RNA Methylation in Gene Expression Regulation
NCI's Center for Cancer Research (CCR) Grand Rounds
Chuan He, Ph.D., is the John T. Wilson Distinguished Service Professor in the Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics at the University of Chicago. He was born in P. R. China in 1972 and received his B.S. (1994) from the University of Science and Technology of China. He received his Ph.D. degree from Massachusetts Institute of Technology in chemistry in 2000 with Professor Stephen J. Lippard. After being trained as a Damon-Runyon postdoctoral fellow with Professor Gregory L. Verdine at Harvard Unive...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Inflammation and hematopoietic stem cell regulation
NIH Director ’ s Wednesday Afternoon Lecture Series
Blood-forming hematopoietic stem cells (HSC) usually remain quiescent until activated to respond to hematopoietic demands. Quiescence is an actively enforced state that is regulated by important bone marrow (BM) niche signals, which prevent entry into the cell cycle and suppress oxidative metabolism. In fact, HSC activation is as much a metabolic remodeling with oxidative phosphorylation (OXPHOS) activation, as a direct triggering of the cell-cycle machinery. It is now becoming clear that the most glycolytic and quiescent HSCs perform the best in transplantation experim...
Source: Videocast - All Events - February 20, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Translating from Chemistry to Clinic with Deep Learning
NLM Informatics and Data Science Lecture Series
Many medicines become toxic only after bioactivation by metabolizing enzymes. Often, metabolic enzymes transformed them into chemically reactive species, which subsequently conjugate to proteins and cause adverse events. For example, carbamazepine is epoxidized by P450 enzymes in the liver, but then conjugates to proteins, causing Stevens Johnson Syndrome in some patients. The most difficult to predict drug reactions, idiosyncratic adverse drug reactions, often depend on bioactivation. Our group has been using deep learning to model the metabolism of diverse chemicals, and th...
Source: Videocast - All Events - February 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
HPV VLPs: Nature ’ s Nanoparticles for Prevention and Treatment of Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. John Schiller graduated from the University of Wisconsin-Madison with a B.S. in molecular biology in 1975. In 1982, he received a Ph.D. from the Department of Microbiology of the University of Washington in Seattle, then joined the NCI Laboratory of Cellular Oncology as a National Research Service Award postdoctoral fellow in 1983. Dr. Schiller became a senior staff fellow in the Laboratory of Cellular Oncology in 1986 and a senior investigator in 1992. He became chief of the Neoplastic Disease Section of the lab in 1998, deputy lab chief in 2000 and designated as...
Source: Videocast - All Events - February 5, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Proteogenomics of Breast Cancer
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Matthew Ellis ’ s clinical and basic research focuses on breast cancer. He has developed neoadjuvant endocrine therapy as an alternative to chemotherapy for promoting breast-conserving therapy in postmenopausal women with ER+ HER2- stage 2 and 3 disease. He developed and validated the Ki67 proliferation marker-based Preoperative Endocrine Prognostic Index which is now undergoing a large validation study (the ALTERNATE study). These clinical studies have provided the clinical context and tumor specimens for seminal investigations into the ER+ breast cancer somatic ge...
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
The molecular logic of synapse formation in the brain
NIH Director's Wednesday Afternoon Lecture Series
Thomas S ü dhof is interested in how synapses form and function in the developing and adult brain. His work focuses on the role of synaptic cell-adhesion molecules in establishing synapses and shaping their properties, on pre- and postsynaptic mechanisms of membrane traffic, and on impairments in synapse formation and synaptic function in neuropsychiatric and neurodegenerative disorders. To address these questions, S ü dhof's laboratory employs a spectrum of approaches ranging from biophysical studies and physiological and behavioral investigations of mutant mice to analy...
