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NRF2 Addiction in Cancer Cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 16, 2018 Category: Cancer & Oncology Authors: Hiroshi Kitamura, Hozumi Motohashi Tags: Review Article Source Type: research

Expression of activating natural killer ‐cell receptors is a hallmark of the innate‐like T‐cell neoplasm in peripheral T‐cell lymphomas
Peripheral T‐ or natural killer (NK)‐cell lymphomas are rare and difficult‐to‐recognize diseases. It remains arduous to distinguish between NK cell‐ and cytotoxic T‐lymphocyte‐derived lymphomas through routine histological evaluation. To clarify the cells of origin, we focused on NK‐cell receptors and examined the expression using immunohistochemistry in 22 cases with T‐ and NK‐cell neoplasms comprising angioimmunoblastic T‐cell lymphoma, anaplastic lymphoma kinase (ALK)‐positive and ‐negative anaplastic large‐cell lymphomas, extranodal NK/T‐cell lymphoma, nasal type, monomorphic epitheliotrop...
Source: Cancer Science - February 15, 2018 Category: Cancer & Oncology Authors: Yu Uemura, Yasushi Isobe, Akiko Uchida, Junko Asano, Yuji Nishio, Hirotaka Sakai, Masahiro Hoshikawa, Masayuki Takagi, Naoya Nakamura, Ikuo Miura Tags: ORIGINAL ARTICLE Source Type: research

Overexpression of IL ‐35 in intrahepatic cholangiocarcinoma isa prognostic indicator after curative resection
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 15, 2018 Category: Cancer & Oncology Authors: Meixia Zhang, Wei Gan, Chuyu Jing, Susu Zheng, Juan Zhang, Hujia Shen, Xin Xu, Jiajia Lin, Boheng Zhang, Shuangjian Qiu Tags: Original Article Source Type: research

Monitoring tyrosine kinase inhibitor therapeutic responses with a panel of metabolic biomarkers in chronic myeloid leukemia patients
This study showed that GC‐MS‐based metabolomics could provide a promising strategy for complementary diagnosis of CML and offer a new insight to monitor therapeutic responses of TKI in CML patients. Notably, myristic acid and glycerol may serve as a biomarker for characterizing CML patients and for the therapeutic responses of TKI. (Source: Cancer Science)
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Bingyu Yang, Chang Wang, Yiyu Xie, Liangjing Xu, Xiaojin Wu, Depei Wu Tags: ORIGINAL ARTICLE Source Type: research

MicroRNA ‐155 promotes gastric cancer growth and invasion by negatively regulating transforming growth factor‐β receptor 2
This study demonstrated for the first time that miR‐155 can target TGFβR2 to promote GC growth and invasion, and we identified the miR‐155 — TGF?R2 axis in GC. (Source: Cancer Science)
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Yajing Qu, Haiyang Zhang, Wu Sun, Yueting Han, Shuang Li, Yanjun Qu, Guoguang Ying, Yi Ba Tags: ORIGINAL ARTICLE Source Type: research

Third ‐generation oncolytic herpes simplex virus inhibits the growth of liver tumors in mice
We examined the antitumor activities of T‐01 in HCC cell lines and mouse tumor xenograft models, and evaluated the host's immune response to HCC cells. Results demonstrate that a third‐generation oncolytic HSV‐1 may serve as a novel treatment for patients with HCC. (Source: Cancer Science)
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Richi Nakatake, Masaki Kaibori, Yusuke Nakamura, Yoshito Tanaka, Hideyuki Matushima, Tadayoshi Okumura, Takashi Murakami, Yasushi Ino, Tomoki Todo, Masanori Kon Tags: ORIGINAL ARTICLE Source Type: research

Cancer immunotherapy ‐targeted glypican‐3 or neoantigens
Immune checkpoint inhibitors have ushered in a new era in cancer therapy, although other therapies or combinations thereof are still needed for many patients for whom these drugs are ineffective. In this light, we have identified glypican‐3 an HLA‐24, HLA‐A2 restriction peptide with extreme cancer specificity. In this paper, we summarize results from a number of related clinical trials showing that glypican‐3 peptide vaccines induce specific CTLs in most patients (UMIN Clinical Trials Registry: UMIN000001395, UMIN000005093, UMIN000002614, UMN000003696, and UMIN000006357). We also describe the current state of perso...
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Yasuhiro Shimizu, Toshihiro Suzuki, Toshiaki Yoshikawa, Nobuhiro Tsuchiya, Yu Sawada, Itaru Endo, Tetsuya Nakatsura Tags: REVIEW ARTICLE Source Type: research

