Development of curcumin-loaded gemini surfactant nanoparticles: synthesis, characterization and evaluation of anticancer activity against human breast cancer cell lines
ConclusionOur data demonstrates the great potential of gemini surfactants for efficient delivery of curcumin and subsequently, the improvement of its anticancer effect. Therefore, it is sagacious to support the idea that Gemini-Cur nano compound might have the potential to be considered as an anticancer agent.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 16, 2018 Category: Drugs & Pharmacology Source Type: research

Ethanolic extract of Kaempferia parviflora interrupts the mechanisms-associated rheumatoid arthritis in SW982 culture model via p38/STAT1 and STAT3 pathways
ConclusionThese results suggest that the anti-arthritic potential of KP extract results from anti-inflammation and anti-migration via the suppression of the cytokines-induced p38/STAT1 and STAT3 pathways.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations
ConclusionGE attenuated mHTT aggregations through the control of mitochondrial fusion and the fission pathway.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Insight to the antifungal properties of Amaryllidaceae constituents
ConclusionThe key feature in the antifungal effects of Amaryllidaceae alkaloids is the inhibition of protein synthesis. This involved the inhibition of peptide bond formation by binding to yeast ribosomes via the 60S subunit. Related effects involved the inhibition of both DNA and RNA synthesis. These adverse effects were reflected morphologically on both the fungal cell wall and cell membrane. Such observations should prove useful in the chemotherapeutic arena should efforts shift towards the development of a clinical candidate.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-metastasis activity of curcumin against breast cancer via the inhibition of stem cell-like properties and EMT
Conclusion: The results of the present study suggest that the inhibitor effects of curcumin on breast cancer cells may be related to resistance to cancer stem-like characters and the EMT process. These data indicate that curcumin could function as a type of anti-metastasis agent for breast cancer.Graphic Abstract (Source: Phytomedicine)
Source: Phytomedicine - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

Salvianolic acid B inhibits Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression
ConclusionSal B inhibited Ang II-induced VSMC proliferation in vitro and intimal hyperplasia in vivo by downregulating miR-146a expression.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 14, 2018 Category: Drugs & Pharmacology Source Type: research

Leishmanicidal and antichemotactic activities of icetexanes from Salvia uliginosa Benth.
ConclusionThis data indicated that IsoICT and ICT exhibit potent antichemotactic and leishmanicidal effects. Further studies are needed in order to evaluate the in vivo activities as well as the toxicity of the compounds.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 12, 2018 Category: Drugs & Pharmacology Source Type: research

Inclusion complex of saikosaponin-d with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-skin cancer activity
ConclusionsSSD-HPBCD inclusion complex shows improvement in water solubility and physicochemical properties, and exhibits anticancer effects against cutaneous squamous cell carcinoma cells. Therefore, it may be a potential drug formulation for the treatment of skin cancer.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Combined delivery of curcumin and the heme oxygenase-1 gene using cholesterol-conjugated polyamidoamine for anti-inflammatory therapy in acute lung injury
ConclusionThe pHO-1/PamChol-Cur complex had a higher pHO-1 gene-delivery efficiency and greater anti-inflammatory effects than the pHO-1/PamChol complex or PamChol-Cur. Therefore, the combined delivery of curcumin and pHO-1 using PamChol-Cur may be useful for treatment of ALI.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Discovery of the mechanisms and major bioactive compounds responsible for the protective effects of Gualou Xiebai Decoction on coronary heart disease by network pharmacology analysis
ConclusionThis study screened out major bioactive compounds from GLXB and offered a new understanding of the protection mechanism of GLXB against CHD by network pharmacology method and provides a combination strategy to explore mechanisms of action of multi-component drugs from a holistic perspective.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Quercetin alleviates high glucose-induced damage on human umbilical vein endothelial cells by promoting autophagy
Publication date: Available online 8 November 2018Source: PhytomedicineAuthor(s): Aysa Rezabakhsh, Reza Rahbarghazi, Hassan Malekinejad, Farzaneh Fathi, Azadeh Montaseri, Alireza GarjaniAbstractBackgroundQuercetin, a flavonoid antioxidant, has been found to exert therapeutic effects in diabetic condition. Autophagy represents a homeostatic cellular mechanism for the turnover of unfolds proteins and damaged organelles through a lysosome-dependent degradation manner. We speculated that quercetin could protect endothelial cells against high glucose-induced damage by promoting autophagic responses.MethodsHUVECs viability was e...
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - Transcriptome-wide microarray analysis of neuroglia cells
ConclusionApplication of cytostatic drugs in combination with adaptogenic plant extracts induced significant changes in transcriptome-wide microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects of adaptogens on FEC induced adverse events in cancer chemotherapy.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

