RESPONSE to Gillibert et al. 2019
Publication date: Available online 13 June 2019Source: PhytomedicineAuthor(s): Lucile Cornet-Vernet, Jerome Munyangi, Lu Chen, Melissa Towler, Pamela Weathers (Source: Phytomedicine)
Source: Phytomedicine - June 13, 2019 Category: Drugs & Pharmacology Source Type: research

The combination of hawthorn extract and camphor significantly increases blood pressure: a meta-analysis and systematic review
ConclusionsKorodin® is an effective and presumably safe complementary therapy for the treatment of hypotension. Its blood pressure increasing effect is confirmed; however, the evidence supporting its use is very limited. The optimum dose and duration of treatment is still unclear. The comprehensive evaluation of efficacy and safety is required in further, high-quality clinical studies, involving larger patient populations and comparable endpoints.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 13, 2019 Category: Drugs & Pharmacology Source Type: research

The Photoactivity of Natural Products – An Overlooked Potential of Phytomedicines?
ConclusionsPhotoactive principles are ubiquitous and can be found in various plant extracts. With the increasing availability of light-irradiation setups for the identification of photoactive natural products, we anticipate the discovery of many new natural PSs in the near future. With the accumulation of chemically diverse PSs, PDT itself might finally reach its clinical breakthrough as a promising alternative treatment against multi-resistant microbes and cancer types.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - June 11, 2019 Category: Drugs & Pharmacology Source Type: research

The standardized herbal combination BNO 2103 contained in Canephron N alleviates inflammatory pain in experimental cystitis and prostatitis
ConclusionOur data support the hypothesis that BNO 2103 reduces pain by virtue of its anti-inflammatory properties, possibly related to suppression of prostaglandin E2 and leukotriene B4 formation, and suggest that this combination has the potential to treat clinical symptoms such as inflammatory pain. Thus BNO 2103 may represent an alternative to reduce the use of antibiotics in urinary tract infections.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Polygonum cuspidatum extract attenuates fructose-induced liver lipid accumulation through inhibiting Keap1 and activating Nrf2 antioxidant pathway
ConclusionsThese results demonstrate that PCE reduces oxidative stress, and prevent lipid accumulation in the liver of fructose-fed rats possibly by targeting the Keap1/Nrf2 pathway. PCE may be a promising therapeutic strategy for fructose-associated liver lipid accumulation.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 10, 2019 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of resibufogenin and its eight metabolites in rat plasma by LC–MS/MS for metabolic profiles and pharmacokinetic study
ConclusionThe results could provide further research foundation for the mechanisms study of activity and toxicity in vivo and facilitate the appropriate clinical application of resibufogenin.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 7, 2019 Category: Drugs & Pharmacology Source Type: research

LC–MS/MS analysis and network pharmacology of Trigonella foenum-graecum – A plant from Ayurveda against hyperlipidemia and hyperglycemia with combination synergy
ConclusionThe network pharmacology analysis strongly suggested the multimode evidences that TFHE largely works on the insulin signalling pathway and mainly based on its antioxidant potential due to its interaction with carbonic anhydrase. Various compounds were found to be interacting with key proteins that activates EGFR/AKT/mTOR signalling cascade which has therapeutic implication in hyperglycemia and hyperlipidemia. The combination synergy network analysis based on neighbourhood approach can help us in further understanding mechanism of multi-molecular fixed dose combinations.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 7, 2019 Category: Drugs & Pharmacology Source Type: research

Deciphering the multicomponent synergy mechanisms of SiNiSan prescription on irritable bowel syndrome using a bioinformatics/network topology based strategy
ConclusionThe integrative investigation based on bioinformatics/network topology strategy may elaborate the multicomponent synergy mechanisms of SNS against IBS and provide the way out to develop new combination medicines for IBS.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - June 4, 2019 Category: Drugs & Pharmacology Source Type: research

