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Activation of  Group II Metabotropic Glutamate Receptors Increases Proliferation but does not Influence Neuronal Differentiation of a Human Neural Stem Cell Line
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 11, 2017 Category: Drugs & Pharmacology Authors: Anne Dindler, Morten Blaabjerg, Morad Kamand, Helle Bogetofte, Morten Meyer Tags: Original Article Source Type: research

Professor Thue W. Schwartz is the BCPT Nordic Prize Winner 2017 in Basic & Clinical Pharmacology & Toxicology
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 9, 2017 Category: Drugs & Pharmacology Authors: Kim Br øsen Tags: Letter from the Editor Source Type: research

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
In conclusion, the rs12443580 and rs8192935 variants reduce CES1 expression in whole blood but not in the liver. These tissue‐specific effects may result in substrate‐dependent effects of the two SNVs on CES1‐mediated drug metabolism. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 8, 2017 Category: Drugs & Pharmacology Authors: Mikko Neuvonen, E Katriina Tarkiainen, Aleksi Tornio, P äivi Hirvensalo, Tuija Tapaninen, Maria Paile‐Hyvärinen, Matti K. Itkonen, Mikko T. Holmberg, Vesa Kärjä, Ville T. Männistö, Pertti J. Neuvonen, Jussi Pihlajamäki, Janne T. Backman, Mikko Ni Tags: Original Article Source Type: research

Population Pharmacokinetic/ Pharmacodynamic Modelling of Auditory ‐Evoked Event‐Related Potentials with Lorazepam
In this study, auditory‐evoked ERPs were generated in 13 older healthy volunteers using an oddball tone paradigm, after administration of single 0.5 and 2 mg doses of lorazepam. Population pharmacokinetics (PK)/pharmacodynamics (PD) models were developed using nonlinear mixed‐effects methods in order to assess the effect of lorazepam on the latency and amplitude of the P3 waveforms. The PK/PD models showed that doses of 0.3 mg of lorazepam achieved approximately half of the maximum effect on the latency of the P3 waveform. For P3 amplitude, half the maximum effect was achieved with a dose of 1.2 mg of lorazepam. The PK...
Source: Basic and Clinical Pharmacology and Toxicology - September 27, 2017 Category: Drugs & Pharmacology Authors: Aur élie Lombard, Claire Brittain, Graham Wishart, Stephen Lowe, Andrew McCarthy, William Landschulz, Georg Dorffner, Peter Anderer, Eunice Yuen Tags: Original Article Source Type: research

Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8 ‐Tetrachlorodibenzo‐p‐Dioxin Intoxication 50 Years After Exposure
Abstract The last eight survivors of 80 workers accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965–1967 in a chemical factory were followed. All were men, mean age 72.4 ± 1.3 years. Their current median TCDD blood level was 112 (46–390) pg/g lipids. Neurological examination revealed central nervous system impairment in all individuals and signs of polyneuropathy in 87.5%, which was confirmed by a nerve conduction study (NCS) in 75%. A Lanthony test demonstrated acquired dyschromatopsia in 87.5% of the patie...
Source: Basic and Clinical Pharmacology and Toxicology - September 27, 2017 Category: Drugs & Pharmacology Authors: Daniela Pelclova, Pavel Urban, Zdenka Fenclova, Stepanka Vlckova, Petr Ridzon, Karel Kupka, Zuzana Meckova, Ondrej Bezdicek, Tomas Navratil, Jan Rosmus, Sergey Zakharov Tags: Original Article Source Type: research

Evaluation of Prolonged Exposure to Varenicline in Adult Rats: Hematological, Biochemical and Anatomopathological Studies
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 25, 2017 Category: Drugs & Pharmacology Authors: Julia Zaccarelli ‐Magalhães, Natalia Moreira, Thaisa Meira Sandini, Gabriel Ramos Abreu, Angélica Maria Sánchez‐Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice Souza Spinosa Tags: Original Article Source Type: research

The Combination of Valsartan and Sacubitril in the Treatment of Hypertension and Heart Failure – an Update
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 25, 2017 Category: Drugs & Pharmacology Authors: Peter Munch Nielsen, Daniela Grimm, Markus Wehland, Ulf Simonsen, Marcus Kr üger Tags: Mini ‐Review Source Type: research