Pretreatment with probiotic Bifico ameliorates colitis ‐associated cancer in mice: Transcriptome and gut flora profiling
Individuals with inflammatory bowel disease are at high risk of developing colitis‐associated cancer (CAC). Strategies to block the process from inflammatory bowel disease to CAC should be considered. In the experiment, we aim to explore the chemopreventive efficacy of the probiotic cocktail Bifico and its potential mechanism in azoxymethane and dextran sodium sulphate‐induced CAC in mice. Oral pretreatment of Bifico was adopted to evaluate its protective effect. The colorectums of 35 C57BL/6 mice were collected and examined for the degree of inflammation and tumorigenesis. Comparative 16S rRNA sequencing was carried o...
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Huan Song, Weiyi Wang, Bo Shen, Hao Jia, Zhaoyuan Hou, Ping Chen, Yunwei Sun Tags: ORIGINAL ARTICLE Source Type: research

Stemness and anti ‐cancer drug resistance in ABCG2 highly expressed pancreatic cancer is induced on 3D‐culture condition
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Norihiko Sasaki, Toshiyuki Ishiwata, Fumio Hasegawa, Masaki Michishita, Hiroki Kawai, Yoko Matsuda, Tomio Arai, Naoshi Ishikawa, Junko Aida, Kaiyo Takubo, Masashi Toyoda Tags: Original Article Source Type: research

C ‐C motif ligand 5 promotes migration of prostate cancer cells in the prostate cancer bone metastasis microenvironment
Chemokines and their receptors have key roles in cancer progression. The present study investigated chemokine activity in the prostate cancer bone metastasis microenvironment. Growth and migration of human prostate cancer cells were assayed in cocultures with bone stromal cells. The migration of LNCaP cells significantly increased when co‐cultured with bone stromal cells isolated from prostate cancer bone metastases. Cytokine array analysis of conditioned medium from bone stromal cell cultures identified CCL5 as a concentration‐dependent promoter of LNCaP cell migration. The migration of LNCaP cells was suppressed when...
Source: Cancer Science - February 14, 2018 Category: Cancer & Oncology Authors: Satoko Urata, Kouji Izumi, Kaoru Hiratsuka, Aerken Maolake, Ariunbold Natsagdorj, Kazuyoshi Shigehara, Hiroaki Iwamoto, Suguru Kadomoto, Tomoyuki Makino, Renato Naito, Yoshifumi Kadono, Wen ‐Jye Lin, Guzailinuer Wufuer, Kazutaka Narimoto, Atsushi Mizoka Tags: ORIGINAL ARTICLE Source Type: research

Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA
Exosomes derived from cells have been found to mediate signal transduction between cells and to act as efficient carriers to deliver drugs and small RNA. Hepatocyte growth factor (HGF) is known to promote the growth of both cancer cells and vascular cells, and the HGF‐cMET pathway is a potential clinical target. Here, we characterized the inhibitory effect of HGF siRNA on tumor growth and angiogenesis in gastric cancer. In addition, we showed that HGF siRNA packed in exosomes can be transported into cancer cells, where it dramatically downregulates HGF expression. A cell co‐culture model was used to show that exosomes ...
Source: Cancer Science - February 11, 2018 Category: Cancer & Oncology Authors: Haiyang Zhang, Yi Wang, Ming Bai, Junyi Wang, Kegan Zhu, Rui Liu, Shaohua Ge, JiaLu Li, Tao Ning, Ting Deng, Qian Fan, Hongli Li, Wu Sun, Guoguang Ying, Yi Ba Tags: ORIGINAL ARTICLE Source Type: research

The stearate ‐to‐palmitate ratio modulates endoplasmic reticulum stress and cell apoptosis in non‐B non‐C hepatoma cells
In conclusion, NHCC appears to adapt to a FA‐rich environment by modulating SPR via ELOVL6. This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 10, 2018 Category: Cancer & Oncology Authors: Yasushi Shibasaki, Makoto Horikawa, Koji Ikegami, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yoshifumi Morita, Hiroyuki Konno, Hiroya Takeuchi, Mitsutoshi Setou, Takanori Sakaguchi Tags: Original Article Source Type: research

