Magnolia polyphenols attenuate oxidative-and inflammatory responses in neurons and microglial cells

Conclusion: This study highlights the important role of NADPH oxidase in mediating oxidative stress in neurons and microglial cells and has unveiled the role of IFNgamma in stimulating the MAPK/ERK1/2 signaling pathway for activation of NADPH oxidase in microglial cells. Hon and Mag offer anti-oxidative or anti-inflammatory effects, at least in part, through suppressing IFNgamma-induced p-ERK1/2 and its downstream pathway.
Source: Journal of Neuroinflammation - Category: Neurology Authors: Source Type: research