Quasi-species Suppression of Viral Drug Resistance
NIH Director ’ s Wednesday Afternoon Lecture Series
This is the annual George Khoury Lecture, which honors the memory of Dr. George Khoury (1943 – 1987), a highly regarded NIH virologist and caring mentor of the postdoctoral fellows in his laboratory.
Dr. Karla Kirkegaard, Ph.D., is the Violetta L. Horton Research Professor of Genetics at the Stanford University School of Medicine. Her laboratory focuses on identification of dominant drug targets for antiviral design, such as small molecules that stabilize oligomeric assemblages. A past recipient of the NIH Director's Pioneer Award, Dr. Kirkegaard combines her interest...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Rounds, Women in Science series
Dear Colleagues,Please join us for the NIDCR Clinical Research Fellowship Grand Rounds, Women in Science seriesLecture Title: " Human Cell Atlas: Mapping the Human Body One Cell at a Time " Presenter: Dr. Sarah TeichmannDate: 3/5/2021Time: 10:00am -11:00amLocation: WebcastOverview:The Human Cell Atlas (HCA) is an ambitious global initiative aiming to create comprehensive reference map of all human cells — the fundamental units of life — as a basis for both understanding human health and diagnosing, monitoring, and treating disease. Co-founded by Dr Sarah Teichmann from the Wellcome Sanger Institute in the UK, and Dr Av...
Source: Videocast - All Events - March 1, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Understanding the Effects of Inflammation over time in Humans: Lessons from Psoriasis
Inflammation is critical to atherosclerosis initiation, progression and complications. The goal of The Laboratory of Inflammation and Cardiometabolic Diseases at the NHLBI Intramural Program is to understand how chronic systemic inflammation drives development of cardiometabolic diseases in humans. For the past decade, Dr. Mehta ’ s research program has utilized psoriasis, a chronic inflammatory skin disease, as a model to probe inflammatory, lipid and metabolic pathways associated with atherosclerosis progression. In 2012, Dr. Mehta founded the Psoriasis Atherosclerosis Cardiometabolic Initiative (PACI) at the NHLBI Int...
Source: Videocast - All Events - February 18, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Dynamic Organelle Shape and Function During Herpesvirus Infection
Research in the Cristea laboratory focuses on characterizing mechanisms of cellular defense against viruses, as well as mechanisms used by viruses to manipulate these critical cellular processes. Towards these goals, her lab has promoted the integration of virology with proteomics and bioinformatics. The development of methods for studying virus-host protein interactions in space and time during the progression of an infection has allowed her group to bridge developments in mass spectrometry to important findings in virology.For more information go tohttps://oir.nih.gov/walsAir date: 6/16/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 11, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Protein Misfolding (full title forthcoming)
Marina Ramirez-Alvarado, Ph.D., studies misfolding and amyloid formation in light chain amyloidosis. The overall goal of her research laboratory is to understand the molecular basis of this disease to find ways to ameliorate the organ damage it causes and find new therapeutic strategies to improve organ function and quality of life for patients, ultimately increasing overall survival.For more information go tohttps://oir.nih.gov/walsAir date: 6/30/2021 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 9, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Special Tuesday WALS Lecture - Three (Formerly) Blind Mice: Reprogramming Tissues to Be Young Again
Special Tuesday WALS Lecture
Dr. Sinclair is a professor of genetics, Blavatnik Institute, and co-director of the Paul F. Glenn Center for Biology of Aging Research, at Harvard Medical School. His lab seeks to understand why we age and whether we can extend human health and longevity.
The Sinclair laboratory has demonstrated that it is possible to epigenetically reprogram cells to safely reverse aging in vivo and regain eyesight. This research, conducted with support from the National Institute on Aging and National Eye Institute, was recently published in Nature (PMID: 33268865; doi: 10.1038/s41586-020-2975-4) and will b...