Rosae multiflorae fructus extract and its four active components alleviate ovalbumin-induced allergic inflammatory responses via regulation of Th1/Th2 imbalance in BALB/c rhinitis mice
ConclusionRMFE may have therapeutic potential for treating AR by modulating the relationships between Th1/Th2 responses.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 9, 2018 Category: Drugs & Pharmacology Source Type: research

25 years after the `Rio Convention'––Lessons learned in the context of sustainable development and protecting indigenous and local knowledge
ConclusionIn the context of the centuries of exploitative use of biodiversity, 25 years is a short time span and this review reiterates Posey and Dutfields’ call (1996) to companies or other outside organization for developing ‘a relationship in which the community is an equal partner’.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Magnetic Dihydroartemisinin Nano-liposome in Inhibiting the Proliferation of Head and Neck Squamous Cell Carcinomas
Publication date: Available online 6 November 2018Source: PhytomedicineAuthor(s): Li Hui, Li Xiaoming, Shi Xinli, Li Zhen, Sun YajingAbstractBackgroundDihydroartemisinin (DHA) was one of the most potent anticancer artemisinin-like compounds that had been proved by many researchers, but its application was limited by its own characteristics.PurposeMagnetic DHA nano-liposomes (DHA-MLPs) were developed to improve the targeting antitumor efficiency and bioavailability of DHA, and their physical properties were characterized.Study Design and MethodsLiposomes were prepared by thin film dispersion and orthogonal experimental desi...
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Identification of phase-II metabolites from human serum samples after oral intake of a willow bark extract
ConclusionThis is the first study to identify human metabolites of flavonoids, proanthocyanidins and salicylic alcohol derivatives of Salicis cortex beside salicylic acid or catechol. For the most characterized metabolites, anti-inflammatory activity has been described in the literature, and the present results are an important step in understanding the anti-inflammatory efficacy of willow bark in-vivo.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition
ConclusionLC53 exerted a retinal protective effect through NF-κB inhibition and was highly potent against MMP-9 activities after high IOP-induced I/R injury, suggesting that LC53 would be a promising drug lead for glaucoma or related medical conditions attributed to retinal ischemia.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Epithelial-mesenchymal transition as a target for botanicals in cancer metastasis
ConclusionAmong the plant products reviewed, phenylpropanoids were the most investigated at preclinical phase, thus exhibiting a promising potential as anticancer drugs, though an evidence-based clinical efficacy is still lacking. (Source: Phytomedicine)
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

(−)-Epigallocatechin-3-gallate (EGCG) enhances healing of femoral bone defect
ConclusionsLocal EGCG may enhance bone defect healing via at least partly by the de novo bone formation of BMP-2.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 7, 2018 Category: Drugs & Pharmacology Source Type: research

Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility
ConclusionRGSE ameliorated myocardial insulin sensitivity under conditions of lipid overload, which was tightly associated with the decrease in mitochondrial oxidative stress via modulating glucose and fatty acid oxidation.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Phyto-sesquiterpene lactone deoxyelephantopin and cisplatin synergistically suppress lung metastasis of B16 melanoma in mice with reduced nephrotoxicity
ConclusionThe CP and DET combination may be an effective intervention for melanoma with reduced side effects.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells
ConclusionThe neuroprotective effect of adaptogens did not attenuate the cytotoxic activity of FEC. Application of cytostatic drugs in combination with adaptogenic plant extracts likely have no impact in cytotoxic effect of FEC. Furthermore, AP and RSE potentiated the cytotoxic effects of FEC.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Rutin protects t‑butyl hydroperoxide-induced oxidative impairment via modulating the Nrf2 and iNOS activity
Publication date: 1 March 2019Source: Phytomedicine, Volume 55Author(s): Shilpi Singh, Dhananjay Kumar Singh, Abha Meena, Vijaya Dubey, Nusrat Masood, Suaib LuqmanAbstractBackgroundRutin (quercetin-3-O-rutinoside), a flavonoid, is predominantly found in the buckwheat, cranberries, mulberry and citrus fruits. It is used as a restorative in the preparation of herbal medicine, multivitamin and known to reduce the fate of heart attack.HypothesisWe aimed to elucidate whether rutin attenuates oxidative stress and its possible mechanism of action in ameliorating the deleterious effect of t-BHP. We also provide evidence that rutin...
Source: Phytomedicine - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Antipsoriatic potential of Annona squamosa seed oil: An in vitro and in vivo evaluation
ConclusionThe present data has demonstrated that ASO is a safe and effective anti-psoriatic agent when tested in animal models. The efficacy of ASO in preclinical studies could further be exploited for the development of potential novel topical antipsoriatic agent for therapy in humans.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Screening of blood-activating active components from Danshen–Honghua herbal pair by spectrum-effect relationship analysis
ConclusionsDH herbal pair showed strong blood-activating effect on blood stasis rat through regulating the parameters involved in haemorheology and plasma coagulation system. Four active compounds, caffeic acid, salvianolic acid B, hydroxysafflor yellow A and lithospermate acid predicted by spectrum-effect relationship analysis had good blood-activating effect. Therefore, spectrum-effect relationship analysis is an effective approach for seeking active components in herbal pairs.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells
ConclusionObviously, the signaling of β1-adrenoceptors depends on the nature of the membrane environment. It can therefore be assumed that Ze117 has a normalizing effect not only on the membrane fluidity of “stressed” cells, but also on lateral mobility and subsequently on the signal transduction of membrane-associated receptors.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

TRPA1 involvement in analgesia induced by Tabernaemontana catharinensis ethyl acetate fraction in mice
ConclusionOur results demonstrate that Eta-induced antinociception and anti-inflammatory effects occur by TRPA1 inhibition making possible the use of this preparation as a potential therapeutic agent to treat pathological pains.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin
ConclusionThe strong antioxidant and anti-apoptosis effects of anemoside B4 may provide therapeutic potential for cisplatin-induced nephrotoxicity without compromising its therapeutic efficiency.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Tetraclinis articulata essential oil mitigates cognitive deficits and brain oxidative stress in an Alzheimer's disease amyloidosis model
ConclusionThe study demonstrates that the essential oil could be a potent pharmacological agent against dementia by modulating cholinergic activity and promoting antioxidant action in the rat hippocampus.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 31, 2018 Category: Drugs & Pharmacology Source Type: research

Terpenes as possible drugs for the mitigation of arthritic symptoms - a systematic review
ConclusionTogether, our finds suggest that terpenes can modulate the immuno-regulatory and destructive tissue events that underlie the clinical presentation and the progression of arthritis and are worthy of further clinical investigation.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 30, 2018 Category: Drugs & Pharmacology Source Type: research

Biopiracy and the right to self-determination of indigenous peoples
Conclusion: By expressly stating that indigenous peoples have a right to self-determination, the Declaration on the Rights of Indigenous Peoples of 2007 complements the protection stipulated in the Charter and the Covenants of 1966. Although the declaration itself is not legally binding as it is a resolution of the UN General Assembly, it can serve as a blueprint to show the rights that indigenous peoples can derive from international law as well as rights which should ideally be granted to them by the states even though they are not yet binding customary or treaty law. Self-determination means exactly that, it is up to th...
Source: Phytomedicine - October 30, 2018 Category: Drugs & Pharmacology Source Type: research

