Evaluation of anti-HSV-1 activity and toxicity of hydroethanolic extract of Tanacetum parthenium (L.) Sch.Bip. (Asteraceae)
Conclusion: These findings indicate that the CHE from aerial parts of Tanacetum parthenium has in vivo anti-HSV-1 activity and is safe for oral and topical application.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 14, 2018 Category: Drugs & Pharmacology Source Type: research

Plasma free amino acid profile in quiescent Inflammatory Bowel Disease patients orally administered with Mastiha (Pistacia lentiscus); a randomised clinical trial
Publication date: Available online 13 August 2018Source: PhytomedicineAuthor(s): Efstathia Papada, Charalampia Amerikanou, Ljilja Torović, Nick Kalogeropoulos, Chara Tzavara, Alastair Forbes, Andriana C. KalioraAbstractBackground: Natural products have been studied regarding their effectiveness on Inflammatory Bowel Disease (IBD).Hypothesis/Purpose: To examine the effects of Mastiha (Pistacia lentiscus var. Chia) on clinical course and amino acid (AA) profile of patients in remission.Study design: This is a randomised, double-blind, placebo-controlled clinical trial.Methods: Patients (N = 68) were randomLy allocated t...
Source: Phytomedicine - August 14, 2018 Category: Drugs & Pharmacology Source Type: research

Synergistic effects of cAMP–dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes
ConclusionKinsenoside increased HSL activation through PKA-mediated phosphorylation at Ser660/563 and concomitantly increased perilipin activation in lipolysis. These lipolytic effects of kinsenoside were validated using 6-Bnz-cAMPs, a PKA agonist. In this study, we demonstrated that in addition to AMPK, PKA also plays a crucial role in kinsenoside-mediated lipolysis.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Arctiin is a specific inhibitor of STAT3 phosphorylation in tyrosine 705 residue and potentiates bortezomib-induced apoptotic, proliferative, and angiogenetic effects in human multiple-myeloma cells
ConclusionOn the whole, our results indicate that arctiin is a potentially new inhibitor of constitutive STAT3 activation through the induction of PTPε in MM, cells and therefore has great value in treating various tumors sheltering constitutively activated STAT3.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Attenuation of isoproterenol-induced cardiotoxicity in rats by Narirutin rich fraction from grape fruit
ConclusionThus, present study provides evidences for efficacy of NRF against isoproterenol induced myocardial infarction in rats.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and antioxidant properties of jervine, a sterodial alkaloid from rhizomes of Veratrum album
ConclusionJervine, DIC and IND reduced the negative effects of CAR due to increasing effects on the SOD, CAT, GSH, GPx and GR antioxidants.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-allergic actions of F-PASA, a novel herbal cocktail, in IgE/antigen-mediated allergic responses in RBL-2H3 cells and passive cutaneous anaphylaxis in mice
ConclusionThese findings indicate that F-PASA, including both artigenin and emodin-8-O-β-D-glucoside, possesses stronger anti-allergic properties. Therefore, F-PASA may be useful as a functional food or as a phytomedicine for allergic diseases.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Ameliorative effects of protodioscin on experimental diabetic nephropathy
Conclusion: These results indicate that protodioscin has ameliorative effects on diabetic nephropathy.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 12, 2018 Category: Drugs & Pharmacology Source Type: research

Panax Quinquefolium Saponin Attenuates Cardiac Remodeling Induced by Simulated Microgravity
Conclusion: PQS provides protection against cardiac remodeling induced by simulated microgravity, partly resulting from changes in the signaling pathways related to energy metabolism reduction, calcium overloading and cell apoptosis.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 11, 2018 Category: Drugs & Pharmacology Source Type: research

