Variation of diterpenoid phytoalexin oryzalexin A production in cultivated and wild rice
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Keisuke Kariya, Koichi Murata, Yu Kokubo, Naoki Ube, Kotomi Ueno, Yukinori Yabuta, Masayoshi Teraishi, Yutaka Okumoto, Naoki Mori, Atsushi IshiharaAbstractRice (Oryza sativa) leaves accumulate phytoalexins in response to pathogen attack. The major phytoalexins in rice are diterpenoids such as oryzalexins, momilactones, and phytocassanes. We measured the amount of oryzalexin A in leaves irradiated by UV light, treated with jasmonic acid, or inoculated with conidia of Bipolaris oryzae in the japonica cultivar Nipponbare and the indica cultivar Kasalat...
Source: Phytochemistry - July 13, 2019 Category: Chemistry Source Type: research

Highly oxygenated isoprenylated cyclohexanoids from the fungus Parastagonospora nodorum SN15
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Amr El-Demerdash, Grégory Genta-Jouve, Margot Bärenstrauch, Caroline Kunz, Emmanuel Baudouin, Soizic PradoAbstractThe chemical investigation of the wheat plant pathogen Parastagonospora nodorum SN15 led to the purification of seven highly oxygenated acetylenic cyclohexanoids named stagonosporynes A-G. Their structures were determined on the basis of extensive NMR and the relative and absolute configurations by an array of computational methods including simulation of NOESY spectrum and electronic circular dichroism (ECD). All compounds w...
Source: Phytochemistry - July 12, 2019 Category: Chemistry Source Type: research

Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Bao-Bao Shi, Jing Chen, Mei-Fen Bao, Ying Zeng, Xiang-Hai CaiAbstractContinued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A–D (1–4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoq...
Source: Phytochemistry - July 12, 2019 Category: Chemistry Source Type: research

A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f.
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Baowei Ma, Xihong Liu, Yun Lu, Xiaochi Ma, Xiaoyi Wu, Xing Wang, Meirong Jia, Ping Su, Yuru Tong, Hongyu Guan, Zhouqian Jiang, Jie Gao, Luqi Huang, Wei GaoAbstractTripterygium wilfordii Hook. f. is a perennial woody vine member of the Celastraceae family. As a traditional Chinese medicine, it contains complex chemical components and exerts various pharmacological activities. In the present study, we identified a glucosyltransferase, TwUGT1, that can catalyze the synthesis of an abietane-type diterpene glucoside, namely, triptophenolide14-O-beta-D-gl...
Source: Phytochemistry - July 10, 2019 Category: Chemistry Source Type: research

Mesembrine: The archetypal psycho-active Sceletium alkaloid
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Felix Makolo, Alvaro Viljoen, Clinton G.L. VealeAbstract(−)-Mesembrine is a chiral alkaloid that features an aryloctahydroindole skeleton and is most commonly found in species of the succulent genus Sceletium. Several Sceletium species are used by various ethnic groups in South Africa to manage disorders of the central nervous system. Binding assays have revealed that mesembrine is a more potent inhibitor of the serotonin transporter (SERT) than fluoxetine (Prozac) which has prompted the commercialization of mesembrine-containing consumer prod...
Source: Phytochemistry - July 9, 2019 Category: Chemistry Source Type: research

2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Yong Zhao, Louise Kjaerulff, Kenneth T. Kongstad, Allison M. Heskes, Birger Lindberg Møller, Dan StaerkAbstractEremophila bignoniiflora is a shrub distributed throughout inland northern and eastern Australia, and it has been used in several medicinal applications by some Australian Aboriginal people. In our continued search for anti-diabetic constituents from natural resources, the crude ethyl acetate extract of E. bignoniiflora was found to have protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity with an IC50 value of 23.9 ±...
Source: Phytochemistry - July 6, 2019 Category: Chemistry Source Type: research

Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Yi-Wen Cao, Ren-Jun Qu, Yu-Jing Miao, Xiao-Qing Tang, Ying Zhou, Lei Wang, Li GengAbstractIsatis indigotica Fortune is a popular herb in traditional Chinese medicine, and various types of metabolites are the basis for its pharmacological efficacy. The biosynthesis and accumulation of these metabolites are closely linked to nitrogen availability; the benefits of low nitrogen application on the environment and herb quality are increasingly prominent. To analyze metabolic changes in the leaves and roots of I.indigotica in nitrogen deficiency conditions...
Source: Phytochemistry - July 6, 2019 Category: Chemistry Source Type: research

Should I stay or should I go: are chlorogenic acids mobilized towards lignin biosynthesis?
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Nathalia Silva, Paulo Mazzafera, Igor CesarinoAbstractChlorogenic acids (CGAs) and the biopolymer lignin are both products of the phenylpropanoid pathway. Whereas CGAs have been reported to play a role during stress responses, lignin is a major component of secondary cell walls, providing physical strength and hydrophobicity to supportive and water-conducting tissues. Because the chemical structure of CGAs largely resembles those of some lignin intermediates and because CGAs can be converted back to hydroxycinnamoyl-CoAs in vitro, CGAs have been con...
Source: Phytochemistry - July 6, 2019 Category: Chemistry Source Type: research

Heterocyte glycolipids indicate polyphyly of stigonematalean cyanobacteria
Publication date: October 2019Source: Phytochemistry, Volume 166Author(s): Thorsten Bauersachs, Scott R. Miller, Muriel Gugger, Opayi Mudimu, Thomas Friedl, Lorenz SchwarkAbstractThe cyanobacterial phylum is currently divided into five subsections (I–V), with the latter two containing no or false-branching (nostocalean) and true-branching (stigonematalean) cyanobacteria. Although morphological traits (such as cellular division and secondary branches) clearly separate both types of heterocytous cyanobacteria, molecular evidence indicates that stigonematalean cyanobacteria (Subsection V) do not form a monophyletic grou...
Source: Phytochemistry - July 6, 2019 Category: Chemistry Source Type: research

Introducing article numbering to Phytochemistry
Publication date: Available online 28 June 2019Source: PhytochemistryAuthor(s): (Source: Phytochemistry)
Source: Phytochemistry - June 30, 2019 Category: Chemistry Source Type: research

Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Daniela Hulcová, Jana Maříková, Jan Korábečný, Anna Hošťálková, Daniel Jun, Jiří Kuneš, Jakub Chlebek, Lubomír Opletal, Angela De Simone, Lucie Nováková, Vincenza Andrisano, Aleš Růžička, Lucie CahlíkováAbstractTwenty-one known Amaryllidaceae alkaloids of various structural types and one undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of Narcissus pseudonarcissus L. cv. Dutch Master. The chemical str...
Source: Phytochemistry - June 30, 2019 Category: Chemistry Source Type: research

Corrigendum to “Analytical investigations on Boswellia occulta essential oils” [Phytochemistry 164 (2019) 78–85]
Publication date: Available online 26 June 2019Source: PhytochemistryAuthor(s): Marina Ayubova, Hugues Brevard, Nicolas Baldovini (Source: Phytochemistry)
Source: Phytochemistry - June 27, 2019 Category: Chemistry Source Type: research

Outside Front Cover
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): (Source: Phytochemistry)
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

Editorial Board/Publication Information
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): (Source: Phytochemistry)
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

Graphical Contents List
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): (Source: Phytochemistry)
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

Aims and Scope
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): (Source: Phytochemistry)
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

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Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): (Source: Phytochemistry)
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

Characterization of MiFUT11 from Mangifera indica L.: A functional core α1,3-fucosyltransferase potentially involved in the biosynthesis of immunogenic carbohydrates in mango fruit
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Takahiro Okada, Hideyuki Ihara, Yoshitaka IkedaAbstractIn higher plants, asparagine-linked oligosaccharides (N-glycans) in glycoproteins carry unique carbohydrate epitopes, namely, a core α1,3-fucose and/or a β1,2-xylose, which are common determinants responsible for the cross-reactivity of plant glycoproteins due to their strong immunogenicity. While these determinants and the relevant genes have been well characterized for herbaceous plants, information concerning whether many food plants cross-react with airborne pollens is not avail...
Source: Phytochemistry - June 25, 2019 Category: Chemistry Source Type: research

