Proposed revision of N categories to the 8th edition AJCC ‐TNM staging system for non‐surgical esophageal squamous cell cancer
This study aimed to propose a revisi on to the N categories of the 8th edition AJCC‐TNM staging system that is easier to perform and better represents the prognosis of non‐surgical esophageal squamous cell cancer (ESCC). We retrospectively reviewed the data of 336 patients with ESCC. The revised N categories were based on the anato mic regions of LN metastasis (cervix, thorax, and abdomen). Survival was analyzed using the Kaplan‐Meier method and compared using the log‐rank test. Multivariate analyses were performed using the Cox proportional hazard model. Survival differences were adequately discriminated when the ...
Source: Cancer Science - November 22, 2018 Category: Cancer & Oncology Authors: Kai Hu, Ning Kang, Yang Liu, Dong Guo, Wang Jing, Jiamei Lu, Tianmeng Tan, Caitiao Lv, Yuyan Deng, Jianxiong Long, Rensheng Wang, Jinming Yu Tags: Original Article Source Type: research

Clinical Outcomes of Carbon ‐Ion Radiotherapy for Locally Advanced Non‐Small‐Cell Lung Cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 22, 2018 Category: Cancer & Oncology Authors: Kazuhiko Hayashi, Naoyoshi Yamamoto, Mio Nakajima, Akihiro Nomoto, Hiroshi Tsuji, Kazuhiko Ogawa, Tadashi Kamada Tags: Original Article Source Type: research

The role of inhibitor of YAP1 in triple negative breast cancer with taxol ‐based chemoresistance
AbstractThe Triple negative breast cancer (TNBC) associates with high aggressive clinical behavior, and the taxol ‐based chemo‐resistance remains a big TNBC therapeutic problem to be solved. Verteporfin, a small molecular The Yes‐associated protein 1 (YAP1) inhibitor, is little known to be a anti‐tumor drug for TNBC. Our data showed that the YAP1 expression was associated with early relapse in tissue sa mple of patients with TNBC taxol chemoresistance (P
Source: Cancer Science - November 22, 2018 Category: Cancer & Oncology Authors: Ying Li, Shunan Wang, Xi Wei, Sheng Zhang, Zian Song, Xiao Chen, Jin Zhang Tags: Original Article Source Type: research

Persistent restoration to the immunosupportive tumor microenvironment in glioblastoma by bevacizumab
SummaryAlthough vascular endothelial growth factor (VEGF) promotes the immunosuppressive microenvironment, the efficacy of bevacizumab (Bev) on tumor immunity has not been fully investigated. The present study used 47 glioblastoma tissues obtained at 3 different settings: tumors of initial resection (na ïve Bev group), tumors resected following Bev therapy (effective Bev group), and recurrent tumors after Bev therapy (refractory Bev group). The paired samples of the initial and post‐Bev recurrent tumors from 9 patients were included. The expression of PD‐1/PD‐L1, CD3, CD8, Foxp3, and CD163 w as analyzed by immun...
Source: Cancer Science - November 22, 2018 Category: Cancer & Oncology Authors: Ryota Tamura, Toshihide Tanaka, Kentaro Ohara, Keisuke Miyake, Yukina Morimoto, Yohei Yamamoto, Ryuichi Kanai, Yasuharu Akasaki, Yuichi Murayama, Takashi Tamiya, Kazunari Yoshida, Hikaru Sasaki Tags: Original Article Source Type: research

Increased NAD(H) pool promotes colon cancer progression by suppressing ROS level
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 20, 2018 Category: Cancer & Oncology Authors: Sun Mi Hong, Sung Wook Hwang, Taejun Wang, Chang Wook Park, Yeon ‐Mi Ryu, Jin‐Hak Jung, Ji Hye Shin, Sang‐Yeob Kim, Jong Lyul Lee, Chan Wook Kim, Gyesoon Yoon, Ki Hean Kim, Seung‐Jae Myung, Kwan Yong Choi Tags: Original Article Source Type: research