The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. PCOS is associated with obesity, dyslipidaemia and insulin resistance, and metformin treatment may improve such metabolic features. The effect of genetic variants in key metformin transporters, their transcriptional regulators or in metformin target genes on metformin response in women with PCOS is unclear. Associations between pharmacodynamic responses to metformin (changes in weight, lipid profile, insulin sensitivity evaluated by oral glucose tolerance testing) and polymorphisms in OCT1 (rs12208357 and rs...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Andreas J. T. Pedersen, Tore Bjerregaard Stage, Dorte Glintborg, Marianne Andersen, Mette Marie Hougaard Christensen Tags: Original Article Source Type: research

Rho Kinase Inhibitor, Fasudil, Attenuates Contrast ‐induced Acute Kidney Injury
In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast‐induced acute kidney injury (CI‐AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (1) control group, (2) CI‐AKI induced by contrast media (CM group), (3) CI‐AKI plus low‐dose fasudil (LD group) and (4) CI‐AKI plus high‐dose fasudil (HD group). Animals from groups 2–4 received iodixanol (4.0 g iodine/kg), and the control group received saline. At 12, 2 hr before iodixanol ...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Yiming Wang, Hao Zhang, Zhijian Yang, Dengshun Miao, Dingguo Zhang Tags: Original Article Source Type: research

Patient ‐ and Cell Type‐Specific Heterogeneity of Metformin Response
Abstract Most FDA‐approved drugs are not equally effective in all patients, suggesting that identification of biomarkers to predict responders to a chemoprevention agent will be needed to stratify patients and achieve maximum benefit. The goal of this study was to investigate both patient‐specific and cell context‐specific heterogeneity of metformin response, using fibroblast cell lines and induced pluripotent stem cells differentiated into lung epithelial lineages. We performed cell survival analysis, transcriptome and whole exome sequencing analysis on both patient‐derived cell lines and cancer cell lines to asse...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Michael K. Asiedu, Matthew Barron, Marie Christine Aubry, Dennis A. Wigle Tags: Original Article Source Type: research

Salidroside, a Chemopreventive Glycoside, Diminishes Cytotoxic Effect of Cisplatin in vitro
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 10, 2017 Category: Drugs & Pharmacology Authors: Martina Zduriencikova, Dana Cholujova, Jozef Duraj, Maria Mastihubova, Vladimir Mastihuba, Elena Karnisova Potocka, Eliska Galova, Andrea Sevcovicova, Martina Klapakova, Eva Horvathova Tags: Original Article Source Type: research

Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating Lipopeptides
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 7, 2017 Category: Drugs & Pharmacology Authors: Malene Winther, Claes Dahlgren, Huamei Forsman Tags: Mini ‐Review Source Type: research

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats
In conclusion, the results suggest that peripheral neuropathy induced by IIH progresses proximo‐distally, that severity and incidence increase with duration of the hypoglycaemia and that these changes are partially reversible within four weeks. Furthermore, IIH‐induced myopathy is most likely secondary to the neuropathy. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Vivi F. H. Jensen, Anne ‐Marie Molck, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Ingrid B. Bogh Tags: Original Article Source Type: research

Protective Effect of Atazanavir Sulphate Against Pulmonary Fibrosis In Vivo and In Vitro
In this study, the effects of atazanavir sulphate on various aspects of PF were examined and CoCl2 was used to induce the hypoxia‐mimicking condition in vitro, including epithelial–mesenchymal transition (EMT) in A549 cells, endothelial–mesenchymal transition (EndMT) in human pulmonary microvascular endothelial cells (HPMECs), proliferation in human lung fibroblasts (HLF‐1) and potential protective effects in human type I alveolar epithelial cells (AT I). Additionally, the effects of atazanavir sulphate were examined using a bleomycin (BLM)‐induced pulmonary fibrosis model. After atazanavir sulphate treat...
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Shina Song, Yunxia Ji, Guanghua Zhang, Xue Zhang, Bin Li, Defang Li, Wanglin Jiang Tags: Original Article Source Type: research

Birth Outcome of Children Fathered by Men Treated with Systemic Corticosteroids during the Conception Period – A Cohort Study based on Nationwide Data
This study is the largest to date examining the effect of paternal use of SCS prior to conception on birth outcome. We found no significantly increased risk of pre‐term birth or SGA. In children of fathers who redeemed at least two prescriptions of SCS within 3 months before conception, we found an increased risk of CAs, though not statistically significant. The types of CAs did not show a distinct pattern. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Michael Due Larsen, Sonia Friedman, Bjarne Magnussen, Bente Mertz N ørgård Tags: Original Article Source Type: research

