Translational traps: sex and aging in stroke research stroke research
NIH Wednesday Afternoon Lecture Series
Dr. McCullough ’ s research interests primarily focus on: 1) understanding sex differences in ischemic cell death 2) age related inflammation and 3) social factors in stroke recovery.
Basic molecular and animal studies in males and females have direct translational relevance, as treatments have revealed the efficacy in one sex has paradoxically shown a detrimental effect in the other sex. This is now increasingly recognized in clinical stroke populations.
Another important area of Dr. McCullough ’ s research is understanding the genetic and hormonal differences in inflammation acr...
Source: Videocast - All Events - June 6, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Accelerating Translation: Strategies for High-Throughput Drug Combination Discovery
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Craig Thomas received his B.S. from the University of Indianapolis in 1995 and received his Ph. D. from Syracuse University in 2000. Dr. Thomas then undertook post-doctoral work in the laboratories of Dr. Sidney Hecht where he earned a fellowship through the American Cancer Society. In 2003, Dr. Thomas moved to the NIH as director of the chemical biology core of the National Institute of Diabetes and Digestive and Kidney Diseases. In 2007, Dr. Thomas moved to the NIH Chemical Genomics Center. Currently, Dr. Thomas serves as the chemistry technology section group ...
Source: Videocast - All Events - June 5, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Sunset at the deepest point in Lake Superior
during the University-National Oceanographic Laboratory System chief scientist training cruise onboard the R/V Blue Heron.
More about this image
University of Minnesota Duluth's Andrew Barnard did his UNOLS chief scientist training ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 31, 2017 Category: Science Source Type: video
The plasticity and migratory responses of innate lymphoid cells: more similarity to T cells than you thought
Immunology Interest Group Seminar Series
The identification of innate lymphoid cells (ILCs) was a major step forward in developing a better understanding of host defense. Although ILC lack the capacity for antigen recognition, they show striking similarities with T cell subsets in both the transcription factors that govern their differentiation and the effector cytokines they produce. One major difference in the existing concepts of ILC and adaptive T cell responses is that the former are considered to act largely as tissue resident effectors whereas T cells migrate from secondary lymphoid tissues of activation to peripher...
Source: Videocast - All Events - May 30, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Myeloid-derived Trefoil Factor 2 (TFF2) controls epithelial regeneration at the mucosal interface
Immunology Interest Group Seminar Series
Trefoil factor proteins, an enigmatic family of mucosal cytokines, are known to promote tissue repair. Despite being discovered decades ago, not much was known until recently about how Trefoil proteins work. Dr. Herbert ’ s laboratory has discovered that these proteins regulate immune responses in allergic asthma and hookworm infection, and that they trigger the regeneration of epithelial cells.
De ’ Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania School of Veterinary Medicine. He received his B.S. in microbiology from Xavier University i...
Source: Videocast - All Events - May 17, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Abscopal Effect: Optimal Radiation Dose and Fractionation
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Formenti is the Chair of Radiation Oncology at Weill Cornell Medical College and the Associate Director of the Cancer Center. Trained as a medical and radiation oncologist she devoted her career to translate novel preclinical information to the clinic. Key to her formation was a year spent in Malcolm Mitchell ’ s laboratory at USC, in cancer immunology. Her initial research on how to best combine radiation and systemic therapy, both pre-clinically and clinically evolved on focusing on the systemic effects of radiotherapy, particularly on the immune system. Her l...
Source: Videocast - All Events - May 15, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
The Contribution of Bone to Whole Organism Physiology
GeroScience Interest Group
The Trans-NIH GeroScience Interest Group (GSIG), cordially invites you to its spring seminar, featuring Dr. Gerard Karsenty, the Paul A. Marks M.D., Professor and Chair of the Department of Genetics and Development at Columbia University Medical Center, New York City.
Dr. Karsenty's main interest is how organs interact with one another to regulate vertebrates' various physiological functions. His research focuses on bone and, through the use of genetics, he has discovered that this organ, in addition to making bone, has remarkable endocrine functions that include the regulation of insulin secreti...
Source: Videocast - All Events - May 1, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Hijacking of immune regulatory mechanisms in lymphoid malignancies
Immunology Interest Group Seminar Series
Signalling through the B cell receptor (BCR) is central to the development and maintenance of B cells. In light of the numerous proliferative and survival pathways activated downstream of the BCR, it comes as no surprise that malignant B cells would co-opt this receptor to promote their own growth and survival. However, direct evidence for BCR signalling in human lymphoma has only come to light recently. Roles for antigen-dependent and antigen-independent, or tonic, BCR signalling have now been described for several different lymphoma subtypes. Furthermore, correlative data implicat...
