Log in to search using one of your social media accounts:

 

High Prevalence of Drug –Drug Interactions in Primary Health Care is Caused by Prescriptions from other Healthcare Units
In this study, we investigated to which extent potential drug–drug interactions originated from single or multiple prescribers. All patients attending any of 20 primary healthcare centres were included in a retrospective observational cohort study. Data on all prescriptions to these patients, irrespectively of the prescriber, were collected for two 4‐month periods. Potential drug interactions were identified using the drug–drug interaction database SFINX. Interactions were classified with respect to the workplace of the prescriber, and the prevalence of interactions according to origin was analysed. We found ...
Source: Basic and Clinical Pharmacology and Toxicology - December 13, 2017 Category: Drugs & Pharmacology Authors: Marine L. Andersson, Ylva B öttiger, Henrik Kockum, Birgit Eiermann Tags: Original Article Source Type: research

Letter from the Editor
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - December 13, 2017 Category: Drugs & Pharmacology Authors: Kim Br øsen Tags: Letter from the Editor Source Type: research

Regulated Cell Death of Lymphoma Cells after Graded Mitochondrial Damage is differentially affected by Drugs Targeting Cell Stress Responses
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - December 1, 2017 Category: Drugs & Pharmacology Authors: Tom ás Lombardo, Martín Gil Folgar, Luciana Salaverry, Estela Rey‐Roldán, Elida M. Alvarez, María C Carreras, Laura Kornblihtt, Guillermo A. Blanco Tags: Original Article Source Type: research

Response to the Letter to the Editor Regarding “Baclofen and Alcohol‐Dependent Patients: A Real Risk of Severe Self‐Poisoning.”
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 29, 2017 Category: Drugs & Pharmacology Authors: David Boels, Caroline Victorri ‐Vigneau, Marie Grall‐Bronnec, Ali Touré, Marion Brunet, Jean‐François Hamel, Gaël Le Roux Tags: Letter to the Editor Source Type: research

Gender ‐specific Association between ABCC2 ‐24C > T SNP and Reduction in Triglycerides in Chilean Patients treated with Atorvastatin
Abstract Statins are the first‐line therapy prescribed to lower plasma cholesterol levels. Although being safe and showing several beneficial cholesterol‐independent pleiotropic effects, a significant variability regarding statin's therapeutic goals has been abundantly documented, but less understood. We aimed to investigate the influence of the ABCC2 ‐24C>T single nucleotide polymorphism on Chilean hypercholesterolaemic subjects treated for 4 weeks with 10 mg/day atorvastatin. A total of 127 individuals medicated with atorvastatin 10 mg/day/4 weeks were included. Lipid profiles were determined before and after dr...
Source: Basic and Clinical Pharmacology and Toxicology - November 27, 2017 Category: Drugs & Pharmacology Authors: Y Prado, A Arancibia, T Zambrano, L A Salazar Tags: Original Article Source Type: research

Interactions of (2S,6S;2R,6R) ‐Hydroxynorketamine, a Secondary Metabolite of (R,S)‐Ketamine, with Morphine
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 24, 2017 Category: Drugs & Pharmacology Authors: Tuomas O. Lilius, Hanna Viisanen, Viljami Jokinen, Mikko Niemi, Eija A. Kalso, Pekka V. Rauhala Tags: Original Article Source Type: research

Activation of Group II Metabotropic Glutamate Receptors Increases Proliferation but does not Influence Neuronal Differentiation of a Human Neural Stem Cell Line
This study emphasizes the importance of glutamate and mGluRs on regulation of human neural stem cells and suggests a significant role of mGluR2/3 during cell proliferation. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 21, 2017 Category: Drugs & Pharmacology Authors: Anne Dindler, Morten Blaabjerg, Morad Kamand, Helle Bogetofte, Morten Meyer Tags: Original Article Source Type: research

Variation in the Response of Clozapine Biotransformation Pathways in Human Hepatic Microsomes to CYP1A2 and CYP3A4 ‐selective Inhibitors
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 20, 2017 Category: Drugs & Pharmacology Authors: Michael Murray, Wei V. Zhang, Robert J. Edwards Tags: Original Article Source Type: research

