Equilin displays similar endothelium-independent vasodilator potential to 17β-estradiol regardless of lower potential to inhibit calcium entry
In conclusion, equilin blocks L-type Ca2+ channels less effectively than 17β-estradiol. Despite its lower effectiveness, equilin equally relaxes resistance mesenteric arteries by acting on smooth muscle blocking Ca2+ entry.Graphical abstract (Source: Steroids)
Source: Steroids - November 18, 2018 Category: Drugs & Pharmacology Source Type: research

Bioavailability and Stuctural Study of 20-Hydroxyecdysone Complexes with Cyclodextrins
Publication date: Available online 17 November 2018Source: SteroidsAuthor(s): Bakhtiyar S. Temirgaziyev, Karolína Kučáková, Yerassyl A. Baizhigit, Michal Jurášek, Petr Džubák, Marián Hajdúch, Bohumil Dolenský, Pavel B. Drašar, Borash I. Tuleuov, Sergazy M. AdekenovAbstract20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexatio...
Source: Steroids - November 18, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of saponins from quinoa on a skin-mimetic lipid monolayer containing cholesterol
Publication date: Available online 17 November 2018Source: SteroidsAuthor(s): Ilona Jurek, Ilona Góral, Krzysztof Gęsiński, Kamil WojciechowskiAbstractThe study discusses the effect of a quinoa seed coat extract on a cholesterol-based Langmuir monolayer mimicking the intercellular lipid mixture in the skin’s outermost layer - stratum corneum. Besides cholesterol (CHOL), the monolayer contains also stearic acid (SA) and ceramide VI (CER), in a molar ratio of 10:14:14. Three quinoa extracts were tested for their surface activity: a) from the whole seed, b) from the dehulled seed, and c) from the seed coat. The...
Source: Steroids - November 18, 2018 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: December 2018Source: Steroids, Volume 140Author(s): (Source: Steroids)
Source: Steroids - November 18, 2018 Category: Drugs & Pharmacology Source Type: research

Control of β-sitosterol biosynthesis under light and watering in desert plant Calotropis procera
This study focused on the effects of lighting before and after irrigation on the BS accumulation pathway namely steroid biosynthesis. Studying the enzymes in BS biosynthetic pathway indicated the upregulation at dawn and predusk of the SMT2 and SMO2 genes encoding sterol methyltransferase 2 and methylsterol monooxygenase, two key enzymes in BS accumulation in C. procera. The results almost indicated no regulation at the different time points of the CYP710A gene encoding sterol 22-desaturase, an enzyme that acts in depleting β-sitosterol towards the biosynthesis of stigmasterol. RNA-Seq data was validated via quantitat...
Source: Steroids - November 16, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity and molecular docking studies on Phytosterols isolated from Polygonum hydropiper L
Publication date: Available online 13 November 2018Source: SteroidsAuthor(s): Muhammad Ayaz, Abdul Sadiq, Abdul Wadood, Muhammad Junaid, Farhat Ullah, Nadir Zaman KhanAbstractBased on our previous studies on cytotoxic potentials of Polygonum hydropiper L, two steroidal compounds beta-sitosterol and stigmasterol were isolated from the most active fraction and were subjected to cell lines cytotoxicity. Isolated compounds were tested against HeLa, MCF-7 and NIH/3T3 cell lines following MTT assay. Furthermore, the compounds were also docked against tyrosine kinase enzyme to predict the binding mode of phytosterols in the activ...
Source: Steroids - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

Sex-Based Differences in Resting MAPK, Androgen, and Glucocorticoid Receptor Phosphorylation in Human Skeletal Muscle
Publication date: Available online 7 November 2018Source: SteroidsAuthor(s): Justin X. Nicoll, Andrew C. Fry, Eric M. MosierAbstractPurposeTo determine if there is differential expression and phosphorylation of the androgen receptor (AR), glucocorticoid receptor (GR), and mitogen-activated protein kinases (MAPK) in skeletal muscle at rest between males and females.MethodsTen college-aged males (mean±SD; age=22±2.4 yrs, ht=175±7 cm, body mass=84.1±11.8 kg) and ten females (mean±SD; age=20±0.9 yrs; ht=169±7 cm; body mass=67.1±8.7 kg) reported to the laboratory following...
Source: Steroids - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

