticosterone injection
This study aimed to investigate the antidepressant-like effects and possible mechanisms of magnolol in CORT-treated mice by utilizing a combination of behavioral and biochemical analysis. The depressive model was developed by subcutaneous injection of CORT for 21 days at a dose of 20 mg/kg. CORT administration formed depressive-like behaviors in mice, as indicated by increased immobility time in the forced swim test (FST) and tail suspension test (TST), as well as decreased sucrose intake in sucrose preference test (SPT). Moreover, we also found that CORT levels in serum were significantly increased, along with the decreas...
Source: Steroids - March 17, 2018 Category: Drugs & Pharmacology Source Type: research
Magnolol treatment attenuates dextran sulphate sodium-induced murine experimental colitis by regulating inflammation and mucosal damage
Publication date: 1 March 2018 Source:Life Sciences, Volume 196 Author(s): Peng Shen, Zecai Zhang, Yue He, Cong Gu, Kunpeng Zhu, Shan Li, Yanxin Li, Xiaojie Lu, Jiuxi Liu, Naisheng Zhang, Yongguo Cao Magnolol, the main and active ingredient of the Magnolia officinalis, has been widely used in traditional prescription to the human disorders. Magnolol has been proved to have several pharmacological properties including anti-bacterial, anti-oxidant and anti-inflammatory activities. However, the effects of magnolol on ulcerative colitis (UC) have not been reported. The aim of this study was to investigate the prot...
Source: Life Sciences - February 2, 2018 Category: Biology Source Type: research
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy.
In this study, the molecular mechanisms of honokiol in suppressing the human oral squamous cell carcinoma (OSCC) cells were evaluated. Treatment of two OSCC cell lines with honokiol resulted in reducing the cell proliferation and arresting the cell cycle at G1 stage which was correlated with the down-regulation of Cdk2 and Cdk4 and the up-regulation of cell cycle suppressors, p21 and p27. In addition, the caspase-dependent programmed cell death was substantially detected, and the autophagy was induced as the autophagosome formation and autophagic flux proceeded. Modulation of autophagy by autophagic inducer, rapamycin or i...
Source: J Cell Mol Med - January 24, 2018 Category: Molecular Biology Authors: Huang KJ, Kuo CH, Chen SH, Lin CY, Lee YR Tags: J Cell Mol Med Source Type: research
Honokiol inhibits in vitro and in vivo growth of oral squamous cell carcinoma through induction of apoptosis, cell cycle arrest and autophagy
In this study, the molecular mechanisms of honokiol in suppressing the human oral squamous cell carcinoma (OSCC) cells were evaluated. Treatment of two OSCC cell lines with honokiol resulted in reducing the cell proliferation and arresting the cell cycle at G1 stage which was correlated with the down‐regulation of Cdk2 and Cdk4 and the up‐regulation of cell cycle suppressors, p21 and p27. In addition, the caspase‐dependent programmed cell death was substantially detected, and the autophagy was induced as the autophagosome formation and autophagic flux proceeded. Modulation of autophagy by autophagic inducer, rapamyci...
Source: Journal of Cellular and Molecular Medicine - January 24, 2018 Category: Molecular Biology Authors: Kao ‐Jean Huang, Chin‐Ho Kuo, Shu‐Hsin Chen, Ching‐Yen Lin, Ying‐Ray Lee Tags: Original Article Source Type: research
Inhibitory Effects of Honokiol on the Voltage-Gated Potassium Channels in Freshly Isolated Mouse Dorsal Root Ganglion Neurons.
Abstract
Voltage-gated potassium (KV) currents, subdivided into rapidly inactivating A-type currents (I A) and slowly inactivating delayed rectifier currents (I K), play a fundamental role in modulating pain by controlling neuronal excitability. The effects of Honokiol (Hon), a natural biphenolic compound derived from Magnolia officinalis, on KV currents were investigated in freshly isolated mouse dorsal root ganglion neurons using the whole-cell patch clamp technique. Results showed that Hon inhibited I A and I K in concentration-dependent manner. The IC50 values for block of I A and I K were 30.5 and 25....
