A review of the phytochemistry and pharmacological activities of Ephedra herb
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Shuang-Man MIAO, Qi ZHANG, Xiao-Bao BI, Jin-Long CUI, Meng-Liang WANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Xue-Ying LI, Homng TAO, Can JIN, Zhen-Yun DU, Wen-Feng LIAO, Qing-Jiu TANG, Kan DING (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

The antibacterial activity of Berberis heteropoda Schrenk and its effect on irritable bowel syndrome in rats
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Li LI, Hui-Min ZHU, Qi YAN, Song-Ya LI, Fei LI (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

Pancreatic lipase inhibitory constituents from Fructus Psoraleae
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Xu-Dong HOU, Li-Lin SONG, Yun-Feng CAO, Yi-Nan WANG, Qi ZHOU, Sheng-Quan FANG, Da-Chang WU, Shi-Zhu ZANG, Lu CHEN, Yue BAI, Guang-Bo GE, Jie HOU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

New meroterpenoids and C-methylated flavonoid isolated from Baeckea frutescens
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Ji-Qin HOU, Heng ZHAO, Jiang-Hong YU, Ling-Jun CHEN, Hao WANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

Alkaloid constituents from the fruits of Flueggea virosa
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Qiu-Jie XIE, Wei-Yan ZHANG, Zhen-Long WU, Ming-Tao XU, Qi-Fang HE, Xiao-Jun HUANG, Chun-Tao CHE, Ying WANG, Wen-Cai YE (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

Overexpression of ribonucleotide reductase small subunit, RNRM, increases cordycepin biosynthesis in transformed Cordyceps militaris
Publication date: May 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 5Author(s): Han ZHANG, Yu-Xian WANG, Xin-Xin TONG, Wallace Yokoyama, Jing CAO, Fang WANG, Cheng PENG, Jin-Lin GUO (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 23, 2020 Category: Complementary Medicine Source Type: research

The importance of researches on the fungal bioactive secondary metabolites in developing the comprehensive health industry
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Guo-Dong CHEN, Dan HU, Hao GAO, Xin-Sheng YAO (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

A new iron(III) chelator of coprogen-type siderophore from the deep-sea-derived fungus Mycosphaerella sp. SCSIO z059
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Zhong-Hui HUANG, Xiao LIANG, Shu-Hua QI (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Four new steroids from the marine soft coral-derived fungus Penicillium sp. SCSIO41201
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Jie-Yi LONG, Jun-Feng WANG, Sheng-Rong LIAO, Xiu-Ping LIN, Xue-Feng ZHOU, Yun-Qiu LI, Bin YANG, Yong-Hong LIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Three new isocoumarin derivatives from the mangrove endophytic fungus Penicillium sp. YYSJ-3
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Pei QIU, Run-Lin CAI, Lin LI, Zhi-Gang SHE (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Long-Fang GUO, Gao-Ran LIU, Ling LIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

New meroterpenoid compounds from the culture of mushroom Panus lecomtei
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Si-Xian WANG, Rui-Lin ZHAO, Cui GUO, Bao-Song CHEN, Huan-Qin DAI, Gao-Qiang LIU, Hong-Wei LIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Gaseous signaling molecules as potential therapeutic agents
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Zhang-Jian HUANG, Bing-He WANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Nitric oxide donating anti-glaucoma drugs: advances and prospects
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Yu-Jie MAO, Jian-Bing WU, Ze-Qiu YANG, Yi-Hua ZHANG, Zhang-Jian HUANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

CO as a therapeutic agent: discovery and delivery forms
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Xiao-Xiao YANG, Bo-Wen KE, Wen LU, Bing-He WANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Prodrugs of hydrogen sulfide and related sulfur species: recent development
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Zheng-Nan YUAN, Yue-Qin ZHENG, Bing-He WANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in rats
Publication date: April 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 4Author(s): Li YAO, Yu-Xia YANG, Hui CAO, Huan-Huan REN, Zheng NIU, Ling SHI (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - May 10, 2020 Category: Complementary Medicine Source Type: research

Fatty liver diseases, mechanisms, and potential therapeutic plant medicines
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Jia-Zhen ZHU, Hong-Wei YI, Wei HUANG, Tao PANG, Hui-Ping ZHOU, Xu-Dong WU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Selenium-enriched Bifidobacterium longum protected alcohol and high fat diet induced hepatic injury in mice
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Hong-Wei YI, Xiao-Xiao ZHU, Xiao-Li HUANG, Yu-Zhu LAI, Yue TANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

