Honokiol alleviates ulcerative colitis by targeting PPAR- γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro
In this study, we investigated the ability of this polyphenolic compound to suppress UC in mice and the possible regulatory mechanism. A mouse model of UC induced with dextran sulfate sodium (DSS) in 40 male C57BL/6J mice was used for the in vivo study, and in vitro experiments were performed in mouse RAW264.7 macrophages. Lipopolysaccharide was used to induce the inflammatory response. The mouse bodyweights, stool consistency, and bleeding were determined and the disease activity indices calculated. RAW264.7 macrophages were cultured with or without either honokiol or lipopolysaccharide. Gene and protein expression was an...
Source: International Immunopharmacology - July 28, 2022 Category: Allergy & Immunology Authors: Nan Wang Rui Kong Wei Han Wen Bao Yihai Shi LiPing Ye Jie Lu Source Type: research
Honokiol alleviates ulcerative colitis by targeting PPAR- γ-TLR4-NF-κB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro
In this study, we investigated the ability of this polyphenolic compound to suppress UC in mice and the possible regulatory mechanism. A mouse model of UC induced with dextran sulfate sodium (DSS) in 40 male C57BL/6J mice was used for the in vivo study, and in vitro experiments were performed in mouse RAW264.7 macrophages. Lipopolysaccharide was used to induce the inflammatory response. The mouse bodyweights, stool consistency, and bleeding were determined and the disease activity indices calculated. RAW264.7 macrophages were cultured with or without either honokiol or lipopolysaccharide. Gene and protein expression was an...
Source: International Immunopharmacology - July 28, 2022 Category: Allergy & Immunology Authors: Nan Wang Rui Kong Wei Han Wen Bao Yihai Shi LiPing Ye Jie Lu Source Type: research
Magnolol as a potent antifungal agent inhibits Candida albicans virulence factors via the PKC and Cek1 MAPK signaling pathways
In conclusion, the findings of this study confirmed the inhibition mechanism of magnolol against Candida albicans virulence factors, which might be related to PKC and Cek1 MAPK pathways, thus laying the theoretical foundation for its clinical antifungal applications. (Source: Frontiers in cellular and infection microbiology)
Source: Frontiers in cellular and infection microbiology - July 22, 2022 Category: Microbiology Source Type: research
Viruses, Vol. 14, Pages 1421: Synthesized Magnolol Derivatives Improve Anti-Micropterus salmoides Rhabdovirus (MSRV) Activity In Vivo
Tianqiang Liu
Micropterus salmoides rhabdovirus (MSRV) is a primary viral pathogen in largemouth bass aquaculture, which leads to tremendous economic losses yearly. Currently, there are no approved drugs for the treatment and control of this virus. Our previous studies screened the herb Magnolia officinalis from many traditional Chinese medicines, and we isolated and identified magnolol as its main active compound against multiple rhabdoviruses, including MSRV. On the basis of the structure–activity relationship and pharmacophore model of magnolol, two new magnolol derivatives, namely, hydrogenated magnol...
Source: Viruses - June 28, 2022 Category: Virology Authors: Yingjie Jin Fei Yang Gengrong Zhang Qing Yu Gaoxue Wang Fei Ling Tianqiang Liu Tags: Article Source Type: research
Molecules, Vol. 27, Pages 3892: Application of Multiple-Source Data Fusion for the Discrimination of Two Botanical Origins of Magnolia Officinalis Cortex Based on E-Nose Measurements, E-Tongue Measurements, and Chemical Analysis
In this study, a combination of e-nose measurements, e-tongue measurements, and chemical analyses coupled with multiple-source data fusion was used to differentiate the two origins. Linear discriminant analysis (LDA) and quadratic discriminant analysis (QDA) were applied to compare the discrimination results. It was shown that the e-nose system presented a good discriminant ability with a low classification error for both LDA and QDA compared with e-tongue measurements and chemical analyses. In addition, the discriminating capacity of LDA for low-level fusion with original data, similar to a combined system, was superior o...
Source: Molecules - June 17, 2022 Category: Chemistry Authors: Wenguang Jing Xiaoliang Zhao Minghua Li Xiaowen Hu Xianlong Cheng Shuangcheng Ma Feng Wei Tags: Article Source Type: research
Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders
In recent years, neurological diseases including Alzheimer’s disease, Parkinson’s disease and stroke are one of the main causes of death in the world. At the same time, the incidence of psychiatric disorders including depression and anxiety has been increasing. Accumulating elderly and stressed people suffer from these brain disorders, which is undoubtedly a huge burden on the modern aging society. Neolignans, the main active ingredients in Magnolia officinalis cortex, were reported to have neuroprotective effects. In addition, the key bioactive ingredients of neolignans, magnolol (1) and honokiol (2), were proved to p...