Rosae multiflorae fructus extract and its four active compounds alleviate ovalbumin-induced allergic inflammatory responses via regulation of Th1/Th2 imbalance in BALB/c rhinitis mice
ConclusionRMFE may have therapeutic potential for treating AR by modulating the relationships between Th1/Th2 responses.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 11, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of Luehea divaricata Mart. extracts on peripheral vascular resistance and the role of nitric oxide and both Ca+2-sensitive and Kir6.1 ATP-sensitive K+ channels in the vasodilatory effects of isovitexin on isolated perfused mesenteric beds
ConclusionThis study showed that AqueFr obtained from Luehea divaricata and its metabolite - isovitexin - has important vasodilatory effects on MVBs. Apparently, these effects are dependent on endothelium-NO release and both SK KCa K+ channels and Kir6.1 ATP-sensitive K+ channels activation in the vascular smooth muscle.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 11, 2018 Category: Drugs & Pharmacology Source Type: research

Contribution of human UDP-glucuronosyltransferases to the antioxidant effects of propolis, artichoke and silymarin
Conclusion: In conclusion, this study provides a possible molecular mechanism for protective antioxidant effects associated with the herbal drugs propolis, artichoke and silymarin. The herbal drug-mediated transcriptional upregulation of human detoxifying UGT1A enzymes via activation of AhR and Nrf2 leads to reduced hydrogen peroxide and oxidative stress. Because of UGT1A activation, the intake of these drugs could affect the therapeutic efficacy of other drugs when these also undergo metabolism by glucuronidation.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and antioxidative effects of the buds from different species of Populus in human gingival fibroblast cells: role of bioflavanones
ConclusionThe potential protective role of pinocembrin and pinostrobin and extracts from buds Populus nigra and P. × berolinensis against AgNPs induced inflammation and cytotoxicity in HGF-1 cells is disclosed. In addition, the antioxidant properties of poplar bud extracts have been demonstrated. P. × berolinensis buds showed the highest activity in both the in vitro model and in the bioautographic tests.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 10, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetic–pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats
ConclusionThe PK-PD model results provided scientific basis for clarifying compatibility mechanisms of GZFLC prescription and a better understanding for biosynthetic mechanisms of four prostaglandins (PGE2, PGF2α, 6-Keto-PGF1α and TXB2) in the treatment of PDM by GZFLC. Investigations on the relationship between the effects and the bioactive ingredients are of benefit to explore the mechanisms of action and combination for traditional Chinese medical prescriptions (TCP) and facilitate the development of future clinical applications of TCP.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 10, 2018 Category: Drugs & Pharmacology Source Type: research

Liver transplantation and the use of KAVA: Case report
ConclusionOur investigation indicates that there was kava-induced hepatotoxicity at standard dosages. In Brazil, self-medication by herbal medicines is frequent and many patients and health professionals do not know the risks associated with their use. Diagnosing and notifying cases in which plants and herbal medicine induce liver damage is of paramount importance to increase the knowledge about DILI and to prevent or treat similar cases quickly.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 9, 2018 Category: Drugs & Pharmacology Source Type: research

Eucalyptol promotes lung repair in mice following cigarette smoke-induced emphysema
Publication date: Available online 8 August 2018Source: PhytomedicineAuthor(s): Emanuel Kennedy-Feitosa, Isabella Cattani-Cavalieri, Marina Valente Barroso, Bruna Romana-Souza, Lycia Brito-Gitirana, Samuel Santos ValencaAbstractBackgroundEucalyptol is a monoterpenoid oil present in many plants, principally the Eucalyptus species, and has been reported to have anti-inflammatory and antioxidative effects.Hypothesis/purposeSince the potential effect of eucalyptol on mouse lung repair has not yet been studied, and considering that chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide, the ...
Source: Phytomedicine - August 9, 2018 Category: Drugs & Pharmacology Source Type: research

Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway
ConclusionsThis study showed that honokiol can enhance TMZ-induced apoptotic insults to glioma cells via an intrinsic mitochondrion-dependent mechanism. Our results suggest the therapeutic potential of honokiol to attenuate TMZ-induced side effects.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 9, 2018 Category: Drugs & Pharmacology Source Type: research

