RANKL-induced osteoclastogenesis is suppressed by 4-O-methylhonokiol in bone marrow-derived macrophages.
Abstract
Magnolol, honokiol, and obovatol are well known bioactive constituents of the bark of Magnolia officinalis and have been reported to have beneficial effects in various diseases. We recently isolated a novel active compound, 4-O-methylhonokiol (4-O-MH) from the ethanol extract of M. officinalis, which was previously reported to have pharmacological effects including anti-inflammatory, anti-oxidative, and anti-aging activities. Here, we examined the pharmacological properties of 4-O-MH on osteoblast (bone-forming cells) and osteoclast (bone-resorbing cells) differentiation, and its underlying signal...
Source: Archives of Pharmacal Research - July 24, 2017 Category: Drugs & Pharmacology Authors: Park KR, Kim JY, Kim EC, Yun HM, Hong JT Tags: Arch Pharm Res Source Type: research
Molecules, Vol. 22, Pages 1218: Magnolol, a Natural Polyphenol, Attenuates Dextran Sulfate Sodium-Induced Colitis in Mice
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Zhao-xiang Bian
Magnolol is a lignan with anti-inflammatory activity identified in Magnolia officinalis. Ulcerative colitis (UC), one of the types of inflammatory bowel disease (IBD), is a disease that causes inflammation and ulcers in the colon. To investigate the effect of magnolol in dextran sulfate sodium (DSS)-induced experimental UC model, male C57 mice were treated with 2% DSS drinking water for 5 consecutive days followed by intragastric administration with magnolol (5, 10 and 15 mg/kg) daily for 7 days. The results showed that magnolol significantly attenuated disease activity index, inhibited colonic shor...
Source: Molecules - July 20, 2017 Category: Chemistry Authors: Ling Zhao Hai-tao Xiao Huai-xue Mu Tao Huang Ze-si Lin Linda Zhong Guang-zhi Zeng Bao-min Fan Cheng-yuan Lin Zhao-xiang Bian Tags: Article Source Type: research
Is there a potential of misuse for Magnolia officinalis compounds/metabolites?
ConclusionsTo the best of our knowledge, this is the first paper commenting on the possible Magnolia derivatives' potential of misuse. Magnolia's recent increase in popularity, mainly as a sedative, may be arguably due to its peculiar pharmacological properties/acceptable affordability levels/virtually worldwide favorable legal status and customers' attraction to a product being perceived as “natural” and hence somehow “safe.” Future/potent/synthetic magnolol and honokiol structural analogues could however contribute to increasing the number of synthetic GABA‐ergic/cannabimimetic misusing compounds. (Source: Huma...
Source: Human Psychopharmacology: Clinical and Experimental - May 18, 2017 Category: Psychiatry Authors: Fabrizio Schifano, Valentina Guarino, Duccio G. Papanti, Jacopo Baccarin, Laura Orsolini, John M. Corkery Tags: SPECIAL ISSUE ON NOVEL PSYCHOACTIVE SUBSTANCES Source Type: research
Transcriptomic analysis of Saccharomyces cerevisiae upon honokiol treatment
Publication date: Available online 10 May 2017 Source:Research in Microbiology Author(s): Xiaolong Zhu, Shenshen Zou, Youbin Li, Yongheng Liang Honokiol (HNK), one of the main medicinal components in Magnolia officinalis, possesses antimicrobial activity against a variety of pathogenic bacteria and fungi. However, little is known of the molecular mechanisms underpinning the antimicrobial activity. To explore the molecular mechanism of its antifungal activity, we determined the effects of HNK on the mRNA expression profile of Saccharomyces cerevisiae using a DNA microarray approach. HNK markedly induced the expression...
Source: Research in Microbiology - May 10, 2017 Category: Microbiology Source Type: research
Antioxidant activities of aqueous extracts from 12 Chinese edible flowers in vitro and in vivo.
Abstract
The antioxidant function of edible flowers have attracted increasing interest. However, information is lacking on the impact of edible flowers on oxidative injury including hypoxia-re-oxygenation and hyperlipidemia. The antioxidant activities of aqueous extracts from 12 Chinese edible flowers were assessed in four different antioxidant models, including total antioxidant capacity (TAC), oxygen radical absorbance capacity (ORAC), scavenging hydroxyl radical capacity (SHRC) and scavenging superoxide anion radical capacity (SSARC). Subsequently, the potential antioxidant effects on rat cardiac microv...
Source: Food and Nutrition Research - March 25, 2017 Category: Nutrition Authors: Wang F, Miao M, Xia H, Yang LG, Wang SK, Sun GJ Tags: Food Nutr Res Source Type: research
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & amp; E. Wilson (Houpo) and its constituents
AbstractTraditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark ofMagnolia officinalis Rehder& E. Wilson, known under the pinyin name “Houpo”, has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover,Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispas...
Source: Journal of Zhejiang University. Science. B. - March 1, 2017 Category: Universities & Medical Training Source Type: research
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.
Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents.
J Zhejiang Univ Sci B. 2017 Mar.;18(3):194-214
Authors: Poivre M, Duez P
Abstract
Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark ext...
Source: J Zhejiang Univ Sci ... - February 28, 2017 Category: Science Authors: Poivre M, Duez P Tags: J Zhejiang Univ Sci B Source Type: research
Magnolol and honokiol from Magnolia officinalis enhanced antiviral immune responses against grass carp reovirus in Ctenopharyngodon idella kidney cells
Publication date: April 2017 Source:Fish & Shellfish Immunology, Volume 63 Author(s): Xiaohui Chen, Yang Hu, Lipeng Shan, Xiaobo Yu, Kai Hao, Gao-xue Wang Medicinal plants have been widely used for a long history. Exploration of pharmacologically active compounds from medicinal plants present a broad prevalent of application. By examining viral mRNA expression in GCRV-infected Ctenopharyngodon idella kidney (CIK) cells treated with thirty kinds of plant extracts, we identified Magnolia officinalis Rehd et Wils. was able to preferably suppress viral replication. Further studies demonstrated that the main ing...
