New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba
Publication date: July 2021Source: Chinese Journal of Natural Medicines, Volume 19, Issue 7Author(s): Van-Tuan VU, Xiao-Juan XU, Kang CHEN, Manh-Tuyen NGUYEN, Bich-Ngoc NGUYEN, Giang-Nam PHAM, Ling-Yi KONG, Jian-Guang LUO (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - July 9, 2021 Category: Complementary Medicine Source Type: research
Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats
Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.PMID:34159200 | PMC:PMC8187047 | DOI:10.1155/2021/6688414 (Source: Biomed Res)
Source: Biomed Res - June 23, 2021 Category: Research Authors: Xiao Wang Shu Fu Chen Zhang Xin Nie Wan Liao Ming Zhao Fang Liu Source Type: research
Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats
Conclusions. The gastroprotective effect of MOE was attributed to the inhibition of oxidative stress and the NF-κB inflammatory pathway. The results provided substantial evidence that MOE could be a promising phytomedicine for gastric ulcer prevention.PMID:34159200 | PMC:PMC8187047 | DOI:10.1155/2021/6688414 (Source: Biomed Res)
Source: Biomed Res - June 23, 2021 Category: Research Authors: Xiao Wang Shu Fu Chen Zhang Xin Nie Wan Liao Ming Zhao Fang Liu Source Type: research
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research
Honokiol inhibits arecoline-induced oral fibrogenesis through transforming growth factor- β/Smad2/3 signaling inhibition
CONCLUSION: Our data suggest that honokiol may be a promising compound to alleviate the progression of oral fibrogenesis and prevent the transformation of OSF oral epithelium into cancer.PMID:33980461 | DOI:10.1016/j.jfma.2021.04.012 (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - May 13, 2021 Category: General Medicine Authors: Pei-Yin Chen Dennis Chun-Yu Ho Yi-Wen Liao Pei-Ling Hsieh Kai-Hsi Lu Lo-Lin Tsai Sheng-Hua Su Cheng-Chia Yu Source Type: research
Corrigendum to “Effects and mechanism of total phenols of Magnolia officinalis combined with Maijunan Tablets on blood pressure of spontaneous hypertensive rats” [Chinese Herbal Medicines 11 (2019) 177–184]
Publication date: April 2021Source: Chinese Herbal Medicines, Volume 13, Issue 2Author(s): Ming-li Zhu, Wei Wang, Feng Qin, Yong Chen (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - April 30, 2021 Category: Complementary Medicine Source Type: research
Magnolol inhibits cancer stemness and IL-6/Stat3 signaling in oral carcinomas.
CONCLUSION: Our data suggest that magnolol is able to target CSCs and suppress the cancer stemness properties, at least in part, via IL-6/Stat3 signaling. Besides, a dietary supplement of magnolol may function as an adjunct to cisplatin treatment.
PMID: 33551310 [PubMed - as supplied by publisher] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - February 4, 2021 Category: General Medicine Authors: Peng CY, Yu CC, Huang CC, Liao YW, Hsieh PL, Chu PM, Yu CH, Lin SS Tags: J Formos Med Assoc Source Type: research
Magnolol Suppresses Pancreatic Cancer Development In Vivo and In Vitro via Negatively Regulating TGF- β/Smad Signaling
Magnolol, a hydroxylated biphenyl extracted from Magnolia officinalis, has recently drawn attention due to its anticancer potential. The present study was aimed to explore the effects of Magnolol on restraining the proliferation, migration and invasion of pancreatic cancer in vivo and in vitro. Magnolol showed significant anti-growth effect in an orthotopic xenograft nude mouse model, and immunohistochemical staining of the xenografts revealed that Magnolol suppressed vimentin expression and facilitated E-cadherin expression. The cytoactive detection using CCK-8 assay showed Magnolol inhibited PANC-1 and AsPC-1 concentrati...
Source: Frontiers in Oncology - December 2, 2020 Category: Cancer & Oncology Source Type: research
The effect of honokiol on ergosterol biosynthesis and vacuole function in Candida albicans.