2 ′‐Hydroxycinnamaldehyde inhibits proliferation and induces apoptosis via signal transducer and activator of transcription 3 inactivation and reactive oxygen species generation
In this study, we found that HCA inhibited constitutive and inducible STAT3 activation in STAT3 ‐activated DU145 prostate cancer cells. HCA selectively inhibited the STAT3 activity by direct binding to STAT3, which was confirmed by biochemical methods, including a pull‐down assay with biotin‐conjugated HCA, a drug affinity responsive target stability (DARTS) experiment and a cellular the rmal shift assay (CETSA). HCA inhibited STAT3 phosphorylation at the tyrosine 705 residue, dimer formation, and nuclear translocation in DU145 cells, which led to a downregulation of STAT3 target genes. The downregulation of cell cyc...
Source: Cancer Science - November 20, 2018 Category: Cancer & Oncology Authors: Yae Jin Yoon, Young ‐Hwan Kim, Yu‐Jin Lee, Jiyeon Choi, Cheol‐Hee Kim, Dong Cho Han, Byoung‐Mog Kwon Tags: ORIGINAL ARTICLE Source Type: research

CD47 agonist peptide pkhb1 induces immunogenic cell death in T ‐cell acute lymphoblastic leukemia cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 20, 2018 Category: Cancer & Oncology Authors: Ashanti Concepci ón Uscanga‐Palomeque, Kenny Misael Calvillo‐Rodríguez, Luis Gómez‐Morales, Eva Lardé, Thomas Denèfle, Diana Caballero‐Hernández, Hélène Merle‐Béral, Santos A. Susin, Philippe Karoyan, Ana Carolina Martínez‐T Tags: Original Article Source Type: research

Genetic evidence implies that primary and relapsed tumors arise from common precursor cells in primary central nervous system lymphoma
It was suggested that primary intra ‐central nervous system (CNS) tumors and relapsed extra‐CNS tumors are derived from common precursor cells with MYD88 mutations in most primary CNS lymphomas. The initiating MYD88 mutations may occur during B‐cell differentiation in BM. Primary central nervous system lymphoma (PCNSL) is a rare subtype of lymphoma that arises within the brain or the eyes. PCNSL recurs within the central nervous system (CNS) in most relapsed cases, whereas extra ‐CNS relapse is experienced in rare cases. The present study aimed at identifying the presence of common precursor cells (CPC) for primary...
Source: Cancer Science - November 18, 2018 Category: Cancer & Oncology Authors: Keiichiro Hattori, Mamiko Sakata ‐Yanagimoto, Manabu Kusakabe, Toru Nanmoku, Yasuhito Suehara, Ryota Matsuoka, Masayuki Noguchi, Yasuhisa Yokoyama, Takayasu Kato, Naoki Kurita, Hidekazu Nishikii, Naoshi Obara, Shingo Takano, Eiichi Ishikawa Tags: ORIGINAL ARTICLE Source Type: research

Identification of genes involved in the regulation of Telomerase Reverse Transcriptase in hepatocellular carcinoma
In conclusion, we identified C15orf55 and C7orf43 as positive regulators ofTERT expression in HCC tissues. These genes are promising targets for HCC treatment.This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 17, 2018 Category: Cancer & Oncology Authors: Masataka Amisaki, Hiroyuki Tsuchiya, Tomohiko Sakabe, Yoshiyuki Fujiwara, Goshi Shiota Tags: Original Article Source Type: research

The impact of UGT1A1 genetic polymorphism on toxicity in unresectable pancreatic cancer patients undergoing FOLFIRINOX
In conclusion, patients with heterozygous UGT1A1 polymorphisms treated with the original FOLFIRINOX regimen experienced severe toxicity more frequently than patients with wild type UGT1A1.This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 17, 2018 Category: Cancer & Oncology Authors: Hiromichi Shirasu, Akiko Todaka, Katsuhiro Omae, Hirofumi Fujii, Nobumasa Mizuno, Masato Ozaka, Hideki Ueno, Satoshi Kobayashi, Kazuhiro Uesugi, Noritoshi Kobayashi, Hideyuki Hayashi, Kentaro Sudo, Naohiro Okano, Yosuke Horita, Keiko Kamei, Tags: Original Article Source Type: research

