The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies

Conclusion This work demonstrated that magnolol significantly inhibited IL-1β-induced PI3K/Akt/NF-κB pathway activation to attenuate inflammation and catabolism in human OA chondrocytes. Meanwhile, molecular docking results showed that magnolol occupied the active pocket of PI3K, which was consistent with the results found in vitro. Furthermore, in DMM-induced OA model, protective effects of magnolol on chondrocytes were also observed. Taken together, the results above may support the use of magnolol as a potential therapeutic regimen for OA. Data Availability The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher. Author Contributions W-FN and J-XX conceived and designed the experiments. Z-CH and Z-CL performed the experiments. Z-CH and B-JJ performed the statistical analysis and wrote the manuscript. J-XX, X-BL, XF, and Y-JB provided assistance with experiments. All authors discussed the results and approved the final manuscript. Funding All the reagents were funded by the Natural Science Foundation of Zhejiang Province (Grant No. LY17H060009). Funder didn’t involve in the experiments and would pad for the open access publication fees. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Footnotes ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research