Source: Frontiers in Pharmacology - June 16, 2022 Category: Drugs & Pharmacology Source Type: research
Effects of Xiao Chengqi Formula on slow transit constipation by assessing gut microbiota and metabolomics analysis in vitro and in vivo 1
In conclusion, XCQ formula can protect ICC activity and effectively promote intestinal peristalsis by promoting the colonization of Roseburia and increasing the content of BAB after metabolism, thus improving the defecation status of STC patients. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - June 8, 2022 Category: Drugs & Pharmacology Source Type: research
Magnolol alleviates hypoxia-induced pulmonary vascular remodeling through inhibition of phenotypic transformation in pulmonary arterial smooth muscle cells
This study aims to evaluate the effects of magnolol on the phenotypic transformation of PASMCs induced by hypoxia. In vivo, Sprague Dawley rats were exposed to hypoxia (10% O2) for four weeks to establish a PH model. The results showed that hypoxia treatment led to an increase in right ventricle systolic pressure, Fulton index, collagen production, accompanied by upregulation in the expression of collagen Ⅰ, collagen Ⅲ, OPN, PCNA, CyclinD1, p-JAK2, and p-STAT3, as well as decreases in expression of SM-22α; these changes were attenuated by magnolol. In vitro, the primary cultured PASMCs were exposed to 3% O2 for 48 h t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2022 Category: Drugs & Pharmacology Authors: Xing-Hua Xiao Fang-Mei Luo E-Li Wang Min-Yi Fu Tao Li Yue-Ping Jiang Shao Liu Jun Peng Bin Liu Source Type: research
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors
Bioorg Med Chem. 2022 May 21;67:116838. doi: 10.1016/j.bmc.2022.116838. Online ahead of print.ABSTRACTHonokiol, isolated from a traditional Chinese medicine (TCM) Magnolia officinalis, is a biphenolic compound with several biological activities. To improve and broaden its biological activity, herein, two series of honokiol thioethers bearing 1,3,4-oxadiazole moieties were prepared and assessed for their α-glucosidase and SARS-CoV-2 entry inhibitory activities. Among all the honokiol thioethers, compound 7l exhibited the strongest α-glucosidase inhibitory effect with an IC50 value of 18.9 ± 2.3 µM, which was superior to...
Source: Bioorganic and Medicinal Chemistry - May 26, 2022 Category: Chemistry Authors: Ting Xu Jie-Ru Meng Wanqing Cheng Jia-Zheng Liu Junyan Chu Qian Zhang Nannan Ma Li-Ping Bai Yong Guo Source Type: research
Discovery of honokiol thioethers containing 1,3,4-oxadiazole moieties as potential α-glucosidase and SARS-CoV-2 entry inhibitors
Bioorg Med Chem. 2022 May 21;67:116838. doi: 10.1016/j.bmc.2022.116838. Online ahead of print.ABSTRACTHonokiol, isolated from a traditional Chinese medicine (TCM) Magnolia officinalis, is a biphenolic compound with several biological activities. To improve and broaden its biological activity, herein, two series of honokiol thioethers bearing 1,3,4-oxadiazole moieties were prepared and assessed for their α-glucosidase and SARS-CoV-2 entry inhibitory activities. Among all the honokiol thioethers, compound 7l exhibited the strongest α-glucosidase inhibitory effect with an IC50 value of 18.9 ± 2.3 µM, which was superior to...
Source: Bioorganic and Medicinal Chemistry - May 26, 2022 Category: Chemistry Authors: Ting Xu Jie-Ru Meng Wanqing Cheng Jia-Zheng Liu Junyan Chu Qian Zhang Nannan Ma Li-Ping Bai Yong Guo Source Type: research
Molecules, Vol. 26, Pages 7390: Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration
In conclusion, both MN and HK decreased the function and expression of BCRP via EGFR/PI3K signaling pathway. Therefore, both compounds were promising candidates for reversing the MDR of chemotherapy. (Source: Molecules)
Source: Molecules - December 6, 2021 Category: Chemistry Authors: Chung-Ping Yu Pei-Ying Li Szu-Yu Chen Shiuan-Pey Lin Yu-Chi Hou Tags: Article Source Type: research
Molecules, Vol. 26, Pages 6899: Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus
ana Scrobotă
Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in...
Source: Molecules - November 16, 2021 Category: Chemistry Authors: Georgiana Cical ău Petru Babes Horia Calniceanu Adelina Popa Gabriela Ciavoi Gilda Iova Mariana Ganea Ioana Scrobot ă Tags: Review Source Type: research
Unveiling the Mechanism of Principal Drugs of Lianpu Drink on Chronic Gastritis by Network Pharmacology
This study preliminarily revealed that CR and MOR play a key role in the treatment of CG. Animal experiments also showed that CR and MOR could significantly improve CG by inhibiting MKK6/p38 and RIP/p38 pathway.PMID:34745289 | PMC:PMC8570864 | DOI:10.1155/2021/5518750 (Source: Evidence-based Complementary and Alternative Medicine)
Source: Evidence-based Complementary and Alternative Medicine - November 8, 2021 Category: Complementary Medicine Authors: Shuhan Zhou Xiaohui Xu Jiangqin Zeng Zhiyi Liu Miao Wang Wenliang Lv Source Type: research
Magnolol Attenuates Right Ventricular Hypertrophy and Fibrosis in Hypoxia-Induced Pulmonary Arterial Hypertensive Rats Through Inhibition of the JAK2/STAT3 Signaling Pathway
This study aims to evaluate the effects and underlying mechanisms of magnolol on RV remodeling in hypoxia-induced PAH. In vivo, male Sprague Dawley rats were exposed to 10% O2 for 4 weeks to establish an RV remodeling model, which showed hypertrophic and fibrotic features (increases of Fulton index, cellular size, hypertrophic and fibrotic marker expression), accompanied by an elevation in phosphorylation levels of JAK2 and STAT3; these changes were attenuated by treating with magnolol. In vitro, the cultured H9c2 cells or cardiac fibroblasts were exposed to 3% O2 for 48 h to induce hypertrophy or fibrosis, which showed ...
Source: Frontiers in Pharmacology - October 26, 2021 Category: Drugs & Pharmacology Source Type: research
