CANCELLED - Frederick National Laboratory Advisory Committee - February 2019
February 20, 2019 – Meeting cancelled due to inclement weather. The rescheduled date will be posted once confirmed.Air date: 2/20/2019 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 20, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee - February 2019
The 3rd Virtual Meeting of the Frederick National Laboratory Advisory CommitteeAir date: 2/20/2019 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 5, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Autoantigens and autoimmunity: a bedside to bench and back again story
NIH Director's Wednesday Afternoon Lecture Series
Noncoding RNAs play critical roles in the metabolism of all cells. The Wolin laboratory studies how noncoding RNAs function, how cells recognize and degrade defective noncoding RNAs, and how failure to degrade these RNAs affects cell function and contributes to human disease. Their studies revealed new mechanisms by which defective RNAs are targeted for degradation and new classes of noncoding RNAs. Most recently, their work has contributed to a novel theory for how the autoimmune disease systemic lupus erythematosus may be triggered in genetically susceptible individuals.A...
Source: Videocast - All Events - February 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Microbial networking ( … it ’ s like Tinder for bugs)
NIH Director's Wednesday Afternoon Lecture Series
Annual Rolla E. Dyer Lecture
Few microbes (viruses, bacteria, fungi) live in isolation or exclusively with members of their own kingdom or domain. Affinities or aversions among microbial members influence the community structure, but these interactions can be reorganized with the arrival of disruptors. In respiratory infections, for example, infectious agents — be they viral or bacterial — are entering an environment within the host where they can impact existing ecological relationships among local residents. Disrupting these " social " networks has ecological and phys...
Source: Videocast - All Events - February 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Integrating Mass Spectrometry-based Proteomics and Lipidomics Reveals Biomarkers and Altered Signaling Pathways During Progressive Neurodegeneration in Niemann-Pick Disease, type C1
Proteomics Interest Group
Advances in mass spectrometry technology have enabled large-scale differential analysis of proteins and lipids to investigate altered pathways in human disease. Our laboratory studies Niemann-Pick Disease, type C1 (NPC1) a lysosomal storage disorder with visceral involvement and progressive cerebellar neurodegeneration. Using a combination of differential proteomics, lipidomics and mass spectrometry imaging, we have identified new candidate biomarkers in a mouse model of NPC1. These alterations now provide a basis for evaluation in NPC1 patients and also can be used for therapeutic development. Se...
Source: Videocast - All Events - February 1, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Everything you wanted to know about microtubules but were afraid to ask
NIH Director's Seminar Series
Dr. Roll-Mecak will discuss the research of the Laboratory of Cell Biology and Biophysics Section, NINDS. The title of her talk is " Everything you wanted to know about microtubules but were afraid to ask " .
In addition to providing structural support, microtubules form a complex and dynamic intracellular " highway " that delivers molecular cargo from one end of the cell to another - which in the case of neuronal cells can span several feet. Given the continually changing cell physiology, this delivery system undergoes constant remodeling as cargo is transported to different destinations with...
Source: Videocast - All Events - January 31, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Nonsense-mediated mRNA Decay in Health and Disease
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Maquat is the J. Lowell Orbison Endowed Chair and Professor of Biochemistry and Biophysics in the School of Medicine and Dentistry, Director of the Center for RNA Biology, and Chair of Graduate Women in Science at the University of Rochester, Rochester, NY. After obtaining her Ph.D. in Biochemistry from the University of Wisconsin-Madison and undertaking post-doctoral work at the McArdle Laboratory for Cancer Research, she joined Roswell Park Cancer Institute before moving to the University of Rochester. Professor Maquat discovered mammalian-cell nonsense-mediated m...
Source: Videocast - All Events - January 7, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Translational studies in patients with Autoinflammatory Diseases...from bedside to bench and back
Director's Seminar Series
Dr. Goldbach-Mansky will present the work of her Laboratory of Clinical Immunology and Microbiology. Autoinflammatory diseases are a group of rare immune dysregulatory syndromes that present with unexplained fevers, rashes, joint pain, and inflammation in multiple organs, such as the central nervous system, the eyes, inner ears, bones, fat, blood vessels, lungs, and muscles. Many of the disease symptoms present very early in life, and patients do not have infections or malignacies. The discovery of single gene mutations, which modify the regulation of inflammatory pathways that are triggered by ex...