Source: Videocast - All Events - April 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - May 2017
The 12th meeting of the Frederick National Laboratory Advisory CommitteeAir date: 5/8/2017 8:30:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - April 5, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Prevention of Progression in Multiple Myeloma
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Irene Ghobrial is an Associate Professor at Dana-Farber Cancer Institute (DFCI), Harvard Medical School, Boston, MA and an Associate member of the Broad Institute, Cambridge, MA. She is the director of the Michele& Stephen Kirsch Laboratory and co-director of the Center for Prevention of Progression of Blood Cancers (CPOP) at DFCI. In addition, she is the co-leader of the Blood Cancer Research Partnership (BCRP), a consortium for innovative clinical trials of community oncology sites coordinated by DFCI.
Dr. Ghobrial received her medical degree from Cairo Universi...
Source: Videocast - All Events - April 3, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Strategies for Neuroprotection and Myelin Repair
NIH Neuroscience Series Seminar
Our ability to move, think, perceive, is dependent on a timely transmission of information among specialized cells called neurons. This information is sent via a series of electrical impulses that travel along specialized structures called " axons " , whose ability to conduct signal is dependent on the presence of " myelin " . Myelin is a fatty substance composed of lipids and proteins that is an integral component of a cell called " oligodendrocyte " . Oligodendrocytes are the myelin-forming cells of the CNS and are essential for brain function. Oligodendrocytes originate from neural stem c...
Source: Videocast - All Events - March 31, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Human T cells in immunity, autoimmunity and immunodeficiencies
Immunology Interest Group Seminar Series
Dr. Sallusto''s laboratory is focused on the understanding of the mechanisms that control T cell priming and regulate cytokine production and homing capacities. These questions are addressed primarily in the human system, combining the ex vivo analysis of memory T cell subsets with in vitro priming of naive T cells. This approach has led to the identification of chemokine receptors expressed in human Th17 and Th22 cells, and to the dissection of the cytokines that drive naive T cells polarization and modulate T cells effector functions. In parallel, Dr. Sallusto''s laboratory has us...
Source: Videocast - All Events - March 16, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Elucidating the regulation of antiviral immune responses in humans
Director's Seminar Series
Research in the laboratory headed by Dr. Su is aimed at understanding the molecular regulation of human immune responses in vivo. The laboratory aims to identify the genetic underpinnings of patients who have rare inherited immunodeficiencies that present with virus infections. These patients serve as " experiments of nature " who can more broadly inform us as to what is happening in the healthy immune system. Viruses of particular interest include those that infect the skin such as herpes simplex virus, as well as systemic viruses such as Epstein-Barr virus, and more recently respiratory tract vi...
Source: Videocast - All Events - March 14, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Myeloid-derived Trefoil Factor 2 (TFF2) controls epithelial regeneration at the mucosal interface
Immunology Interest Group Seminar Series
Trefoil factor proteins, an enigmatic family of mucosal cytokines, are known to promote tissue repair. Despite being discovered decades ago, not much was known until recently about how Trefoil proteins work. Dr. Herbert ’ s laboratory has discovered that these proteins regulate immune responses in allergic asthma and hookworm infection, and that they trigger the regeneration of epithelial cells.
De ’ Broski Herbert is an Associate Professor of Immunology at the University of Pennsylvania School of Veterinary Medicine. He received his B.S. in microbiology from Xavier University i...
Source: Videocast - All Events - March 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
CANCELLED - Getting to an Effective HIV Vaccine: Perspectives on Progress
DUE TO THE LIKELIHOOD OF INCLEMENT WEATHER IMPACTING THE DC METRO AREA AND THE NORTHEAST COAST, THIS LECTURE HAS BEEN POSTPONED.
James C. Hill Memorial Lecture
Virologist and vaccine expert Dr. Lawrence Corey will deliver the 2017 James C. Hill Memorial Lecture. His talk, titled “ Getting to an Effective HIV Vaccine: Perspectives on Progress, ” will review the state of HIV vaccine development and describe current strategies to advance the field.
Since 1999, Corey has served as principal investigator of the NIAID-supported HIV Vaccine Trials Network (HVTN), which is dedicated to accelerating development of a safe and ef...
Source: Videocast - All Events - March 13, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