Mechanistic Model for Blood Pressure and Heart Rate Changes Produced by Telmisartan in Human Beings
This study aimed to develop a mechanistic model of telmisartan drug effect in human beings using non‐invasive markers. Data were acquired from a previous study where telmisartan 80 mg was given once daily for 6 days. Systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR) were measured before dosing for days 1–5 and serially after the last dose. Mean arterial pressure (MAP) and pulse pressure (PP) were calculated from SBP and DBP. Relationships between MAP, PP, HR and total peripheral resistance (TPR) were developed. Circadian variation was incorporated into PP and HR, and TPR was assumed to...
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Dongwoo Chae, Mijeong Son, Yukyung Kim, Hankil Son, Kyungsoo Park Tags: Original Article Source Type: research

Patient and Cell Type ‐Specific Heterogeneity of Metformin Response
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 1, 2017 Category: Drugs & Pharmacology Authors: Michael K. Asiedu, Matthew Barron, Marie Christine Aubry, Dennis A. Wigle Tags: Original Article Source Type: research

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 30, 2017 Category: Drugs & Pharmacology Authors: Anja Urbschat, Patrick Baer, Kai Zacharowski, Vera Sprunck, Bertram Scheller, Florian Raimann, Thorsten J ürgen Maier, Axel Hegele, Rainer Hofmann, Jan Mersmann Tags: Original Article Source Type: research

Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: from Mechanisms to Novel Test Methods
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 26, 2017 Category: Drugs & Pharmacology Authors: Ali Alavian ‐Ghavanini, Joëlle Rüegg Tags: Mini ‐Review Source Type: research

Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 20, 2017 Category: Drugs & Pharmacology Authors: Seonghae Yoon, Kyoung Ryun Park, SeungHwan Lee, Sang ‐Hoon Song, Wan Beom Park, In‐Jin Jang, Kyung‐Sang Yu Tags: Original Article Source Type: research

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hind Limbs of Chronic Hypoglycaemic Rats
In conclusion, the results suggest that peripheral neuropathy induced by IIH progresses proximo‐distally, that severity and incidence increase with duration of the hypoglycaemia, and that these changes are partially reversible within four weeks. Furthermore, IIH‐induced myopathy is most likely secondary to the neuropathy. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 16, 2017 Category: Drugs & Pharmacology Authors: Vivi F. H. Jensen, Anne ‐Marie Molck, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Ingrid B. Bogh Tags: Original Article Source Type: research

Birth Outcomes of Children Fathered by Men Treated with Systemic Corticosteroids during the Conception Period – A Cohort Study based on Nationwide Data
This study is the largest to date examining the effect of paternal use of SCS prior to conception on birth outcomes. We found no significantly increased risk of pre‐term birth or SGA. In children of fathers who redeemed at least two prescriptions of SCS within 3 months before conception, we found an increased risk of CAs, though not statistically significant. The types of CAs did not show a distinct pattern. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 14, 2017 Category: Drugs & Pharmacology Authors: M D Larsen, S Friedman, B Magnussen, B M N ørgård Tags: Original Article Source Type: research

Effects of gastric inhibitory polypeptide, glucagon ‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism
Abstract The relationship between gut and skeleton is increasingly recognized as part of the integrated physiology of the whole organism. The incretin hormones gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are secreted from the intestine in response to nutrient intake and exhibit several physiological functions including regulation of islet hormone secretion and glucose levels. A number of GLP‐1 receptor agonists (GLP‐1RAs) are currently used in treatment of type 2 diabetes and obesity. However, GIP and GLP‐1 cognate receptors are widely expressed suggesting that incretin hormones med...
Source: Basic and Clinical Pharmacology and Toxicology - August 11, 2017 Category: Drugs & Pharmacology Authors: Morten S. S. Hansen, Michaela Tencerova, Jacob Fr ølich, Moustapha Kassem, Morten Frost Tags: MiniReview Source Type: research

