4‐O‐methylhonokiol Inhibits Serious Embryo Anomalies Caused by Nicotine via Modulations of Oxidative Stress, Apoptosis, and Inflammation
CONCLUSIONSThese findings indicate that 4‐O‐methylhonokiol reduces serious embryo anomalies caused by nicotine in mouse embryos via the modulations of oxidative stress, apoptosis, and inflammation, suggesting that 4‐O‐methylhonokiol may be a preventive and therapeutic agent against the dysmorphology induced by maternal smoking during pregnancy. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - April 1, 2014 Category: Perinatology & Neonatology Authors: Chunmei Lin, Jung‐Min Yon, Jin Tae Hong, Jong Kwon Lee, Jayoung Jeong, In‐Jeoung Baek, Beom Jun Lee, Young Won Yun, Sang‐Yoon Nam Tags: Research Article Source Type: research
Honokiol, a low molecular weight natural product, prevents inflammatory response and cartilage matrix degradation in human osteoarthritis chondrocytes
ABSTRACT
Proinflammatory cytokine interleukin‐1β (IL‐1β) stimulates several mediators of cartilage degradation and plays an important role in the pathogenesis of osteoarthritis (OA). Honokiol, a low molecular weight natural product isolated from the Magnolia officinalis, has been shown to possess anti‐inflammatory effect. Here, we used an in vitro model of cartilage inflammation to investigate the therapeutic potential of honokiol in OA. Human OA chondrocytes were cultured and pretreated with honokiol (2.5–10 µM) with or without IL‐1β (10 ng/ml). Nitric oxide (NO) production was quantified by Griess reage...
Source: Journal of Orthopaedic Research - December 27, 2013 Category: Orthopaedics Authors: Ying Ju Chen, Keh Sung Tsai, Ding Cheng Chan, Kuo Cheng Lan, Cheng Feng Chen, Rong Sen Yang, Shing Hwa Liu Tags: Research Article Source Type: research
Honokiol suppresses TNF-α-induced migration and matrix metalloproteinase expression by blocking NF-κB activation via the ERK signaling pathway in rat aortic smooth muscle cells.
In conclusion, these results indicate that honokiol suppresses TNF-α-induced migration and MMP expression by blocking NF-κB activation via the ERK signaling pathway in RASMCs. Our findings support honokiol as a promising novel agent for the prevention and treatment of atherosclerosis.
PMID: 24360976 [PubMed - as supplied by publisher] (Source: Acta Histochemica)
Source: Acta Histochemica - December 19, 2013 Category: Biochemistry Authors: Zhu X, Wang Z, Hu C, Li Z, Hu J Tags: Acta Histochem Source Type: research
Honokiol inhibits androgen receptor activity in prostate cancer cells
CONCLUSIONSThe present study demonstrates, for the first time, that HNK inhibits activity of AR in prostate cancer cells regardless of the p53 status. Prostate © 2013 Wiley Periodicals, Inc. (Source: The Prostate)
Source: The Prostate - December 11, 2013 Category: Urology & Nephrology Authors: Eun‐Ryeong Hahm, A. Isabella Karlsson, Michael Y. Bonner, Jack L. Arbiser, Shivendra V. Singh Tags: Original Article Source Type: research
Discovery of soluble epoxide hydrolase inhibitors from natural products.
Abstract
With the goal of developing soluble epoxide hydrolase (sEH) inhibitors with novel chemical structures, the sEH inhibitory activities of 30 natural compounds were evaluated using both a fluorescent substrate, 3-phenyl-cyano(6-methoxy-2-naphthalenyl)methyl ester- 2-oxiraneacetic acid, and a physiological substrate, 14,15-epoxyeicosatrienoic acid. To evaluate the selectivity of sEH inhibition, the inhibition of microsomal epoxide hydrolase (mEH), which plays a critical role in detoxification of toxic epoxides, was determined using human liver microsomes. Honokiol and β-amyrin acetate, isolated from ...
