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Pharmacokinetics and cytotoxic study of euphol from Euphorbia umbellata (Bruyns) Pax latex
Conclusions This study demonstrated that euphol exhibited cytotoxic effects against a variety of cancer cells lines, selectivity against leukemia and possibly, the mechanism involved is apoptosis. The evaluation of stability, distribution, and metabolism properties showed that euphol was unstable in gastric and intestinal fluids, presenting moderate plasma protein binding with two hours elimination half-life and possible phase II liver metabolism. All the results suggested that further studies could be developed to prove the viability of euphol as an anticancer agent. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2018 Category: Drugs & Pharmacology Source Type: research

25 years after the 'Rio Convention' – Lessons learned in the context of sustainable development and protecting indigenous and local knowledge
Conclusion In the context of the centuries of exploitative use of biodiversity, 25 years is a short time span and this review reiterates Posey and Dutfields’ call (1996) to companies or other outside organization for developing ‘a relationship in which the community is an equal partner’. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ovicidal effect of essential oils from Zingiberaceae plants and Eucalytus globulus on eggs of head lice, Pediculus humanus capitis De Geer
Conclusion These results demonstrated that Zingiberaceae EOs augmented with E. globulus EO are promising ovicidal agents for head lice control. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of total phenolic fraction derived from extra virgin olive oil for its antileishmanial activity
Conclusion This study brings a new low-cost candidate to the leishmaniasis drug discovery pipeline, upon further pharmacological investigation. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Curcumin enhances cisplatin sensitivity of human NSCLC cell lines through influencing Cu-Sp1-CTR1 regulatory loop
Conclusions Our results demonstrated copper chelator curcumin enhances the benefits of platinum-containing chemotherapeutic agents and CTR1 could be a promising therapeutic target for non-small cell lung cancer treatment. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Oral administration of Zuccagnia punctata extract improves lipid profile, reduces oxidative stress and prevents vascular dysfunction in hypercholesterolemic rabbits
Conclusion Oral administration of ZpE as natural product in the prevention of cardiovascular disease related with hypercholesterolemia and endothelial dysfunction is very promising. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Novel nor-monoterpenoid indole alkaloids inhibiting glioma stem cells from fruits of Alstonia scholaris
Conclusion New nor-monoterpenoid indole alkaloids from the fruits of A. scholaris provide new type promising molecule for the selective killing of human glioma stem cells. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 10, 2018 Category: Drugs & Pharmacology Source Type: research