Current knowledge on Parmelia genus: Ecological interest, phytochemistry, biological activities and therapeutic potential
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Elena González-Burgos, Carlos Fernández-Moriano, M. Pilar Gómez-SerranillosAbstractParmelia Acharius is one of the most representative genera within Parmeliaceae family which is the largest and the most widespread family of lichen-forming fungi. Parmelia lichens present a medium to large foliose thallus and they are distributed from the Artic to the Antartic continents, being more concentrated in temperate regions. According to its current description, the genus encompasses up to 41 different species and it is phylogenetically...
Source: Phytochemistry - June 22, 2019 Category: Chemistry Source Type: research

Phenolic constituents with neuroprotective activities from Hypericum wightianum
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Ling Yang, Zi-Ming Wang, Yun Wang, Rong-Sheng Li, Fei Wang, Kou WangAbstractFive undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum. Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hy...
Source: Phytochemistry - June 21, 2019 Category: Chemistry Source Type: research

Nor-guanacastepene pigments from the Chilean mushroom Cortinarius pyromyxa
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Yen T.H. Lam, Götz Palfner, Celia Lima, Andrea Porzel, Wolfgang Brandt, Andrej Frolov, Haider Sultani, Katrin Franke, Christoph Wagner, Kurt Merzweiler, Ludger A. Wessjohann, Norbert ArnoldAbstractFor the first time, the pigment composition of basidiocarps from the Chilean mushroom Cortinarius pyromyxa was studied under various aspects like phylogeny, chemistry and antibiotic activity. A molecular biological study supports the monotypic position of C. pyromyxa in subgenus Myxacium, genus Cortinarius. Four undescribed diterpenoids, named pyrom...
Source: Phytochemistry - June 21, 2019 Category: Chemistry Source Type: research

Anthraquinones from Cassiae semen as thrombin inhibitors: in vitro and in silico studies
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Xiao Yu, Ling-Hua Wei, Jia-Kai Zhang, Tian-Ran Chen, Qiang Jin, Yi-Nan Wang, Shui-Jun Zhang, Tong-Yi Dou, Yun-Feng Cao, Wen-Zhi Guo, Guang-Bo Ge, Ling YangAbstractThrombin inhibitor therapy is one of the most effective therapeutic strategies for the prevention and treatment of cardiovascular and thrombotic diseases. Although several marketed direct thrombin inhibitors (DTIs) have been widely used in clinic, the potentially serious complications of these DTIs prompted the researchers to find more DTIs with improved safety profiles. Herein, we repor...
Source: Phytochemistry - June 15, 2019 Category: Chemistry Source Type: research

Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Changxing Qi, Qun Zhou, Weixi Gao, Mengting Liu, Chunmei Chen, Xiao-Nian Li, Yongji Lai, Yuan Zhou, Dongyan Li, Zhengxi Hu, Hucheng Zhu, Yonghui ZhangAbstractSpiroterreusnoids A–F, six undescribed spiro-dioxolane-containing adducts bearing 3,5-dimethylorsellinic acid-based meroterpenoid and 2,3-butanediol moieties were isolated from the endophytic fungus Aspergillus terreus Thom from Tripterygium wilfordii Hook. f. (Celastraceae). The structures of these adducts were established by spectroscopy, single-crystal X-ray diffraction, and experime...
Source: Phytochemistry - June 15, 2019 Category: Chemistry Source Type: research

Lignans and sesquiterpene lactones from Hypochaeris radicata subsp. neapolitana (Asteraceae, Cichorieae)
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Oleksandr Shulha, Serhat Sezai Çiçek, Helle Wangensteen, Janina Kroes, Malte Mäder, Ulrich Girreser, Jandirk Sendker, Karin Jöhrer, Richard Greil, Wolfgang Schühly, Alfonso Mangoni, Laura Grauso, Christoph van Thriel, Christian ZidornAbstractFour undescribed lignans and two undescribed sesquiterpenic acids, together with three known compounds (hypochoeroside C, hypochoeroside D, and 5-O-caffeoylshikimic acid) were isolated from the roots of Hypochaeris radicata subsp. neapolitana (Asteraceae, Cichorieae). The lignans w...
Source: Phytochemistry - June 15, 2019 Category: Chemistry Source Type: research