Labdanum and Labdanes of Cistus creticus and C. ladanifer: Anti-Borrelia Activity and its Phytochemical Profiling
ConclusionThe application of C. creticus preparations by Lyme disease self-help groups may be considered as a reasonable therapy approach. For the first time, isolated epi-manoyloxide and carvacrol could be evaluated as most promising candidates for drug development and labdanum based phytomedicine development, respectively. They should serve as vital active markers for quality assessments of C. creticus preparations.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - June 1, 2019 Category: Drugs & Pharmacology Source Type: research

Antiulcer activity of Cyperus alternifolius in relation to its UPLC-MS metabolite fingerprint: a mechanistic study
ConclusionThis is the first study to report on the antiulcer activity of C. alternifolius tubers with identification of the key bioactive compounds and the mode of action. Future phytochemical and biological evaluation of the identified bioactive compounds are needed to confirm the plant tubers as safer alternative or adjunct therapy compared to conventional antiulcer drugs.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization
ConclusionSSBE exerts a marked anti-inflammatory effect and alleviates kidney injury, at least in part, by suppressing M1-macrophage polarization.Graphical abstract1. SSBE exerts an anti-inflammatory effect on kidney injury by inhibiting M1-macrophage polarization.2. SBE reduces the activities of IRF5 and NF-κB p65 independent of TLR4/MyD88.3. SSBE decreases HIF-1α expression, resulting in the inhibition of anaerobic glycolysis and M1-macrophage polarization (Source: Phytomedicine)
Source: Phytomedicine - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-hyperuricemic effect of Alpinia oxyphylla seed extract by enhancing uric acid excretion in the kidney
ConclusionsThese findings suggest that AE exerts anti-hyperuricemic and uricosuric effects, which are related to the promotion of uric acid excretion via enhanced secretion and inhibition of uric acid reabsorption in the kidneys. Thus, AE may be a potential treatment for hyperuricemia and gout.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 31, 2019 Category: Drugs & Pharmacology Source Type: research

LC-MS/MS analysis and Network Pharmacology of Trigonella foenum-graecum- a plant from Ayurveda against Hyperlipidemia and Hyperglycemia with combination synergy
ConclusionThe network pharmacology analysis strongly suggested the multimode evidences that TFHE largely works on the insulin signalling pathway and mainly based on its antioxidant potential due to its interaction with carbonic anhydrase. Various compounds were found to be interacting with key proteins that activates EGFR/AKT/mTOR signalling cascade which has therapeutic implication in hyperglycemia and hyperlipidemia. The combination synergy network analysis based on neighbourhood approach can help us in further understanding mechanism of multi-molecular fixed dose combinations.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 29, 2019 Category: Drugs & Pharmacology Source Type: research

Simultaneous determination of resibufogenin and its eight metabolites in rat plasma by LC-MS/MS for metabolic profiles and pharmacokinetic study
ConclusionThe results could provide further research foundation for the mechanisms study of activity and toxicity in vivo and facilitate the appropriate clinical application of resibufogenin.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 29, 2019 Category: Drugs & Pharmacology Source Type: research

The influence of microbial isoflavonoid specific metabolites on platelets and transition metals iron and copper
ConclusionThis study has shown that S-equol, O-desmethylangolensin and 4-ethylphenol, arising from isoflavonoid intake, can have biologically relevant effects on platelet aggregation.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 29, 2019 Category: Drugs & Pharmacology Source Type: research

Rosa canina – Rose hip pharmacological ingredients and molecular mechanics counteracting osteoarthritis – A systematic review
ConclusionThe antioxidant and anti-inflammatory effects of Rosa canina match its clinical action – especially considering new findings on the pharmacological disease pattern of OA. The entirety of several compounds including phenolics, terpenoids, galactolipids, carotenoids, fruit acids and fatty oils can be considered responsible for the observed pharmacological and clinical effects. Further research is needed to eludicate how and in which manner single rose hip compounds interact with their molecular pharmacological targets.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 26, 2019 Category: Drugs & Pharmacology Source Type: research