Source: Neurochemical Research - November 24, 2017 Category: Neuroscience Authors: Sheng A, Zhang Y, Li G, Zhang G Tags: Neurochem Res Source Type: research
Magnolia Officinalis Bark Extract Induces Depolarization of Pacemaker Potentials Through M < sub > 2 < /sub > and M < sub > 3 < /sub > Muscarinic Receptors in Cultured Murine Small Intestine Interstitial Cells of Cajal
Conclusion: These results suggest that MOE dose-dependently depolarizes ICCs pacemaker potentials through M2 and M3 receptors via internal and external Ca2+ regulation through G protein pathwaysin vitro. Moreover, MOE increased GE and ITRsin vivo in normal and GMD mouse models. Taken together, the results of this study show that MOE have the potential for development as a gastroprokinetic agent in GI motility function.Cell Physiol Biochem 2017;43:1790 –1802 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - October 19, 2017 Category: Cytology Source Type: research
Honokiol inhibits bladder cancer cell invasion through repressing SRC-3 expression and epithelial-mesenchymal transition.
Authors: Shen L, Zhang F, Huang R, Yan J, Shen B
Abstract
Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition ...
Source: Oncology Letters - September 26, 2017 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Magnolol Reduces Renal Ischemia and Reperfusion Injury via Inhibition of Apoptosis.
In conclusion, magnolol reduces renal I/R injury. The underlying mechanisms for this effect might be related to the prevention of apoptosis, possibly via the inhibition of both extrinsic and intrinsic apoptotic pathways, including the reduction of TNF-[Formula: see text] production and the modulation of pro- and anti-apoptotic signaling elements.
PMID: 28946769 [PubMed - as supplied by publisher] (Source: The American Journal of Chinese Medicine)
Source: The American Journal of Chinese Medicine - September 25, 2017 Category: Complementary Medicine Authors: Tang CY, Lai CC, Huang PH, Yang AH, Chiang SC, Huang PC, Tseng KW, Huang CH Tags: Am J Chin Med Source Type: research
Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction
Publication date: Available online 15 September 2017 Source:Chemico-Biological Interactions Author(s): Kwang Sik Suh, Suk Chon, Woon-Won Jung, Eun Mi Choi Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotropic benefits of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, in pancreatic β-cells exposed to MG in vitro. When exposed to cytotoxic l...
Source: Chemico Biological Interactions - September 16, 2017 Category: Biochemistry Source Type: research
Magnolol protects pancreatic β-cells against methylglyoxal-induced cellular dysfunction.
Abstract
Chronic hyperglycemia aggravates insulin resistance, in part due to increased formation of advanced glycation end-products (AGEs). Methylglyoxal (MG), a major precursor of AGEs, accumulates abnormally in various tissues and organs and participates in oxidative damage. We investigated the insulinotropic benefits of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, in pancreatic β-cells exposed to MG in vitro. When exposed to cytotoxic levels of MG for 48 h, RIN-m5F β-cells exhibited a significant loss of viability and impaired insulin secretion, whereas pretreatment ...
Source: Chemico-Biological Interactions - September 15, 2017 Category: Molecular Biology Authors: Suh KS, Chon S, Jung WW, Choi EM Tags: Chem Biol Interact Source Type: research
New botanical drug, HL tablet, reduces hepatic fat as measured by magnetic resonance spectroscopy in patients with nonalcoholic fatty liver disease: A placebo-controlled, randomized, phase II trial.
CONCLUSION: HL tablet is effective in reducing HFC without any negative lipid profiles, BMI changes and adverse effects.
PMID: 28932090 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 28, 2017 Category: Gastroenterology Authors: Jeong JY, Sohn JH, Baek YH, Cho YK, Kim Y, Kim H Tags: World J Gastroenterol Source Type: research
