Basic and Clinical Pharmacology and Toxicology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Differences in cardiovascular safety with non ‐steroidal anti‐inflammatory drug therapy ‐ a nationwide study in patients with osteoarthritis
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 28, 2018 Category: Drugs & Pharmacology Authors: Carlo Alberto Barcella, Morten Lamberts, Patricia McGettigan, Emil Loldrup Fosb øl, Jesper Lindhardsen, Christian Torp‐Pedersen, Gunnar Hilmar Gislason, Anne‐Marie Schjerning Olsen Tags: Original Article Source Type: research

Bisphosphonate use and risk of renal cell carcinoma: a population ‐based case‐control study
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 25, 2018 Category: Drugs & Pharmacology Authors: Benjamin I. Chung, Maja Hellfritzsch, Sinna Pilgaard Ulrichsen, Henrik Toft S ørensen, Vera Ehrenstein Tags: Short Communication Source Type: research

Effect of pharmacist intervention on blood conservation therapy in total knee arthroplasty: a retrospective, observational study
ConclusionsAnticoagulant pharmacist intervention on blood conservation treatment of TKA patients leads to favourable clinical and economic outcomes.This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 25, 2018 Category: Drugs & Pharmacology Authors: Ling Zhou, Jingjing Ma, Jianan Bao Tags: Original Article Source Type: research

Impact of chronic lead exposure on liver and kidney function and hematologic parameters
ConclusionThe results indicated that people with chronic lead exposure with BLLs greater than10 μg/dl are at risk of renal, liver and haematologic impairments.This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 24, 2018 Category: Drugs & Pharmacology Authors: Samaneh Nakhaee, Alireza Amirabadizadeh, Jeffery Brent, Omid Mehrpour Tags: Original Article Source Type: research

Risk factors associated with pseudoaldosteronism in patients with chronic hepatitis: A retrospective cohort study
This study aimed to evaluate the relationship between elevated direct‐bilirubin levels and hypokalaemia, which is the most sensitive marker of pseudoaldosteronism. This retrospective cohort study was conducted in a Japanese university hospital. The occurrence of hypokalaemia, defined as a serum potassium level of ≤ 3.5 mEq/ L after the administration of a glycyrrhizin‐containing medication, and a further decline of ≥ 0.5 mEq/L or an increase of ≥ 0.5 mEq/L after discontinuing the glycyrrhizin‐containing medication were examined in patients with chronic hepatitis between January 2009 and December 2015. This anal...
Source: Basic and Clinical Pharmacology and Toxicology - November 24, 2018 Category: Drugs & Pharmacology Authors: Akihiro Komatsu, Tetsuhiro Yoshino, Takeshi Suzuki, Tomonori Nakamura, Takanori Kanai, Kenji Watanabe Tags: Original Article Source Type: research

Chronic administration of theobromine inhibits mTOR signal in rats
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 19, 2018 Category: Drugs & Pharmacology Authors: Naotoshi Sugimoto, Masanori Katakura, Kentaro Matsuzaki, Eri Sumiyoshi, Akihiro Yachie, Osamu Shido Tags: Original Article Source Type: research

Red Blood cell IMPDH activity in adults and children with or without azathioprine: relationship between thiopurine metabolites, ITPA and TPMT activities
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 19, 2018 Category: Drugs & Pharmacology Authors: A Citterio ‐Quentin, A El Mahmoudi, T Perret, A Conway, A Ryan, A Beringer, A Lachaux, R Boulieu Tags: Original Article Source Type: research

Evaluation of DNA damage in spinal cord and mutagenic effect of a Ph α1β recombinant toxin with analgesic properties from the Phoneutria nigriventer spider
In conclusion, the recombinant form has cytotoxic, genotoxic and mutagenic effects, ev idenced in doses five time above the therapeutic dose.This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 17, 2018 Category: Drugs & Pharmacology Authors: Alessandra Hubner de Souza, Luiza Gabriela da Rosa, Michel Rossi Uliano, Lismare da Silva Prado, Alice Gomes Ferraz, Lucas Umpierre Conter, Ivana Grivicich, Eliane Dallegrave, Marcus Vin ícius Gomez, Jaqueline Nascimento Picada Tags: Original Article Source Type: research