Crosstalk of DNA double ‐strand break repair pathways in PARP inhibitor treatment of BRCA1/2‐mutated Cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 10, 2018 Category: Cancer & Oncology Authors: Shigeaki Sunada, Akira Nakanishi, Yoshio Miki Tags: Review Article Source Type: research

Impact of novel oncogenic pathways regulated by anti ‐tumor miR‐451a in renal cell carcinoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 8, 2018 Category: Cancer & Oncology Authors: Yasutaka Yamada, Takayuki Arai, Sho Sugawara, Atsushi Okato, Mayuko Kato, Satoko Kojima, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki Tags: Original Article Source Type: research

Mutations in the STAT family of genes in cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 8, 2018 Category: Cancer & Oncology Authors: Nahid Shahmarvand, Alexandra Nagy, Jahanbanoo Shahryari, Robert S. Ohgami Tags: Review Article Source Type: research

2 ‐anilino‐4‐amino‐5‐aroylthiazole‐type compound AS7128 inhibits lung cancer growth through decreased iASPP and p53 interaction
In this study, compound AS7128 was selected from a 2‐million entry chemical library screening and identified as a candidate drug against non‐small cell lung cancer in vitro and in vivo. Further investigation indicated that AS7128 could induce cell apoptosis and cell cycle arrest, especially in the mitosis stage. In addition, we also found that iASPP, an oncogenic protein that functionally inhibits p53, might be associated with AS7128 through mass identification. Further exploration indicated that AS7128 treatment could restore the transactivation ability of p53 and, thus, increase the expressions of its downstream targ...
Source: Cancer Science - February 6, 2018 Category: Cancer & Oncology Authors: Hao ‐Wei Cheng, Rong‐Jie Chein, Ting‐Jen Cheng, Pei‐Shan Wu, Hsin‐Yi Wu, Pei‐Fang Hung, Chia‐Jen Wang, Yuan‐Ling Hsu, Jau‐Min Wong, Ang Yuan, Chi‐Huey Wong, Pan‐Chyr Yang, Szu‐Hua Pan Tags: ORIGINAL ARTICLE Source Type: research

Proposal for reclassification of N staging system in penile cancer patients, based on number of positive lymph nodes
In the present study, we aim to compare the rationality of proposed N classification based on the number of metastatic lymph nodes (LNs) with the current one. A total of 509 penile cancer patients at our institute were analyzed. Univariable and multivariable statistical analyses were used to assess cancer‐specific survival (CSS) in 2 staging systems. Harrell's concordance index was applied to evaluate predictive accuracy of the current and proposed N classification in predicting CSS. We propose a new classification: pN1 (metastasis in 1‐2 regional LNs), pN2 (metastasis in 3 regional LNs, or 3 or fewer regional lymph no...
Source: Cancer Science - February 5, 2018 Category: Cancer & Oncology Authors: Zhiyong Li, Shengjie Guo, Zhiming Wu, Hui Han, Zaishang Li, Yanjun Wang, Jieping Chen, Chuangzhong Deng, Zike Qin, Zhuowei Liu, Yonghong Li, Dong Chen, Fangjian Zhou, Kai Yao Tags: ORIGINAL ARTICLE Source Type: research

In This Issue
(Source: Cancer Science)
Source: Cancer Science - February 4, 2018 Category: Cancer & Oncology Tags: In this issue Source Type: research

Issue Information
Cover of this issue. Expression of 15‐PGDH (brown) in pancreatic cancer is reduced by co‐culture of activated macrophages (Green). See also Arima et al. (pp. 462–470 of this issue). (Source: Cancer Science)
Source: Cancer Science - February 4, 2018 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research

Tumor ‐associated CD204+ M2 macrophages are unfavorable prognostic indicators in uterine cervical adenocarcinoma
Uterine cervical adenocarcinoma is rare, but its prevalence has increased. To improve outcomes and ensure the suitability of recent immunotherapies, the aim of this study was to evaluate the clinicopathological impact of the tumor immune microenvironment of uterine cervical adenocarcinoma. We investigated 148 adenocarcinoma cases, including 21 cases of adenocarcinoma in situ (AIS) and 127 cases of invasive adenocarcinoma, using immunohistochemistry to detect tumor‐infiltrating immune cells and the expression of programmed cell death 1 ligand‐1 (PD‐L1) and p16 on tumor cells. We then carried out correlation and surviv...
Source: Cancer Science - February 2, 2018 Category: Cancer & Oncology Authors: Asuka Kawachi, Hiroshi Yoshida, Shigehisa Kitano, Yoshinori Ino, Tomoyasu Kato, Nobuyoshi Hiraoka Tags: ORIGINAL ARTICLE Source Type: research

