Inhibition of Ca < sup > 2+ < /sup > -permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes
Biochem Biophys Res Commun. 2023 Nov 27;692:149332. doi: 10.1016/j.bbrc.2023.149332. Online ahead of print.ABSTRACTTransient receptor potential vanilloid-3 (TRPV3) ion channels are prominently expressed in keratinocytes, playing a vital role in skin functions. Honokiol and magnolol (H&M) the primary bioactive constituents in Magnolia officinalis extract, demonstrate anti-inflammatory and skin-protective properties. Nevertheless, the underlying mechanism regarding their effect on Ca2+-permeable ion channels remain unclear. Our purpose in this study is to investigate the effect of H&M on TRPV3 and cytokine release in...
Source: Cell Research - December 3, 2023 Category: Cytology Authors: Huyen Dang Thi Ji Yeong Kim Hyun Jong Kim Woo Kyung Kim Sung Joon Kim Joo Hyun Nam Source Type: research
Inhibition of Ca < sup > 2+ < /sup > -permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes
Biochem Biophys Res Commun. 2023 Nov 27;692:149332. doi: 10.1016/j.bbrc.2023.149332. Online ahead of print.ABSTRACTTransient receptor potential vanilloid-3 (TRPV3) ion channels are prominently expressed in keratinocytes, playing a vital role in skin functions. Honokiol and magnolol (H&M) the primary bioactive constituents in Magnolia officinalis extract, demonstrate anti-inflammatory and skin-protective properties. Nevertheless, the underlying mechanism regarding their effect on Ca2+-permeable ion channels remain unclear. Our purpose in this study is to investigate the effect of H&M on TRPV3 and cytokine release in...
Source: Biochemical and Biophysical Research communications - December 3, 2023 Category: Biochemistry Authors: Huyen Dang Thi Ji Yeong Kim Hyun Jong Kim Woo Kyung Kim Sung Joon Kim Joo Hyun Nam Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634 (Source: Current Eye Research)
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634 (Source: Current Eye Research)
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634 (Source: Current Eye Research)
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634 (Source: Current Eye Research)
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-inducible Factor- α/Vascular Endothelial Growth Factor Axis via Nuclear transcription factor-kappa B Activation
CONCLUSION: We demonstrated that honokiol attenuated CNV formation by inactivating the HIF-1α/VEGF axis through NF-κB signaling pathway.PMID:37707827 | DOI:10.1080/02713683.2023.2259634 (Source: Current Eye Research)
Source: Current Eye Research - September 14, 2023 Category: Opthalmology Authors: Ningxin Pan Jian Shi Shu Du Zhaoxian Qiu Qiliang Ran Yangchen Guo Anping Ma Qi Zhang Aimin Sang Xiaowei Yang Source Type: research
Research Progress on the Structural Modification of Magnolol and Honokiol and the Biological Activities of Their Derivatives
Chem Biodivers. 2023 Jul 4:e202300754. doi: 10.1002/cbdv.202300754. Online ahead of print.ABSTRACTMagnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits for a wide range of illnesses, research on and the implementation of these compounds have been hindered by their poor water solubility and low bioavailability. Researchers are continually using chemical methods to alter their structures to make them more effective in treating ...
Source: Chemistry and Biodiversity - July 4, 2023 Category: Biochemistry Authors: Mingxin Guo Xia Wu Yi-Fan Feng Zhi-Qiang Hu Source Type: research
Research Progress on the Structural Modification of Magnolol and Honokiol and the Biological Activities of Their Derivatives
Chem Biodivers. 2023 Jul 4:e202300754. doi: 10.1002/cbdv.202300754. Online ahead of print.ABSTRACTMagnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits for a wide range of illnesses, research on and the implementation of these compounds have been hindered by their poor water solubility and low bioavailability. Researchers are continually using chemical methods to alter their structures to make them more effective in treating ...
Source: Chemistry and Biodiversity - July 4, 2023 Category: Biochemistry Authors: Mingxin Guo Xia Wu Yi-Fan Feng Zhi-Qiang Hu Source Type: research
Research Progress on the Structural Modification of Magnolol and Honokiol and the Biological Activities of Their Derivatives
Chem Biodivers. 2023 Jul 4:e202300754. doi: 10.1002/cbdv.202300754. Online ahead of print.ABSTRACTMagnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits for a wide range of illnesses, research on and the implementation of these compounds have been hindered by their poor water solubility and low bioavailability. Researchers are continually using chemical methods to alter their structures to make them more effective in treating ...
Source: Chemistry and Biodiversity - July 4, 2023 Category: Biochemistry Authors: Mingxin Guo Xia Wu Yi-Fan Feng Zhi-Qiang Hu Source Type: research
Effects of honokiol protects against chronic kidney disease via BNIP3/NIX and FUNDC1-mediated mitophagy and AMPK pathways
CONCLUSION: HKL exerted a renoprotective effect on CKD rats, which was possibly associated with BNIP3/NIX and FUNDC1-mediated mitophagy and the AMPK pathway.PMID:37338733 | DOI:10.1007/s11033-023-08592-1 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - June 20, 2023 Category: Molecular Biology Authors: Xian Wei Yuzhi Wang Yunlan Lao Jiali Weng Ruyu Deng Shunmin Li Jiandong Lu Shudong Yang Xinhui Liu Source Type: research
Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models
In this study, we found that honokiol and magnolol, two compounds derived fromMagnolia officinalis, significantly facilitated the differentiation of primary oligodendrocyte precursor cells (OPCs) into mature oligodendrocytes, with a more prominent effect of the former compound. Moreover, our results demonstrated that honokiol treatment improved myelin injury, induced mature oligodendrocyte protein expression, attenuated cognitive decline, promoted oligodendrocyte regeneration, and inhibited astrocytic activation in the bilateral carotid artery stenosis model. Mechanistically, honokiol increased the phosphorylation of serin...
Source: Neuroscience Bulletin - June 9, 2023 Category: Neuroscience Source Type: research
Efficiency and Mechanism Evaluation of < em > Magnolia officinalis < /em > Water Extract in Preventing Gastric Ulcer
In this study we aimed at demonstrating the ability of Magnolia officinalis water extract to ameliorate gastric ulcers in in vitro and in vivo experiments. The gastric mucosa epithelial cell line, RGM 1, was pretreated with Magnolia officinalis water extract (0, 0.1, 1, 2, 5, or 10 mg/ml) and cultured in DMEM/F12 medium (pH 7.4) for 2 h and then in DMEM/F12 medium (pH 4.0) for 10 min. Magnolia officinalis water extract protected the cell viability and decreased reactive oxygen species formation by the acidic medium. In the in vivo experiment, Magnolia officinalis water extract (100 mg/kg) was administrated daily for 28 day...
Source: Evidence-based Complementary and Alternative Medicine - April 17, 2023 Category: Complementary Medicine Authors: Kuo-Ping Shen Ching-Dong Chang Meng-Hsun Hsieh Hso-Chi Chaung Source Type: research