Abstract
Ergosterol, an essential constituent of membrane lipids of yeast, is distributed in both the cell membrane and the intracellular endomembrane system such as vacuoles. Honokiol, a major polyphenol isolated from Magnolia officinalis, has been shown to inhibit the growth of Candida albicans. Here, we assessed the effect of honokiol on ergosterol biosynthesis and vacuole function in C. albicans. Honokiol could decrease the ergosterol content and upregulate the expression of genes related with the ergosterol biosynthesis pathway. The exogenous supply of ergosterol attenuated the toxicity of honokiol ag...
Source: Journal of Microbiology and Biotechnology - November 27, 2020 Category: Biotechnology Authors: Sun L, Liao K Tags: J Microbiol Biotechnol Source Type: research
Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.
Abstract
Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines. Among the isolated compounds, nine compounds (3, 5, 7, 8, 12, 14, 20, 22, and 24) showed moderate cytotoxicities, and compound 23 showed the best cytotoxicity with IC50 value lower than 10 μM.
PMID: 33152462 [PubMed - as supplied by publisher] (Source: Fitoterapia)
Source: Fitoterapia - November 2, 2020 Category: Biochemistry Authors: Ni HF, Cai X, Qiu X, Liu L, Ma X, Wan L, Ye H, Chen L Tags: Fitoterapia Source Type: research
Magnolol inhibits sodium currents in freshly isolated mouse dorsal root ganglion neurons.
Abstract
The voltage gated sodium channel (VGSC) currents in dorsal root ganglion (DRG) neurons contain mainly TTX-sensitive (TTX-S) and TTX-resistant (TTX-R) Na+ currents. Magnolol (Mag), a hydroxylated biphenyl compound isolated from the bark of Magnolia officinalis, has been well documented to exhibit analgesic effects, but its mechanism is not yet fully understood. The aim of the present study was to investigate whether the antinociceptive effects of Mag is through inhibition of Na+ currents. Na+ currents in freshly isolated mouse DRG neurons were recorded with the whole-cell patch clamp technique. Res...
Source: Clinical and Experimental Pharmacology and Physiology - October 16, 2020 Category: Drugs & Pharmacology Authors: Qiu J, Zhang L, Hong J, Ni X, Li J, Li G, Zhang G Tags: Clin Exp Pharmacol Physiol Source Type: research
Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy.
Abstract
Magnolol and honokiol are the two major active ingredients with similar structure and anticancer activity from traditional Chinese medicine Magnolia officinalis, and honokiol is now in a phase I clinical trial (CTR20170822) for advanced non-small cell lung cancer (NSCLC). In search of potent lead compounds with better activity, our previous study has demonstrated that magnolol derivative C2, 3-(4-aminopiperidin-1-yl)methyl magnolol, has better activity than honokiol. Here, based on the core of 3-(4-aminopiperidin-1-yl)methyl magnolol, we synthesized fifty-one magnolol derivatives. Among them, comp...
Source: European Journal of Medicinal Chemistry - October 10, 2020 Category: Chemistry Authors: Zhao M, Zheng YH, Zhao QY, Zheng W, Yang JH, Pei HY, Liu L, Liu KJ, Xue LL, Deng DX, Wang L, Ma X, Fu SH, Peng AH, Tang MH, Luo YZ, Ye HY, Chen LJ Tags: Eur J Med Chem Source Type: research
Antidepressant-like mechanism of honokiol in a rodent model of corticosterone-induced depression.
Abstract
Depression is closely linked to hypothalamus-pituitary-adrenal axis hyperactivity. Honokiol, a biphenolic lignan compound obtained from the traditional Chinese medicine Magnolia officinalis, can reduce the activity of the hypothalamus-pituitary-adrenal axis and improve depression-like behavior caused by hypothalamus-pituitary-adrenal axis hyperactivity. The current study investigated the specific mechanism of action of this effect. A depression model was established by repeated injections of corticosterone to study the antidepressant-like effect of honokiol and its potential mechanism. Honokiol pr...
Source: Journal of Integrative Neuroscience - September 30, 2020 Category: Neuroscience Authors: Zhang B, Li Y, Liu M, Duan XH, Hu KL, Li LN, Yu X, Chang HS Tags: J Integr Neurosci Source Type: research