Delicaflavone induces apoptosis via mitochondrial pathway accompanying G2/M cycle arrest and inhibition of MAPK signaling cascades in cervical cancer HeLa cells
Conclusions: The results of the current study show that apoptosis is induced by the mitochondrial pathway accompanying with G2/M cycle arrest and inhibition of MAPK signaling cascades in human CCa HeLa cells, which can be used as a promising therapeutic drug for CCa.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 26, 2019 Category: Drugs & Pharmacology Source Type: research

Re-opening the Stage for Echinacea Research - Characterization of Phylloxanthobilins as a Novel Anti-oxidative Compound Class in Echinacea purpurea
ConclusionPhylloxanthobilins are important constituents of Echinacea purpurea extracts, and our first exploratory studies hint towards promising bioactivities of these natural products, which may be relevant for understanding Echinacea efficacies.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 23, 2019 Category: Drugs & Pharmacology Source Type: research

Artemisinin and its derivatives prevent Helicobacter pylori-induced gastric carcinogenesis via inhibition of NF-κB signaling
Conclusion:ART, DHA and ARTS have potent preventive effects in H. pylori-induced gastric carcinogenesis. These effects are, at least in part, attributed to the inhibition of NF-κB signaling pathway. Our findings provide a molecular justification of using ART and its derivatives for the prevention and treatment of gastric cancer.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Mechanism-based pharmacokinetics-pharmacodynamics studies of harmine and harmaline on neurotransmitters regulatory effects in healthy rats: Challenge on monoamine oxidase and acetylcholinesterase inhibition
Conclusions: NT analysis results showed that HAL and HAR selectively affect AChE in vivo. HAL and HAR may be highly and suitably developed for the treatment of Alzheimer's disease.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Danshen extract (Salvia miltiorrhiza Bunge) attenuate spinal cord injury in a rat model: a metabolomic approach for the mechanism study
Conclusion: In summary, this study provides an overview of neuroprotective effects and investigates possible mechanism of danshen extract in SCI treatment. However, further research is needed to uncover its regulatory mechanisms more clearly.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 22, 2019 Category: Drugs & Pharmacology Source Type: research

Therapeutic effects of artesunate on lupus-prone MRL/lpr mice are dependent on T follicular helper cell differentiation and activation of JAK2-STAT3 Signaling Pathway
ConclusionART showed therapeutic effects on lupus-prone MRL/lpr mice by inhibiting the differentiation of Tfh cells as well as altering the activation status of Jak2-Stat3 signaling cascade.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 21, 2019 Category: Drugs & Pharmacology Source Type: research

Phloretin Suppresses Metastasis by Targeting Protease and Inhibits Cancer Stemness and Angiogenesis in Human Cervical Cancer Cells
Conclusion: In summary, the findings indicate that phloretin inhibits the metastatic and angiogenic abilities and cancer stemness of SiHa cells, thereby suggesting that this flavonoid is a promising therapeutic agent for the treatment of human cervical cancer cells.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 18, 2019 Category: Drugs & Pharmacology Source Type: research

Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients
Conclusion: An extract of an artemisinin-deficient Artemisia annua herbal preparation exhibits potent anticancer activity against triple negative human breast cancer. New active ingredients of Artemisia annua extract with potential anticancer activity have been identified.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Duchesnea indica extract attenuates oral cancer cells metastatic potential through the inhibition of the matrix metalloproteinase-2 activity by down-regulating the MEK/ERK pathway
Conclusion: DIE triggers the antimetastatic activity in OSCC cells by suppressing the MMP-2 activity via the MEK/ERK signaling pathways. Therefore, these findings are promising for the use of DIE antimetastatic activity in oral cancer metastasis treatment.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Byakangelicin as a Modulator for Improved Distribution and Bioactivity of Natural Compounds and Synthetic Drugs in the Brain
ConclusionByn could serve as a modulator to allow improved brain accumulation of diverse active compounds (Umb, Cur, and Dox) and enhanced therapeutic effects.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 17, 2019 Category: Drugs & Pharmacology Source Type: research