Oligostilbenes from the leaves of Gnetum latifolium and their biological potential to inhibit neuroinflammation
Publication date: September 2019Source: Phytochemistry, Volume 165Author(s): Hyo Moon Cho, Thi Kim Quy Ha, Ha Thanh Tung Pham, Jin-Pyo An, Jungmoo Huh, Ba-Wool Lee, Hee Ju Lee, Won Keun OhAbstractOligostilbenes are polyphenol oligomers derived from resveratrol and are commonly produced by members of the Gnetaceae family, and many researchers have focused on their anti-inflammatory activities. The EtOAc fraction of a Gnetum latifolium extract showed inhibitory activity against neuroinflammation induced by the transfection of Aβ1-42 into microglial BV-2 cells. The bioassay-guided isolation of the 70% EtOH extract of t...
Source: Phytochemistry - June 13, 2019 Category: Chemistry Source Type: research

Mangiterpenes A–C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene–shikimate–conjugated spirocyclic meroterpenoids from Guignardia mangiferae
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Keliang Chen, Chunmei Chen, Jieru Guo, Weiguang Sun, Junjun Liu, Jing Yang, Xiulan Liu, Jianping Wang, Zengwei Luo, Hucheng Zhu, Yonghui ZhangAbstractMangiterpenes A–C and 2′,3′-seco-manginoid C, four undescribed sesquiterpene/monoterpene–shikimate–conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpen...
Source: Phytochemistry - June 9, 2019 Category: Chemistry Source Type: research

Repurposing of ginseng extract as topoisomerase I inhibitor based on the comparative analysis of gene expression patterns
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Mi Ran Byun, Cheol Hyun Kim, Ho Sub Lee, Jin Woo Choi, Sang Kwan LeeAbstractRepositioning of plant extracts and chemical drugs can accelerate drug development. However, its success rate may depend on what the clue is for the repositioning. Recently, repositioning based on correction of unwarranted gene expression pattern has suggested the possibility of new drug development. Here, we designed a similar method for the repositioning of nutraceutical ginseng (Panax ginseng C.A.Mey.), which is one of the most validated natural therapeutic products for va...
Source: Phytochemistry - June 8, 2019 Category: Chemistry Source Type: research

Termipaniculatones A-F, chalcone-flavonone heterodimers from Terminthia paniculata, and their protective effects on hyperuricemia and acute gouty arthritis
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Tong-Hua Yang, De-Xiu Yan, Xiao-Yan Huang, Bo Hou, Yun-Bao Ma, Hua Peng, Xue-Mei Zhang, Ji-Jun Chen, Chang-An GengAbstractTerminthia paniculata (Sanyeqi) is widely used for treating inflammation and rheumatic arthritis in the folk areas of Yunnan province, China. Its total extract was first revealed with xanthine oxidase (XO) inhibitory activity in vitro and anti-hyperuricemic effect in vivo. Bioassay-guided separation on Fr. A5 yielded six chalcone-flavonone heterodimers, termipaniculatones A-F. Their structures were elucidated based on extensive sp...
Source: Phytochemistry - June 8, 2019 Category: Chemistry Source Type: research

Structure and bioactivity of cholestane glycosides from the bulbs of Ornithogalum saundersiae Baker
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Qing-Wei Chen, Xu Zhang, Ting Gong, Wan Gao, Shuai Yuan, Pei-Cheng Zhang, Jian-Qiang KongAbstractEight undescribed cholestane glycosides named osaundersioside A-H, along with three previously known compounds named osaundersioside I–K were isolated from Ornithogalum saundersiae Baker bulbs (Asparagaceae). Their structures were elucidated by extensive spectroscopic analysis and chemical methods. All isolates were evaluated for their cytotoxic activity and inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production. Osaunde...
Source: Phytochemistry - June 7, 2019 Category: Chemistry Source Type: research