1,25-dihydroxyvitamin D3 induces formation of neutrophil extracellular trap-like structures and modulates the transcription of genes whose products are neutrophil extracellular trap-associated proteins: a pilot study
Publication date: Available online 7 November 2018Source: SteroidsAuthor(s): Juan Manuel Agraz-Cibrian, Diana M. Giraldo, Silvio Urcuqui-InchimaAbstractNeutrophils are components of the innate immune system that participate in controlling infectious diseases through microbicidal mechanisms such as phagocytosis, degranulation and the release of neutrophil extracellular traps (NETs). NETs are DNA structures that are released through the decondensation and spreading of chromatin and the adherence of various proteins, including neutrophil elastase (NE), myeloperoxidase (MPO) and peptidyl arginine deiminase 4 (PDA4). Since NETs...
Source: Steroids - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Measurement of midnight ACTH levels is useful for the evaluation of midnight cortisol levels
ConclusionWe demonstrated that midnight ACTH-associated cortisol values were not correlated with other endocrinological findings or hypercortisolism state. Measurement of midnight ACTH levels is important, and careful evaluation is needed for patients with higher midnight ACTH levels.Graphical abstract (Source: Steroids)
Source: Steroids - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Two new 4-methylidene containing steroids, craterol A and B, from the New Zealand two sponge association between Stelletta crater and Desmacella dendyi
Publication date: Available online 7 November 2018Source: SteroidsAuthor(s): Taitusi Taufa, Peter T. Northcote, Robert A. KeyzersAbstractNMR-directed investigation of the two sponge association between Stelletta crater and Desmacella dendyi has resulted in the isolation of two new members of the rare 4-methylidene class of sterols. Craterol A (1) and B (2) represent the first examples of natural products reported from the species S. crater. The isolation of these compounds challenges the role of 4-methylidene sterols as chemotaxonomic markers for the sponge genus Theonella.Graphical abstract (Source: Steroids)
Source: Steroids - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Control of β- sitosterol biosynthesis under light and watering in desert plant Calotropis procera
This study focused on the effects of lighting before and after irrigation on the BS accumulation pathway namely steroid biosynthesis. Studying the enzymes in BS biosynthetic pathway indicated the upregulation at dawn and predusk of the SMT2 and SMO2 genes encoding sterol methyltransferase 2 and methylsterol monooxygenase, two key enzymes in BS accumulation in C. procera. The results almost indicated no regulation at the different time points of the CYP710A gene encoding sterol 22-desaturase, an enzyme that acts in depleting β-sitosterol towards the biosynthesis of stigmasterol. RNA-Seq data was validated via quantitat...
Source: Steroids - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical Synthesis of 7-Oxygenated 12α-Hydroxy Steroid Derivatives to Enable the Biochemical Characterization of Cytochrome P450 8B1, the Oxysterol 12α-Hydroxylase Enzyme Implicated in Cardiovascular Health and Obesity
Publication date: Available online 3 November 2018Source: SteroidsAuthor(s): Samuel D. Offei, Hadi D. Arman, Mirza Oais Baig, Lazaro S. Chavez, Carlos A. Paladini, Francis K. YoshimotoAbstractCholic acid is the endogenous 12α-hydroxylated bile acid, which possesses enhanced cholesterol absorption properties compared to its 12-desoxy counterpart, chenodeoxycholic acid. The oxysterol 12α-hydroxylase enzyme is cytochrome P450 8B1 (P450 8B1), which regioselectively and stereoselectively incorporates the 12α-hydroxy group in 7α-hydroxycholest-4-en-3-one, the biosynthetic precursor of cholic acid. Despite...
Source: Steroids - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