KIAA0247 inhibits growth, migration, invasion of non ‐small‐cell lung cancer through regulating the Notch pathway
Summary Lung cancer remains the leading cause of cancer‐related death worldwide. Previous studies have shown that the novel KIAA0247 gene potentially targeted by the tumor suppressor p53 may inhibit the development of several cancers. However, the exact function of KIAA0247 in non‐small‐cell lung cancer (NSCLC) is unknown. The purpose of this study was to clarify the role of KIAA0247 in NSCLC. KIAA0247 expression was evaluated in tumors and adjacent normal tissues of 197 NSCLC patients by immunohistochemistry and real‐time PCR and analyzed for association with clinicopathological parameters. The results indicated t...
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Yitong Xu, Hongjiu Ren, Jun Jiang, Qiongzi Wang, Muli Wudu, Qingfu Zhang, Hongbo Su, Chenglong Wang, Lihong Jiang, Xueshan Qiu Tags: Original Article Source Type: research

Down ‐regulation of LRIG1 by microRNA‐20a modulates gastric cancer multidrug resistance
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Lin Zhou, Xiaowei Li, Fan Zhou, Zhi'an Jin, Di Chen, Pin Wang, Shu Zhang, Yuzheng Zhuge, Yulong Shang, Xiaoping Zou Tags: Original Article Source Type: research

Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor ‐2 inhibitor
In this study, we detailed the pharmacologic properties of anlotinib, a highly potent and selective VEGFR2 inhibitor, in preclinical models. Anlotinib occupied the ATP‐binding pocket of the VEGFR2 tyrosine kinase and showed high selectivity and inhibitory potency (IC50
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Chengying Xie, Xiaozhe Wan, Haitian Quan, Mingyue Zheng, Li Fu, Yun Li, Liguang Lou Tags: Original Article Source Type: research

Establishment of an in vivo simulating  co‐culture assay platform for genotoxicity of multi‐walled carbon nanotubes
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Emi Fukai, Haruna Sato, Masatoshi Watanabe, Dai Nakae, Yukari Totsuka Tags: Original Article Source Type: research

Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma
In conclusion, four serum metabolites were identified by serum metabolomics in endometrial cancer patients and functional analyses suggested that they may play roles in modulation of tumour cell behavior, although their exact mode of action still needs to be determined. This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Kun Shi, Qiong Wang, Yao Su, Xingcui Xuan, Yaqiong Liu, Weiwei Chen, Yuanmin Qian, Gendie E. Lash Tags: Original Article Source Type: research

FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Jing Lin, Aihui Ji, Guanzhong Qiu, Huaizhi Feng, Jian Li, Shuo Li, Yongxiang Zou, Yong Cui, Chaoli Song, Hua He, Yicheng Lu Tags: Original Article Source Type: research

Multiple roles of SIM2 in esophageal squamous cell carcinoma and its clinical implications
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Masashi Tamaoki, Rie Komatsuzaki, Masayuki Komatsu, Keiko Minashi, Kazuhiko Aoyagi, Takao Nishimura, Fumiko Chiwaki, Tomoko Hiroki, Hiroyuki Daiko, Kazuhiro Morishita, Yoshiharu Sakai, Hiroshi Seno, Tsutomu Chiba, Manabu Muto, Teruhiko Yoshida, Hiroki Sas Tags: Original Article Source Type: research

Metastatic ability and the epithelial ‐mesenchymal transition in induced cancer stem‐like hepatoma cells
Summary Cancer stem cells (CSCs) are thought to play important roles in cancer malignancy. Previously, we successfully induced sphere cancer stem‐like cells (CSLCs) from several cell lines and observed the property of chemoresistance. In the present study, we examined the metastatic potential of these induced CSLCs. CSLCs were induced from a human hepatoma cell line (SK‐HEP‐1) in a unique medium containing neural survival factor‐1. Splenic injection of cells into immune‐deficient mice was used to assess hematogenous liver metastasis. Transcriptomic strand‐specific RNA‐sequencing analysis, the quantitative rea...
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Mitsuo Nishiyama, Ryouichi Tsunedomi, Kiyoshi Yoshimura, Noriaki Hashimoto, Satoshi Matsukuma, Hiroyuki Ogihara, Shinsuke Kanekiyo, Michihisa Iida, Kazuhiko Sakamoto, Nobuaki Suzuki, Shigeru Takeda, Shigeru Yamamoto, Shigefumi Yoshino, Tomio Ueno, Yoshihi Tags: Original Article Source Type: research