Ailanthone inhibits cell growth and migration of cisplatin resistant bladder cancer cells through down-regulation of Nrf2, YAP, and c-Myc expression.
ConclusionsAila, inhibited proliferation and invasiveness of bladder cancer cells. Its high effectiveness in CDDP resistant cells could be related to the inhibition of Nrf2, YAP, and c-Myc expressions. Aila could represent a new tool to treating CDDP-resistant bladder cancers.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 29, 2018 Category: Drugs & Pharmacology Source Type: research

Potential detoxification effect of active ingredients in liquorice by upregulating efflux transporter
ConclusionThe study clarified potential detoxification mechanism of liquorice by up-regulating efflux transporter as to reduce absorption of xenobiotics across small intestinal membrane, which provided a new insight into pharmacological function of liquorice.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - October 29, 2018 Category: Drugs & Pharmacology Source Type: research

Biopiracy in India: Seed diversity and the scramble for knowledge
ConclusionThe paper concludes that given the roots of biopiracy in colonial legacies, forms of resistance may need to appropriate colonialist epistemologies. One example of such appropriation is Vandana Shiva's own campaign, which casts seed ownership in the imagery and rhetoric of Mahatma Gandhi's fight against British colonialism in India. Finally, the article ends by suggesting that issues of biopiracy need to be seen in larger context. Drawing on the work of cultural philosopher Hans-Ulrich Gumbrecht, it argues that the problem of the twenty-first century may be a scramble for natural resources such as the right for cl...
Source: Phytomedicine - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Access and benefit sharing – the perspective of basic research
ConclusionApart from all legal uncertainties on both sides the provider country and the researcher, respect of legal commitments and mutual trust are indispensable for overcoming ABS-difficulties in basic research. (Source: Phytomedicine)
Source: Phytomedicine - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1
ConclusionOur findings suggest that GMI can attenuate osteoclast formation by suppressing RANKL-mediated MAPKs and NFATc1 signaling pathways and the anti-osteoclastogenic activity of GMI may extend our understanding of molecular mechanisms underlying biological activities and pharmacological use of G. lucidum as a traditional anti-osteoporotic medicine.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Implementation of the Nagoya Protocol in the European Union and in Germany
ConclusionsThe paper concludes that the implementation of ABS in general and the Nagoya Protocol in particular remain a highly complicated task influenced by rapid technological developments and a general lack of trust between countries as well as stakeholders. (Source: Phytomedicine)
Source: Phytomedicine - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

High-performance counter-current chromatography isolation and initial neuroactivity characterization of furanocoumarin derivatives from Peucedanum alsaticum L. (Apiaceae)
ConclusionOur findings underscore the utility of HPCCC for the rapid isolation of rare coumarin derivatives, and the potential of microscale in vivo bioassays based on zebrafish disease models for the rapid assessment of neuroactivity of these drug-like natural products.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic nephropathy in mice
ConclusionsOur data showed that salidroside plays a beneficial role against diabetic nephropathy in mice, which probably via Sirt1/PGC-1α mediated mitochondrial biogenesis.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 25, 2018 Category: Drugs & Pharmacology Source Type: research