Citrus peels prevent cancer
Conclusion: Our results encourage the use of Citrus peels, which is wasted in huge amounts, as cancer preventive food additives and as anticancer agents.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Vitis amurensis Rupr: A review of chemistry and pharmacology
ConclusionFrom a health perspective, Vitis amurensis Rupr. presents excellent options for treating various diseases due to its bioactive compounds (drug candidates) that exhibit important activities or for developing new products. (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Metabolomic and Biotechnological approaches to determine therapeutic potential of Withania somnifera (L.) Dunal: A Review
Conclusion: The implementation of latest bioinformatic tools in combination with biotechnological techniques for breeding platforms are important in conservation of medicinal plant species in danger. The current review is based on molecular and in vitro methodologies employed in W. somnifera for accepting their importance in the improvement of this valuable medicinal species.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Metal –plant frameworks in nanotechnology: an overview
ConclusionNano-sized dosage systems have a potential for enhancing the activity and overcoming problems associated with phyto medicines. Hence, synthesis of metallic nanoparticles using various plant extracts, emerge as safe alternative to conventional methods for biomedical applications. (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Naringenin suppresses growth of human placental choriocarcinoma via reactive oxygen species-mediated P38 and JNK MAPK pathways
ConclusionsCollectively, results of this study indicate that naringenin is a potential therapeutic molecule with anti-cancer effects on choriocarcinoma cells by inducing generation of ROS and activation of the MAPK pathways.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Prevention from radiation damage by natural products
ConclusionsSome secondary metabolites from plants reveal radioprotective features against cellular damage caused by irradiation. These results warrant further analysis to develop phytochemicals as radioprotectors for clinical use. (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Induction of apoptosis by essential oil from P.missionis in skin epidermoid cancer cells
ConclusionThe present study revealed cancer chemotherapeutic potential of EO from P.missionis. EO induces cell death through intrinsic (mitochondrial) and extrinsic apoptotic pathway in A431 and HaCaT cells. These results suggest that EO could be used as a potential therapeutic agent for the treatment of to skin epidermoid cancer.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Withania somnifera (Indian ginseng) in male infertility: An evidence-based systematic review and meta-analysis
Publication date: Available online 29 November 2017Source: PhytomedicineAuthor(s): Sharanbasappa Durg, Shivakumar Badamaranahalli Shivaram, Sachin BavageAbstractBackground: Withania somnifera Dunal, commonly known as Indian ginseng, has been in use since ancient times as anti-stress agent, aphrodisiac, for impotence and infertility treatment.Purpose: To evaluate the efficacy and safety of W. somnifera treatment in infertile men.Study design: An evidence-based systematic review and meta-analysis using Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.Methods: published literature was sea...
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Rapid discovery of quality-markers from Kaixin San using chinmedomics analysis approach
Conclusions: This study demonstrate that KXS significantly improved cognitive function of transgenic mice of AD, repaired the damage caused by Aβ, regulated amino acid metabolism and lipid metabolism abnormalities and determined the effective material basis of KXS treating AD. Clarifying the quality-markers of KXS can establish scientific quality standard to reflect the safety and effectiveness of Traditional Chinese Medicine (TCM).Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway
Conclusion: The results demonstrated that COP induces apoptosis in HCT-116 cells through PI3K/Akt and mitochondrial-associated apoptotic pathway. Our findings suggest that COP has potential to be a therapeutic candidate for colon cancer patients.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Ginger causes subfertility and abortifacient in mice by targeting both estrous cycle and blastocyst implantation without teratogenesis
ConclusionsThese findings suggest that Ginger can disrupt the oestrous cycle and blastocyst implantation without teratogenesis.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Secondary metabolite profiling, cytotoxicity, anti-inflammatory potential and in vitro inhibitory activities of Nardostachys jatamansi on key enzymes linked to hyperglycemia, hypertension and cognitive disorders
ConclusionIn vitro-derived plants revealed a substantial anti-cholinesterases, anti-hyperglycemic anti-inflammatory, anti-hypertensive and anti-tyrosinase potential with higher yield of various bioactive metabolites and significantly higher antioxidant activity which substantially explain medicinal importance of N. jatamansi in traditional medicine, used for centuries in different Ayurvedic formulations. The present findings suggest that cultured plants could be a promising alternative for the production of bioactive metabolites with comparative biological activities to the wild plants.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity of epunctanone and four other phytochemicals isolated from the medicinal plants Garcinia epunctata and Ptycholobium contortum towards multi-factorial drug resistant cancer cells
ConclusionsCompounds 1–5 are valuable cytotoxic compounds that could be used to combat MDR cancer cells. Benzophenoe 5 is the most active molecule and deserve more investigations to develop new anticancer drugs.Graphical abstractBetulin (1), mundulea lactone (2), seputhecarpan A (3), seputheisoflavone (4) and epunctanone (5) had cytotoxic effects on a panel of 9 cancer cell lines with IC50 values below 70 µM. Compound 5 had the best activity and induced apoptosis in CCRF-CEM leukemia cells through alteration of MMP and increase in ROS production. Compound 5 also induced ferroptotic cell death. (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