Cyclodextrin ‐Based Formulations: A Non‐Invasive Platform for Targeted Drug Delivery
Abstract Cyclodextrins (CDs) are recognized as promising pharmaceutical excipients due to their unique ability to form water‐soluble inclusion complexes with various poorly soluble compounds. The numerous investigations on CDs and their use in nanomedicine have received considerable attention in the last three decades, leading to the rapid development of new CD‐containing formulations that significantly facilitate targeted drug delivery and controlled drug release, with consequent improvements in drug bioavailability. This MiniReview highlights the efficacy and recent uses of CDs for non‐invasive drug delivery. Using...
Source: Basic and Clinical Pharmacology and Toxicology - November 20, 2017 Category: Drugs & Pharmacology Authors: Chutimon Muankaew, Thorsteinn Loftsson Tags: MiniReview Source Type: research

Post ‐Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 19, 2017 Category: Drugs & Pharmacology Authors: Ningjun Zhao, Pengchong Liang, Xiaoying Zhuo, Chenglei Su, Xuemei Zong, Bingnan Guo, Han Dong, Xianliang Yan, Shuqun Hu, Quanguang Zhang, Xu Tie Tags: Original Article Source Type: research

High Prevalence of Drug ‐Drug Interactions in Primary Health Care is Caused by Prescriptions from other Health Care Units
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 16, 2017 Category: Drugs & Pharmacology Authors: Marine L. Andersson, Ylva B öttiger, Henrik Kockum, Birgit Eiermann Tags: Original Article Source Type: research

SII Ang II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 15, 2017 Category: Drugs & Pharmacology Authors: Samra Joke Sanni, Christina Lyngs ø, Steen Gammeltoft, Jakob Lerche Hansen Tags: Original Article Source Type: research

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 14, 2017 Category: Drugs & Pharmacology Authors: Miriam Saiz ‐Rodríguez, Carmen Belmonte, Manuel Román, Dolores Ochoa, Dora Koller, María Talegón, María C. Ovejero‐Benito, Rosario López‐Rodríguez, Teresa Cabaleiro, Francisco Abad‐Santos Tags: Original Article Source Type: research

Issue Information
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 10, 2017 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Advanced Electrocardiogram (ECG) analysis in the Amitriptyline poisoned pig treated with Activated Charcoal Hemoperfusion (CAC ‐HP)
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 8, 2017 Category: Drugs & Pharmacology Authors: Tejs Jansen, Lotte C.G. Hoegberg, Thomas Eriksen, Christian Haarmark, Kim Dalhoff, Bo Belhage Tags: Original Article Source Type: research

Policy Change and the National Essential Medicines List Development Process in Brazil between 2000 and 2014: Has the Essential Medicine Concept been Abandoned?
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 8, 2017 Category: Drugs & Pharmacology Authors: Claudia Garcia Serpa Osorio ‐de‐Castro, Thiago Botelho Azeredo, Vera Lúcia Edais Pepe, Luciane Cruz Lopes, Sueli Yamauti, Brian Godman, Lars L. Gustafsson Tags: Original Article Source Type: research

Evaluation of the Influence of Three Newly Developed Bispyridinium Anti ‐Nicotinic Compounds (MB408, MB442, MB444) on the Efficacy of Antidotal Treatment of Nerve Agent Poisoning in Mice
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 8, 2017 Category: Drugs & Pharmacology Authors: Jiri Kassa, Christopher M. Timperley, Mike Bird, Rebecca L. Williams, A. Christopher Green, John E. H. Tattersall Tags: Original Article Source Type: research

New Insights into SN ‐38 Glucuronidation: Evidence for the Important Role of UDP Glucuronosyltranseferase 1A9
This study re‐investigates the pathway through testing effects of bovine serum albumin (BSA) and the selective inhibitor on SN‐38 glucuronidation in pooled human liver microsomes (HLM) and recombinant UGT1A1/1A9. For UGT1A1, SN‐38 glucuronidation was little affected by BSA. Whether in the presence of BSA or not, the reactions both obey Michaelis‐Menten kinetics with closed Vmax/Km values. For UGT1A9 and HLM, BSA can significantly accelerate SN‐38 glucuronidation activities and similar effects are fatherly observed on kinetic patterns. In the absence of BSA, reactions by HLM and UGT1A9 both display substrate inhib...
Source: Basic and Clinical Pharmacology and Toxicology - October 27, 2017 Category: Drugs & Pharmacology Authors: Ling Xiao, Liangliang Zhu, Wenjuan Li, Conghu Li, Yunfeng Cao, Guangbo Ge, Xiaoyu Sun Tags: Original Article Source Type: research

