Positional Isomerization of Phenylethanoid Glycosides from Magnolia officinalis.
Authors: Xue Z, Li H, Yang B
Abstract
Positional isomerization, an inducement leading to instability of phenylethanoid glycosides (PhGs) containing the caffeoyl moiety linked to C-3/4 of the central saccharide, is reported. Magnolosides M, A and F from Magnolia officinalis were found to be transformed into their isomers magnolosides A, D, M and B, respectively, which indicated that PhGs containing the caffeoyl moiety linking to C-3/4 of the central saccharide were unstable, and the caffeoyl group could be transferred to either C-4/3 or C-6 of the central saccharide. In addition, among the factors of temper...
Source: Natural Product Communications - June 15, 2019 Category: Biochemistry Tags: Nat Prod Commun Source Type: research
Molecules, Vol. 24, Pages 2140: Antifungal Effect of Magnolol and Honokiol from Magnolia officinalis on Alternaria alternata Causing Tobacco Brown Spot
In this study, two phenol compounds, magnolol and honokiol, were extracted from Magnolia officinalis and identified by LC-MS, 1H- and 13C-NMR. The magnolol and honokiol were shown to be effective against seven pathogenic fungi, including Alternaria alternata (Fr.) Keissl, Penicillium expansum (Link) Thom, Alternaria dauci f.sp. solani, Fusarium moniliforme J. Sheld, Fusarium oxysporum Schltdl., Valsa mali Miyabe & G. Yamada, and Rhizoctonia solani J.G. Kühn, with growth inhibition of more than 57%. We also investigated the mechanisms underlying the potential antifungal activity of magnolol and hono...
Source: Molecules - June 5, 2019 Category: Chemistry Authors: Ya-Han Chen Mei-Huan Lu Dong-Sheng Guo Ying-Yan Zhai Dan Miao Jian-Ying Yue Chen-Hong Yuan Ming-Min Zhao De-Rong An Tags: Article Source Type: research
Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism
In this study, the inhibitory effects and inhibition mechanism of magnolol on human carboxylesterases (hCEs), the key enzymes responsible for the hydrolytic metabolism of a variety of endogenous esters as well as ester-bearing drugs, have been well-investigated. The results demonstrate that magnolol strongly inhibits hCE1-mediated hydrolysis of various substrates, whereas the inhibition of hCE2 by magnolol is substrate-dependent, ranging from strong to moderate. Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intr...
Source: Chemico Biological Interactions - June 4, 2019 Category: Biochemistry Source Type: research
Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism.
In this study, the inhibitory effects and inhibition mechanism of magnolol on human carboxylesterases (hCEs), the key enzymes responsible for the hydrolytic metabolism of a variety of endogenous esters as well as ester-bearing drugs, have been well-investigated. The results demonstrate that magnolol strongly inhibits hCE1-mediated hydrolysis of various substrates, whereas the inhibition of hCE2 by magnolol is substrate-dependent, ranging from strong to moderate. Inhibition of intracellular hCE1 and hCE2 by magnolol was also investigated in living HepG2 cells, and the results showed that magnolol could strongly inhibit intr...
Source: Chemico-Biological Interactions - June 2, 2019 Category: Molecular Biology Authors: Song YQ, Weng ZM, Dou TY, Finel M, Wang YQ, Ding LL, Jin Q, Wang DD, Fang SQ, Cao YF, Hou J, Ge GB Tags: Chem Biol Interact Source Type: research
Molecules, Vol. 24, Pages 2035: Antidepressant-Like Effect and Mechanism of Action of Honokiol on the Mouse Lipopolysaccharide (LPS) Depression Model
In this study, the lipopolysaccharide (LPS) mouse model was used to study the effect of honokiol on depression-like behavior induced by LPS in mice and its potential mechanism. A single administration of LPS (1 mg/kg, intraperitoneal injection) increased the immobility time in the forced swimming test (FST) and tail suspension test (TST), without affecting autonomous activity. Pretreatment with honokiol (10 mg/kg, oral administration) for 11 consecutive days significantly improved the immobility time of depressed mice in the FST and TST experiments. Moreover, honokiol ameliorated LPS-induced NF-κB activation ...