Role of the Long Non ‐Coding RNA Growth Arrest‐Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease
Abstract Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first‐line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant number of side‐effects, that are particularly severe in paediatric patients, the identification of subjects that are most likely to respond poorly to GCs is extremely important. Recent evidence suggests that the long non‐coding RNA (lncRNA) GAS5 could be a potential marker of GC resistance. To addr...
Source: Basic and Clinical Pharmacology and Toxicology - August 9, 2017 Category: Drugs & Pharmacology Authors: Marianna Lucaf ò, Alessia Di Silvestre, Maurizio Romano, Alice Avian, Roberta Antonelli, Stefano Martelossi, Samuele Naviglio, Alberto Tommasini, Gabriele Stocco, Alessandro Ventura, Giuliana Decorti, Sara De Iudicibus Tags: Original Article Source Type: research

Physicians' Non ‐Uniform Approach to Prescribing Drugs to Older Patients – A Qualitative Study
Abstract Multi‐morbidity and polypharmacy are common in older patients and increase their susceptibility to adverse drug events and hospitalizations. Rational drug prescription is critical; however, little is known about physicians' perspectives on how to prescribe drugs for older patients. The aim of this study was to explore physicians' approach to prescribe drugs to older patients, including identifying the drugs that physicians perceive to be risk drugs for older patients and comparing them with established lists of potentially inappropriate medications. Short semi‐structured interviews were conducted with 50 medic...
Source: Basic and Clinical Pharmacology and Toxicology - August 6, 2017 Category: Drugs & Pharmacology Authors: Line Due Christensen, Janne Petersen, Ove Andersen, Susanne Kaae Tags: Original Article Source Type: research

The Catechol ‐O‐methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings
This study was nested in the METADAP cohort, a real‐world naturalistic treatment study in psychiatric settings. A total of 206 Caucasian patients with a unipolar major depressive episode (DSM‐IVTR) treated with venlafaxine and evaluated with the Hamilton Depression Rating Scale (HDRS) were studied. One hundred and eighty patients were genotyped for the COMT Val(108/158)Met, rs4680 genetic polymorphism and classified into three genotype subgroups: Val/Val, Val/Met and Met/Met. The COMT genotype was the explanatory variable, and the variables to be explained were HDRS score, HDRS score improvement over time, response rat...
Source: Basic and Clinical Pharmacology and Toxicology - August 6, 2017 Category: Drugs & Pharmacology Authors: Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, C éline Verstuyft Tags: Original Article Source Type: research

Statins and Angiotensin ‐Converting Enzyme Inhibitors are Associated with Reduced Mortality and Morbidity in Chronic Liver Disease
Abstract Liver fibrosis is a common response to many chronic liver diseases. The aim of our study was to explore whether pharmacotherapy for concurrent diseases affects overall mortality, liver‐related mortality and liver‐related morbidity in patients with chronic liver disease. We performed a register‐based cohort study of all patients with a first‐time diagnosis of chronic liver disease between 2005 and 2012 in Sweden (n = 70 546). Data from the Patient Register, the Prescribed Drug Register and the Death Certificate Register were linked. We studied whether the use of statins, angiotensin‐convert...
Source: Basic and Clinical Pharmacology and Toxicology - July 30, 2017 Category: Drugs & Pharmacology Authors: Knut Stokkeland, Christine Takami Lageborn, Anders Ekbom, Jonas H öijer, Matteo Bottai, Per Stål, Karin Söderberg‐Löfdal Tags: Original Article Source Type: research

Suspected Methadone Toxicity: from Hospital to Autopsy Bed
Abstract High mortality rates have been reported for methadone in both adults and children. We aimed to determine the pattern of toxicity, possible underlying diseases and treatment challenges in patients referred to our centre with early diagnosis of methadone toxicity and who later died. Medical files of all methadone‐poisoned patients who had been admitted to a referral centre of toxicology between March 2011 and March 2016, died during the hospital stay and sent for autopsy to Legal Medicine Organization were retrospectively evaluated. In a total of 94 patients, autopsy findings and laboratory evaluations showed that...
Source: Basic and Clinical Pharmacology and Toxicology - July 25, 2017 Category: Drugs & Pharmacology Authors: Jaber Gharehdaghi, Asieh Takalloo ‐Bakhtiari, Hossein Hassanian‐Moghaddam, Nasim Zamani, Mohammad‐Javad Hedayatshode Tags: Original Article Source Type: research

Effects of GIP, GLP ‐1 and GLP‐1RAs on Bone Cell Metabolism
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 19, 2017 Category: Drugs & Pharmacology Authors: Morten S S Hansen, Michaela Terencova, Jacob Fr ølich, Moustapha Kassem, Morten Frost Tags: Mini ‐Review Source Type: research