Baicalin protects mice against Salmonella typhimurium infection via the modulation of both bacterial virulence and host response
Conclusions These results demonstrated that baicalin is a promising agent for the prevention of S. typhimurium infection via the modulation of both bacterial virulence and host response. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis
Conclusions: The findings suggest that garlic supplementation for 12 weeks might reduce pain severity in overweight or obese women with knee OA, which may, at least in part, be mediated via a reduction in the pro-inflammatory adipocytokine, resistin. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Synergistic interaction of β-caryophyllene with aromadendrene oxide 2 and phytol induces apoptosis on skin epidermoid cancer cells
Conclusion The present study demonstrates interactions among β-C, AO-(2) and P in the induction of apoptosis on A431 and HaCaT cells. These data suggest the combination of β-caryophyllene with aromadendrene oxide 2 and phytol could be potential therapeutics for the treatment of skin epidermoid cancer and precancerous cells. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-angiogenic activity of para-coumaric acid methyl ester on HUVECs in vitro and zebrafish in vivo
Conclusion pCAME may be a multi-target anti-angiogenic drug candidate and hold great potential for developing novel therapeutic strategy for cancer treatment. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Ginkgo biloba extract-761 on motor functions in permanent middle cerebral artery occlusion rats
Conclusions EGb 761 could improv motor function especially gait impairments among pMCAO rat model related to the decreased neuronal damage. Therefore, it might be the potential to be explored further as an effective therapeutic drug to treat post stroke motor dysfunctions. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production
Conclusion These results suggested that DGLHT-E offers a possible treatment for psoriasis, and that berberine hydrochloride might be a useful component of ointment-based treatments for psoriatic lesions. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Lespedeza cuneata protects the endothelial dysfunction via eNOS phosphorylation of PI3K/Akt signaling pathway in HUVECs
Conclusion Our findings suggest that LCE increase NO production via eNOS phosphorylation of PI3K/Akt signaling pathway. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Study on spectrum-effect correlation for screening the effective components in Fangji Huangqi Tang basing on ultra-high performance liquid chromatography-mass spectrometry
Conclusions The model successfully discovered the spectrum-effect relationships of FHT, which showed a representative way to discover the primary active ingredients from the complex herbal medicine system. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 9, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant Effects of an olive oil total polyphenolic fraction from a Greek Olea Europea variety in different Cell cultures
Conclusion The TPF appeared to protect cells from oxidative stress due to the strong antioxidant activity of its polyphenols. This could have interesting implications in development of new products based on this olive oil to provide protection and treatment against harmful effects of free radicals. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Ovatodiolide suppresses nasopharyngeal cancer by targeting stem cell-like population, inducing apoptosis, inhibiting EMT and dysregulating JAK/STAT signaling pathway
Conclusions Our results demonstrated the anticancer efficacy of Ova in NPC and its potential as a putative inhibitor of JAK2 and STAT3, which are essential in tumorigenesis of NPC. Further development of Ova is encouraged. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: A randomized, double-blind, placebo-controlled clinical trial
Conclusion We found that supplementation with EGP reduced “anxiety proneness” in subjects under chronic psychological stress, as shown by a decrease in the score of T-STAI and the tendency for decrease in the total score of STAI. This result suggests that EGP supplementation can be used as a regimen to safely reduce stress and anxiety; however, more studies are needed to establish the long-term safety and effectiveness. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Ethanolic extract of the aerial parts of Passiflora cincinnata Mast. (Passifloraceae) reduces nociceptive and inflammatory events in mice
Conclusion The present study suggests that Pc-EtOH possesses peripheral and central antinociceptive action, and showed potential in inhibition of release of mediators of the inflammatory process. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Role of the serotonergic pathway in uterotonic activity of Ananas comosus (L.) Merr. - an in vitro and in vivo study
Conclusions Our data clearly indicate that the uterotonic effect of ripe F4 is mediated via the serotonergic pathway and suggest that serotonin rich diet may increase the peripheral serotonin and implicate in diverse physiological functions, including uterine motility. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review
Conclusion Several natural compounds, existing in seaweeds, such as fucoxanthin and phoroglucinol have shown cytotoxic activity in in vitro and in vivo models acting through different molecular mechanisms, such as antioxidant, antiproliferative, DNA damage/DNA repair, proapoptotic, antiangiogenic and antimetastic. Within the scope of interactions with conventional drugs, there are evidences that some seaweed compounds could be used to potentiate the action of anticancer drugs. However, their effects and mechanisms of action, alone or in combination with anticancer drugs, namely TMZ, in glioblastoma cell, still few explored...
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Pyrus ussuriensis Maxim. leaves extract ameliorates DNCB-induced atopic dermatitis-like symptoms in NC/Nga mice
Conclusion Our studies indicate that PUL ameliorates atopic dermatitis-like symptoms by suppressing the proinflammatory cytokines and immune stimuli in both in vitro and in vivo animal models. Therefore, these data suggest that PUL might be an effective natural resource for the treatment of AD. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 8, 2018 Category: Drugs & Pharmacology Source Type: research

Zingiber officinale extract administration diminishes steroyl-CoA desaturase gene expression and activity in hyperlipidemic hamster liver by reducing the oxidative and endoplasmic reticulum stress
Conclusion GIN reduces SCD1 estimated activity and expression, as well as the lipids accumulated in the livers of HL hamsters. This is achieved through a mechanism involving the decrease of the oxidative and ERS, and the enhancement of cholesterol efflux. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 7, 2018 Category: Drugs & Pharmacology Source Type: research

Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study
Conclusion These findings suggest that the extract could be a potent neuropharmacological agent against amnesia via modulating cholinergic activity, neuroinflammation and promoting antioxidant action in the rat hippocampus. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 7, 2018 Category: Drugs & Pharmacology Source Type: research

jAnti-Mycobacterium tuberculosis activity of essential oil and 6,7-dehydroroyleanone isolated from leaves of Tetradenia riparia (Hochst.) Codd (Lamiaceae)
Conclusion These results revealed that TrEO isolated from leaves of T. riparia and the pure compound 6,7-dehydroroyleanone display good activity against M. tuberculosis clinical isolates, including MDR isolates, with low cytotoxicity to murine macrophages. The 6,7-dehydroroyleanone compound is a potential candidate for anti-TB drug. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach
Conclusion This study has demonstrated that chinmedomics is novel strategy for discovering the potential effective constituents from herbal formula, which are recognized as Q-markers. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 23, 2018 Category: Drugs & Pharmacology Source Type: research

Precise species detection of traditional Chinese patent medicine by shotgun metagenomic sequencing
Conclusion The results highlight that shotgun metagenomic sequencing is a complementary method for the precise species detection of TCPMs. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 20, 2018 Category: Drugs & Pharmacology Source Type: research