Source: Food and Chemical Toxicology - December 2, 2013 Category: Food Science Authors: Lee GH, Oh SJ, Lee SY, Lee JY, Ma JY, Kim YH, Kim SK Tags: Food Chem Toxicol Source Type: research
Honokiol inhibits U87MG human glioblastoma cell invasion through endothelial cells by regulating membrane permeability and the epithelial-mesenchymal transition.
In conclusion, these results suggest that honokiol inhibits metastasis by targeting the interaction between U87MG and BMECs, regulating the adhesion of U87MG to BMECs by inhibiting VCAM-1, and regulating the invasion of U87MG through BMECs by reducing membrane permeability and EMT processes of U87MG cells.
PMID: 24247297 [PubMed - in process] (Source: International Journal of Oncology)
Source: International Journal of Oncology - November 24, 2013 Category: Cancer & Oncology Authors: Joo YN, Eun SY, Park SW, Lee JH, Chang KC, Kim HJ Tags: Int J Oncol Source Type: research
Magnolol Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis by Inhibiting Ras-Dependent Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase/Akt Signaling Pathways.
Abstract
Magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, has been reported to possess anticancer activity. Recent studies have also demonstrated that magnolol inhibits cell growth and induces the apoptosis of cancer cells. However, the effects of magnolol on vascular endothelial growth factor (VEGF)-induced angiogenesis in endothelial cells have not been studied. In the present study, we have used human umbilical vein endothelial cells (HUVECs) to investigate the antiangiogenic effect and molecular mechanism of magnolol. Magnolol inhibited the VEGF-induced proliferation, chem...
Source: Nutrition and Cancer - September 25, 2013 Category: Cancer & Oncology Authors: Kim KM, Kim NS, Kim J, Park JS, Yi JM, Lee J, Bang OS Tags: Nutr Cancer Source Type: research
Magnolol induces apoptosis via caspase-independent pathways in non-small cell lung cancer cells.
Abstract
Magnolol, a hydroxylated biphenyl agent isolated from herbal planet Magnolia officinalis, is a component of traditional Asian herbal teas. It has been reported to have anti-microbial, anti-inflammatory, and anti-cancer activity. Non-small cell lung cancer (NSCLC) cell lines (A549, H441 and H520) and normal human bronchial epithelial cells (HBECs) were used to evaluate the cytotoxic effect of magnolol. We show that magnolol inhibited cellular proliferation, increased DNA fragmentation, and decreased mitochondrial membrane potential in all NSCLC cells, but had no cytotoxic effect on HBECs. Magnolol ...
Source: Archives of Pharmacal Research - August 14, 2013 Category: Drugs & Pharmacology Authors: Tsai JR, Chong IW, Chen YH, Hwang JJ, Yin WH, Chen HL, Chou SH, Chiu CC, Liu PL Tags: Arch Pharm Res Source Type: research
Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects
Background:
Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety. Modern dietary supplements are intended to induce relaxation and reduce stress as well as stress-related eating. Previous studies have shown the combination of Magnolia/Phellodendron (MP) to reduce both cortisol exposure and the perception of stress/anxiety, while improving weight loss in subjects with stress-related eating. Competitive athletes are "stressed" by their intense exercise regimens in addition to their normal activities of daily...
Source: Journal of the International Society of Sports Nutrition - August 7, 2013 Category: Sports Medicine Authors: Shawn TalbottJulie TalbottMike Pugh Source Type: research
Effect of Magnolia officinalis and Phellodendron amurense (Relora(R)) on cortisol and psychological mood state in moderately stressed subjects
Background:
Magnolia (Magnolia officinalis) and Phellodendron (Phellodendron amurense) barks are medicinal plants commonly used as traditional remedies for reducing stress and anxiety. Modern dietary supplements are intended to induce relaxation and reduce stress as well as stress-related eating. Previous studies have shown the combination of Magnolia/Phellodendron (MP) to reduce both cortisol exposure and the perception of stress/anxiety, while improving weight loss in subjects with stress-related eating. Competitive athletes are "stressed" by their intense exercise regimens in addition to their normal activities of daily...
