Effects and mechanism of total phenols of Magnolia officinalis combined with Maijunan Tablets on blood pressure of spontaneous hypertensive rats
ConclusionThese results indicated that M-MJA could regulate the renin-angiotensin-aldosterone system, improve endothelial function, and inhibit CYP4A activity to reduce the production of 20-HETE, alleviate the oxidative stress disorder of the visceral organs, and eventually exert antihypertensive effect. Additionally, the anti-oxidant ability, regulating the renin-angiotensin-aldosterone system and improving endothelial function of M-MJA are more powerful than that of MJA, suggesting that M-MJA may have a better anti-hypertensive effect than MJA. (Source: Chinese Herbal Medicines)
Source: Chinese Herbal Medicines - March 10, 2019 Category: Complementary Medicine Source Type: research
Integrated Therapy Decreases the Mortality of Patients with Polymyositis and Dermatomyositis: A Taiwan-wide Population-Based Retrospective Study
ConclusionIntegrated therapy has reduced mortality in patients with PM/DM in Taiwan. Further investigation of the clinical effects and pharmaceutical mechanism involved is needed.Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 26, 2019 Category: Drugs & Pharmacology Source Type: research
A review of the phytochemistry and pharmacological activities of Magnoliae Officinalis Cortex
ConclusionsMagnoliae Officinalis Cortex is an essential traditional Chinese medicine with pharmacological activities that mainly affect the digestive system, nervous system and cardiovascular and cerebrovascular systems. This review summarises its botany, ethnopharmacology, phytochemistry, pharmacology and toxicology. These informations suggest that we should focus on the development of new drugs related to Magnoliae Officinalis Cortex, including specific constituents, so that Magnoliae Officinalis Cortex can exert greater therapeutic potential. Meanwhile, it is important to pay attention to the rational use of Magnolia re...
Source: Journal of Ethnopharmacology - February 26, 2019 Category: Drugs & Pharmacology Source Type: research
Magnolol prevents ovariectomy ‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways.
Magnolol prevents ovariectomy‑induced bone loss by suppressing osteoclastogenesis via inhibition of the nuclear factor‑κB and mitogen‑activated protein kinase pathways.
Int J Mol Med. 2019 Feb 18;:
Authors: Fei WY, Huo Q, Zhao PQ, Qin LJ, Li T
Abstract
Magnolol is the active component of the traditional Chinese medicine Magnolia officinalis, and has antioxidant, anti‑inflammatory and anticancer activities, as well as an effect on bone metabolism in vitro. In the present study, it is reported that magnolol suppresses osteoclastogenesis in vivo and in vitro. Magnolol preven...
Source: International Journal of Molecular Medicine - February 17, 2019 Category: Molecular Biology Authors: Fei WY, Huo Q, Zhao PQ, Qin LJ, Li T Tags: Int J Mol Med Source Type: research
Structural modification, fungicidal and insecticidal activity of 5-arylbenzofuran neolignan from Magnolia officinalis
Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Ding Lin, Zhongzhong Yan, Yangjie Yi, Kangming Li, Jiao Ye, Aixi Hu, Chuyun Long, Aiping LiuAbstractAs shown in a number of previous researches, the extracts of Magnolia officinalis exhibited broad-spectrum fungicidal and insecticidal activity. In our preliminary study, 5-arylbenzofuran neolignans, the secondary metabolite of Magnolia officinalis, was found to inherit the activity of Magnolia officinalis. For developing novel agrochemicals, natural 5-arylbenzofuran neolignan was selected as lead compound. After structural optimization, the fung...
Source: Phytochemistry Letters - January 20, 2019 Category: Chemistry Source Type: research
Four new honokiol derivatives from the stem bark of Magnolia officinalis and their anticholinesterase activities
Publication date: February 2019Source: Phytochemistry Letters, Volume 29Author(s): Baobao Zhang, Haitao Yu, Wei Lu, Bo Yu, Lei Liu, Weijuan Jia, Zongtao Lin, Hong Wang, Shizhong ChenAbstractFour new honokiol derivatives, namely 8′,9′-dihydroxymagnaldehyde E (1), 8′,9′-dihydroxyhonokiol (2), erythro-7-O-methylhonokitriol (3), and threo-7-O-methylhonokitriol (4), together with seven known compounds, erythro-honokitriol (5), threo-honokitriol (6), magnaldehyde E (7), magnotriol B (8), magnaldehyde B (9), honokiol (10), and magnolol (11), were isolated from the stem bark of Magnolia officinalis. Their structures were e...
Source: Phytochemistry Letters - December 19, 2018 Category: Chemistry Source Type: research
Induction of apoptosis by magnolol via the mitochondrial pathway and cell cycle arrest in renal carcinoma cells.
Abstract
Magnolol (Mag), an effective natural compound isolated from the stem bark of Magnolia officinalis, was found to have the potential for antitumor activity by inducing apoptosis in tumor cells. However, the effect of Mag on renal carcinoma cells and its molecular mechanism are unexplored. Our study provided evidence that Mag induced apoptosis in 786-O and OS-RC-2 cell lines via the mitochondrial pathway and cell cycle arrest. In this work, we found that Mag induced morphological changes and inhibited the proliferation of 786-O and OS-RC-2 cells in a dose- and time-dependent manner but exerted no...
Source: Biochemical and Biophysical Research communications - December 17, 2018 Category: Biochemistry Authors: Wen H, Zhou S, Song J Tags: Biochem Biophys Res Commun Source Type: research
Isolation of anti-Saprolegnia lignans from Magnolia officinalis and SAR evaluation of honokiol/magnolol analogs.