MUC1 promotes glycolysis through inhibiting BRCA1 expression in pancreatic cancer
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Xiao FU, Neng TANG, Wei-Qi XIE, Liang MAO, Yu-Dong QIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Berbamine ameliorates ethanol-induced liver injury by inhibition of hepatic inflammation in mice
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Xin-Yu LIU, Guan-Nan CHEN, Guo-Ming DU, Yue PAN, Wu-Qi SONG, Ting-Wang JIANG, Hai-Liang LIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Organic anion transporter 1 and 3 contribute to traditional Chinese medicine-induced nephrotoxicity
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Qing-Qing SHEN, Jing-Jing WANG, Debmalya ROY, Li-Xin SUN, Zhen-Zhou JIANG, Lu-Yong ZHANG, Xin HUANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP)
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Hong-Zhi DU, Xiao-Ying HOU, Yu-Huan MIAO, Bi-Sheng HUANG, Da-Hui LIU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Targeted bile acids and gut microbiome profiles reveal the hepato-protective effect of WZ tablet (Schisandra sphenanthera extract) against LCA-induced cholestasis
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Dong-Shun LI, Quan-Fei HUANG, Li-Huan GUAN, Hui-Zhen ZHANG, Xi LI, Kai-Li FU, Yi-Xin CHEN, Jian-Bo WAN, Min HUANG, Hui-Chang BI (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Construction and application of carbohydrate microarrays to detect foodborne bacteria
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Jing HU, Yong XIAO, Shu-An SHAO, Rui GU, Qi-Min SHI, Zhong-Hua LIU, Jian YIN (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Shenfu injection attenuates lipopolysaccharide-induced myocardial inflammation and apoptosis in rats
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Rui-Juan CHEN, Qing-Lin RUI, Qiong WANG, Fang TIAN, Jian WU, Xiang-Qing KONG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Pharmacokinetic interaction of Forsythia suspensa extract and azithromycin injection after single and co-intravenous administration in rats
Publication date: March 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 3Author(s): Xin-Gang LI, Jian NI, Su SHEN, Xiao-Ping WANG, Jing-Chen TIAN (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - April 2, 2020 Category: Complementary Medicine Source Type: research

Antitumor activity of nervosine VII, and the crosstalk between apoptosis and autophagy in HCT116 human colorectal cancer cells
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Shuai HUANG, Shuang-Mei ZHAO, Lian-Hai SHAN, Xian-Li ZHOU (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Profiling the mid-adult cecal microbiota associated with host healthy by using herbal formula Kang Shuai Lao Pian treated mid-adult mice
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Shu-Qing GONG, Ting-Ting YE, Mei-Xia WANG, Zhu-Ping HONG, Li LIU, Huan CHEN, Jing QIAN (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Dandelion polyphenols protect against acetaminophen-induced hepatotoxicity in mice via activation of the Nrf-2/HO-1 pathway and inhibition of the JNK signaling pathway
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Yong-Shen REN, Yao ZHENG, Huan DUAN, Lei LEI, Xin DENG, Xin-Qiao LIU, Zhi-Nan MEI, Xu-Kun DENG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Jong-Eun Lee, Sung Sik Yoon, Jae-Wook Lee, Eun-Yi Moon (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Quantitative proteomics analysis of Fructus Psoraleae-induced hepatotoxicity in rats
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Zhi-Jian LI, Abulizi Abudumijiti, Deng-Qiu XU, Maimaiti Youlidouzi, Aibai Silafu, Zhen-Zhou JIANG, Guo-Lin ZHAO, Tao WANG, Refukati Aiximujiang, Maimaiti Zulikaer, Simayi Yiliyaer, Chun-Yu CAO, Lu-Yong ZHANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Liver metabonomics study on the protective effect of glycyrrhetinic acid against realgar-induced liver injury
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Tao-Guang HUO, Ying FANG, Ying-Hua ZHANG, Cong FENG, Hong JIANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

Comprehensive analysis of the chemical constituents in sulfur-fumigated Lonicerae Japonicae Flos using UHPLC-LTQ-Orbitrap mass spectrometry
Publication date: February 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 2Author(s): Zi-Han LIU, Yu-Qi WANG, Xiao-Dan MEI, Fei WANG, Xian-Zhao YANG, Xiao-Dong LI, Feng JIANG, Jia-Yu ZHANG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - March 13, 2020 Category: Complementary Medicine Source Type: research

