Novel oligomeric neolignans with PTP1B inhibitory activity from the bark of Magnolia officinalis var. biloba.
In this study, phytochemical investigation of M. officinalis var. biloba bark extract afforded five pairs of novel enantiomeric oligomeric neolignans, (±)-mooligomers A-E (1-5). (±)-1 and (±)-2 were two diastereomeric pairs of enantiomers with six C6-C3 subunits, and (±)-4 was a pair of previously unreported tetrameric neolignans bearing eight C6-C3 subunits. (±)-5 is the first example of a naturally occurring trilignan featuring an eight-membered ring with a magnolol moiety. The absolute configurations of (±)-1-(±)-5 were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopy and electronic circular dichroi...
Source: Bioorganic Chemistry - September 24, 2020 Category: Chemistry Authors: Li C, Li CJ, Xu KL, Ma J, Huang JW, Ye F, Zang YD, Zhang DM Tags: Bioorg Chem Source Type: research
COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?
ConclusionsOur work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical discussion about their potential use as adjuvants in the treatment of early/mild common flu in otherwise healthy adults within the context of COVID-19. While these herbal medicines will not cure or prevent the flu, they may both improve general patient well-being and offer them an opportunity to personalize the therapeutic approaches. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 22, 2020 Category: Drugs & Pharmacology Source Type: research
Bioassay-guided isolation of two antifungal compounds from Magnolia officinalis, and the mechanism of action of honokiol
Publication date: Available online 15 September 2020Source: Pesticide Biochemistry and PhysiologyAuthor(s): Yin-Fang Yan, Cheng-Jie Yang, Xiao-Fei Shang, Zhong-Min Zhao, Ying-Qian Liu, Rui Zhou, Hua Liu, Tian-Lin Wu, Wen-Bin Zhao, Yu-Ling Wang, Guan-Fang Hu, Fang Qin, Ying-Hui He, Hai-Xin Li, Sha-Sha Du (Source: Pesticide Biochemistry and Physiology)
Source: Pesticide Biochemistry and Physiology - September 16, 2020 Category: Biochemistry Source Type: research
Magnolia officinalis and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates
Foodborne Pathogens and Disease, Ahead of Print. (Source: Foodborne Pathogens and Disease)
Source: Foodborne Pathogens and Disease - July 22, 2020 Category: Food Science Authors: Hyojin Kim Chae Yeon Lim Mi Sook Chung Source Type: research
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus ®-Poloxamer 188.
Enhanced oral bioavailability of magnolol via mixed micelles and nanosuspensions based on Soluplus®-Poloxamer 188.
Drug Deliv. 2020 Dec;27(1):1010-1017
Authors: Li G, Lu Y, Fan Y, Ning Q, Li W
Abstract
Magnolol, known to have extensive biological activities, is the major bioactive ingredient isolated from the root and stem bark of Magnolia officinalis. However, the clinical application of magnolol is limited by poor aqueous solubility and absorption. The aim of this study is to develop novel mixed micelles and nanosuspensions composed of two biocompatible copolymers, Soluplus® a...
Source: Drug Delivery - July 8, 2020 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
The Therapeutic Effects of Magnolia Officinalis Extraction on an Antibiotics-Induced Intestinal Dysbacteriosis in Mice.
In this study, we explored the effects of M. officinalis extraction on intestinal flora to reveal its mechanism. Thirty SPF mice were divided into five groups: C (control), M (M. officinalis), A (antibiotics: cefradine and gentamicin sulfate), A&M (antibiotics + M. officinalis) and A&N (antibiotics + natural recovery). Faecal samples of all groups were collected and the taxonomic composition and diversity of bacteria was characterized using the 16S rRNA gene (16S). Alpha diversity showed gut bacteria diversity significantly decreased in the A group of mice but increased markedly after administration of M. o...
Source: Current Microbiology - June 18, 2020 Category: Microbiology Authors: Tian H, Zhao L, Zhang Q, Zhang Y, Mao X, Wang J, Li T, Li J, You Z, Ruan Q, Jiang L Tags: Curr Microbiol Source Type: research
Magnolol induces human Ewing sarcoma SK-ES-1 cell apoptosis via the mitochondrial and death receptor pathways.
We examined the effect of magnolol on ES cell proliferation and apoptosis in vitro as well as the mechanism of its anticancer effect. The results demonstrated that magnolol inhibited the proliferation of ES and induced ES cell apoptosis through the mitochondrial and death receptor pathways. Magnolol reduced MEK1/2, ERK1/2, and STAT3 phosphorylation in ES cells, suggesting that the MAPK/ERK and JAK/STAT3 signal transduction pathways are involved in the inhibition of ES cell growth by magnolol. In short, magnolol is a potential anti-ES drug.
PMID: 32509168 [PubMed] (Source: American Journal of Translational Research)
Source: American Journal of Translational Research - June 10, 2020 Category: Research Tags: Am J Transl Res Source Type: research
[ASAP] Pharmacokinetic and Metabolic Profiling of Key Active Components of Dietary Supplement < italic toggle="yes" > Magnolia officinalis < /italic > Extract for Prevention against Oral Carcinoma
Journal of Agricultural and Food ChemistryDOI: 10.1021/acs.jafc.0c01475 (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - June 4, 2020 Category: Food Science Authors: Dinh Bui †, Li Li†, Taijun Yin†, Xinli Wang†‡, Song Gao§, Ming You?, Rashim Singh*†, and Ming Hu*† Source Type: research
Honokiol inhibits carotid artery atherosclerotic plaque formation by suppressing inflammation and oxidative stress.