Solute carrier family 35 member F2 is indispensable for papillary thyroid carcinoma progression through activation of transforming growth factor ‐β type I receptor/apoptosis signal‐regulating kinase 1/mitogen‐activated protein kinase signaling axis
Solute carrier family members control essential physiological functions and are tightly linked to human diseases. Solute carrier family 35 member F2 (SLC35F2) is aberrantly activated in several malignancies. However, the biological function and molecular mechanism of SLC35F2 in papillary thyroid carcinoma (PTC) are yet to be fully explored. Here, we showed that SLC35F2 was prominently upregulated in PTC tissues at both protein and mRNA expression level compared with matched adjacent normal tissues. Besides, the high expression of SLC35F2 was significantly associated with lymph node metastasis in patients with PTC. CRISPR/C...
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Jing He, Yiting Jin, Mingxia Zhou, Xiaoyan Li, Wanna Chen, Yiwei Wang, Siwen Gu, Yun Cao, Chengyu Chu, Xiuping Liu, Qiang Zou Tags: ORIGINAL ARTICLE Source Type: research

Helicobacter pylori induces caudal ‐type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells
Dysregulation of microRNAs (miRNAs) has been linked to virulence factors of Helicobacter pylori. The role of H. pylori in esophageal disease has not been clearly defined. We previously reported that H. pylori esophageal colonization promotes the incidence of Barrett's esophagus and esophageal adenocarcinoma in vivo. Here, we studied the direct effects of H. pylori on the transformation of esophageal epithelial cells, with particular focus on whether H. pylori exerts its effects by modulating miRNAs and their downstream target genes. The normal human esophageal cell line HET‐1A was chronically exp...
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Guigen Teng, Yun Dai, Yunxiang Chu, Jing Li, Hongchen Zhang, Ting Wu, Xiaowei Shuai, Weihong Wang Tags: ORIGINAL ARTICLE Source Type: research

Area of residual tumor is a robust prognostic marker for patients with rectal cancer undergoing preoperative therapy
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - February 1, 2018 Category: Cancer & Oncology Authors: Naoki Sakuyama, Motohiro Kojima, Shingo Kawano, Yoko Matsuda, Mari Mino ‐Kenudson, Atsushi Ochiai, Masaaki ito Tags: Original Article Source Type: research

Optimal cumulative cisplatin dose in nasopharyngeal carcinoma patients receiving additional induction chemotherapy
To clarify the optimal cumulative cisplatin dose (CCD) in locoregionally‐advanced nasopharyngel carcinoma (NPC) patients receiving induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT). Using the NPC‐specific database from the established big‐data intelligence platform at Sun Yat‐Sen University Cancer Center, 583 non‐disseminated, locoregionally‐advanced NPC patients receiving IC plus CCRT were enrolled. Propensity score matching (PSM) analysis was conducted to control for confounding factors. The median CCD was 160 mg/m2 after IC (range, 40‐300 mg/m2); only 74 patients (12.7%) achieved CCD>...
Source: Cancer Science - January 31, 2018 Category: Cancer & Oncology Authors: Jia ‐Wei Lv, Zhen‐Yu Qi, Guan‐Qun Zhou, Xiao‐Jun He, Yu‐Pei Chen, Yan‐Ping Mao, Lei Chen, Ling‐Long Tang, Wen‐Fei Li, Ai‐Hua Lin, Jun Ma, Ying Sun Tags: ORIGINAL ARTICLE Source Type: research