Source: Fish and Shellfish Immunology - February 26, 2017 Category: Biology Source Type: research
UP601, a standardized botanical composition composed of Morus alba, Yerba mate and Magnolia officinalis for weight loss
The prevalence of obesity is surging in an alarming rate all over the world. Pharmaceutical drugs are considered potential adjunctive therapy to lifestyle modification. However, for most, besides being too exp... (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 16, 2017 Category: Complementary Medicine Authors: Mesfin Yimam, Ping Jiao, Mei Hong, Lidia Brownell, Young-Chul Lee, Eu-Jin Hyun, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim and Qi Jia Source Type: research
Honokiol induces proteasomal degradation of AML1-ETO oncoprotein via increasing ubiquitin conjugase UbcH8 expression in leukemia.
Abstract
AML1-ETO is the most common oncoprotein leading to acute myeloid leukemia (AML), in which 5-year survival rate is only about 30%. However, currently there are no specific therapies for AML patients with AML1-ETO. Here, we report that AML1-ETO protein is rapidly degraded by Honokiol (HNK), a natural phenolic compound isolated from the plant Magnolia officinalis. HNK induced the degradation of AML1-ETO in a concentration-and time-dependent manner in leukemic cell lines and primary AML blasts with t(8;21) translocation. Mechanistically, HNK obviously increased the expression of UbcH8, an E2-conjugase...
Source: Biochemical Pharmacology - December 29, 2016 Category: Drugs & Pharmacology Authors: Zhou B, Li H, Xing C, Ye H, Feng J, Wu J, Lu Z, Fang J, Gao S Tags: Biochem Pharmacol Source Type: research
Magnolol Attenuates Concanavalin A ‐induced Hepatic Fibrosis, Inhibits CD4+ T Helper 17 (Th17) Cell Differentiation and Suppresses Hepatic Stellate Cell Activation: Blockade of Smad3/Smad4 Signalling
This study was aimed at exploring the potential effect of magnolol on immune‐related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA, 8 mg/kg/week) up to 6 weeks to establish hepatic fibrosis, and magnolol (10, 20, 30 mg/kg/day) was given to these mice orally throughout the whole experiment. We found that magnolol preserved liver function and attenuated liver fibrotic injury in vivo. In response to ConA stimulation, the CD4+ T cells preferred to polarizing towards CD4+ T helper 17 (Th17) cells in liver. Magnolol was observed to inhibit Th17 cell differentiation in ConA‐treated liver in addit...
Source: Basic and Clinical Pharmacology and Toxicology - December 28, 2016 Category: Drugs & Pharmacology Authors: Hongjun Zhang, Baoling Ju, Xiaoli Zhang, Yanfei Zhu, Ying Nie, Yuanhong Xu, Qiuxia Lei Tags: Original Article Source Type: research
Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract
(Source: Contact Dermatitis)
Source: Contact Dermatitis - November 9, 2016 Category: Dermatology Authors: Trine D. Nilausen, Jeanne D. Johansen, Jacob P. Thyssen Tags: Contact Point Source Type: research
Appetite Suppression and Antiobesity Effect of a Botanical Composition Composed of Morus alba, Yerba mate, and Magnolia officinalis.
Conclusion. UP601, a standardized botanical composition from Morus alba, Yerba mate, and Magnolia officinalis could be used as a natural alternative for appetite suppression, maintaining healthy body weight and metabolism management.
PMID: 27699065 [PubMed - in process] (Source: Journal of Obesity)
Source: Journal of Obesity - October 6, 2016 Category: Eating Disorders and Weight Management Tags: J Obes Source Type: research
Magnolia officinalis L. Fortified Gum Improves Resistance of Oral Epithelial Cells Against Inflammation.
Abstract
Inflammatory diseases of the periodontal tissues are known health problems worldwide. Therefore, anti-inflammatory active compounds are used in oral care products to reduce long-term inflammation. In addition to inducing inflammation, pathogen attack leads to an increased production of reactive oxygen species (ROS), which may lead to oxidative damage of macromolecules. Magnolia officinalis L. bark extract (MBE) has been shown to possess antioxidant and anti-inflammatory potential in vitro. In the present study, the influence of MBE-fortified chewing gum on the resistance against lipopolysaccharide...
Source: The American Journal of Chinese Medicine - September 14, 2016 Category: Complementary Medicine Authors: Walker J, Imboeck JM, Walker JM, Maitra A, Haririan H, Rausch-Fan X, Dodds M, Inui T, Somoza V Tags: Am J Chin Med Source Type: research
Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3 β and β-catenin signaling pathway in PC12 cells
Publication date: July 2016 Source:Neurochemistry International, Volume 97 Author(s): Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zhi-Xiu Lin Beta-amyloid (Aβ) accumulation, one of the most important pathogenic traits of Alzheimer's disease (AD), has been reported to induce neurotoxicity in vitro as well as in vivo. Honokiol, isolated from the bark of Magnolia officinalis, has neuroprotective effects in different models of AD in vivo and in vitro. However, the exact mechanism for its neuroprotective effect is not well understood. The present study aimed to investigate the molecular mechanisms underlying the pr...
Source: Neurochemistry International - July 19, 2016 Category: Neuroscience Source Type: research