A facile synthesis of ursodeoxycholic acid and obeticholic acid from cholic acid
Publication date: Available online 31 October 2018Source: SteroidsAuthor(s): Xiao-Long He, Li-Ting Wang, Xiang-Zhong Gu, Jie-Xin Xiao, Wen-Wei QiuAbstractA novel synthetic route of producing ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) was developed through multiple reactions from cheap and readily-available cholic acid. The reaction conditions of the key elimination reaction of mesylate ester group were also investigated and optimized, including solvent, base and reaction temperature. In the straightforward synthetic route for preparation of UDCA and OCA, most of the reaction steps have high conversions with ave...
Source: Steroids - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis and antiproliferative activity of 17-[1′,2′,3′]-selenadiazolylpregnenolone compounds
Publication date: December 2018Source: Steroids, Volume 140Author(s): Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan, Yanmin HuangAbstractUsing pregnenolone as a starting material, some 3-substituted 17-[1′,2′,3′]-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The results show that some compounds display selective antiproliferative activity against PC-3 and SKOV3 cells lines and are almo...
Source: Steroids - October 24, 2018 Category: Drugs & Pharmacology Source Type: research

Serum biomarkers of glucocorticoid response and safety in anti-neutrophil cytoplasmic antibody-associated vasculitis and juvenile dermatomyositis
Publication date: Available online 21 October 2018Source: SteroidsAuthor(s): Laurie S. Conklin, Peter A. Merkel, Lauren M. Pachman, Hemang Parikh, Shefa Tawalbeh, Jesse M. Damsker, David D. Cuthbertson, Gabrielle A. Morgan, Paul A. Monach, Yetrib Hathout, Kanneboyina Nagaraju, John van den Anker, Carol A. McAlear, Eric P. HoffmanAbstractGlucocorticoids are standard of care for many chronic inflammatory conditions, including juvenile dermatomyositis (JDM) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We sought to define pharmacodynamic biomarkers of therapeutic efficacy and safety concerns of ...
Source: Steroids - October 21, 2018 Category: Drugs & Pharmacology Source Type: research

Highly oxygenated isoprenoid lipids derived from fungi and fungal endophytes: origin and biological activities
Publication date: Available online 14 October 2018Source: SteroidsAuthor(s): Nick Savidov, Tatyana A. Gloriozova, Vladimir V. Poroikov, Valery M. DembitskyAbstractThis mini review is devoted to highly oxygenated isoprenoid lipids (HOIL) that are produced by fungi and fungal endophytes from various ecological niches, both terrestrial and aquatic. Steroids were distributed as from edible cultivated fungi, as well as fungi collected in forests. Fungal endophytes were generally isolated from plants and cultured to obtain sufficient biomass. Marine fungi were obtained from marine brown and red algae and marine invertebrates suc...
Source: Steroids - October 14, 2018 Category: Drugs & Pharmacology Source Type: research

Study on the reaction of diosgenin acetate with trimethylsilylazide catalyzed by Lewis acids
Publication date: Available online 14 October 2018Source: SteroidsAuthor(s): Agnieszka Wojtkielewicz, Urszula Kiełczewska, Beata Banel, Jacek W. MorzyckiAbstractThe ring opening reaction of diosgenin acetate in presence of Lewis acids and trimethylsilyl azide was explored as a facile approach to the synthesis of an open chain derivative with a nitrogen-containing substituent at C26. The reaction, under optimal conditions (TMSOTf, 1 equiv.; TMSN3, 1.1 equiv.; DCM; 48 h; rt), provided satisfactory yield (40%) of furostane-26-nitrile in a single step.Graphical abstract (Source: Steroids)
Source: Steroids - October 14, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, cytotoxic evaluation, and molecular docking studies of the semi-synthetic “triterpenoid-steroid” hybrids
Publication date: Available online 11 October 2018Source: SteroidsAuthor(s): Irina A. Tolmacheva, Alexey V. Nazarov, Daria V. Eroshenko, Victoria V. GrishkoAbstractSynthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expand the spectrum of biologically active steroidal agents via synthesis of the so-called “triterpenoid-steroid” hybrids. In the presented...
Source: Steroids - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