Characterization and quantification of thiol-peptides in Arabidopsis thaliana using combined dilution and high sensitivity HPLC-ESI-MS-MS
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Erika Bellini, Marco Borsò, Camilla Betti, Laura Bruno, Andrea Andreucci, Monica Ruffini Castiglione, Alessandro Saba, Luigi Sanità di ToppiAbstractAlthough thiol-peptide compounds, such as reduced glutathione (GSH), γ-glutamylcysteine (γ-EC), and phytochelatins, play fundamental roles in plants, their analytical determination and characterization is still somewhat problematic, mainly due to their high polarity and oxidation propensity. Thus, in this work a reliable and sensitive HPLC-ESI-MS-MS method was developed, in order...
Source: Phytochemistry - June 7, 2019 Category: Chemistry Source Type: research

NMR characterization and evaluation of antibacterial and antiobiofilm activity of organic extracts from stationary phase batch cultures of five marine microalgae (Dunaliella sp., D. salina, Chaetoceros calcitrans, C. gracilis and Tisochrysis lutea)
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Ma José Iglesias, Raquel Soengas, Ian Probert, Emilie Guilloud, Priscillia Gourvil, Mohamed Mehiri, Yuly López, Virginio Cepas, Ignacio Gutiérrez-del-Río, Saúl Redondo-Blanco, Claudio J. Villar, Felipe Lombó, Sara Soto, Fernando López OrtizAbstractThe chemical composition of five marine microalgae (Dunaliella sp., Dunaliella salina, Chaetoceros calcitrans, Chaetoceros gracilis and Tisochrysis lutea) was investigated through nuclear magnetic resonance (NMR) spectroscopic study of the soluble material ob...
Source: Phytochemistry - June 6, 2019 Category: Chemistry Source Type: research

Highly oxygenated meroterpenoids from the Antarctic fungus Aspergillus terreus
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Wenya Feng, Chunmei Chen, Shuyuan Mo, Changxing Qi, Jiaojiao Gong, Xiao-Nian Li, Qun Zhou, Yuan Zhou, Dongyan Li, Yongji Lai, Hucheng Zhu, Jianping Wang, Yonghui ZhangAbstractEleven highly oxygenated meroterpenoids, named terreustoxins A−K, along with five known analogues, were isolated from the Antarctic fungus Aspergillus terreus. The structures and absolute configurations of these undescribed compounds were characterized by NMR spectroscopy, single-crystal X-ray crystallography, and ECD experiments. Terreustoxins A−D are the first exam...
Source: Phytochemistry - June 2, 2019 Category: Chemistry Source Type: research

Antiproliferative steroidal glycosides from rhizomes of Polygonatum sibiricum
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Di Zhou, Xuezheng Li, Wenhui Chang, Yueqing Han, Bo Liu, Gang Chen, Ning LiAbstractScreening assays showed that total glycoside-rich fraction (TG) of rhizomes of Polygonatum sibiricum unveiled remarkable anti-proliferative activities against three cancer cell lines (A549, HepG2, and Caco2). Activity-guided isolation of TG afforded seven undescribed steroidal glycosides (polygonosides 1–7), along with 24 known glycosides. Their structures were established by 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and chemical ev...
Source: Phytochemistry - May 31, 2019 Category: Chemistry Source Type: research

Identification and characterization of (+)-α-bisabolol and 7-epi-silphiperfol-5-ene synthases from Artemisia abrotanum
In this study, we aimed to identify the sesquiterpene synthase responsible for the synthesis of 7-epi-silphiperfol-5-ene. We performed RNA sequencing of A. abrotanum leaves and gene candidates were mined by homology searches using the triquinane α-isocomene synthase of chamomile (MrTPS2) as query. After gene cloning, we obtained five variants of putative sesquiterpene synthase showing greater than 85% amino acid identity to MrTPS2 and greater than 95% amino acid identity to each other. Heterologous expression of these variants in a FPP-high-producing yeast strain revealed the first four variants to be (+)-α-bis...
Source: Phytochemistry - May 30, 2019 Category: Chemistry Source Type: research