Antiproliferative Effect and Ultrastructural Alterations Induced by 5-O-methylembelin on Trypanosoma cruzi.
Conclusion : ME inhibited amastigotes proliferation, thus being a potential lead compound for the treatment of Chagas’ disease. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 19, 2018 Category: Drugs & Pharmacology Source Type: research

Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice
Conclusions We suggest that TSL-IHL inhibited the development of AD-like skin symptoms by regulating cytokine expression and may be an effective alternative therapy for AD. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 19, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro activity of collinin isolated from the leaves of Zanthoxylum schinifolium against multidrug- and extensively drug-resistant Mycobacterium tuberculosis
Conclusions : Collinin extracted from the leaves of Z. schinifolium significantly inhibits the growth of MDR and XDR M. tuberculosis in the culture broth. In addition, it also inhibits the growth of intracellular drug-susceptible and drug-resistant tuberculosis in Raw264.7 and A549 cells. To our knowledge, this is the first report on the in vitro anti-tubercular activity of collinin, and our data suggest collinin as a potential drug to treat drug-resistant tuberculosis. Further studies are warranted to assess the in vivo efficacy and therapeutic potential of collinin. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Family medicine Physicians ’ perception and attitudes of herbal substances use in greater Lisbon region
Conclusion : Low adherence to HS and little use of HM/HP were confirmed, highlighting the need for specific knowledge in Phytotherapy and its regulatory framework. This knowledge will enable the evaluation of herb-drug interactions and HM/HP adverse effects by the physicians thus justifying the integration of programmatic contents about HS in Medical Education. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic-Pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats
Conclusion The PK-PD model results provided scientific basis for clarifying compatibility mechanisms of GZFLC prescription and a better understanding for biosynthetic mechanisms of four prostaglandins (PGE2, PGF2α, 6-Keto-PGF1α and TXB2) in the treatment of PDM by GZFLC. Investigations on the relationship between the effects and the bioactive ingredients are of benefit to explore the mechanisms of action and combination for traditional Chinese medical prescriptions (TCP) and facilitate the development of future clinical applications of TCP. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Urtica dioica L. leaf extract modulates blood pressure and oxidative stress in spontaneously hypertensive rats
Conclusion : Chronic UE dietary supplementation had beneficial effects in the experimental model of essential hypertension. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of oral Panax Notoginseng saponins for unstable angina patients: a meta-analysis and systematic review
Conclusion Oral PNS could reduce the end point, and improve the ECG, the frequency and duration of angina pectoris, dosage of nitroglycerin and lipids in UA patients. And the results indicated oral PNS is safe up to now. However, we need more multi-centre, large-sample, high-quality RCTs to provide high-quality evidence. (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Cardioprotective role of azafrin in against myocardial injury in rats via activation of the Nrf2-ARE pathway
Conclusion Azafrin exhibited cardioprotective effects against myocardial injury via activation of the Nrf2-ARE pathway. As a natural carotenoid antioxidant, this molecule represents a promising cardioprotective adjuvant for the prophylaxis and treatment of ischaemic heart diseases. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Discovery of cardio-protective constituents of Gualou Xiebai Decoction, a classical traditional Chinese medicinal formula
Conclusion An array of effective constituents of GLXB were discovered, and discovery of these compounds contributed to elucidating the substantial basis for the therapeutic effects of this formula, and provides fundaments for establishing Q-markers for further reliable quality control of GLXB. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Total Phenolic and Flavonoid Contents and Antihypertensive Effect of the Crude Extract and Fractions of Calamintha vulgaris
Conclusion : Results obtained indicate that the antihypertensive effect of C. vulgaris is the outcome of vasodilation, which is mediated through combination of muscarinic receptor-linked NO, activation of TEA-sensitive K+ channels, prostacyclin and Ca+2 antagonism. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 18, 2018 Category: Drugs & Pharmacology Source Type: research