Separation and identification of the epimeric doping agents – Dexamethasone and betamethasone in equine urine and plasma: A reversed phase chiral chromatographic approach
This study also focused on optimizing the mobile phase for elution strength, nature of the organic modifier, additives, and column temperature.Graphical abstract (Source: Steroids)
Source: Steroids - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1
Publication date: Available online 28 September 2018Source: SteroidsAuthor(s): Maxime Lespérance, Xavier Barbeau, Jenny Roy, René Maltais, Patrick Lagüe, Donald PoirierAbstract17β-Hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising therapeutic target known to play a pivotal role in the progression of estrogen-dependent diseases such as breast cancer, and endometriosis. This enzyme is responsible for the last step in the biosynthesis of the most potent estrogen, estradiol (E2) and its inhibition would prevent the growth of estrogen-sensitive tumors. Based on molecular modeling with doc...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Expression of oestrogen receptor beta was negatively correlated with disease activity in patients with Crohn's disease involving the terminal ileum
Publication date: Available online 29 September 2018Source: SteroidsAuthor(s): Hongxia Li, Hong Chen, Lu Chen, Duo Shen, Xiaoxin XuAbstractCrohn's disease (CD) is a chronic inflammatory disease. The recurrence and remission of symptoms in CD patients are associated with changes in hormones, such as in puberty, pregnancy, postpartum and menopause, reflecting that oestrogen and its receptor might play an important role in CD. The study aimed to investigate the expression and clinical significance of oestrogen receptor in patients with CD involving the terminal ileum. Expression of oestrogen receptor alpha (ERα) and oes...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Crystal structures and Hirshfeld surface analyses of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol: significant differences in the hydrogen bonding patterns and supramolecular arrangements
Publication date: Available online 29 September 2018Source: SteroidsAuthor(s): Ligia R. Gomes, John N Low, Alan B Turner, Thomas C. Baddeley, James L. WardellAbstractThe crystal structures, Hirshfeld surface analyses and electrostatic potential surfaces of the di- and tri-hydrates of (5α,17E)-17-hydrazonoandrostan-3-ol, 3, namely [3.(H2O)2] and [3.(H2O)3], are reported. The trihydrate, isolated from a solution of 3 in moist methanol, recrystallizes in the orthorhombic space group, P212121,while that of the dihydrate, isolated from a 1:1 aqueous methanol solution, recrystallizes in the monoclinic space group, P21. The...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Separation and identification of the epimeric doping agents- dexamethasone and betamethasone in equine urine and plasma: a reversed phase chiral chromatographic approach
This study also focused on optimizing the mobile phase for elution strength, nature of the organic modifier, additives, and column temperature.Graphical abstract (Source: Steroids)
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Fluorine-containing lupane triterpenoid acid derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory agents
Publication date: Available online 5 October 2018Source: SteroidsAuthor(s): Tatyana S. Khlebnicova, Yuri A. Piven, Alexander V. Baranovsky, Fedor A. Lakhvich, Iryna V. Sorokina, Tatyana G. TolstikovaAbstractA series of novel fluorine-containing lupane triterpenoid acid derivatives with fluoroaromatic amide moieties at the C-28 position (1−8) or with 2-(fluoroacyl)cyclopentane-1,3-dione fragments at the C-3 position (9−18) of lupane skeleton was synthesized. A simple synthesis of novel lupane triterpenoid hybrids with 2-(fluoroacyl)-2-cyclopenten-1-one moieties was developed. An interaction of 2-acyl-3-chlorocyc...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Steroid Profiling in Nails Using Liquid Chromatography-Tandem Mass Spectrometry
In conclusion, it could be shown that nails are a suitable matrix for the retrospective monitoring of cumulative steroid hormone levels. (Source: Steroids)
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Pregn-5-en-3β-ol and androst-5-en-3β-ol dicarboxylic acid esters as potential therapeutics for NMDA hypofunction: In vitro safety assessment and plasma stability
Publication date: Available online 5 October 2018Source: SteroidsAuthor(s): Marika Matousova, Radko Soucek, Eva Tloustova, Barbora Slavikova, Hana Chodounska, Helena Mertlikova-Kaiserova, Eva KudovaAbstractNeurosteroids are endogenous steroidal compounds that can modulate neuronal receptors.N-Methyl-D-aspartate receptors (NMDARs) are glutamate-gated, calcium-permeable ion channels that are of particular interest, as they participate in synaptic transmission and are implicated in various processes, such as learning, memory, or long-term neuronal potentiation. Positive allosteric modulators that increase the activity of NMDA...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Timosaponin AIII: a novel potential anti-tumor compound from Anemarrhena asphodeloides
Publication date: Available online 5 October 2018Source: SteroidsAuthor(s): Feng-Ying Han, Xiao-Yu Song, Jing-Jie Chen, Guo-Dong Yao, Shao-Jiang SongAbstractTimosaponin AIII, a major steroidal saponin found in Anemarrhena asphodeloides Bge., which has been widely used as anti-pyretic, anti-diabetic, anti-inflammatory, anti-platelet aggregator and anti-depressant agents in traditional Chinese medicine. Recent pharmacological study showed that timosaponin AIII had potent cytotoxicity, which was potential to be developed as an anticancer agent, however the molecular mechanism underlying the anticancer activity has not been fu...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis and AntiproliferativeActivity of 17-[1’,2’,3’]-selenadiazolylpregnenolone compounds
Publication date: Available online 6 October 2018Source: SteroidsAuthor(s): Jianguo Cui, Liping Pang, Meizhen Wei, Chunfang Gan, Dandan Liu, Haiyan Yuan, Yanmin HuangAbstractUsing pregnenolone as a starting material, some 3-substituted 17-[1’,2’,3’]-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The results show that some compounds display selective antiproliferative activity against PC-3 and SKOV3 cells lines and ar...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Steroids-specific target library for steroids target prediction
Publication date: Available online 6 October 2018Source: SteroidsAuthor(s): Xiaoxue Dang, Zheng Liu, Yanzhuo Zhou, Peizi Chen, Jiyuan Liu, Xiaojun Yao, Beilei LeiAbstractSteroids exist universally and play critical roles in various biological processes. Identifying potential targets of steroids is of great significance in studying their physiological and biochemical activities, the side effects and for drug repurposing. Herein, aiming at more precise steroids targets prediction, a steroids-specific target library integrating 3325 PDB or homology modeling structures categorized into 196 proteins was built by considering che...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