Role of the Long Non ‐Coding RNA GAS5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 19, 2017 Category: Drugs & Pharmacology Authors: Marianna Lucaf ò, Alessia Di Silvestre, Maurizio Romano, Alice Avian, Roberta Antonelli, Stefano Martelossi, Samuele Naviglio, Alberto Tommasini, Gabriele Stocco, Alessandro Ventura, M D Giuliana Decorti, Sara De Iudicibus Tags: Original Article Source Type: research

Huprine X attenuates the neurotoxicity induced by kainic acid, especially brain inflammation
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 19, 2017 Category: Drugs & Pharmacology Authors: J. Relat, B. P érez, P. Camps, D. Muñoz‐Torrero, A. Badia, M.V. Clos Tags: Original Article Source Type: research

Efficacy and Tolerability of an Inhaled Selective Glucocorticoid Receptor Modulator – AZD5423 – in Chronic Obstructive Pulmonary Disease Patients: Phase II Study Results
This study suggests that the selected population of patients with COPD does not respond to treatment with AZD5423 as regards lung function, while showing the expected systemic effects. It cannot be ruled out that a favourable lung function response of AZD5423 can be evoked using another experimental setting and/or within a different population of patients with COPD. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 17, 2017 Category: Drugs & Pharmacology Authors: Piotr Kuna, Magnus Aurivillius, Carin Jorup, Susanne Prothon, Ziad Taib, Staffan Edsb äcker Tags: Original Article Source Type: research

Severity of Baclofen Self ‐Poisoning Linked to Psychiatric Co‐morbidity in Alcohol‐Dependent Patients: Better Measurement of Risk and Benefit
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2017 Category: Drugs & Pharmacology Authors: Fanny Pelissier, Luc Haro, Benjamin Rolland, Nicolas Franchitto Tags: Letter to the Editor Source Type: research

Pharmacokinetic Properties of Memantine after a Single Intraperitoneal Administration and Multiple Oral Doses in Euploid Mice and in the Ts65Dn Mouse Model of Down's Syndrome
Abstract Memantine is a drug approved for the treatment of moderate‐to‐severe Alzheimer's disease (AD), and there is ongoing research on the potential expansion of its clinical applicability. Published data on the pharmacokinetics of memantine in the mouse are still incomplete, particularly for chronic administration regimens and mouse models of specific genetic disorders. Down's syndrome (DS) is a genetic disorder known to affect multiple organs and systems, with the potential to alter significantly drug pharmacokinetics. Here, we describe a simple, efficient and sensitive GC/MS‐based procedure for the determination...
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2017 Category: Drugs & Pharmacology Authors: Daniella B. Victorino, Ilya R. Bederman, Alberto C. S. Costa Tags: Original Article Source Type: research

Crotalus atrox Venom Exposed to Carbon Monoxide Has Decreased Fibrinogenolytic Activity In Vivo in Rabbits
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2017 Category: Drugs & Pharmacology Authors: Vance G. Nielsen Tags: Original Article Source Type: research

A Flow Cytometry ‐based Method for the Screening of Nanomaterial‐induced Reactive Oxygen Species Production in Leukocyte Sub‐Populations in Whole Blood
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2017 Category: Drugs & Pharmacology Authors: Ali Kermanizadeh, Kim Jantzen, David M Brown, Peter M øller, Steffen Loft Tags: Original Article Source Type: research

Statins and ACE Inhibitors are Associated with Reduced Mortality and Morbidity in Chronic Liver Disease
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - July 10, 2017 Category: Drugs & Pharmacology Authors: Knut Stokkeland, Christine Takami Lageborn, Anders Ekbom, Jonas H öijer, Matteo Bottai, Per Stål, Karin Söderberg‐Löfdal Tags: Original Article Source Type: research