Acquired resistance of phosphatase and tensin homolog ‐deficient cells to poly(ADP‐ribose) polymerase inhibitor and Ara‐C mediated by 53BP1 loss and SAMHD1 overexpression
This study demonstrates a consistent resistance profile to PARPis and a unique cross‐resistance profile to non‐PARPi drugs in different PARPi‐resistant U251 cells and reveals 53BP1 loss and SAMHD1 overexpression as the primary mechanisms responsible for their resistance to PARPis and cytarabine, respectively. (Source: Cancer Science)
Source: Cancer Science - January 30, 2018 Category: Cancer & Oncology Authors: Yu ‐Ting Wang, Bo Yuan, Hua‐Dong Chen, Lin Xu, Yu‐Nan Tian, Ao Zhang, Jin‐Xue He, Ze‐Hong Miao Tags: Original Article Source Type: research

lncRNA BC005927 upregulates EPHB4 and promotes gastric cancer metastasis under hypoxia
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 30, 2018 Category: Cancer & Oncology Authors: Xiangqiang Liu, Yafang Wang, Li Sun, Jie Min, Jiaming Liu, Di Chen, Hongbo Zhang, Hongwei Zhang, Helong Zhang, Yongan Zhou, Lili Liu Tags: Original Article Source Type: research

Downregulation of 15 ‐hydroxyprostaglandin dehydrogenase by interleukin‐1β from activated macrophages leads to poor prognosis in pancreatic cancer
Chronic inflammation has a crucial role in cancer development and the progression of various tumors, including pancreatic ductal adenocarcinoma (PDAC). The arachidonate cascade is a major inflammatory pathway that produces several metabolites, such as prostaglandin E2. The enzyme 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms of 15‐PGDH suppression are unclear. The current study was carried out to elucidate the molecular mechanisms and clinical significance of 15‐PGDH suppression in PDAC. Here, we showe...
Source: Cancer Science - January 27, 2018 Category: Cancer & Oncology Authors: Kota Arima, Yoshihiro Komohara, Luke Bu, Masayo Tsukamoto, Rumi Itoyama, Keisuke Miyake, Tomoyuki Uchihara, Yoko Ogata, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Yo ‐ichi Yamashita, Hideo Baba, Takatsugu Ishim Tags: ORIGINAL ARTICLE Source Type: research

Regulatory mechanisms of hypoxia ‐inducible factor 1 activity: Two decades of knowledge
This article reviews the last two decades of knowledge, since 1997, on the regulatory mechanisms of HIF‐1 activity from conventional oxygen‐ and proteolysis‐dependent mechanisms to up‐to‐the‐minute information on cancer‐associated genetic and functional alteration‐mediated mechanisms. (Source: Cancer Science)
Source: Cancer Science - January 27, 2018 Category: Cancer & Oncology Authors: Sho Koyasu, Minoru Kobayashi, Yoko Goto, Masahiro Hiraoka, Hiroshi Harada Tags: REVIEW ARTICLE Source Type: research

New metformin derivative HL156A prevents oral cancer progression by inhibiting the insulin ‐like growth factor/AKT/mammalian target of rapamycin pathways
Metformin is a biguanide widely prescribed as an antidiabetic drug for type 2 diabetes mellitus patients. The purpose of the present study was to observe the effects of the new metformin derivative, HL156A, on human oral cancer cell and to investigate its possible mechanisms. It was observed that HL156A significantly decreased FaDu and YD‐10B cell viability and colony formation in a dose‐dependent way. HL156A also markedly reduced wound closure and migration of FaDu and YD‐10B cells. We observed that HL156A decreased mitochondrial membrane potential and induced reactive oxygen species (ROS) levels and apoptotic cells...
Source: Cancer Science - January 27, 2018 Category: Cancer & Oncology Authors: Thuy Giang Lam, Yun Soo Jeong, Soo ‐A Kim, Sang‐Gun Ahn Tags: ORIGINAL ARTICLE Source Type: research

Expression profile analysis of long non ‐coding RNA in acute myeloid leukemia by microarray and bioinformatics
Long non‐coding RNAs (lncRNAs) are transcripts longer than 200 nt that are involved in tumorigenesis and play a key role in cancer progression. To determine whether lncRNAs are involved in acute myeloid leukemia (AML), we analyzed the expression profile of lncRNAs and mRNAs in AML. Five pairs of AML patients and iron deficiency anemia (IDA) controls were screened by microarray. Through coexpression analysis, differently expressed transcripts were divided into modules, and lncRNAs were functionally annotated. We further analyzed the clinical significance of crucial lncRNAs from modules in public data. Finally, the express...
Source: Cancer Science - January 27, 2018 Category: Cancer & Oncology Authors: Yuandong Feng, Ying Shen, Hongli Chen, Xiaman Wang, Ru Zhang, Yue Peng, Xiaoru Lei, Tian Liu, Jing Liu, Liufang Gu, Fangxia Wang, Yun Yang, Ju Bai, Jianli Wang, Wanhong Zhao, Aili He Tags: ORIGINAL ARTICLE Source Type: research