In this study, the role of honokiol in the development of carotid artery atherosclerotic lesions was evaluated in an ApoE-/- mouse model fed with a normal diet (ND) or a Western-type diet (WD) for ten weeks. After first two weeks, a perivascular collar was surgically placed on the right common carotid arteries of the mice. Then, WD-fed mice were intraperitoneally injected with honokiol (10 or 20 mg/kg) or administrated with 10 mg/kg atorvastatin calcium by gavage once a day for eight weeks. After that, the right common carotid arteries were excised for further experiments. The result showed that honokiol substantially inhi...
Source: Aging - May 3, 2020 Category: Biomedical Science Authors: Liu Y, Cheng P, Wu AH Tags: Aging (Albany NY) Source Type: research
Molecules, Vol. 25, Pages 1450: Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells
This study was further aimed to evaluate the effects of honokiol on human drug-resistant glioblastoma cells and the possible mechanisms. The results by data mining in the cancer genome atlas (TCGA) database and immunohistochemistry displayed that expression of caspase-9 mRNA and protein in human glioblastomas was induced. Human TMZ-resistant U87-MG-R9 glioblastoma cells were selected and prepared from human drug-sensitive U87-MG cells. Compared to human drug-sensitive U87-MG cells, TMZ did not affect viability of U87-MG-R9 glioblastoma cells. Interestingly, treatment with honokiol suppressed proliferation and survival of h...
Source: Molecules - March 22, 2020 Category: Chemistry Authors: Gong-Jhe Wu Sun-Ta Yang Ruei-Ming Chen Tags: Article Source Type: research
Magnolia officinalis reduces inflammation and damage induced by recurrent status epilepticus in immature rats.
CONCLUSION: The results indicating that Magnolia officinalis is an alternative preventive treatment for early stages of epileptogenesis are encouraging.
PMID: 32196444 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 19, 2020 Category: Drugs & Pharmacology Authors: Orozco-Suarez S, Vega-García A, Rocha L, Guevara-Guzmán R, Guerra-Araiza C, Feria-Romero I, Gallardo JM, Neri-Gomez T, Suárez-Santiago JE Tags: Curr Pharm Des Source Type: research
Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis.
This study indicates that these honokiol derivatives could be used as leads for the further derivation and development of the potential pesticide candidates for crop protection.
PMID: 32165043 [PubMed - as supplied by publisher] (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - March 4, 2020 Category: Chemistry Authors: Zhi XY, Jiang LY, Li T, Song LL, Wang Y, Cao H, Yang C Tags: Bioorg Med Chem Lett Source Type: research
[ASAP] Zebrafish-Based Screening of Antiseizure Plants Used in Traditional Chinese Medicine: < italic toggle="yes" > Magnolia officinalis < /italic > Extract and Its Constituents Magnolol and Honokiol Exhibit Potent Anticonvulsant Activity in a Therapy-Resistant Epilepsy Model
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00610 (Source: ACS Chemical Neuroscience)
Source: ACS Chemical Neuroscience - February 21, 2020 Category: Neuroscience Authors: Jing Li †, Danie¨lle Copmans†, Miche`le Partoens†, Borba´la Hunyadi‡, Walter Luyten§, and Peter de Witte*† Source Type: research
Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
Cancer chemotherapy induces sarcopenia, which is a rapid loss of muscle mass that directly restricts daily activities and leads to poor quality of life and increased mortality. Although hormone-related therapies have been used to improve appetite and nutritional status, current treatments are considered palliative. Thus, the protection of skeletal muscle loss without adverse effects is essential to allow the maintenance of chemotherapy in cancer patients. Magnolol from Magnolia officinalis has several pharmacological effects including anti-cancer and anti-inflammatory activities, but the protection from muscle atrophy is n...
Source: Frontiers in Immunology - February 6, 2020 Category: Allergy & Immunology Source Type: research
Honokiol: A polyphenol neolignan ameliorates pulmonary fibrosis by inhibiting TGF- β/Smad signaling, matrix proteins and IL-6/CD44/STAT3 axis both in vitro and in vivo.
This study has been conducted in TGF-β1 induced in vitro model and 21 day in vivo murine model of Bleomycin induced PF. The findings of our study suggest that HNK was able to inhibit fundamental pathways of epithelial to mesenchymal transition (EMT) and TGF-β/Smad signaling both in vitro and in vivo. Additionally, HNK also attenuated collagen deposition and inflammation associated with fibrosis. We also hypothesized that HNK interfered with IL-6/CD44/STAT3 axis. As hypothesized, HNK significantly mitigated IL-6/CD44/STAT3 axis both in vitro and in vivo as evident from outcomes of various protein expression studies like...
Source: Toxicology and Applied Pharmacology - February 3, 2020 Category: Toxicology Authors: Pulivendala G, Bale S, Godugu C Tags: Toxicol Appl Pharmacol Source Type: research