Prediction of Drug –Drug Interaction between Tacrolimus and Principal Ingredients of Wuzhi Capsule in Chinese Healthy Volunteers Using Physiologically‐Based Pharmacokinetic Modelling
In conclusion, we utilized PBPK modelling to quantify the contribution of schisantherin A and schisandrin A to DDI between tacrolimus and Wuzhi capsule. This may provide more insights for the rational use of this drug combination. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 25, 2017 Category: Drugs & Pharmacology Authors: Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai ‐Shu Lin, Jae‐Gook Shin, Xiaoqiang Xiang Tags: Original Article Source Type: research

Antidote Availability in Saudi Arabia Hospitals in the Riyadh Province
Abstract Inadequate antidote stocking is a global problem in hospitals. Insufficient supplies and delays in the administration of antidotes could lead to death and additional potentially negative clinical consequences. Our objective was to determine the availability of antidotes in hospitals listed on the Saudi Ministry of Health website in the Riyadh Province and to evaluate the leading poison in Saudi Arabia. A cross‐sectional study was conducted using questionnaires. The questionnaires were distributed to pharmacist directors and emergency room‐treating physicians in 17 public hospitals throughout the Riyadh Provinc...
Source: Basic and Clinical Pharmacology and Toxicology - October 25, 2017 Category: Drugs & Pharmacology Authors: Abdullah AlTamimi, Nidal K. Malhis, Najla M. Khojah, Saleh A. Manea, Abdulrahman AlTamimi, Sami Ayed AlShammary Tags: Original Article Source Type: research

The New Acetylcholinesterase Inhibitors PC ‐37 and PC‐48 (7‐MEOTA‐Donepezil‐like Compounds): Characterization of Their Metabolites in Human Liver Microsomes; Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 25, 2017 Category: Drugs & Pharmacology Authors: Jana Zdarova Karasova, Martin Mzik, Milos Hroch, Jan Korabecny, Eugenie Nepovimova, Viktor Vorisek, Vladimir Palicka, Kamil Kuca Tags: Original Article Source Type: research

Evaluation of Prolonged Exposure to Varenicline in Adult Rats: Haematological, Biochemical and Anatomopathological Studies
Abstract Varenicline is a synthetic chemical substance produced from the alkaloid cytisine, used for smoking treatment, which acts as a partial agonist for α4β2 and α3β4 nicotinic cholinergic receptors and as a total agonist for α7 receptor. While there are studies regarding varenicline's non‐smoking‐related effects, as in treatment for drug dependence, there are no studies in the literature evaluating the long‐term toxicity of varenicline through a physiological approach. Thus, the aim of this study was to evaluate possible toxicity through haematological, biochemical and anatomopathologi...
Source: Basic and Clinical Pharmacology and Toxicology - October 18, 2017 Category: Drugs & Pharmacology Authors: Julia Zaccarelli ‐Magalhães, Natalia Moreira, Thaísa Meira Sandini, Gabriel Ramos Abreu, Angélica Maria Sánchez‐Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice Souza Spinosa Tags: Original Article Source Type: research

Overdoses with Aripiprazole: Signs, Symptoms and Outcome in 239 Exposures Reported to the Danish Poison Information Centre
In conclusion, we found that aripiprazole overdoses had few and mild symptoms predominantly related to the sedative properties. We detected a benign cardiovascular safety profile and no new safety concerns. Our findings may support an increased threshold of 300 mg for hospital admission after a single‐drug exposure with aripiprazole and symptoms not worse than light sedation. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 11, 2017 Category: Drugs & Pharmacology Authors: Amalie P. Christensen, Soeren Boegevig, Mikkel B. Christensen, Kasper M. Petersen, Kim P. Dalhoff, Tonny S. Petersen Tags: Original Article Source Type: research

Activation of  Group II Metabotropic Glutamate Receptors Increases Proliferation but does not Influence Neuronal Differentiation of a Human Neural Stem Cell Line
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 11, 2017 Category: Drugs & Pharmacology Authors: Anne Dindler, Morten Blaabjerg, Morad Kamand, Helle Bogetofte, Morten Meyer Tags: Original Article Source Type: research

