Unraveling the complexities of tryptase form and function in humans
Immunonology IG Seminar
Dr. Jonathan Lyons received his undergraduate education from Pomona College, and a Doctorate of Medicine from the University of Southern California in 2007. Dr. Lyons completed residency training in Internal Medicine at the University of California, San Diego, in 2010, remaining an additional year as a Chief Medical Resident. He concluded his formal medical training as a clinical fellow in Allergy and Immunology at NIAID in 2014. Following completion of fellowship, Jonathan was selected for the NIAID Transition Program in Clinical Research, and he is currently an Assistant Clinical Investigator in t...
Source: Videocast - All Events - November 14, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Transcriptional Regulation of Neuroinflammation
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Lazarevic received her B.Sc. Microbiology degree from the University of Nottingham (UK) and Ph.D. degree in Molecular Virology and Microbiology from the University of Pittsburgh. Following her post-doctoral training in the laboratory of Dr. Laurie Glimcher at Harvard School of Public Health, Dr. Lazarevic was recruited as a tenure-track investigator in the Experimental Immunology Branch, CCR. Her laboratory is interested in how transcription factors regulate differentiation and effector function of CD4+ T helper (Th) cells in the context of autoimmune disorders with e...
Source: Videocast - All Events - November 13, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Stem Cell Aging
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its fall seminar, featuring Dr. Sean Morrison. Dr. Morrison is the Director of the Children ’ s Medical Center Research Institute at UT Southwestern and is the Mary McDermott Cook Chair in Pediatric Genetics as well as an Investigator of the Howard Hughes Medical Institute. The Morrison laboratory studies the cellular and molecular mechanisms that regulate the function of stem cells and cancer cells in the nervous and hematopoietic systems. The laboratory is particularly interested in the mechanisms that regulate stem cel...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Translational fidelity and neurodegeneration
NIH Director's Wednesday Afternoon Lecture Series
The goal of the Ackerman laboratory is to define the molecular pathways necessary to maintain homeostasis in both developing and aging mammalian neurons. To do this they utilize forward genetics to identify mutations that are associated with loss of neurons in the aging mouse brain. To further dissect pathways underlying homeostatic disruption and disease, they also use forward genetics to identify genetic variants that enhance or suppress neural phenotypes. Their approach allows the identification, without a priori assumptions, of molecules critical for neuron homeostasis ...
Source: Videocast - All Events - October 26, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
NSF supports "Array of Things" prototype in Chicago -- Science Nation
University of Chicago scientists supported by NSF are collaborating with researchers at the Argonne National Laboratory to build out a wide-ranging urban sensing project in Chicago known as the Array of Things (AoT). One could think of it as a fitness tracker for a city -- a network of 500 ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - October 20, 2017 Category: Science Source Type: video
Transforming Electronic Health Records from Annoyances to Assistants: A Research Agenda for the Next Decade
Clinical informatics research, and before that, medical informatics research, has made great strides in developing tools to help clinicians improve clinical decision-making and patient care. Yet, electronic health records (EHR) systems today show little aptitude for even simple tasks, like retrieving relevant patient information, while suppressing that which is irrelevant. When bringing artificial intelligence to bear, the best EHRs seem to do is to overwhelm us with alerts that a clinician must override to take action. When the “ learning health system ” attempts to use data from these systems, it must rely on indirec...
Source: Videocast - All Events - October 13, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Prevention of Progression in Multiple Myeloma
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Irene Ghobrial is an Associate Professor at Dana-Farber Cancer Institute (DFCI), Harvard Medical School, Boston, MA and an Associate member of the Broad Institute, Cambridge, MA. She is the director of the Michele& Stephen Kirsch Laboratory and co-director of the Center for Prevention of Progression of Blood Cancers (CPOP) at DFCI. In addition, she is the co-leader of the Blood Cancer Research Partnership (BCRP), a consortium for innovative clinical trials of community oncology sites coordinated by DFCI.
Dr. Ghobrial received her medical degree from Cairo University S...
Source: Videocast - All Events - October 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - October 2017
The 13th meeting of the Frederick National Laboratory Advisory CommitteeAir date: 10/30/2017 9:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - October 2, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Midwest Photonics Education Center
At the Midwest Photonics Education Center (MPEC) at Indian Hills Community College, a technician operates an ultra-high-intensity laser system in the Extreme Light Laboratory.