Fibroblast growth factor receptor 3 ‐mediated reactivation of ERK signaling promotes head and neck squamous cancer cell insensitivity to MEK inhibition
In this study, we investigated the cause of the limited therapeutic effect of the MEK inhibitor, selumetinib, in head and neck squamous cell carcinoma cells. The FGFR3 inhibitor PD173074 prevented MAPK rebound and sensitized the response of HNSCC cells to selumetinib. Recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) has been a longstanding challenge for head and neck oncologists, and current treatments still have limited efficacy. ERK is aberrantly overexpressed and activated in HNSCC. Herein, we aimed to investigate the cause of the limited therapeutic effect of selumetinib, a selective inhibitor of M...
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Myung Jin Ban, Hyung Kwon Byeon, Yeon Ju Yang, Sojung An, Jae Wook Kim, Ji ‐Hoon Kim, Da Hee Kim, Jaemoon Yang, Hyunjung Kee, Yoon Woo Koh Tags: ORIGINAL ARTICLE Source Type: research

Dual inhibition of enhancer of zeste homolog 1/2 overactivates WNT signaling to deplete cancer stem cells in multiple myeloma
Long ‐term continuous administration of OR‐S1 completely cured all mice bearing orthotopic xenografts without eliciting any serious side‐effects. We confirmed this result by counting minimal residual cells by flow cytometric analysis. These results suggest that long‐term continuous administration of OR‐S1 impairs the self‐renewal activity of myeloma stem cells, rendering these cells unable to reconstitute disease and leading to the complete cure of MM. Multiple myeloma (MM) is an incurable hematological malignancy caused by accumulation of abnormal clonal plasma cells. Despite the recent development of novel th...
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Makoto Nakagawa, Shuhei Fujita, Takuo Katsumoto, Kazutsune Yamagata, Yoko Ogawara, Ayuna Hattori, Yuki Kagiyama, Daisuke Honma, Kazushi Araki, Tatsuya Inoue, Ayako Kato, Koichiro Inaki, Chisa Wada, Yoshimasa Ono, Masahide Yamamoto, Osamu Mi Tags: ORIGINAL ARTICLE Source Type: research

Immunomodulatory activity of lenvatinib contributes to antitumor activity in the Hepa1 ‐6 hepatocellular carcinoma model
Lenvatinib is a multitargeted tyrosine kinase inhibitor that selectively inhibits VEGFR1 ‐3, FGFR1‐4, PDGFRα, RET and KIT. Here, we show that lenvatinib has immunomodulatory activity, which plays a role in the antitumor activity of single lenvatinib treatment, and enhances the antitumor activity of anti‐PD‐1 antibody in the combination treatment in the Hepa1‐6 mouse HCC synge neic tumor model. AbstractAngiogenesis inhibitors such as lenvatinib and sorafenib, and an immune checkpoint inhibitor (ICI), nivolumab, are used for anticancer therapies against advanced hepatocellular carcinoma (HCC). Combination tre...
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Takayuki Kimura, Yu Kato, Yoichi Ozawa, Kotaro Kodama, Junichi Ito, Kenji Ichikawa, Kazuhiko Yamada, Yusaku Hori, Kimiyo Tabata, Kazuma Takase, Junji Matsui, Yasuhiro Funahashi, Kenichi Nomoto Tags: ORIGINAL ARTICLE Source Type: research

Coupling function of CDK2 and SEPT2 in the promotion of hepatocellular carcinoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Chenzhou Xu, Wei Zhang, Xuening Zhang, Danhua Zhou, Qu Lishuai, Jinxia Liu, Mingbing Xiao, Runzhou Ni, Feng Jiang, Wenkai Ni, Cuihua Lu Tags: Original Article Source Type: research

Antibiotics Suppress Colon Tumorigenesis Through Inhibition of Aberrant DNA Methylation in an AOM/DSS Colitis Model
SummaryChronic inflammation is involved in the development of colon cancer by inducing mutations and aberrant DNA methylation in colon epithelial cells. Furthermore, there is growing evidence showing that the colonic microbiota modulates the inflammation response in the host and influences colon tumorigenesis. However, the influence of the colonic microbiota on aberrant DNA methylation remains unknown. Here, we show the effect of colonic microbes on DNA methylation and tumorigenicity using a mouse model of human ulcerative colitis. Mice treated with azoxymethane (AOM) and dextran sulfate sodium (DSS) showed an increase in ...
Source: Cancer Science - November 16, 2018 Category: Cancer & Oncology Authors: Naoko Hattori, Tohru Niwa, Tatsuya Ishida, Kyosuke Kobayashi, Toshio Imai, Akiko Mori, Kana Kimura, Takeshi Mori, Yukio Asami, Toshikazu Ushijima Tags: Original Article Source Type: research

