Magnolia polyphenols attenuate oxidative-and inflammatory responses in neurons and microglial cells
Conclusion:
This study highlights the important role of NADPH oxidase in mediating oxidative stress in neurons and microglial cells and has unveiled the role of IFNgamma in stimulating the MAPK/ERK1/2 signaling pathway for activation of NADPH oxidase in microglial cells. Hon and Mag offer anti-oxidative or anti-inflammatory effects, at least in part, through suppressing IFNgamma-induced p-ERK1/2 and its downstream pathway.
Source: Journal of Neuroinflammation - Category: Neurology Authors: Dennis ChuangMing-Huan ChanYijia ZongWenwen ShengYan HeJing Hua JiangAgnes SimonyiZezong GuKevin FritscheJiankun CuiJames LeeWilliam FolkDennis LubahnAlbert SunGrace Sun Source Type: research