How mothers give the best and enough mitochondria
NIH Directors Seminar Series
Dr. Xu ’ s Laboratory of Molecular Genetics, Systems Biology Center, NHLBI is interested in the basic mechanism guiding the transmission of our second genome- mitochondrial DNA. Mutations in mitochondrial genome have emerged as important factors compromising human health. Although mitochondrial genome is prone to accumulating mutations due to the high spontaneous mutation frequency and a lack of repair mechanisms, the crippling mitochondrial mutation is exceedingly rare in populations. It is puzzling how mothers are able to restrict the transmission of damaging mutations to the next generatio...
Source: Videocast - All Events - October 10, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Of mice and men: what we can learn about human cancer by studying mouse models
NIH Director's Wednesday Afternoon Lecture Series
The research in Cory Abate-Shen ’ s laboratory is focused on understanding basic mechanisms of transcriptional regulation and differentiation, and how these become dysregulated in cancer. The laboratory takes a multi-disciplinary approach to investigate genitourinary malignancies, which includes using mechanism-based studies, analyses of genetically-engineered mouse models (GEMMs), and state-of-the-art systems biology approaches.For more information go tohttps://oir.nih.gov/walsAir date: 12/19/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Can you catch dementia? Insights and solutions from prion disease
NIH Director's Wednesday Afternoon Lecture Series
The Department of Neurodegenerative Disease ’ s research portfolio encompasses prion diseases (predominantly within the embedded MRC Prion Unit), Alzheimer ’ s disease and related disorders, Huntington ’ s disease, motor neurone disease and frontotemporal dementia and studies of the pathways of cellular senescence. The research philosophy is to combine basic and clinical translational research; many of the key contributions towards understanding the basic biology of these diseases have come from clinical and neuropathological observations, and efficient translation of...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Standing on the shoulders of mice: adventures in human immunology
NIH Director's Wednesday Afternoon Lecture Series
While inbred mice have been a very powerful model for analyzing the immune system, recent advances, both technological and conceptual, have begun to make direct studies of the human immune system possible. This is vitally important from a translational perspective, as mouse models of disease have not been as productive as hoped for in producing “ actionable intelligence ” with which to diagnose and treat patients. Another benefit is that human work is almost unexplored territory for immunologists in our present time, where asking basic questions often results in unexpec...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Knowledge Discovery in Clinical and Biomedical Data: Case Studies in Pediatrics and Mental Health
With the widespread adoption of electronic health records and increasing discoveries reported in biomedical literature, computational approaches are needed for further knowledge discovery and hypothesis generation. Challenges include the capture of key information within text and standardization issues, requiring use of natural language processing and data integration techniques. Clinical data mining and biomedical literature mining have been used in a range of contexts to discover disease knowledge such as comorbidities and patterns related to social, behavioral, and familial (SBF) factors. In this lecture, a series of ca...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Wednesday Afternoon Lecture Series – Special Tuesday Lecture
NIH Director's Wednesday Afternoon Lecture Series
The major interest of Dr. Hotamisligil's laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. His lab's biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.For more information go tohttps://oir.nih.gov/walsAir date: 11/13/2018 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series
NIH Directors Seminar Series
Dr. Xu ’ s Laboratory of Molecular Genetics, Systems Biology Center, NHLBI is interested in the basic mechanism guiding the transmission of our second genome- mitochondrial DNA. Mutations in mitochondrial genome have emerged as important factors compromising human health. Although mitochondrial genome is prone to accumulating mutations due to the high spontaneous mutation frequency and a lack of repair mechanisms, the crippling mitochondrial mutation is exceedingly rare in populations. It is puzzling how mothers are able to restrict the transmission of damaging mutations to the next generatio...
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - October 2018
The 15th meeting of the Frederick National Laboratory Advisory CommitteeAir date: 10/29/2018 9:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - October 9, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Eminent Lecture: The Multifaceted Function of the PD-1 Pathway
NCI Center for Cancer Research Eminent Lecture
Arlene Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women ’ s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women ’ s Hospital.
Dr. Sharpe earned h...
Source: Videocast - All Events - September 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Oregon blue clay has potential to fight MRSA, other " superbugs " in wounds
Arizona State University and Mayo Clinic researchers have found that one type of clay, Oregon blue clay, may help fight disease-causing bacteria in wounds, including treatment-resistant bacteria. In laboratory tests, the researchers found that the clay has antibacterial effects against bacteria ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - September 10, 2018 Category: Science Source Type: video
Strain improves semiconductor material performance (Image 1)
University of Connecticut undergraduate Nico Wright at work in Professor Michael Pettes' mechanical engineering laboratory. [Image 1 of 2 related images. See Image 2.]
More about this image
Researchers in the University of Connecticut's ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - August 10, 2018 Category: Science Source Type: video
20th Annual Norman P. Salzman Memorial Award and Symposium in Virology
The Dr. Norman P. Salzman Memorial Fund was established in 1999 to present the annual Norman P. Salzman Memorial Symposium and Award in Virology to an outstanding Postdoctoral Fellow, Research Fellow or Clinical Fellow working in the field of virology at the NIH, the Center for Biologics Evaluation and Research at the U.S. Food and Drug Administration or Leidos community. The Symposium and Award are hosted by the FNIH and the NIH Virology Interest Group. The symposium highlights current research of eminent extramural and NIH intramural virologists.
The Fund was established by Dr. Salzman ’ s family, colleagues and friend...
Source: Videocast - All Events - June 26, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
The ATP synthase: a gifted protein that keeps on giving
NIH Director's Seminar Series
ATP synthases produce most of the ATP that sustains living cells – that is, in a human body, over 150 pounds of ATP per day! Found in the membranes of mitochondria, chloroplasts and bacteria, these paradigmatic enzymes harness the electrochemical energy that results from nutrient metabolism or light harvesting to power a turbine-like mechanism, through which they recycle the two by-products of ATP hydrolysis, ADP and inorganic phosphate, into brand-new ATP. Dr. Faraldo-Gomez will discuss recent breakthroughs in the structural characterization of these systems at the molecular and supramolecu...
Source: Videocast - All Events - June 18, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Heterogeneity and Plasticity of CD4 T Helper (Th) and Innate Lymphoid Cell (ILC) Subsets
Immunonology IG Seminar
Dr. Jinfang Zhu received his Ph.D. in biochemistry and molecular biology from the Shanghai Institute of Biochemistry, Chinese Academy of Sciences. He completed his postdoctoral training at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, with late Dr. William E. Paul, studying CD4 T helper cell differentiation controlled by key transcription factors including GATA3 and T-bet. He started his own group in the Laboratory of Immunology as an Earl Stadtman investigator, and is now the section chief of the Molecular and Cellular Immunoregulation Section in the Laborator...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Artificial Intelligence for Oncology
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Regina Barzilay is a Professor in the Department of Electrical Engineering and Computer Science and a member of the Computer Science and Artificial Intelligence Laboratory at the Massachusetts Institute of Technology. Her research interests are in natural language processing. Currently, Dr. Barzilay is focused on bringing the power of machine learning to oncology. In collaboration with physicians and her students, Dr. Barzilay is devising deep learning models that utilize imaging, free text, and structured data to identify trends that affect early diagnosis, treatment...
Source: Videocast - All Events - June 12, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