Source: Videocast - All Events - January 4, 2019 Category: General Medicine Tags: Upcoming Events Source Type: video
Journey into the Black Hole of the Epigenome
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Yamini Dalal became interested in chromosome structure and epigenetic gene regulation during her Baccalaureate years at St. Xavier's College, Bombay, India, where she graduated with a double major in Biochemistry and Life Sciences in 1995. She moved to the United States for her post-graduate work. In Arnold Stein's laboratory at Purdue University, she used classical chromatin biochemistry tools to understand how DNA sequence motifs and linker histones can shape the chromatin structure in silico, in vitro, and in vivo. During this time, she discovered that the regi...
Source: Videocast - All Events - December 11, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Metabolic Constraints of Tumor Growth
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Matthew Vander Heiden is an Associate Professor in the Department of Biology at the Massachusetts Institute of Technology and Associate Director of the Koch Institute for Integrative Cancer Research. He is also an HHMI Faculty Scholar, an Institute Member of the Broad Institute of Harvard and MIT, and an Instructor of Medicine at the Dana-Farber Cancer Institute and Harvard Medical School. Dr. Vander Heiden received his M.D. and Ph.D. degree from the University of Chicago. He also completed clinical training in internal medicine and medical oncology at the Brigham and...
Source: Videocast - All Events - December 4, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Grantees Meeting: RFA AG-16-020 Impact of Aging on Currently Employed Animal Models (UH2-UH3 Demonstration Projects)
The Division of Aging Biology (DAB) is planning to hold a grantees meeting to report on their progress and engage in a panel discussion to gauge the state of the science and exchange viewpoints on the impact of aging in studies of diseases and conditions in laboratory animals (mice of different strains and genetic modifications). Grantees are in the UH3 phase of the awards. They will discuss the aging components of their studies as derived from human conditions, review preliminary findings in their respective animal models and participate in a panel discussion on outcomes and ways to optimize exposure and impact of their f...
Source: Videocast - All Events - November 29, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Defining mechanisms of pathogenesis in cutaneous leishmaniasis to develop new approaches to therapy
IIG Seminar
Phil Scott received his Ph.D. from the University of Pennsylvania in 1980 where he studied immunoregulatory mechanisms in experimental cutaneous leishmaniasis, and from there went to Dr. Alan Sher ’ s laboratory at NIH where he defined the role of CD4+ Th1 and Th2 cells in controlling leishmaniasis. He left NIH in 1989 to return to Penn, and rose through the ranks to become Professor of Immunology in 1995. During his time at Penn he served for 12 years as Chair of the Department of Pathobiology in the School of Veterinary Medicine, and is currently Vice Dean for Research& Academic Resources. Dr. Scott ’ s c...
Source: Videocast - All Events - November 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Endoplasmic reticulum and immunometabolic homeostasis
NIH Director's Wednesday Afternoon Lecture Series – Special Tuesday Lecture
The major interest of Dr. Hotamisligil's laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. His lab's biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.For more information go tohttps://oir.nih.gov/walsAir date: 11/13/2018 3:00:00 PM (Source: ...
Source: Videocast - All Events - November 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Blood-based biomarkers that shape recovery from traumatic brain injuries
NIH Director's Seminar Series
Dr. Gill is a nurse researcher within the National Institutes of Nursing Research (NINR), and will present data on studies that link biomarkers to recovery from traumatic brain injuries (TBIs), and place individuals at higher risk to develop long-term behavioral and neurological symptoms. The impact of repeated TBIs, as well as blast and sub-concussive hits on neurological recovery will also be presented. Studies from Dr. Gill ’ s Tissue Injury Branch include samples of military personnel and veterans, civilians recruited from emergency rooms, and athletes within the National Collegiate Athl...
Source: Videocast - All Events - November 6, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
2018 Kinyoun Lecture - Opioids: Epidemic of our time and impact on infectious disease
Robert R. Redfield, M.D., director of the Centers for Disease Control and Prevention (CDC), will deliver the 2018 Joseph J. Kinyoun Memorial Lecture on the intersection between the national opioid crisis and the management of infectious diseases.
Titled, “ Opioids: Epidemic of Our Time and Impact on Infectious Disease, ” Dr. Redfield ’ s talk will explore the impacts of the unprecedented use of opioids in the United States on the management of infectious diseases. While overdose remains the leading cause of death among people who use opioids, this population is also disproportionately affected by viral hepatitis, bac...
Source: Videocast - All Events - November 6, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