Biosynthesis of cannflavins A and B from Cannabis sativa L
This study focused on two such compounds, known as cannflavin A and cannflavin B. These prenylated flavonoids specifically accumulate in C. sativa and are known to exhibit potent anti-inflammatory activity in various animal cell models. However, almost nothing is known about their biosynthesis. Using a combination of phylogenomic and biochemical approaches, an aromatic prenyltransferase from C. sativa (CsPT3) was identified that catalyzes the regiospecific addition of either geranyl diphosphate (GPP) or dimethylallyl diphosphate (DMAPP) to the methylated flavone, chrysoeriol, to produce cannflavins A and B, respectively. F...
Source: Phytochemistry - May 30, 2019 Category: Chemistry Source Type: research

Sesquiterpenoids and mycotoxin swainsonine from the locoweed endophytic fungus Alternaria oxytropis
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Xiangmei Tan, Xiaoyan Zhang, Meng Yu, Yongtao Yu, Zhe Guo, Ting Gong, Shubin Niu, Jianchun Qin, Zhongmei Zou, Gang DingAbstractOxytropiols A-J, ten undescribed guaiane-type sesquiterpenoids, and the mycotoxin swainsonine (SW) were isolated from the locoweed endophytic fungus Alternaria oxytropis. The chemical structures of these sesquiterpenoids were elucidated on the basis of HR-ESI-MS and NMR data including 1H, 13C, HSQC, 1H-1H COSY, HMBC, and NOESY spectra, and the absolute configurations of these compounds were determined using a modified Mosher'...
Source: Phytochemistry - May 30, 2019 Category: Chemistry Source Type: research

Arsenolipids in the green alga Coccomyxa (Trebouxiophyceae, Chlorophyta)
Publication date: Available online 23 May 2019Source: PhytochemistryAuthor(s): Tomáš Řezanka, Linda Nedbalová, Dovilė Barcytė, Milada Vítová, Karel SiglerAbstractLipid-like compounds containing a dimethylarsinoyl group, i.e. Me2As(O)-, have been identified by liquid chromatography/inductively coupled plasma mass spectrometry (LC/ICP-MS) and non-aqueous reversed-phase high-performance liquid chromatography (positive and/or negative high-resolution tandem electrospray ionization mass spectrometry (NARP-HPLC/HR-ESI+(−)-MS/MS) from three strains of green algae of the genus Coccomyxa ...
Source: Phytochemistry - May 24, 2019 Category: Chemistry Source Type: research

Isolation and functional characterization of an antifungal hydrophilic peptide, Skh-AMP1, derived from Satureja khuzistanica leaves
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Soghra Khani, Sima Sadat Seyedjavadi, Hadi Zare-Zardini, Hamideh Mahmoodzadeh Hosseini, Mehdi Goudarzi, Shohreh Khatami, Jafar Amani, Abbas Ali Imani Fooladi, Mehdi Razzaghi-AbyanehAbstractThe increasing resistance of pathogenic fungi to conventional antifungal therapies is a major global health concern. Currently, antifungal peptides are receiving increasing attention as suitable candidates for antifungal drug discovery. In the present study, an antifungal peptide was isolated from Satureja khuzistanica by reverse phase-HPLC column and sequenced by ...
Source: Phytochemistry - May 24, 2019 Category: Chemistry Source Type: research

Isotopic ratio outlier analysis improves metabolomics prediction of nitrogen treatment in maize
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Chris Vlahakis, Jan Hazebroek, Chris Beecher, Felice de JongAbstractWe evaluated Isotope Ratio Outlier Analysis (IROA) as a metabolome-wide internal standard approach to improve the quality of LC/MS data collected from a large-scale greenhouse experiment designed to metric the ability of metabolomics to model quantitatively nitrogen treatments. We further looked at how IROA would be incorporated into a metabolomics workflow. For this we compared IROA processed data with that generated without the benefit of metabolome-wide internal standards using ou...
Source: Phytochemistry - May 24, 2019 Category: Chemistry Source Type: research