C21 steroids from Streptocaulon juventas (Lour) Merr. induce apoptosis in HepG2
Publication date: Available online 6 October 2018Source: SteroidsAuthor(s): Wanfang Zhu, Shengzhi Su, Yunhui Xu, Zijian Xie, Yidan Bai, Wenyuan Liu, Masahiko Abe, Toshihiro Akihisa, Feng Feng, Jie ZhangAbstractThree new C21 steroids, i.e., (3β,17α,20S)-pregn-5(6)-ene-3, 17, 20-triol-3-O-β-D- digitalopyranosyl-(1→4)-β-D-digitalopyranoside (4), (3β,17α,20S)- pregn-5(6)-ene-3, 17, 20-triol-20-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl-(1→2)-β-D-digital- opyranoside (8), (3β, 20R)-pregn-14(15)-ene-3, 20, 21-triol-3-O-β-D-glucopy- ranoside (10), along wi...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: November 2018Source: Steroids, Volume 139Author(s): (Source: Steroids)
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Ichnocarpus frutescens (L.) R. Br. root derived phyto-steroids defends inflammation and algesia by pulling down the pro-inflammatory and nociceptive pain mediators: An in-vitro and in-vivo appraisal
Publication date: November 2018Source: Steroids, Volume 139Author(s): Niranjan Das, Abhijit Bhattacharya, Sudip Kumar Mandal, Utsab Debnath, Biswanath Dinda, Subhash C. Mandal, Prabir Kumar Sinhamahapatra, Amresh Kumar, M. Dutta Choudhury, Sabyasachi Maiti, Partha PalitAbstractIchnocarpus frutescens, a climber plant, is distributed all over India. As its different parts are used as anti-inflammatory agent, so we re-investigated the roots to isolate compounds and evaluate its biological efficacy. Also, in-silico molecular docking was carried out to elucidate the structure activity relationship (SAR) of isolated compounds to...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory furostanol saponins from the rhizomes of Smilax china L
Publication date: December 2018Source: Steroids, Volume 140Author(s): Yang Xie, Deng Hu, Cheng Zhong, Kai-Fei Liu, En Fang, Ying-Jun Zhang, Chun Zhou, Li-Wen TianAbstractSeven new furostanol saponins (1–7), chongrenosides A-G, were isolated from the rhizomes of Smilax china L., together with nine known furostanol saponins (8–16). The structures of the new furostanol saponins (1–7) were elucidated by extensive spectroscopic data analyses (1D and 2D NMR, HRESIMS) and chemical evidence. Compounds 1–6 and 8–16 were evaluated for TNF-α mRNA expression inhibitory activity on LPS induced RAW264...
Source: Steroids - October 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Glucocorticoid on the Eye Development in Guinea Pigs
In conclusion, glucocorticoid may influence both normal and LIM eye development. The balance of the hormones is fundamental for the eye development. (Source: Steroids)
Source: Steroids - September 20, 2018 Category: Drugs & Pharmacology Source Type: research