Curcumin potentiates the antitumor activity of Paclitaxel in rat glioma C6 cells
ConclusionIn conclusion, our findings demonstrated that combination of PTX and curcumin exerts a potentiated anti-glioma efficacy in vitro that may help in reducing dosage and/or minimizing side effects of cytotoxic therapy.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 8, 2018 Category: Drugs & Pharmacology Source Type: research

p73 induction by Abrus agglutinin facilitates Snail ubiquitination to inhibit epithelial to mesenchymal transition in oral cancer
ConclusionsIn summary, AGG stimulates p73 in restricting EGF-induced EMT, invasiveness, and stemness by inhibiting the ERK/Snail pathway to facilitate the development of alternative therapeutics for oral cancer.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 7, 2018 Category: Drugs & Pharmacology Source Type: research

The natural phenolic compounds as modulators of NADPH oxidases in hypertension
ConclusionIt is clear that natural phenolic compounds have some potential inhibitory effect on NADPH oxidase activity. In comparison to other phenolic plant compounds, the structural varability of the flavonoids should off different impacts on oxidative stress in hypertension including inhibition of nadph oxisdase and direct scavenging of free radicals. (Source: Phytomedicine)
Source: Phytomedicine - August 7, 2018 Category: Drugs & Pharmacology Source Type: research

Berberine down-regulates IL-8 expression through inhibition of the EGFR/MEK/ERK pathway in triple-negative breast cancer cells
ConclusionHere, we demonstrate that BBR may be a promising drug to suppress cell invasiveness and growth of TNBC through IL-8-related mechanisms.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 7, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-ulcerogenic activity of dentatin from Clausena excavata Burm.f. against ethanol-induced gastric ulcer in rats: possible role of mucus and anti-oxidant effect
Conclusion: Dentatin possesses gastro-protective activity, which could be attributed to the anti-secretory, mucus production, anti-oxidant, and HSP70 activities.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 4, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-inflammation Action of Xanthones from Swertia chirayita by Regulating COX-2/NF-κB/MAPKs/Akt Signaling Pathways in RAW 264.7 Macrophage cells
ConclusionsThe potent suppressive effects of 1 from S. chirayita on inflammatory mediators by blocking the expression of COX-2 and phosphorylation of Akt, IKK-β, MAPK and NF-κB, activation in LPS-stimulated macrophages suggest that 1 can be a preventive therapeutic candidate for the management of inflammatory-mediated immune disorders.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 4, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant effects of an olive oil total polyphenolic fraction from a Greek Olea europaea variety in different cell cultures
ConclusionThe TPF appeared to protect cells from oxidative stress due to the strong antioxidant activity of its polyphenols. This could have interesting implications in development of new products based on this olive oil to provide protection and treatment against harmful effects of free radicals.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 3, 2018 Category: Drugs & Pharmacology Source Type: research

The anti-anaphylactoid effects of hydroxysafflor yellow A on the suppression of mast cell Ca2+ influx and degranulation
ConclusionIn summary, HSYA has anti-anaphylactoid pharmacological activity, which makes it a potential candidate for the development of a novel agent to suppress drug-induced anaphylactoid reactions.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 3, 2018 Category: Drugs & Pharmacology Source Type: research