Professor Thue W. Schwartz is the BCPT Nordic Prize Winner 2017 in Basic & Clinical Pharmacology & Toxicology
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 9, 2017 Category: Drugs & Pharmacology Authors: Kim Br øsen Tags: Letter from the Editor Source Type: research

Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects
In conclusion, the rs12443580 and rs8192935 variants reduce CES1 expression in whole blood but not in the liver. These tissue‐specific effects may result in substrate‐dependent effects of the two SNVs on CES1‐mediated drug metabolism. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - October 8, 2017 Category: Drugs & Pharmacology Authors: Mikko Neuvonen, E Katriina Tarkiainen, Aleksi Tornio, P äivi Hirvensalo, Tuija Tapaninen, Maria Paile‐Hyvärinen, Matti K. Itkonen, Mikko T. Holmberg, Vesa Kärjä, Ville T. Männistö, Pertti J. Neuvonen, Jussi Pihlajamäki, Janne T. Backman, Mikko Ni Tags: Original Article Source Type: research

Population Pharmacokinetic/ Pharmacodynamic Modelling of Auditory ‐Evoked Event‐Related Potentials with Lorazepam
In this study, auditory‐evoked ERPs were generated in 13 older healthy volunteers using an oddball tone paradigm, after administration of single 0.5 and 2 mg doses of lorazepam. Population pharmacokinetics (PK)/pharmacodynamics (PD) models were developed using nonlinear mixed‐effects methods in order to assess the effect of lorazepam on the latency and amplitude of the P3 waveforms. The PK/PD models showed that doses of 0.3 mg of lorazepam achieved approximately half of the maximum effect on the latency of the P3 waveform. For P3 amplitude, half the maximum effect was achieved with a dose of 1.2 mg of lorazepam. The PK...
Source: Basic and Clinical Pharmacology and Toxicology - September 27, 2017 Category: Drugs & Pharmacology Authors: Aur élie Lombard, Claire Brittain, Graham Wishart, Stephen Lowe, Andrew McCarthy, William Landschulz, Georg Dorffner, Peter Anderer, Eunice Yuen Tags: Original Article Source Type: research

Neurological and Neurophysiological Findings in Workers with Chronic 2,3,7,8 ‐Tetrachlorodibenzo‐p‐Dioxin Intoxication 50 Years After Exposure
Abstract The last eight survivors of 80 workers accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965–1967 in a chemical factory were followed. All were men, mean age 72.4 ± 1.3 years. Their current median TCDD blood level was 112 (46–390) pg/g lipids. Neurological examination revealed central nervous system impairment in all individuals and signs of polyneuropathy in 87.5%, which was confirmed by a nerve conduction study (NCS) in 75%. A Lanthony test demonstrated acquired dyschromatopsia in 87.5% of the patie...
Source: Basic and Clinical Pharmacology and Toxicology - September 27, 2017 Category: Drugs & Pharmacology Authors: Daniela Pelclova, Pavel Urban, Zdenka Fenclova, Stepanka Vlckova, Petr Ridzon, Karel Kupka, Zuzana Meckova, Ondrej Bezdicek, Tomas Navratil, Jan Rosmus, Sergey Zakharov Tags: Original Article Source Type: research

Evaluation of Prolonged Exposure to Varenicline in Adult Rats: Hematological, Biochemical and Anatomopathological Studies
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 25, 2017 Category: Drugs & Pharmacology Authors: Julia Zaccarelli ‐Magalhães, Natalia Moreira, Thaisa Meira Sandini, Gabriel Ramos Abreu, Angélica Maria Sánchez‐Sarmiento, Esther Lopes Ricci, André Rinaldi Fukushima, Helenice Souza Spinosa Tags: Original Article Source Type: research

The Combination of Valsartan and Sacubitril in the Treatment of Hypertension and Heart Failure – an Update
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 25, 2017 Category: Drugs & Pharmacology Authors: Peter Munch Nielsen, Daniela Grimm, Markus Wehland, Ulf Simonsen, Marcus Kr üger Tags: Mini ‐Review Source Type: research