Correlation between chronological and physiological age of males from their multivariate urinary endogenous steroid profile and prostatic carcinoma-induced deviation
Publication date: Available online 16 September 2018Source: SteroidsAuthor(s): Eleonora Amante, Eugenio Alladio, Alberto Salomone, Marco Vincenti, Federico Marini, Giorgio Alleva, Stefano De Luca, Francesco PorpigliaAbstractThe biosynthesis of endogenous androgenic anabolic steroids (EAAS) in males varies with age. Knowledge of the general urinary EAAS profile’s dependence from aging - not reported up to now - may represents a prerequisite for its exploitation in the screening and diagnostic support for several pathologies. Extended urinary EAAS profiles were obtained from healthy and pathological individuals, using ...
Source: Steroids - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Clickable Conjugates of Bile acids and Nucleosides: Synthesis, Characterization, in vitro anticancer and antituberculosis studies
Publication date: Available online 17 September 2018Source: SteroidsAuthor(s): Devesh S. Agarwal, Vagolu Siva Krishna, Dharmarajan Sriram, Perumal Yogeeswari, Rajeev SakhujaAbstractA series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three cancer cell lines (PC-3, MCF-7, IMR-32). In addition, the synthesized derivatives were also tested for their antimycobacterial activi...
Source: Steroids - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis of dimeric spirostanols linked through a 1,4-dimethylidenebenzene moiety by double BF3·Et2O-catalyzed aldol condensation of steroid sapogenins and terephtalaldehyde
Publication date: December 2018Source: Steroids, Volume 140Author(s): Manuel A. Ramos-Enríquez, Lucie Rárová, Martín A. Iglesias-ArteagaAbstractBF3·Et2O-catalyzed double aldol condensation between acetylated steroid sapogenins and terephtalaldehyde led to acetylated dimeric spirostanols linked through a 1,4-dimethylidenebenzene moiety in moderate to good yields. The E configurations of the introduced double bonds were corroborated by NOE experiments. Saponification of the dimeric steroids led to the corresponding dimeric spirostanols.Graphical abstract (Source: Steroids)
Source: Steroids - September 19, 2018 Category: Drugs & Pharmacology Source Type: research