Source: Molecules - May 27, 2019 Category: Chemistry Authors: Bo Zhang Ping-Ping Wang Kai-Li Hu Li-Na Li Xue Yu Yi Lu Hong-Sheng Chang Tags: Article Source Type: research
Honokiol alleviates acetaminophen-induced hepatotoxicity via decreasing generation of acetaminophen-protein adducts in liver
Publication date: Available online 24 May 2019Source: Life SciencesAuthor(s): Feng-Ling Yu, Jun-Wen Wu, He ZhuAbstractAimAcetaminophen (APAP) overdose is the most frequent cause of drug-induced liver damage. Magnolia officinalis is a traditional hepatoprotective Chinese medicine and Honokiol (HO) is the major active constituent. The present study was to investigate the effect of HO on APAP-induced hepatotoxicity and related mechanisms.Main methodsFour groups of mice were subjected to treatment as vehicle, APAP, APAP + HO and APAP + HO + NRF2 inhibitor. The morphological and biochemical assessments were used to ...
Source: Life Sciences - May 25, 2019 Category: Biology Source Type: research
A FLIPR Assay for Discovery of GABAA Receptor Modulators of Natural Origin
Planta Med DOI: 10.1055/a-0921-7602A fluorometric imaging plate reader (FLIPR) assay utilizing Chinese hamster ovary (CHO) cells stably transfected with GABAA receptors of α
1
β
2
γ
2 subunit composition was evaluated and validated for rapid screening of plant extract libraries and efficient localization of active compounds in extracts. Validation was performed with pure compounds and extracts known to contain allosteric GABAA receptor modulators. Plants extracts that had been previously reported as active in an assay using Xenopus laevis oocytes transiently expressing GABAA receptors of α
...
Source: Planta Medica - May 23, 2019 Category: Drugs & Pharmacology Authors: Faleschini, Maria Teresa Maier, Anne Fankhauser, Sarah Thasis, Katharina Hebeisen, Simon Hamburger, Matthias Butterweck, Veronika Tags: Original Papers Source Type: research
Magmenthanes A-H: Eight new meroterpenoids from the bark of Magnolia officinalis var. Biloba.
Abstract
Eight new meroterpenoids with different types of monoterpene units, namely, magmenthanes A-H (1-8), were identified from the bark of Magnolia officinalis var. biloba. Magmenthane A (1) possesses a 1,3-dioxabicyclo [4.3.01,5] nonane skeleton, 1-5 possess five pairs of enantiomers and 6 possesses a 1,1'-diallyl-biphenyl fragment. The structures of 1-8 were elucidated on the basis of 1D and 2D NMR, HRESIMS and electronic circular dichroism (ECD) calculations. Compounds 5 and 8 displayed significant PTP1B inhibitory activities with IC50 values of 4.38 and 3.88 μM, respectively.
PMID: 310544...
Source: Bioorganic Chemistry - April 26, 2019 Category: Chemistry Authors: Li C, Li CJ, Ma J, Huang JW, Wang XY, Wang XL, Ye F, Zhang DM Tags: Bioorg Chem Source Type: research
Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish.
Abstract
Honokiol, the main bioactive component of Magnolia officinalis, has a variety of pharmacological actions. However, its toxicity has rarely been reported. According to previous studies performed in our laboratory, honokiol microemulsion has embryo developmental toxicity. For further exploration, Zebrafish embryos were exposed to different doses of honokiol microemulsion to record the rates of mortality, malformation, and hatching. We found that high doses of honokiol microemulsion (0.6 and 0.9 μg/mL) increased mortality, inhibited hatching, caused malformation and reduced swimming activities. Th...
Source: Toxicology and Applied Pharmacology - April 21, 2019 Category: Toxicology Authors: Li H, Zhang Q, Li W, Li H, Bao J, Yang C, Wang A, Wei J, Chen S, Jin H Tags: Toxicol Appl Pharmacol Source Type: research
The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies
Conclusion
This work demonstrated that magnolol significantly inhibited IL-1β-induced PI3K/Akt/NF-κB pathway activation to attenuate inflammation and catabolism in human OA chondrocytes. Meanwhile, molecular docking results showed that magnolol occupied the active pocket of PI3K, which was consistent with the results found in vitro. Furthermore, in DMM-induced OA model, protective effects of magnolol on chondrocytes were also observed. Taken together, the results above may support the use of magnolol as a potential therapeutic regimen for OA.