Use of Moderate ‐Intensity Statins for Low‐Density Lipoprotein Cholesterol Level above 190 mg/dL at Baseline in Koreans
Abstract The ACC/AHA 2013 guideline recommends high‐intensity statin therapy for a decrease in low‐density lipoprotein cholesterol (LDL‐C) level by>50% among patients with baseline values of ≥190 mg/dL (approximately 4.872 mmol/L); however, this value should be modified before applying it to Korean populations. We investigated the statin‐specific LDL‐C‐lowering effects in Korean patients with baseline LDL‐C value ≥4.872 mmol/L. Data of patients prescribed a statin for the first time from January 2009 to December 2013 were assessed. In patients with baseline LDL‐C value ≥4.872 ...
Source: Basic and Clinical Pharmacology and Toxicology - July 9, 2017 Category: Drugs & Pharmacology Authors: Hun ‐Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung‐Hwan Lee, Jae Hyoung Cho, In‐Young Choi, Kun‐Ho Yoon, Ju Han Kim Tags: Original Article Source Type: research

Oral Administration of Polaprezinc Attenuates Fluorouracil ‐induced Intestinal Mucositis in a Mouse Model
This study aimed to investigate the prophylactic efficacy of Polaprezinc administered orally against intestinal mucositis induced by 5‐FU in mice on the condition that the anti‐tumour effect could not be compromised. We induced intestinal mucositis in SPF grade ICR mice with 5‐FU, and evaluated intestinal damage in the absence or presence of Polaprezinc. We examined the score of diarrhoea and the loss of weight following the 5‐FU treatment, and assessed the integrity of villus and the proliferation of small intestine crypt cells by Hematoxylin&Eosin staining and PCNA immunohistochemical detection. The anti‐tu...
Source: Basic and Clinical Pharmacology and Toxicology - July 1, 2017 Category: Drugs & Pharmacology Authors: Zhaoyang Liu, Wenbo Xie, Mingru Li, Nan Teng, Xiao Liang, Ziqiang Zhang, Zhaogang Yang, Xiaobing Wang Tags: Original Article Source Type: research

Sensitivity and Reliability of Halothane ‐Anaesthetized Microminipigs to Assess Risk of Drug‐induced Long QT Syndrome
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 27, 2017 Category: Drugs & Pharmacology Authors: Xin Cao, Takeshi Wada, Yuji Nakamura, Suchitra Matsukura, Hiroko Izumi ‐Nakaseko, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama Tags: Original Article Source Type: research

Analysis of National Pharmacovigilance Data Associated with Statin Use in Korea
Abstract The aim of this study was to evaluate clinical manifestations, age distribution and risk factors of adverse drug reactions (ADRs) of statins. Korean Adverse Event Reporting System (KAERS) database records (July 2009–June 2014) on statin‐treated adults were used. ADRs classified as ‘certain’, ‘probable’ and ‘possible’ based on the WHO‐Uppsala Monitoring Centre criteria were analysed. The frequency of ADRs was compared between adults (18–64 years) and older people (age ≥65 years) groups. In total, 2161 ADRs from 1690 patients (579, 34.3% older people) were inclu...
Source: Basic and Clinical Pharmacology and Toxicology - June 22, 2017 Category: Drugs & Pharmacology Authors: Hyunah Kim, Namhyo Kim, Da Hee Lee, Hun ‐Sung Kim Tags: Original Article Source Type: research

A Critical Note on Treatment of a Severe Diltiazem Intoxication: High ‐Dose Calcium and Glucagon Infusions
We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high‐dose calcium and glucagon infusions. A 53‐year‐old woman was admitted to the emergency department with a cardiogenic shock with complete AV block, not responding to atropine, isoprenaline and an external pacemaker. Later on, it became clear that she had a severe diltiazem intoxication which was successfully treated with isotone fluids, inotropes, vasopressors and continuous infusion of high‐dose calcium and glucagon. The patient developed, however, an acute, necrotizing pancreatitis, probably related to iatro...
Source: Basic and Clinical Pharmacology and Toxicology - June 22, 2017 Category: Drugs & Pharmacology Authors: Mathilde Van Veggel, Gijs Van der Veen, Tim Jansen, Elsbeth Westerman Tags: Case Report Source Type: research

Multiple and Opposite Effects of Angiotensin II Receptor Blockers on the Bioavailability of Epoxyeicosatrienoic Acids
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 22, 2017 Category: Drugs & Pharmacology Authors: Jeremy Bellien, Matthieu Leuillier, Safa Louhichi, Thomas Duflot, Robinson Joannides Tags: Letter to the Editor Source Type: research

