Translating thought into blood flow in the brain: capillaries as sensors of neural activity
NIH Director's Wednesday Afternoon Lecture Series
The Nelson laboratory ’ s research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neurons and how these mechanisms are disrupted in small vessel disease (SVD) — a major cause of stroke and dementia.Air date: 3/25/2020 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 28, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Grand Rounds: Women in Science – Stem Cells in Jaw Growth and Disease
NIDCR Grand Rounds
The temporomandibular joint (TMJ) is a complex joint and the only bilateral joints that must function together as one unit to support mastication and speech. TMJ trauma and diseases, such as osteoarthritis, can be debilitating and severely reduce quality of life. Current TMJ treatments generally involve either pain management or invasive surgeries, such as total joint replacement surgery. There are no minimally invasive, regenerative TMJ therapies. Dr. Embree and her lab have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat, and vascularized bone. She has...
Source: Videocast - All Events - February 27, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI Audacious Goals: Cytoplasmic material exchange between sensory neurons in vivo
Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-bas...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Sayer Vision Research Lecture: Translating RPE Biology into Disease Treatments using iPS Cells
12th Sayer Vision Research Lecture
Dr. Bharti's laboratory developed and functionally validated in vitro models of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelial cells (RPE). The RPE cells, matured on a biodegradable scaffold, formed a functional monolayer patch. The FDA recently approved a phase I/IIa safety and feasibility clinical trial to test an autologous iPSC-RPE patch in patients with the geographic atrophy form of age-related macular degeneration.Air date: 4/21/2020 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Rear Admiral (Upper Half) Richard W. Childs Flag Promotion Ceremony
The United States Public Health Service Flag Promotion ceremony for Rear Admiral (RADM) Richard W. Childs, promoted to RADM Upper Half O-8 in January 2020, is being webcast live on 3/27/2020 from Masur Auditorium. Richard Childs, MD serves as the Clinical Director of the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH). He was commissioned in the USPHS Commissioned Corps as a Lieutenant in 1995 when joined the NCI as an Oncology Fellow. Following fellowship training, he was appointed a tenure-track investigator in the Hematology Branch of the NHLBI where he continues to conduct r...
Source: Videocast - All Events - February 24, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
AGI Seminar in Neuroregeneration
Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-bas...
Source: Videocast - All Events - February 18, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar - Phantoms in the transcriptome: post-transcriptional mRNA regulation through DNA and RNA modifications
NIH Director's Seminar Series
Research in Dr. Oberdoerffer ’ s laboratory broadly examines how DNA and RNA epigenetics dynamically regulate gene expression. They ask how methylation of cytidine in DNA affects pre-mRNA splicing decisions, and how subsequent acetylation of cytidine in processed mRNA affects translation. They use a variety of tools to investigate the enzymatic regulation of cytidine modifications and the net impact at target genes and genome-wide. Current efforts in the laboratory are focused on developing methods to achieve base-resolution analysis of the modification landscape in single cells.Air date: 2/...
Source: Videocast - All Events - February 11, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Hereditary Cancer Mutation and Drug Development
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Pamela Munster is Co-Director of the Center for BRCA Research, a BRCA-focused clinical and research program at the Helen Diller Family Comprehensive Cancer Center at University of California San Francisco (UCSF). She received her medical degree from the University of Bern, Switzerland; completed her residency in Internal Medicine at Indiana University Medical Center then moved to Memorial Sloan-Kettering Cancer Center, New York for her oncology and hematology fellowship. Dr. Munster served at Memorial Sloan Kettering as a faculty member in the breast cancer progra...
Source: Videocast - All Events - February 3, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Poly-Aneuploid Cancer Cells: Actuators of Cancer Resistance
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Pienta is a Professor of Urology, Oncology, Pharmacology and Molecular Sciences and Chemical and Biomolecular Engineering as well an American Cancer Society Clinical Research Professor. Between 1995 and 2013, Dr. Pienta served as the Director of the Prostate Specialized Program of Research Excellence (SPORE) at the University of Michigan and has served as co-PI of the Johns Hopkins Prostate SPORE from 2013-2018. He has a proven, peer-reviewed track record in organizing and administering a translational research program that successfully incorporates bench research...