The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial
Abstract Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting women of reproductive age. PCOS is associated with obesity, dyslipidaemia and insulin resistance, and metformin treatment may improve such metabolic features. The effect of genetic variants in key metformin transporters, their transcriptional regulators or in metformin target genes on metformin response in women with PCOS is unclear. Associations between pharmacodynamic responses to metformin (changes in weight, lipid profile, insulin sensitivity evaluated by oral glucose tolerance testing) and polymorphisms in OCT1 (rs12208357 and rs...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Andreas J. T. Pedersen, Tore Bjerregaard Stage, Dorte Glintborg, Marianne Andersen, Mette Marie Hougaard Christensen Tags: Original Article Source Type: research

Rho Kinase Inhibitor, Fasudil, Attenuates Contrast ‐induced Acute Kidney Injury
In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast‐induced acute kidney injury (CI‐AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (1) control group, (2) CI‐AKI induced by contrast media (CM group), (3) CI‐AKI plus low‐dose fasudil (LD group) and (4) CI‐AKI plus high‐dose fasudil (HD group). Animals from groups 2–4 received iodixanol (4.0 g iodine/kg), and the control group received saline. At 12, 2 hr before iodixanol ...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Yiming Wang, Hao Zhang, Zhijian Yang, Dengshun Miao, Dingguo Zhang Tags: Original Article Source Type: research

Patient ‐ and Cell Type‐Specific Heterogeneity of Metformin Response
Abstract Most FDA‐approved drugs are not equally effective in all patients, suggesting that identification of biomarkers to predict responders to a chemoprevention agent will be needed to stratify patients and achieve maximum benefit. The goal of this study was to investigate both patient‐specific and cell context‐specific heterogeneity of metformin response, using fibroblast cell lines and induced pluripotent stem cells differentiated into lung epithelial lineages. We performed cell survival analysis, transcriptome and whole exome sequencing analysis on both patient‐derived cell lines and cancer cell lines to asse...
Source: Basic and Clinical Pharmacology and Toxicology - September 19, 2017 Category: Drugs & Pharmacology Authors: Michael K. Asiedu, Matthew Barron, Marie Christine Aubry, Dennis A. Wigle Tags: Original Article Source Type: research

Salidroside, a Chemopreventive Glycoside, Diminishes Cytotoxic Effect of Cisplatin in vitro
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 10, 2017 Category: Drugs & Pharmacology Authors: Martina Zduriencikova, Dana Cholujova, Jozef Duraj, Maria Mastihubova, Vladimir Mastihuba, Elena Karnisova Potocka, Eliska Galova, Andrea Sevcovicova, Martina Klapakova, Eva Horvathova Tags: Original Article Source Type: research

Formyl Peptide Receptors in Mice and Men: Similarities and Differences in Recognition of Conventional Ligands and Modulating Lipopeptides
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 7, 2017 Category: Drugs & Pharmacology Authors: Malene Winther, Claes Dahlgren, Huamei Forsman Tags: Mini ‐Review Source Type: research

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hindlimbs of Chronic Hypoglycaemic Rats
In conclusion, the results suggest that peripheral neuropathy induced by IIH progresses proximo‐distally, that severity and incidence increase with duration of the hypoglycaemia and that these changes are partially reversible within four weeks. Furthermore, IIH‐induced myopathy is most likely secondary to the neuropathy. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Vivi F. H. Jensen, Anne ‐Marie Molck, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Ingrid B. Bogh Tags: Original Article Source Type: research

Protective Effect of Atazanavir Sulphate Against Pulmonary Fibrosis In Vivo and In Vitro
In this study, the effects of atazanavir sulphate on various aspects of PF were examined and CoCl2 was used to induce the hypoxia‐mimicking condition in vitro, including epithelial–mesenchymal transition (EMT) in A549 cells, endothelial–mesenchymal transition (EndMT) in human pulmonary microvascular endothelial cells (HPMECs), proliferation in human lung fibroblasts (HLF‐1) and potential protective effects in human type I alveolar epithelial cells (AT I). Additionally, the effects of atazanavir sulphate were examined using a bleomycin (BLM)‐induced pulmonary fibrosis model. After atazanavir sulphate treat...
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Shina Song, Yunxia Ji, Guanghua Zhang, Xue Zhang, Bin Li, Defang Li, Wanglin Jiang Tags: Original Article Source Type: research

Birth Outcome of Children Fathered by Men Treated with Systemic Corticosteroids during the Conception Period – A Cohort Study based on Nationwide Data
This study is the largest to date examining the effect of paternal use of SCS prior to conception on birth outcome. We found no significantly increased risk of pre‐term birth or SGA. In children of fathers who redeemed at least two prescriptions of SCS within 3 months before conception, we found an increased risk of CAs, though not statistically significant. The types of CAs did not show a distinct pattern. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Michael Due Larsen, Sonia Friedman, Bjarne Magnussen, Bente Mertz N ørgård Tags: Original Article Source Type: research