Yokukansan contains compounds that antagonize the 5-HT3 receptor
Conclusion Each alkaloid contributes to antagonism of the 5-HT3 receptor. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Tiger nut and walnut extracts modulate extracellular metabolism of ATP and adenosine through the NOS / cGMP / PKG signaling pathway in kidney slices
Conclusion Tiger nut and walnut extracts showed a protective effect on L-NAME induced kidney slices by reducing the activities of NTPDase (ATP as substrate) and adenosine deaminase, increased NO levels as well as prevent oxidative damage. The effect observed may be attributed to the phenolic compounds present in both nuts as depicted by HPLC finger printing. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of a standardized extract of Centella asiatica ECa233 in rotenone-induced parkinsonism rats
Conclusion ECa233 can protect against rotenone-induced motor deficits and dopaminergic neuronal death. These effects are mediated through the protection of mitochondrial complex I activity, the effects of antioxidants and the enhancement of antioxidant enzyme expression. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Eupatilin ameliorates dextran sulphate sodium -induced colitis in mice partly through promoting AMPK activation
Conclusion The study successfully demonstrated that Eup ameliorated DSS-induced mice colitis by suppressing inflammation and maintaining the integrity of the intestinal epithelial barrier via AMPK activation. The results provide valuable guidance for using Eup in UC treatment. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Role of curcumin in the management of pathological pain
Conclusion: This review focuses on pre-clinical and clinical studies in the treatment of pathological pain. Although the mechanisms of pain mitigating effects are not very clear, there is compelling evidence proved that curcumin plays an essential role. However, further high-quality clinical studies should be undertaken to establish the clinical effectiveness of curcumin in patients suffering from pathological pain. Potential methods of increase the water solubility and bioavailability of curcumin still need to be studied. These approaches will help in establishing it as remedy for pathological pain. (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Carnosic acid improves diabetic nephropathy by activating Nrf2/ARE and inhibition of NF- κB pathway
Conclusion These findings suggest that CA is a safe compound which exerts the protective effects on diabetes-induced kidney complications. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Justicia adhatoda induces megakaryocyte differentiation through mitochondrial ROS generation
Conclusion Justicia adhatoda could enhance mitochondrial ROS generation and increase the permeability of mitochondrial membrane, thereby inducing megakaryocytic maturation. Our findings suggest thrombopoietic potential of Justicia adhatoda leaf extract on megakaryocyte differentiation. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

The potential effect of garlic extract and curcumin nanoparticles against complication accompanied with experimentally induced diabetes in rats
Conclusion Nano-Curcumin and AGE suspension have a great therapeutic potential in the treatment of DCM, Diabetic cardiomyopathy, by attenuating cardiac inflammation, myocardial fibrosis, and programmed myocardial cell deaths through inhibiting OS and AGEPs accumulation in diabetic heart tissue. Furthermore, the hypoglycemic antioxidant properties of AGE resulted in more potent therapeutic effect than Nano-Curcumin in the treatment of diabetic hearts. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 17, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation of Ovatodiolide, a Macrocyclic Diterpenoid, as a potential inhibitor of Oral Cancer Stem-Like Cells Properties via the Inhibition of the JAK2/STAT3/JARID1B Signal Circuit
Conclusion These results demonstrate that Ova effectively suppressed oral tumorigenesis and stemness properties via JAK2/STAT3 signaling. Ova may be considered for future clinical usage. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 13, 2018 Category: Drugs & Pharmacology Source Type: research

Botany, traditional use, phytochemistry, pharmacology, quality control, and authentication of Radix Gentianae Macrophyllae-A traditional medicine: A review
Conclusions : Although the identification of compounds from Qinjiao and demonstration of medicinal uses in vitro and in vivo have been carried out, various other studies on these plants should deserve our more attention. More efforts should be concentrated on the underlying mechanisms of their beneficial bioactivities. The proper toxic evaluation is indispensable to guarantee the safety, efficacy, and eligibility for medical use. To sum up, the summarized achievements could highlight the importance of Qinjiao and provide a solid foundation for scientists not only to further exploit the therapeutic potentials, but also poss...
Source: Phytomedicine - April 12, 2018 Category: Drugs & Pharmacology Source Type: research

β-N-oxalyl-L-α,β-diaminopropionic acid induces wound healing by stabilizing HIF-1α and modulating associated protein expression
Conclusion : The present investigation explores potential of L-ODAP as a wound healing agent. L-ODAP positively affected wound healing both in vitro and in vivo and thus could be considered a natural wound healing agent. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 12, 2018 Category: Drugs & Pharmacology Source Type: research

DNA barcoding for specific and sensitive detection of Cuminum cyminum adulteration in Bunium persicum
Conclusion Among the tested barcoding loci, psbA-trnH has proven to be best barcode in authentication of kala zeera as its amplification and sequencing success was high and it showed the presence of polymorphic sites to detect interspecific variation. This barcode could differentiate between safed zeera and kala zeera in a single reaction, simultaneously. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 11, 2018 Category: Drugs & Pharmacology Source Type: research

PG201 protects mice from experimental autoimmune encephalomyelitis via suppression of effector T cell activation
Conclusion These findings indicate that PG201 may exert strong immunomodulatory effects in the EAE model via suppression of T cell activation, and that PG201 is a therapeutic reagent for the treatment of multiple sclerosis. Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - April 10, 2018 Category: Drugs & Pharmacology Source Type: research