Reply to ‘Multiple and Opposite Effects of Angiotensin II Receptor Blockers on the Bioavailability of Epoxyeicosatrienoic Acids’
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 22, 2017 Category: Drugs & Pharmacology Authors: Asuna Senda, Yuji Mukai, Toru Hayakawa, Yuka Kato, Erik Eliasson, Anders Rane, Takaki Toda, Nobuo Inotsume Tags: Letter to the Editor Source Type: research

Decrease in Oxidative Stress Parameters after Post ‐Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 21, 2017 Category: Drugs & Pharmacology Authors: Jasenka Mr šić‐Pelčić, Kristina Pilipović, Goran Pelčić, Dinko Vitezić, Gordana Župan Tags: Original Article Source Type: research

Vascular Calcification, Vitamin K and Warfarin Therapy – Possible or Plausible Connection?
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 21, 2017 Category: Drugs & Pharmacology Authors: Aino Siltari, Heikki Vapaatalo Tags: Mini ‐Review Source Type: research

The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers
In conclusion, none of the selected variations of CES1 had a clinically relevant impact on the metabolism of enalapril. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - June 21, 2017 Category: Drugs & Pharmacology Authors: Claus Stage, Gesche J ürgens, Louise Schow Guski, Ragnar Thomsen, Ditte Bjerre, Laura Ferrero‐Miliani, Yassine Kamal Lyauk, Henrik Berg Rasmussen, Kim Dalhoff, Tags: Original Article Source Type: research

The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid ‐lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low‐density Lipoprotein
This study included 18 volunteers with LDL levels above 130 mg/dL. Rosuvastatin (20 mg) was administered once a day for 8 weeks. Blood samples were drawn before and after the 8‐week treatment to measure changes in lipid levels. The presence of single nucleotide polymorphisms (SNPs) of SLCO2B1 (c.935G>A and c.1457C>T), SLCO1B1 (c.521C>T, c.388A>G, and c.‐11187G>A) and ABCG2 (c.421C>A) were determined by genotyping. Responses to rosuvastatin were compared between wild‐type and variant genotypes using permutation test on each polymorphism. In volunteers with SLCO2B1 c.935G>A (rs12422149) variant, ro...
Source: Basic and Clinical Pharmacology and Toxicology - June 19, 2017 Category: Drugs & Pharmacology Authors: Tae ‐Eun Kim, Dong‐Seong Shin, Namyi Gu, Byung Hwa Jung, Jayoun Kim, Young Min Cho, Kyung‐Sang Yu, Joo‐Youn Cho Tags: Original Article Source Type: research

The COMT Val(108/158)Met Genetic Polymorphism can not be Recommended as a Biomarker of Prediction of Venlafaxine Efficacy in Patients treated in Psychiatric settings
This study was nested in the METADAP cohort, a real‐world naturalistic treatment study in psychiatric settings. 206 Caucasian patients with a unipolar Major Depressive Episode (DSM‐IVTR) treated with venlafaxine and evaluated with the Hamilton Depression Rating Scale (HDRS) were studied. 180 patients were genotyped for the COMT Val(108/158)Met, rs4680 genetic polymorphism and classified into 3 genotype subgroups: Val/Val, Val/Met, Met/Met. The COMT genotype was the explanatory variable and the variables to be explained were the HDRS score, the HDRS score improvement over time, response and remission rates. Ve...
Source: Basic and Clinical Pharmacology and Toxicology - June 19, 2017 Category: Drugs & Pharmacology Authors: Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, C éline Verstuyft Tags: Original Article Source Type: research

Ivabradine Reduces Digitalis ‐induced Ventricular Arrhythmias
Abstract The I(f) channel inhibitor ivabradine is recommended for treatment of heart failure but also affects potassium currents and thereby prolongs ventricular repolarization. The aim of the present study was to examine the electrophysiological effects of ivabradine on digitalis‐induced ventricular arrhythmias. Thirteen rabbit hearts were isolated and Langendorff‐perfused. After obtaining baseline data, the digitalis glycoside ouabain was infused (0.2μM). Monophasic action potentials and ECG showed a significant abbreviation of QT interval (‐34ms,p
Source: Basic and Clinical Pharmacology and Toxicology - June 19, 2017 Category: Drugs & Pharmacology Authors: Gerrit Frommeyer, Jan Weller, Christian Ellermann, Nils B ögeholz, Patrick Leitz, Dirk G. Dechering, Simon Kochhäuser, Kristina Wasmer, Lars Eckardt Tags: Original Article Source Type: research