Mechanistic Model for Blood Pressure and Heart Rate Changes Produced by Telmisartan in Human Beings
This study aimed to develop a mechanistic model of telmisartan drug effect in human beings using non‐invasive markers. Data were acquired from a previous study where telmisartan 80 mg was given once daily for 6 days. Systolic (SBP) and diastolic blood pressure (DBP) and heart rate (HR) were measured before dosing for days 1–5 and serially after the last dose. Mean arterial pressure (MAP) and pulse pressure (PP) were calculated from SBP and DBP. Relationships between MAP, PP, HR and total peripheral resistance (TPR) were developed. Circadian variation was incorporated into PP and HR, and TPR was assumed to...
Source: Basic and Clinical Pharmacology and Toxicology - September 6, 2017 Category: Drugs & Pharmacology Authors: Dongwoo Chae, Mijeong Son, Yukyung Kim, Hankil Son, Kyungsoo Park Tags: Original Article Source Type: research

Patient and Cell Type ‐Specific Heterogeneity of Metformin Response
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - September 1, 2017 Category: Drugs & Pharmacology Authors: Michael K. Asiedu, Matthew Barron, Marie Christine Aubry, Dennis A. Wigle Tags: Original Article Source Type: research

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 30, 2017 Category: Drugs & Pharmacology Authors: Anja Urbschat, Patrick Baer, Kai Zacharowski, Vera Sprunck, Bertram Scheller, Florian Raimann, Thorsten J ürgen Maier, Axel Hegele, Rainer Hofmann, Jan Mersmann Tags: Original Article Source Type: research

Understanding Epigenetic Effects of Endocrine Disrupting Chemicals: from Mechanisms to Novel Test Methods
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 26, 2017 Category: Drugs & Pharmacology Authors: Ali Alavian ‐Ghavanini, Joëlle Rüegg Tags: Mini ‐Review Source Type: research

Assessment of Appropriateness of an Initial Dosing Regimen of Vancomycin and Development of a New Dosing Nomogram
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 20, 2017 Category: Drugs & Pharmacology Authors: Seonghae Yoon, Kyoung Ryun Park, SeungHwan Lee, Sang ‐Hoon Song, Wan Beom Park, In‐Jin Jang, Kyung‐Sang Yu Tags: Original Article Source Type: research

Proximal Neuropathy and Associated Skeletal Muscle Changes Resembling Denervation Atrophy in Hind Limbs of Chronic Hypoglycaemic Rats
In conclusion, the results suggest that peripheral neuropathy induced by IIH progresses proximo‐distally, that severity and incidence increase with duration of the hypoglycaemia, and that these changes are partially reversible within four weeks. Furthermore, IIH‐induced myopathy is most likely secondary to the neuropathy. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 16, 2017 Category: Drugs & Pharmacology Authors: Vivi F. H. Jensen, Anne ‐Marie Molck, Henrik Soeborg, Jette Nowak, Melissa Chapman, Jens Lykkesfeldt, Ingrid B. Bogh Tags: Original Article Source Type: research

Birth Outcomes of Children Fathered by Men Treated with Systemic Corticosteroids during the Conception Period – A Cohort Study based on Nationwide Data
This study is the largest to date examining the effect of paternal use of SCS prior to conception on birth outcomes. We found no significantly increased risk of pre‐term birth or SGA. In children of fathers who redeemed at least two prescriptions of SCS within 3 months before conception, we found an increased risk of CAs, though not statistically significant. The types of CAs did not show a distinct pattern. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - August 14, 2017 Category: Drugs & Pharmacology Authors: M D Larsen, S Friedman, B Magnussen, B M N ørgård Tags: Original Article Source Type: research