Isolation of enantiomeric furolactones and furofurans from Rubus idaeus L. with neuroprotective activities
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Le Zhou, Feng-Ying Han, Li-Wei Lu, Guo-Dong Yao, Ying-Ying Zhang, Xiao-Bo Wang, Bin Lin, Xiao-Xiao Huang, Shao-Jiang SongAbstractA phytochemical study on the fruits of Rubus idaeus L. (Rosaceae) yielded eight pairs of enantiomeric lignans, including one undescribed furolactone named (−)-idaeusinol A and six undescribed furofuran derivatives named (+/−)-idaeusinol B–D. The structures of these isolated compounds were elucidated by spectroscopic analyses and a combination of computational techniques including gauge-independent atomic o...
Source: Phytochemistry - May 22, 2019 Category: Chemistry Source Type: research

Phenylethanoid glycosides from the Schnabelia nepetifolia (Benth.) P.D.Cantino promote the proliferation of osteoblasts
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Hong-Tao Xu, Cheng-Gang Zhang, Yu-Qiong He, Song-Shan Shi, Yong-Li Wang, Gui-Xin ChouAbstractAn investigation of the n-BuOH fraction of Schnabelia nepetifolia (Benth.) P.D.Cantino led to the isolation and identification of 12 undescribed phenylethanoid glycosides (nepetifosides A–L) and one undescribed phenylmethanoid glycoside (nepetifoside M), together with 23 known compounds. The structures of these compounds were determined by spectroscopic analyses including two-dimensional nuclear-magnetic-resonance (2D-NMR) spectroscopy and chemical-hydr...
Source: Phytochemistry - May 22, 2019 Category: Chemistry Source Type: research

Cytotoxic lignans from the stems of Herpetospermum pedunculosum
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Yingxiong Ma, Hong Wang, Rui Wang, Fancheng Meng, Zhaoyue Dong, Guowei Wang, Xiaozhong Lan, Hong Quan, Zhihua Liao, Min ChenAbstractA bioassay-guided chemical investigation on the ethyl acetate extract of the stems of Herpetospermum pedunculosum led to the isolation and identification of 22 lignans including 6 previously undescribed ones, herpetosiols A-F. Their structures including stereochemistries were elucidated by analysis of NMR, HRMS and ECD data. The in vitro cytotoxic activities of all isolates were studied against human gastric carcinoma SG...
Source: Phytochemistry - May 19, 2019 Category: Chemistry Source Type: research

Phenylpropanoid derivatives from the fruit of Crataegus pinnatifida Bunge and their distinctive effects on human hepatoma cells
Publication date: Available online 17 May 2019Source: PhytochemistryAuthor(s): Rui Guo, Xin-Yue Shang, Tian-Ming Lv, Guo-Dong Yao, Bin Lin, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang SongAbstractTen undescribed phenylpropanoid derivatives including four pairs of enantiomers and two 8–9′ linked neolignans, together with fifteen known ones were isolated from the fruit of Crataegus pinnatifida Bunge. Their structures were established by comprehensive spectroscopic analyses. Enantiomers were separated successfully by chiral chromatographic column and their absolute configurations were determined by comparison of the...
Source: Phytochemistry - May 18, 2019 Category: Chemistry Source Type: research

Immobilized α-amylase magnetic beads for ligand fishing: Proof of concept and identification of α-amylase inhibitors in Ginkgo biloba
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Malene J. Petersen, Rita de Cássia Lemos Lima, Louise Kjaerulff, Dan StaerkAbstractDiabetes mellitus is a widespread metabolic disorder that affects millions of people around the world. The disease is a major burden on both economic and social levels, and there is a need for improved drugs with fewer side effects in the management of the disease. Current methods for isolation of anti-diabetic lead compounds from complex mixtures suffer from low resolution and sensitivity, and there is a need for improved alternatives. In this work, magnetic li...
Source: Phytochemistry - May 18, 2019 Category: Chemistry Source Type: research