Ichnocarpus frutescens root derived phyto-steroids defends inflammation and algesia by pulling down the pro-inflammatory and nociceptive pain mediators: an in-vitro and in-vivo appraisal
Publication date: Available online 12 September 2018Source: SteroidsAuthor(s): Niranjan Das, Abhijit Bhattacharya, Sudip Kumar Mandal, Utsab Debnath, Biswanath Dinda, Subhash C. Mandal, Prabir Mahapatra, Amresh Kumar, M. Dutta Choudhury, Sabyasachi Maiti, Partha PalitiAbstractIchnocarpus frutescens, a climber plant, is distributed all over India. As its different parts are used as anti-inflammatory agent, so we re-investigated the roots to isolate compounds and evaluate its biological efficacy. Also, in-silico molecular docking was carried out to elucidate the structure activity relationship (SAR) of isolated compounds tow...
Source: Steroids - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Estimating testosterone concentrations in adolescent girls: comparison of two direct immunoassays to liquid chromatography-tandem mass spectrometry
Publication date: Available online 12 September 2018Source: SteroidsAuthor(s): Christopher R. McCartney, Christine M. Burt Solorzano, James T. Patrie, John C. Marshall, Daniel J. HaisenlederAbstractContext: The appropriate role of direct total testosterone (T) immunoassays in reproductive research is controversial.ObjectiveTo assess the concordance between two direct immunoassays and a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for total T in adolescent girls with measured concentrations
Source: Steroids - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Bile acids: lipase-catalyzed synthesis of new hyodeoxycholic acid derivatives
Publication date: Available online 12 September 2018Source: SteroidsAuthor(s): Santiago N. Chanquia, Erika Ripani, Alicia Baldessari, Guadalupe García LiñaresAbstractIn this work we present an efficient, environmentally friendly approach to the synthesis of a series of hyodeoxycholic acid derivatives applying Biocatalysis. Fifteen acetyl and ester derivatives, twelve of them new, were obtained through an enzymatic strategy in a fully regioselective way and in very good to excellent yield. In order to find the optimal reaction conditions, the influence of several parameters such as enzyme source, alcohol or ac...
Source: Steroids - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

The sulfatase pathway as estrogen supply in endometrial cancer
ConclusionA novel highly sensitive and accurate protocol to assess SULT1E1 activity is presented. STS enzyme activity and the STS:SULT1E1 activity ratio seem to be lower in ECs than in controls. STS is an important route for estrogen supply in endometrial cells. (Source: Steroids)
Source: Steroids - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Lysophosphatidylcholine induces expression of genes involved in cholesterol biosynthesis in THP-1 derived macrophages
In this study, we conducted RNA profiling in THP-1 derived macrophages treated with LPC and uncovered a relationship between LPC and the cholesterol biosynthesis pathway. Principal component analysis (PCA) of RNA profiling showed that untreated THP-1 cells and those treated with 10, 20, or 40 µM LPC were distinctly distributed. Functional annotation revealed that LPC affected the expression of genes involved in cytokine–cytokine receptor interaction, TNF signaling, and MAPK signaling. Interestingly, LPC also altered the expression of 11 genes involved in cholesterol synthesis such as those in terpenoid backbone...
Source: Steroids - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Adipokine and cytokine levels in patients with adrenocortical cancer, subclinical Cushing's syndrome and healthy controls
ConclusionIt is possible that higher adipokine and pro-inflammatory cytokine concentrations as well as lower anti-inflammatory adiponectin concentrations comprise an additional risk factor of metabolic and cardiovascular diseases in SCS patients. It seems that at least among patients with SCS adipokine and cytokine secretion is independent of hormonal activity (except for IL6). (Source: Steroids)
Source: Steroids - September 6, 2018 Category: Drugs & Pharmacology Source Type: research

β-Sitosterol-2-hydroxypropyl-β-cyclodextrin inclusion complex: characterization and Inhibitory effect on adipogenesis in 3T3-L1 pre-adipocytes
Publication date: Available online 31 August 2018Source: SteroidsAuthor(s): Song-Cu Yu, Ta Chen Chen, Yi-Ting Hou, Lei Wan, Fuu-Jen Tsai, Yuhsin TsaiAbstractβ-Sitosterol (Sit) has been used as a functional food additive. Among its many beneficial effects, this phytosterol plays a role in controlling obesity by inhibiting the adipogenesis process of pre-adipocytes. However, the highly lipophilic character of Sit limits its bioavailability. In the present study, 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) was used to form a complex with Sit, namely the Sit-HP-β-CD inclusion complex, and the inhibitory effect...
Source: Steroids - September 2, 2018 Category: Drugs & Pharmacology Source Type: research