A review of isolation methods, structure features and bioactivities of polysaccharides from Dendrobium species
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Han YUE, Hui ZENG, Kan DINGAbstractDendrobium, orchid, is a traditional Chinese herb medicine applied extensively as tonic and precious food for thou-sands of years recorded in ancient Chinese medical book “Shen Nong’s Materia Medica”. It’s well known that bioactivities are usually related to the ingredients’ basis. Based on the previous research, Dendrobium species contain amino acid, sesquiterpenoids, alkaloids and polysaccharides. As the bioactive substances, carbohydrate shows extensive...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Compounds of traditional Chinese medicine and neuropathic pain
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Shun-Hua LI, Lin LI, Ru-Nan YANG, Shang-Dong LIANGAbstractNeuropathic pain (NP) has become a serious global health issue and a huge clinical challenge without available effective treatment. P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention. Traditional Chinese medicine (TCM) contains multiple components which are effective in targeting different pathological mechanisms involved in NP. Different from traditional analgesics, which target a single pathwa...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Recent advances of long noncoding RNAs involved in the development of multiple sclerosis
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Qian-Wen LI, Wen LEI, Cong CHEN, Wei GUOAbstractGiven the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies, the discovery of novel and effective therapeutic targets have been in an urgent demand. Recent studies have revealed that long noncoding RNAs (lncRNAs) play crucial roles in the development of multiple sclerosis (MS), which provides a new opportunity of uncovering novel mechanism associated with the progression of MS. This review highlights the dysregulation of lncRNAs in ...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Mechanistic evaluation of gastro-protective effects of KangFuXinYe on indomethacin-induced gastric damage in rats
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Qi-Juan LI, Zhan-Guo WANG, Yu XIE, Qiao LIU, Hui-Ling HU, Yong-Xiang GAOAbstractKangFuXinYe (KFX), the ethanol extract of the dried whole body of Periplaneta americana, is a well-known important Chinese medicine preparation that has been used to treat digestive diseases such as gastric ulcers for many years in China. However, its therapeutic effect and mechanism are not yet well understood. Thus, the aim of this study was to investigate the gastro-protective effects of KangFuXinYe (KFX) in indomethacin-induced gastric d...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

The crucial role of metabolic regulation in differential hepatotoxicity induced by furanoids in Dioscorea bulbifera
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Zi-Tian WU, Zhuo-Qing LI, Wei SHI, Ling-Li WANG, Yan JIANG, Ping LI, Hui-Jun LIAbstractDiterpenoid lactones (DLs), a group of furan-containing compounds found in Dioscorea bulbifera L. (DB), have been reported to be associated with hepatotoxicity. Different hepatotoxicities of these DLs have been observed in vitro, but reasonable explanations for the differential hepatotoxicity have not been provided. Herein, the present study aimed to confirm the potential factors that contribute to varied hepatotoxicity of four repres...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Three new secoiridoid glycosides from the flower buds of Lonicera japonica
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Ran YANG, Hao HAO, Jia LI, Jing XUAN, Ming-Feng XIA, Yong-Qing ZHANGAbstractThree new secoiridoid glycosides, named lonijapoglycol A (1), aldosecolohanin C (2) and aldosecolohanin B (3), together with three known ones (4–6), have been isolated from the flower the buds of Lonicera japonica. All the structures were identified by spectroscopic analyses. Lonijapoglycol A (1) expressed significant anti-inflammatory activity to inhibit the release of β-glu-curonidase induced by platelet-activating factor in rat pol...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Three new polyoxygenated bergamotanes from the endophytic fungus Penicillium purpurogenum IMM 003 and their inhibitory activity against pancreatic lipase
Publication date: January 2020Source: Chinese Journal of Natural Medicines, Volume 18, Issue 1Author(s): Gui-Yang XIA, Ling-Yan WANG, Jing-Fang ZHANG, Yu-Zhuo WU, Guang-Bo GE, Ya-Nan WANG, Peng-Cheng LIN, Sheng LINAbstractPurpurolides D–F (1–3), three new polyoxygenated bergamotanes bearing a 6/4/5/5 tetracyclic ring system, were isolated from the endophytic fungus Penicillium purpurogenum IMM 003. Their structures were unambiguously elucidated based on extensive spectroscopic data analyses, 13C NMR chemical shifts calculations coupled with the DP4+ probability method, and the calculated and experimental electr...
Source: Chinese Journal of Natural Medicines - January 18, 2020 Category: Complementary Medicine Source Type: research