An amino acid metabolism ‐related gene expression‐based risk signature can better predict overall survival for glioma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Yu ‐Qing Liu, Rui‐Chao Chai, Yong‐Zhi Wang, Zheng Wang, Xing Liu, Fan Wu, Tao Jiang Tags: Original Article Source Type: research

20(S) ‐ginsenoside‐Rg3 reverses temozolomide resistance and restrains epithelial‐mesenchymal transition progression in glioblastoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Zheng Chen, Xiangyu Wei, Lin Shen, Hanshuo Zhu, Xuesheng Zheng Tags: Original Article Source Type: research

Downregulation of lncRNA OIP5 ‐AS1 inhibits breast cancer progression by targeting SOX2 via miRNA‐129‐5p upregulation
This study investigated the role of the lncRNA OIP5‐AS1 in the progression of breast cancer. OIP5‐AS1 was significantly upregulated in breast cancer tissues and breast cancer cell lines, and OIP5‐AS1 downregulation inhibited the malignant be haviors of breast cancerin vitro andin vivo. For the depth exploration of mechanism of OIP5 ‐AS1 in breast cancer, we found that miR‐129‐5p which was found had bind sites in the sequence of OIP5‐AS1, expression in breast cancer tissues was negatively correlated with OIP5‐AS1 and luciferase assays indicated that OIP5‐AS1 acted as miR‐129‐5p sponge, resulting in upr...
Source: Cancer Science - November 15, 2018 Category: Cancer & Oncology Authors: Huijuan Zeng, Jingjie Wang, Tao Chen, Kai Zhang, Jing Chen, Lulu Wang, Hanjun Li, Dilihumaer Tuluhong, Jieshou Li, Shaohua Wang Tags: Original Article Source Type: research

Functionally impaired follicular helper T cells induce regulatory B cells and CD14+ human leukocyte antigen ‐DR− cell differentiation in non‐small cell lung cancer
Non ‐small cell lung cancer patients have high levels of Tfh cells, especially Tfh2 and Tfh17 subtypes, but Tfh cells from NSCLC patients have impaired function of IL‐21 production and Tfh cells induced the differentiation of regulatory B cells and CD14+ HLA ‐DR− cells. Non ‐small cell lung cancer (NSCLC) represents one of the most common and aggressive cancers worldwide, as it typically displays irreversible progression and poor prognosis. Interaction between programmed death 1 (PD‐1) and its ligand, PD‐L1, plays important roles in tumor immunology. Follicular h elper T (Tfh) cells have characteristicall...
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Liannv Qiu, Qinhua Yu, Yonglie Zhou, Sujie Zheng, Jiaojiao Tao, Qian Jiang, Guorong Yuan Tags: Original Article Source Type: research

Phosphorylation of serine/arginine ‐rich splicing factor 1 at tyrosine 19 promotes cell proliferation in pediatric acute lymphoblastic leukemia
In conclusion, we identify for the first time that the phosphorylation state of SRSF1 is linked to different phases in pediat ric ALL. The Tyr‐19 phosphorylation of SRSF1 disrupts its subcellular localization and promotes proliferation in leukemia cells by driving cell‐cycle progression. Inhibitors targeting Tie2 kinase that could catalyze Tyr‐19 phosphorylation of SRSF1 offer a promising therapeutic target for treat ment of pediatric ALL. (Source: Cancer Science)
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Liting Xu, Han Zhang, Mei Mei, Chaohao Du, Xiahe Huang, Jing Li, Yingchun Wang, Shilai Bao, Huyong Zheng Tags: ORIGINAL ARTICLE Source Type: research