Effects of gastric inhibitory polypeptide, glucagon ‐like peptide‐1 and glucagon‐like peptide‐1 receptor agonists on Bone Cell Metabolism
Abstract The relationship between gut and skeleton is increasingly recognized as part of the integrated physiology of the whole organism. The incretin hormones gastric inhibitory polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) are secreted from the intestine in response to nutrient intake and exhibit several physiological functions including regulation of islet hormone secretion and glucose levels. A number of GLP‐1 receptor agonists (GLP‐1RAs) are currently used in treatment of type 2 diabetes and obesity. However, GIP and GLP‐1 cognate receptors are widely expressed suggesting that incretin hormones med...
Source: Basic and Clinical Pharmacology and Toxicology - August 11, 2017 Category: Drugs & Pharmacology Authors: Morten S. S. Hansen, Michaela Tencerova, Jacob Fr ølich, Moustapha Kassem, Morten Frost Tags: MiniReview Source Type: research

Role of the Long Non ‐Coding RNA Growth Arrest‐Specific 5 in Glucocorticoid Response in Children with Inflammatory Bowel Disease
Abstract Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first‐line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant number of side‐effects, that are particularly severe in paediatric patients, the identification of subjects that are most likely to respond poorly to GCs is extremely important. Recent evidence suggests that the long non‐coding RNA (lncRNA) GAS5 could be a potential marker of GC resistance. To addr...
Source: Basic and Clinical Pharmacology and Toxicology - August 9, 2017 Category: Drugs & Pharmacology Authors: Marianna Lucaf ò, Alessia Di Silvestre, Maurizio Romano, Alice Avian, Roberta Antonelli, Stefano Martelossi, Samuele Naviglio, Alberto Tommasini, Gabriele Stocco, Alessandro Ventura, Giuliana Decorti, Sara De Iudicibus Tags: Original Article Source Type: research

Physicians' Non ‐Uniform Approach to Prescribing Drugs to Older Patients – A Qualitative Study
Abstract Multi‐morbidity and polypharmacy are common in older patients and increase their susceptibility to adverse drug events and hospitalizations. Rational drug prescription is critical; however, little is known about physicians' perspectives on how to prescribe drugs for older patients. The aim of this study was to explore physicians' approach to prescribe drugs to older patients, including identifying the drugs that physicians perceive to be risk drugs for older patients and comparing them with established lists of potentially inappropriate medications. Short semi‐structured interviews were conducted with 50 medic...
Source: Basic and Clinical Pharmacology and Toxicology - August 6, 2017 Category: Drugs & Pharmacology Authors: Line Due Christensen, Janne Petersen, Ove Andersen, Susanne Kaae Tags: Original Article Source Type: research

The Catechol ‐O‐methyltransferase Val(108/158)Met Genetic Polymorphism cannot be Recommended as a Biomarker for the Prediction of Venlafaxine Efficacy in Patients Treated in Psychiatric Settings
This study was nested in the METADAP cohort, a real‐world naturalistic treatment study in psychiatric settings. A total of 206 Caucasian patients with a unipolar major depressive episode (DSM‐IVTR) treated with venlafaxine and evaluated with the Hamilton Depression Rating Scale (HDRS) were studied. One hundred and eighty patients were genotyped for the COMT Val(108/158)Met, rs4680 genetic polymorphism and classified into three genotype subgroups: Val/Val, Val/Met and Met/Met. The COMT genotype was the explanatory variable, and the variables to be explained were HDRS score, HDRS score improvement over time, response rat...
Source: Basic and Clinical Pharmacology and Toxicology - August 6, 2017 Category: Drugs & Pharmacology Authors: Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, C éline Verstuyft Tags: Original Article Source Type: research

Statins and Angiotensin ‐Converting Enzyme Inhibitors are Associated with Reduced Mortality and Morbidity in Chronic Liver Disease
Abstract Liver fibrosis is a common response to many chronic liver diseases. The aim of our study was to explore whether pharmacotherapy for concurrent diseases affects overall mortality, liver‐related mortality and liver‐related morbidity in patients with chronic liver disease. We performed a register‐based cohort study of all patients with a first‐time diagnosis of chronic liver disease between 2005 and 2012 in Sweden (n = 70 546). Data from the Patient Register, the Prescribed Drug Register and the Death Certificate Register were linked. We studied whether the use of statins, angiotensin‐convert...
Source: Basic and Clinical Pharmacology and Toxicology - July 30, 2017 Category: Drugs & Pharmacology Authors: Knut Stokkeland, Christine Takami Lageborn, Anders Ekbom, Jonas H öijer, Matteo Bottai, Per Stål, Karin Söderberg‐Löfdal Tags: Original Article Source Type: research