Hepatotoxicity evaluation of Euphorbia kansui on zebrafish larvae in vivo
ConclusionThe results bring us closer to an in-depth understanding of the toxic effects of Euphorbia kansui on zebrafish liver, which will be significantly helpful in effectively guiding safer clinical application of this herb in the clinic. Furthermore, our results also showed the zebrafish model is reliable for evaluation of Euphorbia kansui extract hepatotoxicity and as a methodological reference for the evaluation of Traditional Chinese Medicine with underlying liver toxicity.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 15, 2019 Category: Drugs & Pharmacology Source Type: research

Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells
Conclusion: To sum up, the present study indicated that Inotodiol possessed the potential to prevent malignant tumor migration and invasion, and it might be a natural active compound candidate for clinical treatment of human cervical cancer.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 14, 2019 Category: Drugs & Pharmacology Source Type: research

Lipidomic analysis reveals therapeutic effects of Yijin-Tang on high-fat/high-cholesterol diet-induced obese mice
ConclusionThese data suggest that YJT ameliorates obesity-induced systemic inflammation and insulin resistance by regulating lipid metabolism, and demonstrated that lipidomic profiling is a useful method to investigate the therapeutic effects of herbal decoctions in traditional Korean and Chinese medicine.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 12, 2019 Category: Drugs & Pharmacology Source Type: research

Rosa canina - Rose Hip Pharmacological Ingredients and Molecular Mechanics Counteracting Osteoarthritis – a Systematic Review
ConclusionThe antioxidant and anti-inflammatory effects of Rosa canina match its clinical action – especially considering new findings on the pharmacological disease pattern of OA. The entirety of several compounds including phenolics, terpenoids, galactolipids, carotenoids, fruit acids and fatty oils can be considered responsible for the observed pharmacological and clinical effects. Further research is needed to eludicate how and in which manner single rose hip compounds interact with their molecular pharmacological targets.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 12, 2019 Category: Drugs & Pharmacology Source Type: research

RESPONSE to Argemi et al. 2019
Publication date: Available online 9 May 2019Source: PhytomedicineAuthor(s): Lucile Cornet-Vernet, Jerome Munyangi, Lu Chen, Melissa Towler, Pamela Weathers (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1
ConclusionPUM1 silencing increased the sensitivity of pancreatic cancer cells to TRAIL in vivo and in vitro, indicating that PUM1 may be a new target for increasing the sensitivity of cancer cells to TRAIL. In addition, our results indicate that TPL enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1. This novel concept may have significant implications for the development of new strategies to enhance TRAIL sensitivity of tumors.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Rubrofusarin-6-β-gentiobioside inhibits lipid accumulation and weight gain by regulating AMPK/mTOR signaling
ConclusionRFG can ameliorate obesity, and thus, could be used as a therapeutic agent for treating obesity.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Cepharanthine: an update of its mode of action, pharmacological properties and medical applications
ConclusionIn this review, the historical discovery and development of CEP are retraced, and the key mediators involved in its mode of action are presented. The past, present, and future of CEP are recapitulated. This review also suggests new opportunities to extend the clinical applications of this well-tolerated old Japanese drug.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Multiple pathways for natural product treatment of Parkinson's disease: A mini review
Publication date: Available online 11 May 2019Source: PhytomedicineAuthor(s): Jingwen Li, Xi Long, Jichuan Hu, Juan Bi, Ting Zhou, Xingfang Guo, Chao Han, Jinsha Huang, Tao Wang, Nian Xiong, Zhicheng LinAbstractBackgroundIt is established that natural medicines for Parkinson's disease (PD) provide an antioxidant activity in preventing dopaminergic neurons from degeneration. However, the underlying and related molecular details remain poorly understood.Methods and AimWe review published in vitro and rodent studies of natural products in PD models with the aim to identify common molecular pathways contributing to the treatme...
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Adjuvant Traditional Chinese Medicine Therapy on Long-term Survival in Patients with Hepatocellular Carcinoma
This study aims to explore the benefits of TCM therapy in the long-term survival of patients with hepatocellular carcinoma in China.Patients and methodsIn total, 3,483 patients with HCC admitted to the Beijing Ditan Hospital of Capital Medical University were enrolled in this study. We used 1:1 frequency matching by sex, age, diagnosis time, Barcelona Clinic Liver Cancer staging, and type of treatments to compare the TCM users (n=526) and non-TCM users (n=526). A Cox multivariate regression model was employed to evaluate the effects of TCM therapy on the HR value and Kaplan-Meier survival curve for mortality risk in HCC pa...
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Schizandrin B attenuates angiotensin II induced Endothelial to Mesenchymal Transition in vascular endothelium by suppressing NF-κB activation
ConclusionEndMT contributes to vascular injury in Ang II-treated mice, and it can be prevented via suppressing NF-κB activation by Sch B treatment. These results also imply that NF-κB might be a promising target to attenuate vascular remodeling induced by inflammation and oxidative stress through an EndMT mechanism.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 11, 2019 Category: Drugs & Pharmacology Source Type: research