Two new bioactive steroids from a mangrove-derived fungus Aspergillus sp.
Publication date: Available online 31 August 2018Source: SteroidsAuthor(s): Zhaoming Liu, Zhitong Dong, Pei Qiu, Qinglin Wang, Jingjing Yan, Yongjun Lu, Pathom-aree Wasu, Kui Hong, Zhigang SheAbstractTwo unusual naturally Diels-Alder additive steroids, ergosterdiacids A and B (1 and 2), constructing a 6/6/6/6/5 pentacyclic steroidal system, together with three known compounds (3–5) were obtained from the mangrove-derived fungus Aspergillus sp. Their structures were elucidated based on the comprehensive spectroscopic analysis, including 1D, 2D NMR and HRESIMS, as well as the quantum chemical ECD calculations. The plau...
Source: Steroids - September 2, 2018 Category: Drugs & Pharmacology Source Type: research

Editorial Board
Publication date: October 2018Source: Steroids, Volume 138Author(s): (Source: Steroids)
Source: Steroids - August 29, 2018 Category: Drugs & Pharmacology Source Type: research

New azole derivatives of [17(20)E]-21-norpregnene: synthesis and inhibition of prostate carcinoma cell growth
Publication date: Available online 25 August 2018Source: SteroidsAuthor(s): Tatsiana S. Dalidovich, Alaksiej L. Hurski, Galina E. Morozevich, Alexandra S. Latysheva, Tatsiana A. Sushko, Natallia V. Strushkevich, Andrei A. Gilep, Alexander Y. Misharin, Vladimir N. Zhabinskii, Vladimir A. KhripachAbstractA number of isoxazole, 1,2,3-triazole, tetrazole, and 1,2,4-oxadiazole derivatives of [17(20)E]-21-norpregnene comprising 3β-hydroxy-5-ene and 3-oxo-4-ene fragments were prepared. Among the key steps for the synthesis of isoxazoles, 1,2,3-triazoles, and tetrazoles were (i) 1,3-dipolar cycloaddition of nitrile oxides or ...
Source: Steroids - August 25, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis of dimeric spirostanols linked through an 1,4-dimethylidenebenzene moiety by double BF3•Et2O-catalyzed aldol condensation of steroid sapogenins and terephtalaldehyde
Publication date: Available online 25 August 2018Source: SteroidsAuthor(s): Manuel A. Ramos-Enríquez, Luice Rárová, Martin A. Iglesias ArteagaAbstractBF3•Et2O-catalyzed double aldol condensation between acetylated steroid sapogenins and terephtalaldehyde led to acetylated dimeric spirostanols linked through an 1,4-dimethylidenebenzene moiety in moderate to good yields. The E configurations of the introduced double bonds were corroborated by NOE experiments. Saponification of the dimeric steroids led to the corresponding dimeric spirostanols.Graphical abstract (Source: Steroids)
Source: Steroids - August 25, 2018 Category: Drugs & Pharmacology Source Type: research

Increased Body Fat Mass and Androgen Metabolism – a Twin Study in Healthy Young Women
Publication date: Available online 25 August 2018Source: SteroidsAuthor(s): Veera Vihma, Sini Heinonen, Jussi Naukkarinen, Jaakko Kaprio, Aila Rissanen, Ursula Turpeinen, Esa Hämäläinen, Antti Hakkarainen, Jesper Lundbom, Nina Lundbom, Tomi S. Mikkola, Matti J. Tikkanen, Kirsi H. PietiläinenAbstractObjectiveObesity may alter serum steroid concentrations and metabolism. We investigated this in healthy young women with increased body fat and their leaner co-twin sisters.DesignAge and genetic background both strongly influence serum steroid levels and body composition. This is a cross-sectional study of 13...
Source: Steroids - August 25, 2018 Category: Drugs & Pharmacology Source Type: research

Alexander “Saša” Kasal, doyen of the isoprenoid crew, goes 85
Publication date: Available online 25 August 2018Source: SteroidsAuthor(s): Eva Kudová (Source: Steroids)
Source: Steroids - August 25, 2018 Category: Drugs & Pharmacology Source Type: research