Influence of thiopurine S ‐methyltransferase polymorphisms in mercaptopurine pharmacokinetics in healthy volunteers
The objective of this study was to evaluate the role ofTPMT polymorphisms on the pharmacokinetics of mercaptopurine. For that purpose, we used collected pharmacokinetic data from 48 healthy volunteers (all males) who received a single oral dose of mercaptopurine 50 mg in two bioequivalence studies. The volunteers were subsequently genotyped forTPMT *2, *3A, *3B and *3C alleles by real ‐time PCR. There were four carriers (8.3%) ofTPMT*2 andTPMT*3A alleles. Mercaptopurine elimination was affected byTPMT loss ‐of‐function polymorphisms, since heterozygous subjects show 18% higher half‐life compared to wild‐type indi...
Source: Basic and Clinical Pharmacology and Toxicology - November 15, 2018 Category: Drugs & Pharmacology Authors: Miriam Saiz ‐Rodríguez, Dolores Ochoa, Carmen Belmonte, Manuel Román, Cristina Martínez‐Ingelmo, Lucía Ortega‐Ruíz, Carmen Sarmiento‐Iglesias, Coral Herrador, Francisco Abad‐Santos Tags: ORIGINAL ARTICLE Source Type: research

Progression ‐free survival (PFS) in oncology: caveat emptor!
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 12, 2018 Category: Drugs & Pharmacology Authors: Troels K. Bergmann, Mette Marie H. Christensen, Daniel Henriksen, Maija Bruun Haastrup, Per Damkier Tags: Annotations & Reflections Source Type: research

Sixteen years of creatinine measurements among 460 000 individuals ‐ The Funen Laboratory Cohort (FLaC), a population‐based pharmacoepidemiological resource to study drug‐induced kidney disease
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 12, 2018 Category: Drugs & Pharmacology Authors: Daniel Pilsgaard Henriksen, Per Damkier, Jesper Hallas, Mads Nybo Tags: Original Article Source Type: research

Exendin ‐4 from Heloderma suspectum venom: From discovery to its latest application as Type II diabetes combatant
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 12, 2018 Category: Drugs & Pharmacology Authors: Michelle Khai Khun Yap, Nurhamimah Misuan Tags: Mini ‐Review Source Type: research

Signalling pathways involved in p47phox ‐dependent reactive oxygen species in platelets of endotoxemic rats
In conclusion, selective inhibitors of cGMP ‐PKG and PKC‐p47phox pathways that regulate ROS generation by LPS in platelets may help control the redox balance in sepsis improving the survival of patients. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 12, 2018 Category: Drugs & Pharmacology Authors: Maria E. Lopes Pires, Ana C. Antunes Naime, Jessica G. F. Oliveira, Gabriel F. Anhe, Oliver Garraud, Fabrice Cognasse, Edson Antunes, Sisi Marcondes Tags: ORIGINAL ARTICLE Source Type: research

Impact of knowledge, attitude and preceptor behaviour in pharmacovigilance education
This study aimed to determine the level of pharmacovigilance (PV) education in pharmacy programs and to evaluate the predictive factors for the intent to report adverse drug reactions (ADRs) by pharmacy students in South Korea. Self ‐administered questionnaires were collected from a regionally stratified nationwide convenience sample of pharmacy students in September 2017. The association between students’ intent to report ADRs and their knowledge and attitude was evaluated by using multivariate logistic regression analysis . In total, 303 pharmacy students participated in the survey; the average age of students was 26...
Source: Basic and Clinical Pharmacology and Toxicology - November 11, 2018 Category: Drugs & Pharmacology Authors: Yun Mi Yu, Seungyeon Kim, Kyung Hee Choi, Kyeong Hye Jeong, Euni Lee Tags: Original Article Source Type: research

Issue Information
Basic&Clinical Pharmacology&Toxicology, Volume 123, Issue 6, Page 641-642, December 2018. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 9, 2018 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research