Pattern and prognostic value of FLT3 ‐ITD mutations in Chinese de novo adult acute myeloid leukemia
A total of 227 FLT3 ‐ITD sequences were analyzed from 227 Chinese adult de novo acute myeloid leukemia (AML) patients. ITD could be classified into 3 types based on molecular profiles. ITD integration sites in the hinge region or beta1‐sheet region are an unfavorable prognostic factor in adult AML patients with FLT 3‐ITD mutations. FMS ‐like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in hematological malignancies.FLT3 internal tandem duplication (FLT3‐ITD) mutations located in juxtamembrane domain (JMD) and tyrosine kinase domain 1 (TKD1) regions account for two‐thirds of allFLT3 mutat...
Source: Cancer Science - November 14, 2018 Category: Cancer & Oncology Authors: Song ‐Bai Liu, Qiao‐Cheng Qiu, Xie‐Bing Bao, Xiao Ma, Hong‐Zhi Li, Yue‐Jun Liu, Su‐Ning Chen, Yao‐Hua Song, De‐Pei Wu, Sheng‐Li Xue Tags: ORIGINAL ARTICLE Source Type: research

Pyruvate secreted from patient ‐derived cancer‐associated fibroblasts supports survival of primary lymphoma cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Akihiko Sakamoto, Shunsuke Kunou, Kazuyuki Shimada, Makoto Tsunoda, Tomohiro Aoki, Chisako Iriyama, Akihiro Tomita, Shigeo Nakamura, Fumihiko Hayakawa, Hitoshi Kiyoi Tags: Original Article Source Type: research

CCL2 Induces Resistance to the Antiproliferative Effect of Cabazitaxel in Prostate Cancer Cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Ariunbold Natsagdorj, Kouji Izumi, Kaoru Hiratsuka, Kazuaki Machioka, Hiroaki Iwamoto, Renato Naito, Tomoyuki Makino, Suguru Kadomoto, Kazuyoshi Shigehara, Yoshifumi Kadono, Wen ‐Jye Lin, Aerken Maolake, Atsushi Mizokami Tags: Original Article Source Type: research

PD ‐L1 expression enhancement by infiltrating macrophage‐derived TNF‐α leads to poor pancreatic cancer prognosis
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Masayo Tsukamoto, Katsunori Imai, Takatsugu Ishimoto, Yoshihiro Komohara, Yo ‐ichi Yamashita, Shigeki Nakagawa, Naoki Umezaki, Takanobu Yamao, Yuki Kitano, Tatsunori Miyata, Kota Arima, Hirohisa Okabe, Yoshifumi Baba, Akira Chikamoto, Taka Tags: Original Article Source Type: research

T cell receptor β‐chain repertoire analysis of tumor infiltrating lymphocytes in pancreatic cancer
This study aimed to test the relationship between the TCR β repertoire of the tumor and peripheral blood, and also to investigate the intra‐tumor spatial heterogeneity of the TCR β repertoire in pancreatic cancer. To the best of our knowledge, this is the first study to evaluate the clonal composition of TCR β repertoire in TILs across the spatial ext ent of pancreatic cancer.In this study, we studied five patients who were diagnosed with primary pancreatic cancer. Ultra ‐deep sequencing was used to assess the rearrangement of the TCR β‐chain (TCR β) gene. HE staining and immunohistochemistry...
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Can Cui, Xiuyun Tian, Jianhui Wu, Chaoting Zhang, Qin Tan, Xiaoya Guan, Bin Dong, Min Zhao, Zheming Lu, Chunyi Hao Tags: Original Article Source Type: research

Y ‐box binding protein‐1 promotes tumorigenesis and progression via the EGFR/AKT pathway in spinal chordoma
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Chen Liang, Yunlong Ma, Lei Yong, Chenlong Yang, Peng Wang, Xiao Liu, Bin Zhu, Hua Zhou, Xiaoguang Liu, Zhongjun Liu Tags: Original Article Source Type: research