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Supported by the National Science Foundation's Advanced Technological Education ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 2, 2017 Category: Science Source Type: video
NIH Screening of Discovery's First in Human
Between September 2015 and June 2016, Discovery film crews followed patients, their families, doctors and researchers, and NIH clinical and care staff to provide a personal and realistic look at the challenges of carrying out cutting edge, experimental medicine. The endeavor was a massive undertaking, with Discovery crews capturing over 1,000 hours of footage in the hospital. More than 1,000 staff members consented to be filmed.
The film is a shining moment for the NIH as a whole and the Clinical Center in particular, and provides an unprecedented glimpse into the triumphs and setbacks that are part of being at the forefro...
Source: Videocast - All Events - August 3, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Hematopoietic Stem Cells Aging – Mechanisms, Consequences and Interventions
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its summer seminar, featuring Dr. Emmanuelle Passegu é . Dr. Passegue is a Professor in the Department of Genetics and Development at the Columbia University Medical Center and Director of the Columbia Stem Cell Initiative (CSCI) in New York. She is widely recognized for her expertise on hematopoietic stem cell (HSC) biology. Her research over the past 10-years has focused on understanding the cellular and molecular processes controlling HSC activity during homeostasis, and addressing how these regulations are changed in myeloid malignancies and phy...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Law of STAT fives, root orchestrators of lymphocyte homeostasis and function
Immunology Interest Group Seminar Series
The transcription factor STAT5 is fundamental to the mammalian immune system. Operating downstream of cytokines and growth factors, it impacts all aspects of lymphocyte biology, from general cellular processes like proliferation and apoptosis, to specialized immunological programs like effector and regulatory T cell differentiation. Genetic studies in humans underscore its widespread influence as mutations of STAT5 or upstream activators manifest varied Alejandro Villarino, NIAMS, NIHimmunological phenotypes including immunodeficiency, autoimmunity and hematological malignancies. Mo...
Source: Videocast - All Events - June 20, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
MIF Signaling Pathway as a Pathogenic Driver and Potential Target in Pancreatic Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Hussain is a Tenure Track investigator in the Laboratory of Human Carcinogenesis, CCR, NCI. He received his Ph.D. degree in Cancer Biology from Jawaharlal Nehru University, New Delhi, India. Dr. Hussain received his post-doctoral training at the Swiss Institute for Cancer Research (ISREC), Lausanne, Switzerland, and the Laboratory of Human Carcinogenesis, CCR and then worked as a Clinical Instructor at the University of Maryland School of Medicine in Baltimore. He was appointed as a Tenure Track investigator at the Laboratory of Human Carcinogenesis in 2009.
Dr. H...
Source: Videocast - All Events - June 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Interferon-induced transmembrane proteins block Zika virus infection and prevent a non-apoptotic, paraptosis-like cell death pathway
We report that ZIKV induces massive vacuolization followed by “ implosive ” cell death in human epithelial cells, primary skin fibroblasts and astrocytes, a phenomenon which is exacerbated when IFITM3 levels are low. It is reminiscent of paraptosis, a caspase-independent, non-apoptotic form of cell death associated with the formation of large cytoplasmic vacuoles. We further show that ZIKV-induced vacuoles are derived from the endoplasmic reticulum (ER) and dependent on the PI3K/Akt signaling axis. Inhibiting the Sec61 ER translocon in ZIKV-infected cells blocked vacuole formation and viral production. Our results prov...
Source: Videocast - All Events - June 12, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Repetitive DNA sequences in health and disease: gift wrappings for precision medicine
NIH Director ’ s Wednesday Afternoon Lecture Series
Dr. Ramos is recognized as a leading expert in the study of gene-gene and gene-environment interactions and genomic medicine. His research program integrates diverse approaches, ranging from molecular genetics to population-based public health studies in efforts to understand the genetic and genomic basis of human disease and to advance the goals of precision medicine. Ongoing basic science studies in his laboratory focus on repetitive genetic elements in the mammalian genome and their role in genome plasticity and disease, while his clinical work focuses on the charact...
Source: Videocast - All Events - June 8, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