Source: Videocast - All Events - January 25, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Mosquito Multipartite Interactions in the Fight Against Arboviruses
This event is a Stadtman Candidate Seminar in the field of Vector Biology presented by Dr. Jos é Luis Ramirez entitled “ Understanding Mosquito Multipartite Interactions in the Fight Against Arboviruses. ” This seminar is hosted by the Laboratory of Malaria and Vector Research (LMVR), Division of Intramural Research (DIR), NIAID.Air date: 2/2/2018 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Making the most of it: How malaria parasites use our fibrinolytic proteins to infect the mammalian host and the mosquito
This event is a Stadtman Candidate Seminar in the field of Vector Biology presented by Dr. Joel Vega-Rodr í guez entitled “ Making the most of it: How malaria parasites use our fibrinolytic proteins to infect the mammalian host and the mosquito. ” This seminar is hosted by the Laboratory of Malaria and Vector Research (LMVR), Division of Intramural Research (DIR), NIAIDAir date: 1/24/2018 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
The salivary proteins of mosquitoes: role in blood feeding and pathogen transmission
This event is a Stadtman Candidate Seminar in the field of Vector Biology presented by Dr. Eric Calvo entitled “ The salivary proteins of mosquitoes: role in blood feeding and pathogen transmission. ” This seminar is hosted by the Laboratory of Malaria and Vector Research (LMVR), Division of Intramural Research (DIR), NIAID.Air date: 1/23/2018 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Effectors versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis
Immunonology IG Seminar
Dr. Stefan Uderhardt is a post-doctoral fellow in Dr. Ronald Germain's group within the Laboratory of Systems Biology (LSB), NIAID. Stefan received his medical degree (Dr. med.) from the University of Erlangen-N ü rnberg, Germany in 2011. Early during medical school he developed a passion for immunological research, and thus spent most his spare time working on an experimental thesis on osteoimmunology in the lab of Georg Schett and Gerhard Kr ö nke, investigating the mechanisms of bone loss during inflammatory arthritis. He then started a residency in rheumatology and clinical immunology at the U...
Source: Videocast - All Events - January 19, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Single cell analysis of the effector T cell transcriptome
Immunonology IG Seminar
Dr. Thomas Ciucci is a post-doctoral fellow in Dr. R é my Bosselut ’ s group within the Laboratory of Immune Cell Biology (LICB). He received a Ph.D. in Genetics and Immunology from the University of Nice, France in 2012. His doctoral research work investigated the relationship between inflammatory immune cells, the tumor environment and bone tissue. Dr. Ciucci joined Dr. Bosselut ’ s group in 2013 to pursue his interests in the regulation of T cell responses. His research has focused on two aspects of T cell differentiation during the immune response. The first, identified a previously unrecog...
Source: Videocast - All Events - January 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Analysis of the stress response in Peromyscus
The University of South Carolina's Hippokratis Kiaris at work in his laboratory. Kiaris is principal investigator for a collaborative project involving the University of South Carolina, Claflin University and Auburn University that aims to dissect the genomic basis of stress response in ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - December 13, 2017 Category: Science Source Type: video
Dysfunction of mRNA translation and neurodegeneration
NIH Director's Wednesday Afternoon Lecture Series
Neurodegenerative disorders affect many people, particularly in the aging population. Yet the cause of these disorders is unknown for the majority of the most prevalent forms of these diseases. Dr. Ackerman ’ s laboratory focuses on identifying the mechanisms underlying neuronal homeostasis in the aging mammalian brain. Using a phenotype-driven approach, her lab has identified several novel molecular mechanisms that underlie neuron death. Recently, they have extended this unbiased approach to identify genes that modify the expressivity of the phenotype caused by primary m...
Source: Videocast - All Events - December 11, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Scientists fight cancers resistance by re-programming chromatin
Scientists have developed an effective new strategy for treating cancer, which has wiped out the disease to near completion in cellular cultures in the laboratory. The treatment works by controlling chromatin, a group of macromolecules -- including DNA, RNA and proteins -- that houses genetic ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - November 29, 2017 Category: Science Source Type: video
Joseph J. Kinyoun Memorial Lecture - Antibodies Against Ebola and Lassa: A Global Collaboration
Joseph J. Kinyoun Memorial Lecture 2017
Dr. Erica Ollmann Saphire, director of the Viral Hemorrhagic Fever Immunotherapeutic Consortium (VIC), will deliver the 2017 Joseph J. Kinyoun Memorial Lecture.
Her talk, “ Antibodies Against Ebola and Lassa: A Global Collaboration, ” will explore the features of antibodies that protect against these deadly viruses and the ongoing need for scientists to collaborate in this research to establish a complete knowledge base. During the past three years, VIC researchers from dozens of labs on five continents have studied these protective antibodies. The VIC aims to fill critical knowl...
Source: Videocast - All Events - November 27, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