RBBP6 increases radioresistance and serves as a therapeutic target for preoperative radiotherapy in colorectal cancer
This study investigated whether the inhibition of RBBP6 expression would improve radiosensitivity in human colorectal cancer cells. After SW620 and HT29 cells were exposed to radiation, the levels of RBBP6 mRNA and protein increased over time in both two cells. Moreover, a significant reduction in clonogenic survival and a decrease in cell viability in parallel with an obvious increase in cell apoptosis were demonstrated in irradiated RBBP6‐knockdown cells. Besides, transfection with RBBP6 shRNA improved levels of G2‐M phase arrest which blocked the cells in a more radiosensitive period of the cell cycle. These observa...
Source: Cancer Science - January 25, 2018 Category: Cancer & Oncology Authors: Chao Xiao, Yupeng Wang, Miao Zheng, Jian Chen, Guohe Song, Zhijie Zhou, Chongzhi Zhou, Xing Sun, Lin Zhong, Erxun Ding, Yi Zhang, Liu Yang, Gang Wu, Shifeng Xu, Hong Zhang, Xiaoliang Wang Tags: Original Article Source Type: research

Modulation of AKR1C2 by Curcumin Decreases Testosterone Production in Prostate Cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 25, 2018 Category: Cancer & Oncology Authors: Hisamitsu Ide, Yan Lu, Takahiro Noguchi, Satoru Muto, Hiroshi Okada, Suguru Kawato, Shigeo Horie Tags: Original Article Source Type: research

Osimertinib in patients with EGFR T790M advanced non ‐small cell lung cancer selected using cytology samples
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 24, 2018 Category: Cancer & Oncology Authors: Katsuyuki Kiura, Kiyotaka Yoh, Nobuyuki Katakami, Naoyuki Nogami, Kazuo Kasahara, Toshiaki Takahashi, Isamu Okamoto, Mireille Cantarini,, Rachel Hodge, Hirohiko Uchida Tags: Original Article Source Type: research

Expression of activating NK ‐cell receptors is a hallmark of the innate‐like T‐cell neoplasm in peripheral T‐cell lymphomas
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 24, 2018 Category: Cancer & Oncology Authors: Yu Uemura, Yasushi Isobe, Akiko Uchida, Junko Asano, Yuji Nishio, Hirotaka Sakai, Masahiro Hoshikawa, Masayuki Takagi, Naoya Nakamura, Ikuo Miura Tags: Original Article Source Type: research

Bone marrow mesenchymal stem cells promote head and neck cancer progression through Periostin ‐mediated phosphoinositide 3‐kinase/Akt/mammalian target of rapamycin
In conclusion, this study indicated that BMMSC promoted proliferation, invasion, survival, tumorigenicity and migration of head and neck cancer through POSTN‐mediated PI3K/Akt/mTOR activation. Bone marrow mesenchymal stem cells promoted proliferation, invasion, survival, tumorigenicity and migration of head and neck cancer through Periostin‐mediated PI3K/Akt/mTOR activation. (Source: Cancer Science)
Source: Cancer Science - January 23, 2018 Category: Cancer & Oncology Authors: Chuanxia Liu, Xiaoxia Feng, Baixiang Wang, Xinhua Wang, Chaowei Wang, Mengfei Yu, Guifen Cao, Huiming Wang Tags: ORIGINAL ARTICLE Source Type: research

Modulation of the tumor microenvironment by Epstein ‐Barr virus latent membrane protein 1 in nasopharyngeal carcinoma
Latent membrane protein 1 (LMP1) is a primary oncogene encoded by the Epstein‐Barr virus, and various portions of LMP1 are detected in nasopharyngeal carcinoma (NPC) tumor cells. LMP1 has been extensively studied since the discovery of its transforming property in 1985. LMP1 promotes cancer cell growth during NPC development and facilitates the interaction of cancer cells with surrounding stromal cells for invasion, angiogenesis, and immune modulation. LMP1 is detected in 100% of pre‐invasive NPC tumors and in approximately 50% of advanced NPC tumors. Moreover, a small population of LMP1‐expressing cells in advanced ...
Source: Cancer Science - January 21, 2018 Category: Cancer & Oncology Authors: Tomokazu Yoshizaki, Satoru Kondo, Kazuhira Endo, Yosuke Nakanishi, Mitsuharu Aga, Eiji Kobayashi, Nobuyuki Hirai, Hisashi Sugimoto, Miyako Hatano, Takayoshi Ueno, Kazuya Ishikawa, Naohiro Wakisaka Tags: REVIEW ARTICLE Source Type: research