Source: Journal of the International Society of Sports Nutrition - August 7, 2013 Category: Sports Medicine Authors: Shawn TalbottJulie TalbottMike Pugh Source Type: research
Identification of Magnolia officinalis L. Bark Extract as the Most Potent Anti-Inflammatory of Four Plant Extracts.
This study was designed to compare the anti-inflammatory potential of a Magnolia officinalis L. bark extract solely or in combination with extracts prepared from either Polygonum aviculare L., Sambucus nigra L., or Isodon japonicus L. in bacterial lipopolysaccharide (LPS) stimulated human gingival fibroblasts (HGF-1) and human U-937 monocytes, as cell models of periodontal disease. HGF-1 and U-937 cells were incubated with LPS from either Porphyromonas gingivalis or Escherichia coli together with the four plant extracts alone or in combination. Secretion of anti-inflammatory cytokines from HGF-1 and U-937 cells was measure...
Source: The American Journal of Chinese Medicine - May 29, 2013 Category: Complementary Medicine Authors: Walker JM, Maitra A, Walker J, Ehrnhoefer-Ressler MM, Inui T, Somoza V Tags: Am J Chin Med Source Type: research
Effect of honokiol on erythrocytes.
In conclusion, honokiol triggers suicidal erythrocyte death or eryptosis, an effect at least in part due to stimulation of Ca(2+) entry and ceramide formation.
PMID: 23673313 [PubMed - as supplied by publisher] (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - May 11, 2013 Category: Toxicology Authors: Zbidah M, Lupescu A, Herrmann T, Yang W, Foller M, Jilani K, Lang F Tags: Toxicol In Vitro Source Type: research
4‐O‐methylhonokiol, a PPARγ agonist, inhibits prostate tumour growth: p21‐mediated suppression of NF‐κB activity
Conclusions and ImplicationMH inhibits growth of human prostate cancer cells through activation of PPARγ, suppression of NF‐κB and arrest of the cell cycle. Thus, MH might be a useful tool for treatment of prostate cancer. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - February 20, 2013 Category: Drugs & Pharmacology Authors: NJ Lee, JH Oh, JO Ban, JH Shim, HP Lee, JK Jung, BW Ahn, DY Yoon, SB Han, YW Ham, JT Hong Tags: Research Paper Source Type: research
Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1α/VEGF signaling pathway in human bladder cancer cells.
Abstract
The hypoxic environment in tumors is an important factor causing tumor angiogenesis by activating the key transcription factor, hypoxia-inducible factors-1α (HIF-1α). Magnolol isolated from Magnolia officinalis has been reported to exhibit an anticancer activity via elevation of apoptosis. However, whether magnolol inhibits tumor angiogenesis remains unknown. In the present study, we demonstrated that magnolol significantly inhibited angiogenesis in vitro and in vivo evidenced by the attenuation of hypoxia and vascular endothelial growth factor (VEGF)-induced tube formation of human umbilical va...
Source: Biochemical Pharmacology - February 14, 2013 Category: Drugs & Pharmacology Authors: Chen MC, Lee CF, Huang WH, Chou TC Tags: Biochem Pharmacol Source Type: research
Magnolia polyphenols attenuate oxidative-and inflammatory responses in neurons and microglial cells
Conclusion:
This study highlights the important role of NADPH oxidase in mediating oxidative stress in neurons and microglial cells and has unveiled the role of IFNgamma in stimulating the MAPK/ERK1/2 signaling pathway for activation of NADPH oxidase in microglial cells. Hon and Mag offer anti-oxidative or anti-inflammatory effects, at least in part, through suppressing IFNgamma-induced p-ERK1/2 and its downstream pathway. (Source: Journal of Neuroinflammation)
Source: Journal of Neuroinflammation - January 29, 2013 Category: Neurology Authors: Dennis ChuangMing-Huan ChanYijia ZongWenwen ShengYan HeJing Hua JiangAgnes SimonyiZezong GuKevin FritscheJiankun CuiJames LeeWilliam FolkDennis LubahnAlbert SunGrace Sun Source Type: research
