Human T cells in immunity, autoimmunity and immunodeficiencies
Immunology Interest Group Seminar Series
Dr. Sallusto''s laboratory is focused on the understanding of the mechanisms that control T cell priming and regulate cytokine production and homing capacities. These questions are addressed primarily in the human system, combining the ex vivo analysis of memory T cell subsets with in vitro priming of naive T cells. This approach has led to the identification of chemokine receptors expressed in human Th17 and Th22 cells, and to the dissection of the cytokines that drive naive T cells polarization and modulate T cells effector functions. In parallel, Dr. Sallusto''s laboratory has used the mouse system to address fundamental questions on the regulation of lymphocyte trafficking during inflammation and in autoimmunity. They have also developed a method for the analysis of human naive and memory CD4 and CD8 T cell repertoires based on high throughput cellular screenings of human T cell libraries. This method is currently used to dissect the human T cell response to pathogens, allergens, and self-antigens.
Federica Sallusto received the degree of Doctor in Biology from the University of Rome and performed postdoctoral training at the Istituto Superiore di Sanit à in Rome working on T cell response to allergens and at the Basel Institute for Immunology in the laboratory of Antonio Lanzavecchia on human monocyte-derived dendritic cells. In 1997 she became member of the Basel Institute and since 2000 she is group leader at the IRB. Her studi...
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