Present status and future perspective of peptide ‐based vaccine therapy for urological cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 18, 2018 Category: Cancer & Oncology Authors: Wataru Obara, Mitsugu Kanehira, Toyomasa Katagiri, Renpei Kato, Yoichiro Kato, Ryo Takata Tags: Review Article Source Type: research

Palbociclib in combination with letrozole as first ‐line treatment for advanced breast cancer: a Japanese phase II study
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 18, 2018 Category: Cancer & Oncology Authors: Norikazu Masuda, Reiki Nishimura, Masato Takahashi, Kenichi Inoue, Shinji Ohno, Hiroji Iwata, Yuko Mori, Satoshi Hashigaki, Yasuaki Muramatsu, Takashi Nagasawa, Yoshiko Umeyama, Masakazu Toi Tags: Original Article Source Type: research

Development of a risk prediction model for lung cancer: the Japan Public Health Center ‐based Prospective Study
In conclusion, we developed a prediction model to estimate the probability of developing lung cancer based on age, gender, and tobacco consumption. This model appears useful in encouraging high‐risk individuals to quit smoking and undergo increased surveillance. This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 18, 2018 Category: Cancer & Oncology Authors: Hadrien Charvat, Shizuka Sasazuki, Taichi Shimazu, Sanjeev Budhathoki, Manami Inoue, Motoki Iwasaki, Norie Sawada, Taiki Yamaji, Shoichiro Tsugane, Tags: Original Article Source Type: research

Whole Genome Sequencing Analysis for Cancer Genomics and Precision Medicine
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - January 18, 2018 Category: Cancer & Oncology Authors: Hidewaki Nakagawa, Masashi Fujita Tags: Review Article Source Type: research

Combined annotation ‐dependent depletion score for BRCA1/2 variants in patients with breast and/or ovarian cancer
Utility of combined annotation‐dependent depletion (CADD) score was recently reported to rank pathogenicity as C‐scores ranging 1‐99 for both confirmed deleterious mutation. Using C‐scores for BRCA1/2 variants, we tried to constitute the classification system for variant of uncertain significance (VUS), which had been a major problem of genetic testing for hereditary breast and/or ovarian cancer. We analyzed BRCA1/2 genes for 283 patients with breast and/or ovarian cancer. The deleterious mutation and missesne mutations, minor variant, and wild type of BRCA1 and ‐2 were 5, 27, 251 and 15, 85, 183, respectively. M...
Source: Cancer Science - January 17, 2018 Category: Cancer & Oncology Authors: Hiroshi Nakagomi, Hitoshi Mochizuki, Masayuki Inoue, Yosuke Hirotsu, Kenji Amemiya, Ikuko Sakamoto, Satoko Nakagomi, Takeo Kubota, Masao Omata Tags: ORIGINAL ARTICLE Source Type: research

Downregulation of dual ‐specificity tyrosine‐regulated kinase 2 promotes tumor cell proliferation and invasion by enhancing cyclin‐dependent kinase 14 expression in breast cancer
Tumor progression is the main cause of death in patients with breast cancer. Accumulating evidence suggests that dual‐specificity tyrosine‐regulated kinase 2 (DYRK2) functions as a tumor suppressor by regulating cell survival, differentiation, proliferation and apoptosis. However, little is known about the mechanisms of transcriptional regulation by DYRK2 in cancer progression, particularly with respect to cancer proliferation and invasion. Here, using a comprehensive expression profiling approach, we show that cyclin‐dependent kinase 14 (CDK14) is a target of DYRK2. We found that reduced DYRK2 expression increases C...
Source: Cancer Science - January 13, 2018 Category: Cancer & Oncology Authors: Yoshimi Imawari, Rei Mimoto, Shinichi Hirooka, Toshiaki Morikawa, Hiroshi Takeyama, Kiyotsugu Yoshida Tags: ORIGINAL ARTICLE Source Type: research