Qishen Granule Attenuates Cardiac Fibrosis by Regulating TGF-β /Smad3 and GSK-3β Pathway
ConclusionQSG improves cardiac function through inhibiting cardiac fibrosis. The anti-fibrotic effects are potentially mediated by the inhibition of the TGF-β/Smad3 pathway and the phosphorylation of GSK-3β.Graphical abstractTGF-β1 causes cardiac fibrosis by stimulating Smad3 and PI3K-Akt-GSK-3β signaling pathways. TGF-β1 phosphorylates and activates the highly-conserved cytoplasmic proteins of the SMADs family, and PI3K-Akt-GSK-3β pathway, thereby regulating the expression of the related genes leading to fibrosis. GSK-3β may inhibit TGF-β1/Smad3 pathway by suppressing Smad3 activity...
Source: Phytomedicine - May 9, 2019 Category: Drugs & Pharmacology Source Type: research

Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury by inhibiting bile acid-stimulated inflammation in DDC-induced mice
ConclusionHQD protected mice against chronic cholestatic liver injury and biliary fibrosis, which may be associated with the induction of the Nrf2 pathway and inhibition of the NF-κB pathway, ameliorating BA-stimulated inflammation.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1.
ConclusionIt appears that bochnaloside at oral dosage greater than 150 mg/kg/day exerts antidiabetic effects in vivo through modulating the action of GLP-1.Graphic AbstractBoschnaloside is the major constituent from Boschniakia rossica, an herb for tonifying kidney and improving impotence. Boschnaloside supplement attenuates diabetic symptoms and islet dysfunction in severely diabetic db/db mice. Underlying mechanism of actions involves in modulating the action of glucagon-like peptide-1. (Source: Phytomedicine)
Source: Phytomedicine - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Tooniliatone A sensitizes multidrug resistant cancer cells by decreasing Bcl-xL via activation of JNK MAPK signaling
CONCLUSIONOur study suggests that TA reverses tumor MDR by activating the SAPK/JNK pathway to inhibit the action of Bcl-xL. TA may be an effective tumor MDR reversal agent.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Caudatin potentiates the anti-tumor effects of TRAIL against human breast cancer by upregulating DR5
ConclusionOur results showed that caudatin sensitized breast cancer cells to TRAIL-induced apoptosis through activation of CHOP, p38 MAPK and JNK-mediated upregulation of DR5 expression. The combination of TRAIL and caudatin may be a promising therapeutic approach for the treatment of breast cancer.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory and antiproliferative compounds from Sphaeranthus africanus
ConclusionFor the first-time, the diastereomeric carvotacetones (6-7) were isolated as separate compounds, and their anti-proliferative activity was determined. Selective COX-2 inhibitory, COX-2 mRNA expression and NO production inhibitory activities by some of the major constituents of S. africanus supports the traditional medical application of this plant for the treatment of inflammation-related disorders.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 6, 2019 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells
ConclusionCuE represents a potential therapeutic candidate for the treatment of certain types of refractory tumors. To best of our knowledge, this is the first time to identify CuE and verapamil as inhibitors for ABCB5 transporter.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Safety of complementary and alternative medicine in children: A 16-years retrospective analysis of the Italian Phytovigilance system database