Exploration of resistance mechanisms for epidermal growth factor receptor ‐tyrosine kinase inhibitors based on plasma analysis by digital polymerase chain reaction and next‐generation sequencing
Quantitation of T790M in plasma is a clinically relevant approach to determine the T790M status of tumors. Liquid biopsy offers a potential alternative to tissue biopsy for detection of genetic alterations in cancer, and it has been introduced into clinical practice to detect the tyrosine kinase inhibitor (TKI) resistance ‐conferring T790M mutation of epidermal growth factor receptor (EGFR) in patients with non ‐small‐cell lung cancer (NSCLC). We prospectively collected tumor and plasma samples from 25 NSCLC patients who harbored activating mutations ofEGFR and experienced failure of treatment with afatinib. The samp...
Source: Cancer Science - November 13, 2018 Category: Cancer & Oncology Authors: Eiji Iwama, Kazuko Sakai, Koichi Azuma, Daijiro Harada, Kaname Nosaki, Katsuyuki Hotta, Makoto Nishio, Takayasu Kurata, Tatsuro Fukuhara, Hiroaki Akamatsu, Koichi Goto, Takayuki Shimose, Junji Kishimoto, Yoichi Nakanishi, Kazuto Nishio, Isa Tags: ORIGINAL ARTICLE Source Type: research

Alternative RNA splicing of the GIT1 gene is associated with neuroendocrine prostate cancer
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Ahn R Lee, Yu Gan, Ning Xie, Varune R Ramnarine, Jessica M Lovnicki, Xuesen Dong Tags: Original Article Source Type: research

Establishment and characterization of CRISPR/Cas9 ‐mediated NF2‐/‐ human mesothelial cell line: Molecular insight into FGFR2 in MPM
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Md Wahiduzzaman, Sivasundaram Karnan, Akinobu Ota, Ichiro Hanamura, Hideki Murakami, Akihito Inoko, Md Lutfur Rahman, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Yoshitaka Hosokawa Tags: Original Article Source Type: research

DEPDC1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 12, 2018 Category: Cancer & Oncology Authors: Qu Di, Feng Cui, Dan Lu, Yu Yang, Yuqing Xu Tags: Original Article Source Type: research

Estrogen Receptor Variant ER ‐α36 Promotes Tamoxifen Agonist Activity in Glioblastoma Cells
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Chao Qu, Jingyun Ma, Yejun Zhang, Chao Han, Liang Huang, Liming Shen, Hongyan Li, Xiaobo Wang, Jing Liu, Wei Zou Tags: Original Article Source Type: research

Identification of TRA ‐1‐60‐positive cells as a potent refractory population in follicular lymphomas
AbstractDespite receiving rituximab ‐combined chemotherapy, follicular lymphoma (FL) patients often suffer tumor recurrence, and understand the cause of relapse in FL would thus significantly ameliorate the tumor therapeutics. Here we demonstrate that the TRA‐1‐60‐expressing cells are a unique population in FLs, converge to th e conventional stem cell marker Oct3/4 and ALDH1‐positive population, and resist current B‐lymphoma agents. TRA‐1‐60 expression was observed only in scattered lymphoma cells in FL tissues as well as resting B‐lymphocytes inside germinal centers. Retrospective comparison between the ...
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Katsuyoshi Takata, Ken Saito, Satoshi Maruyama, Tomoko Miyata ‐Takata, Hidekazu Iioka, Shujiro Okuda, Yiwei Ling, Kennosuke Karube, Yukari Miki, Yoshinobu Maeda, Tadashi Yoshino, Christian Steidl, Eisaku Kondo Tags: Original Article Source Type: research

Primary breast diffuse large B ‐cell lymphoma in the rituximab era: Therapeutic strategies and patterns of failure
Primary breast diffuse large B ‐cell lymphoma (PB‐DLBCL) has a continuous pattern of relapse, especially with frequent late relapses in the central nervous system (CNS) and contralateral breast. Rituximab and radiotherapy confer complementary benefit in the reduction of relapse. However, neither the addition of rituximab nor prophylactic intrathecal chemotherapy could effectively prevent CNS relapse for PB‐DLBCL patients. Primary breast diffuse large B ‐cell lymphoma (PB‐DLBCL) is a rare subtype of DLBCL with limited data on patterns of failure. This multicenter study aimed to define the optimum treatment strateg...
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Shaoxuan Hu, Yuqin Song, Xiuhua Sun, Liping Su, Wei Zhang, Jing Jia, Ou Bai, Sheng Yang, Rong Liang, Xiaoling Li, Huilai Zhang, Yuhuan Gao, Weijing Zhang, Xiubin Xiao, Huizheng Bao, Ningju Wang, Hanyun Ren, Xinan Cen, Shun'e Yang, Yu Zh Tags: ORIGINAL ARTICLE Source Type: research

