Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.
Fitoterapia. 2020 Nov 02;:104769
Authors: Ni HF, Cai X, Qiu X, Liu L, Ma X, Wan L, Ye H, Chen L
Abstract
Six new biphenyl-type neolignans (1-6), and eighteen known compounds (7-24) were isolated from the EtOH extract of Magnolia officinalis. Their structures were determined by 1D and 2D NMR, and by HRMS. The anti-tumor activities of the isolated compounds were evaluated on HepG2, HCT-116, H1975 and HUVEC cell lines. Among the isolated compounds, nine compounds (3, 5, 7, 8, 12, 14, 20, 22, and 24) showed moderate cytotoxicities, and compound 23 showed the best cytotoxicity with IC50 value lower than 10 μM.
PMID: 33152462 [PubMed - as supplied by publisher]

Source: Fitoterapia - November 2, 2020 Category: Biochemistry Authors: Ni HF, Cai X, Qiu X, Liu L, Ma X, Wan L, Ye H, Chen L Tags: Fitoterapia Source Type: research