A strategy for the discovery and validation of toxicity quality marker of Chinese medicine based on network toxicology
ConclusionThis extensive review provides a study method for the toxicity Q-marker of CM, which helps to systemically and thoroughly reveal the internal toxicity mechanism of CM. The in-depth study of the toxicity Q-marker provides the material basis and technical support for the safety evaluation of CM.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Wilforine, the Q-marker and PK-maker of Tripterygium glycosides tablet: Based on preparation quantitative analysis and PK-PD study
Conclusions: Wilforine is proposed as a biologically active and toxic component of TGT that can be served both as Q-marker and PK-marker. The quality, clinical safety, and efficacy of TGT should be evaluated by the quality of wilforine.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line
Conclusion: These results indicate that E3 and its main active component norswertianin may serve as a potential candidate for differentiation therapy of glioblastoma.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Immunometabolic regulation by triterpenes of Eucalyptus tereticornis in adipose tissue cell line models.
ConclusionThe mixtures of the three triterpenes in the proportions obtained from the plant material may act on different components of the cell, generating a different response, which, in some cases, is more powerful than that seen when exposure to only two triterpenes. It makes this three triterpenes mix a good phytotherapeutic prototype for pathologies as complex as those associated with obesity.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells
Conclusion: These findings indicate that PS may constitute a potential new alternative or complementary medicine for PC.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Utility of alkaloids as chemical and biomarkers for quality, efficacy, and safety assessment of botanical ingredients
ConclusionThe current review article covers the fundamental roles played by alkaloids as chemical and biomarkers in assessing the essential parameters of the quality of botanical ingredients, as briefly described earlier. The utilization of alkaloids as biomarkers to determine the efficacy-linked pharmacokinetic parameters is limited to reviewing studies on human subjects.Graphical abstractUtility of alkaloids as chemical and biomarkers for quality, efficacy, and safety assessment of botanical ingredients. (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Establishment of a Quality Marker (Q-marker) System for Chinese Herbal Medicines using Burdock as an Example
Conclusion:The Q-markers for the quality control of Chinese herbal medicines are the basis for CMM. The concept and theory of Q-marker provide guidance and correction for colleagues involved in the healthy development of the CMM industry.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Sesquiterpene lactones from Ambrosia arborescens Mill. inhibit pro-inflammatory cytokine expression and modulate NF-κB signaling in human skin cells
ConclusionWe show that coronopilin and damsin from A. arborescens inhibit pro-inflammatory IL-6 and MCP-1 expression in human skin cells via NF-κB inhibition, suggesting that they may be useful for antagonizing inflammatory conditions of the human skin.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

trans-3-Methoxy-5-hydroxystilbene (MHS) from the rhizome of Alpinia nantonensis inhibits metastasis in human lung cancer cells
ConclusionTo the best of our knowledge, this is the first report demonstrating that MHS, a plant-derived stilbene has a promising ability to inhibit lung cancer cell metastasis in vitro.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

High-throughput chinmedomics strategy for discovering the quality-markers and potential targets for Yinchenhao decoction
ConclusionsThis work provides a powerful method for clarifying the efficacy of TCM and discovering the effective ingredients as Q-markers.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluations of the effect of Huangqi against heart failure based on comprehensive echocardiography index and metabonomics
ConclusionCurrent evidences revealed that HQ was effective in control of HF from cardiac dysfunction and metabolic alterations. This study provided a useful approach for evaluating the efficacy of TCMs against HF.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Hexane fraction of adlay (Coix lachryma-jobi L.) testa ethanolic extract inhibits human uterine sarcoma cancer cells growth and chemosensitizes human uterine sarcoma cells to doxorubicin
ConclusionThese results suggest that ATE-Hex can inhibit human uterine sarcoma cancer cells by inducing apoptosis and increasing the chemosensitivity of the multidrug-resistant human uterine sarcoma cancer cell MES-SA/Dx5 to Dox. Furthermore, the combination of ATE-Hex and Dox could decrease MDR and increase the synergistic effect.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - August 2, 2018 Category: Drugs & Pharmacology Source Type: research