Single fraction carbon ion radiotherapy for colorectal cancer liver metastasis:A dose escalation study
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 11, 2018 Category: Cancer & Oncology Authors: Hirokazu Makishima, Shigeo Yasuda, Yuka Isozaki, Goro Kasuya, Naomi Okada, Masaru Miyazaki, Osama Mohamad, Naruhiro Matsufuji, Shigeru Yamada, Hiroshi Tsuji, Tadashi Kamada, The Liver Cancer Working Group Tags: Original Article Source Type: research

Chemokine (C ‐X‐C motif) ligand 1 and CXCL2 produced by tumor promote the generation of monocytic myeloid‐derived suppressor cells
Our results elucidated that CXCL1 and CXCL2, which were originally characterized as chemokines of neutrophils, specifically promoted the expansion of mo ‐MDSC, a subtype of MDSC, in the presence of GM‐CSF. Moreover, we found that, in addition to the tumor cells, tumor‐infiltrated CD11b+ myeloid cells also expressed CXCL1 and CXCL2. Therefore, inhibition of CXCL1 and CXCL2 could decrease mo‐MDSC generation and improve host immunosurveillance. Accumulation of myeloid ‐derived suppressor cells (MDSC) in tumor‐bearing hosts is a hallmark of tumor‐associated inflammation, which is thought to be a barrier to immuno...
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Huifang Shi, Xiaoqing Han, Yingying Sun, Chao Shang, Min Wei, Xueqing Ba, Xianlu Zeng Tags: ORIGINAL ARTICLE Source Type: research

Tumor ‐derived exosomal proteins as diagnostic biomarkers in non‐small cell lung cancer
AbstractAccumulating evidence supports a role for exosomal protein in diagnosis. The purpose of this study was to identify the tumor ‐derived exosomal biomarkers in the serum that improve the diagnostic value in Chinese non‐small cell lung cancer (NSCLC) patients. Serum exosomes were isolated from healthy donors (n=46) and NSCLC patients (n=125) by ultracentrifugation and were characterized using TEM, qNano and immunoblotting . Proteomic profiles (by mass spectrometry) revealed multiple differentially expressed proteins in the healthy and NSCLC groups. The exosomal expression levels of alpha‐2‐HS‐glycoprotein (AH...
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Limin Niu, Xingguo Song, Ning Wang, Linlin Xue, Xianrang Song, Li Xie Tags: Original Article Source Type: research

NEDD8 promotes the tumor progression and predicts the poor prognosis of patients with bladder cancer
In conclusion,NEDD8 possessed important roles in regulating the progression of BC cells and was associated with the poor prognosis of patients, which may become a potential therapeutic target of BC.This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Da ‐Wei Tian, Zhou‐Liang Wu, Li‐Ming Jiang, Jie Gao, Chang‐Li Wu, Hai‐Long Hu Tags: Original Article Source Type: research

PODXL promotes gastric cancer progression through interacting with RUFY1 protein
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Qiaoming Zhi, Huo Chen, Fei Liu, Ye Han, Daiwei Wan, Zhihua Xu, Yuting Kuang, Jin Zhou Tags: Original Article Source Type: research

MORC2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG1
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - November 8, 2018 Category: Cancer & Oncology Authors: Jiao Liu, Yangguang Shao, Yuxin He, Ke Ning, Xi Cui, Furong Liu, Zhenning Wang, Feng Li Tags: Original Article Source Type: research

Functional intronic variant of SLC5A10 affects DRG2 expression and survival outcomes of early ‐stage non‐small‐cell lung cancer
This study was approved by the Institutional Review Broad of Kyungpook National University of Hospital (Approval No. KNUMC 2014‐04‐210‐003). (Source: Cancer Science)
Source: Cancer Science - November 7, 2018 Category: Cancer & Oncology Authors: Mi Jeong Hong, Seung Soo Yoo, Jin Eun Choi, Hyo ‐Gyoung Kang, Sook Kyung Do, Jang Hyuck Lee, Won Kee Lee, Jaehee Lee, Shin Yup Lee, Seung Ick Cha, Chang Ho Kim, Eung Bae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park Tags: ORIGINAL ARTICLE Source Type: research