Endless exploration for natural products: dedicated to the 80th birthday of Prof. SUN Han-Dong
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Ling-Yi KONG (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Difficulties in research of Chinese medicine polysaccharides
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Li-Feng LI, Tin-Long WONG, Quan-Bin HANAbstractPolysaccharides from Chinese medicines are attracting increasing attention to their wide range of valuable biological activities. As these polysaccharides are mostly from edible materials, their safety can be greatly ensured. Therefore, the Chinese medicine polysaccharides have been the focus of research and development of new drugs and health products. However, there are rarely successful cases. Here, based on the authors' own research experience, the difficulties and ch...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Chemical constituents and biological activities of lycophytes and ferns
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Qin-Feng ZHU, Qin-Shi ZHAOAbstractLycophytes and ferns are unique and charismatic members of many terrestrial ecosystems and occupy the pivotal position in land plant origin and evolution. The Chinese lycophytes and ferns flora, with approximately 2000 species, contributes a substantial component to the global lycophytes and ferns diversity, with estimates of 12 000 species. Among them, about 433 species are medicinally recorded and researches based on their phytochemical properties are important topics in natural med...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Leucosceptroid B from glandular trichomes of Leucosceptrum canum reduces fat accumulation in Caenorhabditis elegans through suppressing unsaturated fatty acid biosynthesis
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Yi LING, Lin-Lin TENG, Juan HUA, De-Sen LI, Shi-Hong LUO, Yan-Chun LIU, Yan LIU, Sheng-Hong LIAbstractObesity that is highly associated with numerous metabolic diseases has become a global health issue nowdays. Plant sesterterpenoids are an important group of natural products with great potential; thus, their bioactivities deserve extensive exploration. RNA-seq analysis indicated that leucosceptroid B, a sesterterpenoid previously discovered from the glandular trichomes of Leucosceptrum canum, significantly regulated ...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Four new sesquiterpene derivatives from Dendrobium findlayanum
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Dan YANG, Zhong-Quan CHENG, Cheng-Ting ZI, Liu YANG, Fa-Wu DONG, Jiang-Miao HU, Jun ZHOUAbstractThree new sesquiterpene glycosides with alloaromadendrane and ylangene-derived type aglycones, named dendrofindlayanosides A–C (1–3), one new cyclopacamphane type sesquiterpene named dendrofindlayanobilin A (4), together with five known compounds have been isolated from stems of Dendrobium findlayanum. Their structures were determined on the basis of spectroscopic and chemical methods. (Source: Chinese Journal of Natural Medicines)
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

A pair of new tirucallane triterpenoid epimers from the stems of Picrasma quassioides
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jie ZHANG, Chuan-Xi WANG, Xiao-Jun SONG, Shuang LI, Huan ZHAO, Guo-Dong CHEN, Dan HU, Hao GAO, Xin-Sheng YAOAbstractA pair of new tirucallane triterpenoid epimers, picraquassins M and N (1> and 2), were isolated from the stems of Picrasma quassioides (D. Don) Benn. Their structures were determined based on comprehensive spectroscopic and X-ray crystallographic analyses. In addition, their AChE inhibitory activity, cytotoxicity against five human tumour cell lines (SW480, MCF-7, HepG2, Hela, and PANC-1), and antimic...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Highly oxygenous trichilin-type limonoids from Trichilia sinensis
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Fa-Liang AN, Yong YIN, Jun LUO, Ling-Yi KONGAbstractSix new trichilin-type limonoids (1–6) with C-19/29 lactol or acetal bridge and a new ring intact limonoid (7) were isolated from the desiccative ripe fruits of Trichilia sinensis. Their structures were determined by extensive spectroscopic methods including 1H NMR, 13C NMR, HSQC, HMBC, ROESY experiments as well as HRESI-MS data. All isolated compounds were evaluated for toxicities against human pulmonary carcinoma A549 and Hela cell lines by sulforhodamine B (...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research

Four new corynanthe-type alkaloids from the roots of Alstonia scholaris
Publication date: December 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 12Author(s): Jian ZHANG, Hua LI, Yong LI, Zi-Wei LI, Chen-Chen SANG, Mei-Hua GAO, Dong-Mei ZHANG, Xiao-Qi ZHANG, Wen-Cai YEAbstractFour new corynanthe-type alkaloids, meloslines C–F (1–4), together with four known ones (5–8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal ...
Source: Chinese Journal of Natural Medicines - December 25, 2019 Category: Complementary Medicine Source Type: research