Tannins and Vascular Complications of Diabetes: An update
ConclusionThis review focuses on the role of various tannins in prevention and management of diabetic complications like diabetic nephropathy, diabetic neuropathy, diabetic retinopathy and diabetic cardiomyopathy. It will researchers to find some leads for the development of new cost effective therapy using dietary source for the management of diabetic complications.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Rb2 inhibits epithelial-mesenchymal transition of colorectal cancer cells by suppressing TGF-β/Smad signaling
ConclusionGinsenoside Rb2 could inhibit EMT of colorectal cancer cells through the TGF-β1/Smad signaling, and might be a potential candidate for the treatment of colorectal cancer.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 23, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-6809-5p mediates luteolin-induced anticancer effects against hepatoma by targeting flotillin 1
Conclusions: These findings indicated that miR-6809-5p mediates the growth-suppressive activity of luteolin in HCC, which is causally linked to FLOT1 downregulation. Induction of miR-6809-5p may provide therapeutic benefits in the treatment of HCC.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 22, 2018 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Anti-inflammatory and antiviral activities of cynanversicoside A and cynanversicoside C isolated from Cynanchun paniculatum in influenza A virus-infected mice pulmonary microvascular endothelial cells” [Phytomedicine 36 (2017) 18–25]
Publication date: Available online 19 October 2018Source: PhytomedicineAuthor(s): Panying Wei, Tao Zhang, Hong Dong, Qiaohong Chen, Xiang Mu, Ge Hu (Source: Phytomedicine)
Source: Phytomedicine - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Possible involvement of alpha B-crystallin in the cardioprotective effect of n-butanol extract of Potentilla anserina L. on myocardial ischemia/reperfusion injury in rat
Conclusion: NP was showed to alleviate I/R injury and inhibit myocardial apoptosis, which might be associated with reduction on oxidative stress and apoptosis. CryAB as a possible target involved in the NP protective effect. This study supplied valuable information to develop novel cardioprotective agents from NP extract.Graphical AbstractOverview of potential mechanisms underlying cardioprotective effect of NP on myocardial I/R injury in rat. I/R promotes generation of oxidative stress and lipid peroxidation, finally causing cardiomyocyte apoptosis. 2D-DIGE coupled to MALDI-TOF/MS analysis revealed CryAB may participated ...
Source: Phytomedicine - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment – Transcriptome-wide microarray profiles of neuroglia cells
ConclusionApplication of cytostatic drugs in combination with apoptogenic plant extracts induced significant changes in transcriptome-wide mRNA microarray profiles of neuroglial cells. These changes indicate on potential beneficial effects on neuronal functions associated with mild cognitive impairments in cancer chemotherapy.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats
ConclusionThese findings suggest that the antihypertensive effect of MOE in L-NAME-hypertensive rats may be mediated by alleviating vascular dysfunction and oxidative stress and promoting endothelium-dependent vasorelaxation. MOE may be potentially useful as a natural product against hypertension.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Allicin improves the function of cardiac microvascular endothelial cells by increasing PECAM-1 in rats with cardiac hypertrophy
ConclusionAllicin provided cardioprotection for CH rats by improving the function of CMECs through increasing the expression of PECAM-1.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 20, 2018 Category: Drugs & Pharmacology Source Type: research

Induction of apoptosis by essential oil from P. missionis in skin epidermoid cancer cells
ConclusionThe present study revealed cancer chemotherapeutic potential of EO from P. missionis. EO induces cell death through intrinsic (mitochondrial) and extrinsic apoptotic pathway in A431 and HaCaT cells. These results suggest that EO could be used as a potential therapeutic agent for the treatment of skin epidermoid cancer.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 17, 2018 Category: Drugs & Pharmacology Source Type: research

Boswellia serrata oleo-gum-resin and β-boswellic acid inhibits HSV-1 infection in vitro through modulation of NF-кB and p38 MAP kinase signaling
ConclusionThus, our results support the ethnomedicinal use of BSE in skin infection by inhibiting HSV-1 through the modulation of NF-κB and p38 MAPK pathway.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Puerarin inhibits hyperglycemia-induced inter-endothelial junction through suppressing endothelial Nlrp3 inflammasome activation via ROS-dependent oxidative pathway
ConclusionsOur findings indicate that puerarin exhibits immense potential and specific therapeutic value in hyperglycemia-related cardiovascular disease and the development of innovative drugs.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - October 13, 2018 Category: Drugs & Pharmacology Source Type: research