FBXW7 modulates malignant potential and cisplatin ‐induced apoptosis in cholangiocarcinoma through NOTCH1 and MCL1
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Akiko Mori, Kunihiro Masuda, Hideo Ohtsuka, Masahiro Shijo, Kyohei Ariake, Koji Fukase, Naoaki Sakata, Masamichi Mizuma, Takanori Morikawa, Hiroki Hayashi, Kei Nakagawa, Fuyuhiko Motoi, Takeshi Naitoh, Fumiyoshi Fujishima, Michiaki Unno Source Type: research

Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B ‐containing N‐methyl‐d‐aspartate–sensitive glutamate receptor signaling
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Kentaro Suina, Kenji Tsuchihashi, Juntaro Yamasaki, Shohei Kamenori, Subaru Shintani, Yuki Hirata, Shogo Okazaki, Oltea Sampetrean, Eishi Baba, Koichi Akashi, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kazuhisa Takahashi, Hideyuki Saya, Osamu N Source Type: research

A group of long noncoding RNAs identified by data mining can predict the prognosis of lung adenocarcinoma
Cancer Science, EarlyView. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Authors: Meijian Liao, Qing Liu, Bing Li, Weijie Liao, Weidong Xie, Yaou Zhang Source Type: research

Correction
Cancer Science,Volume 109, Issue 11, Page 3663-3664, November 2018. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Source Type: research

Issue Information
Cancer Science,Volume 109, Issue 11, Page 3363-3365, November 2018. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Source Type: research

In this Issue
Cancer Science,Volume 109, Issue 11, Page 3366-3367, November 2018. (Source: Cancer Science)
Source: Cancer Science - November 5, 2018 Category: Cancer & Oncology Source Type: research

Mutational activation of the EGFR down ‐regulates MHC class I expression via the ERK in non–small cell lung cancer
Cancer Science,Volume 0, Issue ja, -Not available-. (Source: Cancer Science)
Source: Cancer Science - November 3, 2018 Category: Cancer & Oncology Authors: Satomi Watanabe, Hidetoshi Hayashi, Koji Haratani, Shigeki Shimizu, Junko Tanizaki, Kazuko Sakai, Hisato Kawakami, Kimio Yonesaka, Junji Tsurutani, Yosuke Togashi, Kazuto Nishio, Akihiko Ito, Kazuhiko Nakagawa Source Type: research

Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl ‐xL pathway
Cancer Science,Volume 0, Issue ja, -Not available-. (Source: Cancer Science)
Source: Cancer Science - November 3, 2018 Category: Cancer & Oncology Authors: Masaki Hara, Yuko Takeba, Taroh Iiri, Yuki Ohta, Masanori Ootaki, Minoru Watanabe, Daiki Watanabe, Satoshi Koizumi, Takehito Otsubo, Naoki Matsumoto Source Type: research

p68 RNA helicase promotes invasion of glioma cells through negatively regulating DUSP5
Cancer Science,Volume 0, Issue ja, -Not available-. (Source: Cancer Science)
Source: Cancer Science - November 2, 2018 Category: Cancer & Oncology Authors: Rui Wang, Hong ‐Bo Bao, Wen‐Zhong Du, Xiao‐Feng Chen, Huai‐Lei Liu, Da‐Yong Han, Li‐Gang Wang, Jia‐Ning Wu, Chun‐Lei Wang, Ming‐Chun Yang, Zhan‐Wen Liu, Na Zhang, Lei Teng Source Type: research

NOTCH1 pathway activating mutations and clonal evolution in pediatric T ‐cell acute lymphoblastic leukemia (T‐ALL)
Cancer Science,Volume 0, Issue ja, -Not available-. (Source: Cancer Science)
Source: Cancer Science - November 2, 2018 Category: Cancer & Oncology Authors: Shunsuke Kimura, Masafumi Seki, Kenichi Yoshida, Yuichi Shiraishi, Masaharu Akiyama, Katsuyoshi Koh, Toshihiko Imamura, Atsushi Manabe, Yasuhide Hayashi, Masao Kobayashi, Akira Oka, Satoru Miyano, Seishi Ogawa, Junko Takita Source Type: research