Source: Videocast - All Events - February 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID-19: Developing a Vaccine During a Pandemic
COVID-19 Scientific Interest GroupDr. Barouch is the William Bosworth Castle Professor of Medicine and Professor of Immunology at Harvard Medical School and director of the Center for Virology and Vaccine Research at the Beth Israel Deaconess Medical Center. His talk will outline the current state of the COVID-19 vaccine field and will describe the development of the Ad26.COV2.S vaccine — a recombinant, replication-incompetent adenovirus serotype 26 (Ad26) vector encoding a full-length and stabilized SARS-CoV-2 spike protein.My laboratory focuses on studying the immunology and virology of HIV-1 infection and developing n...
Source: Videocast - All Events - February 3, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - February 2021
The 6th Virtual Meeting of the Frederick National Laboratory Advisory Committee (FNLAC)Air date: 2/23/2021 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Demystifying Medicine - Viruses and Immunodeficiency and Skin Microbiome
Demystifying Medicine Lecture Series
How do virus and other pathogens penetrate the fortress that is human skin? What tricks do they use to slip past the guards? How do they compromise the immune system, and how do they take advantage of and reveal inherited immunodeficiency? These are the topics of the next Demystifying Medicine.
Philip Murphy, M.D., is chief of the NIAID Laboratory of Molecular Immunology and its Molecular Signaling Section. His laboratory studies G protein-coupled receptors of the immune system with the goal of elucidating mechanisms by which the receptors relay chemotactic signals to cells and identify...
Source: Videocast - All Events - January 29, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Young Blood for Old Brains
Speaker Tony Wyss-Coray's laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimer ’ s disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.For more information go tohttps://oir.nih.gov/walsAir date: 3/31...
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Integrating Inflammation and Coagulation in COVID-19
Speaker Yogen Kanthi is a cardiologist and clinical vascular medicine specialist. His laboratory aims to understand how inflammation and coagulation contribute to vascular disease. He is interested in developing a deeper understanding of how innate immune circuits and communicate with coagulation and the vessel wall to license or restrict thrombosis.For more information go tohttps://oir.nih.gov/sigs/covid-19-scientific-interest-groupAir date: 3/4/2021 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Sure, your phone may be smart. But how about your earphones?
Some researchers at the University of Illinois believe earphones will be the next significant milestone in wearable devices, and that new hardware, software and apps will all run on this platform. The National Science Foundation-funded team is part of the Coordinated Science Laboratory's Systems ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 31, 2020 Category: Science Source Type: video
COVID 19 Vaccine Development
My laboratory focuses on studying the immunology and virology of HIV-1 infection and developing novel vaccine strategies. I have also recently demonstrated the therapeutic efficacy of potent monoclonal antibodies and the early seeding of the viral reservoir. My laboratory received three NIH U19 Integrated Preclinical/Clinical AIDS Vaccine Development (IPCAVD) program grants in 2005, 2008, and 2012 to construct alternative serotype adenovirus vaccine vectors, to explore their immunogenicity and protective efficacy in rhesus monkeys, and to advance optimal vaccine candidates into clinical trials. Four phase 1 clinical trials...
Source: Videocast - All Events - December 10, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Round: Stem Cells in Jaw Growth and Disease
NIDCR Clinical Research Fellowship Grand Round
The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous popul...
Source: Videocast - All Events - November 6, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID-19 Insights Webinar Series: Challenges of SARS-CoV-2 Testing in the Hospital Laboratory
We invite you to join a new biweekly NHLBI webinar series entitled “ COVID-19 Insights ” to learn about groundbreaking research focusing on the host response to SARS-CoV-2 infection. This exciting cross-disciplinary series, featuring both NHLBI staff and researchers throughout the scientific community, will enhance NHLBI listeners ’ understanding of the latest advances in this fast-moving research, especially as they relate to the NHLBI mission.For more information go tohttps://intranet.nhlbi.nih.gov/content/covid-19-insights-webinar-seriesAir date: 11/2/2020 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - October 22, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