Source: Videocast - All Events - January 6, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Might seem counterintuitive, but some farm crops may be better if they let their defenses down.
One way to boost the productivity of a plant is to redirect some of its resources away from maintaining an overprepared immune system and into enhanced seed production. So say NSF-funded scientists at Cold Spring Harbor Laboratory, who have found a gene that could help them tweak that balance. This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 3, 2020 Category: Science Source Type: video
Mining the Unexplored Cancer Kinome for Novel Therapeutic Targets in Squamous Cell Carcinomas
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Cancer genomic sequencing has significantly impacted the understanding of the temporal and spatial genetic alterations that lead to tumorigenesis. This information enables the development of targeted therapies that result in durable and less toxic responses in patients. In regard to kinases, the biomedical community has focused research efforts on approximately 200 kinases among the 538 kinases present in the human kinome, yet siRNA screens and cancer genomic studies indicate that the vast majority of these unexplored kinases (approximately 300) are implicated in canc...
Source: Videocast - All Events - December 9, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Traversing the Gut-Brain Axis: Translation to Addiction Medicine
Director's Seminar Series
Alcohol and substance use disorders represent the leading causes of mortality and morbidity worldwide. There is a crucial need to develop novel effective treatments for patients struggling with addiction. Dr. Leggio's laboratory conducts preclinical and human studies to identify possible novel medications for addiction. His group uses a combination of state of the art, innovative bio behavioral, neuroimaging and pharmacological procedures performed under well-controlled human laboratory conditions. Collaborative bed-to-bench approaches are also employed using behavioral, pharmacological, and trans...
Source: Videocast - All Events - December 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Metabolic Barriers to Effective Cancer Immunotherapy
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Delgoffe is a tenured Associate Professor of Immunology at the University of Pittsburgh School of Medicine and the University of Pittsburgh Medical Center Hillman Cancer Center. Dr. Delgoffe graduated summa cum laude from Western Michigan University in 2004 before completing doctoral training at the Johns Hopkins School of Medicine in 2010. His Ph.D research, under the direction of Dr. Jonathan Powell, made seminal discoveries regarding the role of nutrient sensing in T cell function and fate, resulting in several first-author contributions in high impact journals...
Source: Videocast - All Events - December 2, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
New Drugs, Old Problems: The Sulfonamide Revolution and Children ’ s Health Care Delivery in the United States, 1933-1949
Using pediatric patient records housed at the National Library of Medicine, Dr. Cynthia Connolly explore the transformation wrought by the sulfonamides in medical and nursing practice at Baltimore ’ s Sydenham Hospital. Published articles, oral histories, and physician memoirs reveal only part of the story of one of the twentieth century ’ s most pivotal scientific breakthroughs. Through patient records, which rarely survive intact, it is possible to appreciate the ways in which the new therapeutics demanded more intense bedside care, enhanced laboratory facilities, and new levels of cooperation. It also reveals how an...
Source: Videocast - All Events - November 22, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Harnessing Genetic Interactions to Advance Precision Targeted and Immune Therapy of Cancer
CCR Grand Rounds
Dr. Eytan Ruppin is a computational biologist whose research is focused on developing and harnessing data science approaches for the integration of multi-omics data to better understand the pathogenesis of cancer, its evolution and treatment. Her laboratory collaborates with many experimental cancer labs, aiming to develop and utilize computational approaches to jointly gain a network-level integrative view of the systems that the researchers study. Together with Dr. Ruppin ’ s collaborators, from a translational perspective, the researchers aim to predict and test novel drug targets and biomarkers to tr...
Source: Videocast - All Events - November 18, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