Overcoming deterrent metabolites by gaining essential nutrients: A lichen/snail case study
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Alice Gadea, Maryvonne Charrier, Mathieu Fanuel, Philippe Clerc, Corentin Daugan, Aurélie Sauvager, Hélène Rogniaux, Joël Boustie, Anne-Cécile Le Lamer, Françoise Lohézic - Le DevehatAbstractSpecialised metabolites in lichens are generally considered repellent compounds by consumers. Nevertheless, if the only food available is lichens rich in specialised metabolites, lichenophages must implement strategies to overcome the toxicity of these metabolites. Thus, the balance between phagostimulant nutrients a...
Source: Phytochemistry - May 16, 2019 Category: Chemistry Source Type: research

Analytical investigations on Boswellia occulta essential oils
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Marina Ayubova, Zahra Osman Guelleh, Moktar Osman Guelleh, Hugues Brévard, Nicolas BaldoviniAbstractThree samples of Boswellia occulta gum resin (Grades I, II and III) were analyzed by GC-MS and GC-FID. Fifty constituents could be identified, and several of them were isolated by flash chromatography and characterized by NMR. The combinatorial synthesis of homologous series of reference constituents permitted the unambiguous identification of five 1-methoxyalkanes and one 1-methoxyalkene. In addition, we measured the 14C content of one sample o...
Source: Phytochemistry - May 16, 2019 Category: Chemistry Source Type: research

Cytotoxic saponins and other natural products from flowering tops of Narthecium ossifragum L
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Andrea Estefanía Carpinteyro Díaz, Lars Herfindal, Bendik Auran Rathe, Kristine Yttersian Sletta, Anni Vedeler, Svein Haavik, Torgils FossenAbstractFor more than four centuries, the intake of Narthecium ossifragum has been associated with poisoning in domesticated animals. Saponins occurring in flowering tops of the plant are considered to cause kidney damage in calves. At present, there are more than 30 papers on the saponins of N. ossifragum in the literature, although the structures of these compounds have hitherto not been determine...
Source: Phytochemistry - May 16, 2019 Category: Chemistry Source Type: research

Phenylpropanoid glycosides from the fruit of Lycium barbarum L. and their bioactivity
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Qing-Wen Li, Rui Zhang, Zheng-Qun Zhou, Wan-Yang Sun, Hong-Xia Fan, Ying Wang, Jia Xiao, Kwok-Fai So, Xin-Sheng Yao, Hao GaoAbstractFifteen phenylpropanoid glycosides, including six undescribed compounds were isolated from the fruit of Lycium barbarum L. (Solanaceae) (goji or wolfberry). Their structures were identified by detailed spectroscopic analyses. Seven known compounds were firstly isolated from the genus Lycium, in which the 1D and 2D NMR data of one compound were reported for the first time. Notably, two undescribed compounds were a pair of...
Source: Phytochemistry - May 15, 2019 Category: Chemistry Source Type: research

Biosynthesis of methyl (E)-cinnamate in the liverwort Conocephalum salebrosum and evolution of cinnamic acid methyltransferase
Publication date: August 2019Source: Phytochemistry, Volume 164Author(s): Chi Zhang, Xinlu Chen, Barbara Crandall-Stotler, Ping Qian, Tobias G. Köllner, Hong Guo, Feng ChenAbstractMethyl (E)-cinnamate is a specialized metabolite that occurs in a variety of land plants. In flowering plants, it is synthesized by cinnamic acid methyltransferase (CAMT) that belongs to the SABATH family. While rarely reported in bryophytes, methyl (E)-cinnamate is produced by some liverworts of the Conocephalum conicum complex, including C. salebrosum. In axenically grown thalli of C. salebrosum, methyl (E)-cinnamate was detected as the do...
Source: Phytochemistry - May 11, 2019 Category: Chemistry Source Type: research

Evolution of phytochemical diversity in Pilocarpus (Rutaceae)
In this study, we used phylogenetic comparative methods to determine whether there is a phylogenetic signal for chemical traits across the genus Pilocarpus; this included ancestral reconstructions of continuous and discrete chemical traits. Bioclimatic variables found to be associated with the distribution of this genus were used to perform OLS regressions between chemical traits and bioclimatic variables. Next, these regression models were evaluated to test whether bioclimatic traits could significantly predict compound concentrations. Our study found that in terms of compound concentration, variation is most significantl...
Source: Phytochemistry - May 10, 2019 Category: Chemistry Source Type: research