Abstract
To control the fish fungal pathogen Saprolegnia, the effects of the petroleum ether extracts of Magnolia officinalis were evaluated by a rapeseed (Brassicanapus) microplate method in vitro. By loading on an open silica gel column and eluting with petroleum ether-ethyl acetate-methanol, honokiol (C18H18O2) and magnolol (C18H18O2) were isolated from Magnolia officinalis. Saprolegnia parasitica growth was inhibited significantly when honokiol concentration was >8.0 mg/L, and magnolol concentration was >9.0 mg/L, with EC50 values of 4.38 and 4.92 mg/L, respectively. Six honokiol and magnol...
Source: Bioorganic and Medicinal Chemistry Letters - December 17, 2018 Category: Chemistry Authors: Hu Y, Shen Y, Tu X, Wu X, Wang GX, Ling F Tags: Bioorg Med Chem Lett Source Type: research
Magnolol ameliorates pneumonectomy and monocrotaline-induced pulmonary arterial hypertension in rats through inhibition of angiotensin II and endothelin-1 expression
ConclusionWe demonstrated that treatment with magnolol reduces the development of PAH induced by pneumonectomy and monocrotaline in rats, and suppressing Ang II and ET-1-mediated processes may contribute to its protective effects. These findings suggest that magnolol may be a potential agent for PAH therapy.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 5, 2018 Category: Drugs & Pharmacology Source Type: research
Honokiol protects pulmonary microvascular endothelial barrier against lipopolysaccharide-induced ARDS partially via the Sirt3/AMPK signaling axis
Publication date: Available online 29 August 2018Source: Life SciencesAuthor(s): Lan Chen, Wen Li, Di Qi, Ling Lu, Zhengwei Zhang, Daoxin WangAbstractAimsAcute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inflammation and oxidative stress. However, whether HKL has protective effects against the dysfunction of pulmonary microvascular endothelial barrier and the potent...
Source: Life Sciences - August 30, 2018 Category: Biology Source Type: research
Protective effects of honokiol against oxidative stress-induced apoptotic signaling in mouse podocytes treated with H2O2.
In conclusion, HNK largely eliminated the role of promoting podocyte apoptosis in an oxidative stress environment, which was a protective factor on podocytes cultured with H2O2. The anti-oxidative stress mechanisms of HNK are partly due to suppressing the expression of caspase-3 and caspase-9 and upregulating phosphorylated-Akt and -Erk 1/2.
PMID: 30116378 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - August 19, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research
Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer.
In this study, twenty honokiol and magnolol derivatives were isolated from the EtOH extract of Magnolia officinalis and the antiproliferative activity was evaluated on HCC827 (19del EGFR mutation), H1975 (L858 R/T790 M EGFR mutation), and H460 (KRAS mutation) cell lines. Among the isolated compounds, piperitylmagnolol (a 3-substituted magnolol derivative) showed the best antiproliferative activity against those three cell lines with the IC50 values of 15.85, 15.60 and 18.60 μM, respectively, which provided a direction for the structural modification of magnolol. Further structural modification led to the synthesis o...
Source: European Journal of Medicinal Chemistry - June 27, 2018 Category: Chemistry Authors: Tang H, Zhang Y, Li D, Fu S, Tang M, Wan L, Chen K, Liu Z, Xue L, Peng A, Ye H, Chen L Tags: Eur J Med Chem Source Type: research
Safety and Toxicology of Magnolol and Honokiol
In conclusion, over the recent years different food safety authorities evaluated magnolol and honokiol and considered them safe. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Planta Medica)
Source: Planta Medica - June 20, 2018 Category: Drugs & Pharmacology Authors: Sarrica, Andrea Kirika, Natalja Romeo, Margherita Salmona, Mario Diomede, Luisa Tags: Reviews Source Type: research
Molecules, Vol. 23, Pages 1470: Modulation of Rat Hepatic CYP1A and 2C Activity by Honokiol and Magnolol: Differential Effects on Phenacetin and Diclofenac Pharmacokinetics In Vivo
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In-Soo Yoon
Honokiol (2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol) and magnolol (4-Allyl-2-(5-allyl-2-hydroxy-phenyl)phenol) are the major active polyphenol constituents of Magnolia officinalis (Magnoliaceae) bark, which has been widely used in traditional Chinese medicine (Houpu Tang) for the treatment of various diseases, including anxiety, stress, gastrointestinal disorders, infection, and asthma. The aim of this study was to investigate the direct effects of honokiol and magnolol on hepatic CYP1A and 2C-mediated metabolism in vitro using rat liver microsomes and in vivo using the Sprague-Dawley rat ...
Source: Molecules - June 17, 2018 Category: Chemistry Authors: Sang-Bum Kim Kyu-Sang Kim Heon-Min Ryu Seong-Ho Hong Bo-Kyoung Kim Dae-Duk Kim Jin Woo Park In-Soo Yoon Tags: Article Source Type: research
[ASAP] Magterpenoids A –C, Three Polycyclic Meroterpenoids with PTP1B Inhibitory Activity from the Bark of < italic toggle="yes" > Magnolia officinalis < /italic > var. < italic toggle="yes" > biloba < /italic >
Organic LettersDOI: 10.1021/acs.orglett.8b01476 (Source: Organic Letters)
Source: Organic Letters - June 4, 2018 Category: Chemistry Authors: Chuan Li, Chuang-Jun Li, Jie Ma, Fang-You Chen, Li Li, Xiao-Liang Wang, Fei Ye, Dong-Ming Zhang Source Type: research