Data Availability
The raw data supporting the conclusions of thi...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
Reynoutria japonica from Traditional Chinese Medicine: A source of Competitive Adenosine Deaminase Inhibitors for Anticancer.
CONCLUSION: Emodin may represent a good candidate anti-cancer therapy and adenosine protective agent.
PMID: 30987561 [PubMed - as supplied by publisher] (Source: Combinatorial Chemistry and High Throughput Screening)
Source: Combinatorial Chemistry and High Throughput Screening - April 13, 2019 Category: Chemistry Authors: Zhang XG, Ma GY, Kou F, Liu WJ, Sun QY, Guo GJ, Ma XD, Guo SJ, Jian-Ning Z Tags: Comb Chem High Throughput Screen Source Type: research
Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats.
Abstract
During critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a preexisting neuroinflammatory condition can trigger, promote and prolong epileptiform activity and facilitate the development of epilepsy. The goal of the present study was to evaluate the long-term neuroprotective effects Magnolia officinalis extract, on a model of recurrent status epilepticus (SE) in immature rats. Sprague-Dawley rats were treated with kainic acid (KA) (3 mg/kg, dissolved in saline solution) beginning at day ...
Source: Brain Research Bulletin - April 8, 2019 Category: Neurology Authors: Vega-García A, Santana-Gómez CE, Rocha L, Magdaleno-Madrigal VM, Morales-Otal A, Buzoianu-Anguiano V, Feria-Romero I, Orozco-Suárez S Tags: Brain Res Bull Source Type: research
Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators
Publication date: June 2019Source: Biomedicine & Pharmacotherapy, Volume 114Author(s): Sidra Khalid, Adnan Khan, Bushra Shal, Hussain Ali, Yeong Shik Kim, Salman KhanAbstractBurn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide. The management of pain made significant progress; however, more research is needed for burn pain. In the present study, the antinociceptive effect of honokiol extracted from Magnolia officinalis was assessed for 3 consecutive days. The third-degree burns were induced by the hot water method. The honokiol both by intraperitoneal (i.p) and intra...
Source: Biomedicine and Pharmacotherapy - March 28, 2019 Category: Drugs & Pharmacology Source Type: research
Suppression of TRPV1 and P2Y nociceptors by honokiol isolated from Magnolia officinalis in 3rd degree burn mice by inhibiting inflammatory mediators.
Abstract
Burn pain is one of the worst imaginable pain, associated with considerable morbidity and mortality worldwide. The management of pain made significant progress; however, more research is needed for burn pain. In the present study, the antinociceptive effect of honokiol extracted from Magnolia officinalis was assessed for 3 consecutive days. The third-degree burns were induced by the hot water method. The honokiol both by intraperitoneal (i.p) and intra plantar (i.pl) route and in combination with tramadol (i.p) was found to be effective in significantly reducing the mechanical allodynia, hyperalge...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 25, 2019 Category: Drugs & Pharmacology Authors: Khalid S, Khan A, Shal B, Ali H, Kim YS, Khan S Tags: Biomed Pharmacother Source Type: research
Identification of minor lignans, alkaloids, and phenylpropanoid glycosides in Magnolia officinalis by HPLC‒DAD‒QTOF-MS/MS
Publication date: Available online 19 March 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Keke Guo, Chaoying Tong, Qiachi Fu, Jinju Xu, Shuyun Shi, Yecheng XiaoABSTRACTAn effective strategy based on high-speed counter-current chromatography (HSCCC) knockout combination with HPLC–DAD–QTOF-MS/MS analysis were developed to identify minor lignans, alkaloids, and phenylpropanoid glycosides in M. officinalis. Petroleum ether/ethyl acetate/methanol/water (8:4:7:5, v/v/v/v) as solvent system was firstly selected to separate the crude extract of M. officinalis. Two major lignans, honokiol and magnolol ...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 20, 2019 Category: Drugs & Pharmacology Source Type: research