ConclusionWe provide new insights on factors that might increase the risk of serious AR associated with CAM use in children: products containing more than two components and simultaneously administered with conventional medications can represent a potential risk in children.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Anticancer potential of NF-κB targeting apoptotic molecule “flavipin” isolated from endophytic Chaetomium globosum
ConclusionThis is the first report on the antiproliferative activity of flavipin isolated from endophytic C. globosum and also proposed that interaction of flavipin with NFкB could be a possible mechanism for this activity. Flavipin induced apoptosis at low concentrations in cancer cell lines (A549, HT-29) and exhibited itself as a potential anticancer agent.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Apoptotic effect of Gyejibokryunghwan on uterine sarcoma cells (SK-UT-1B)
ConclusionThese results are the first observation of uterine sarcoma cell death induced by GBH and confirmation of the mechanism of cell death, which occurred through the intrinsic apoptotic pathway. Clinically, uterine sarcoma has a poor prognosis with no appropriate treatment. GBH may become a new treatment modality for uterine sarcoma.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

A natural anticancer pigment,Pheophytin a,from a seagrass acts as a high affinity human mitochondrial translocator protein (TSPO) ligand, in silico, to reduce mitochondrial membrane Potential (∆ψmit) in adenocarcinomic A549 cells.
ConclusionHence Pheophytin a could be seen as a possible TSPO ligand for targeting metastatic alveolar cancers like A549 via intrinsic apoptotic pathway.General significanceGiven the inherent non-toxic nature of the compound and easy extractability from almost all autotrophic eukaryotes, one could be confident to testing in animal models.Graphical abstract (Source: Phytomedicine)
Source: Phytomedicine - May 3, 2019 Category: Drugs & Pharmacology Source Type: research

Extract of Ilex rotunda Thunb alleviates experimental colitis-associated cancer via suppressing inflammation-induced miR-31-5p/YAP overexpression
Publication date: Available online 30 April 2019Source: PhytomedicineAuthor(s): Gang Chen, Yueqing Han, Yuan Feng, Aiping Wang, Xuezheng Li, Song Deng, Lin Zhang, Jiao Xiao, Yanwu Li, Ning LiAbstractBackground: Ilex rotunda Thunb is a traditional medicine used in China treating colitis clinically. Triterpenoids is one of its main components. However, the detailed pharmacological activity and the component responsible for its clinical effects are still elusive.Purpose: To test the in vivo colitis-associated cancer (CAC) preventive effect of the water fraction extracted from the roots of I. rotunda, and to evaluate its micro...
Source: Phytomedicine - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

KGC3P attenuates ovalbumin-induced airway inflammation through downregulation of p-PTEN in asthmatic mice
ConclusionsKGC3P and nepetin are anti-asthmatic because they reduce various immune cells such as eosinophils and Th2 cell as well as Th2 cytokines. These mechanisms may be accompanied by the regulation of PPARγ expression and the PTEN pathway. Taken together, our results indicate that KGC3P and nepetin may potentially prevent and treat asthma.Graphical Abstract (Source: Phytomedicine)
Source: Phytomedicine - April 30, 2019 Category: Drugs & Pharmacology Source Type: research