Linking TCR Signaling to Variations in Gene Expression
The control of T cell lineage development in the thymus and T cell differentiation pathways following activation are strongly influenced by T cell receptor (TCR) signaling. Yet the details of how variations in the strength of TCR stimulation produce distinct gene expression programs is poorly understood. Dr. Berg ’ s work has focused on understanding the contribution of ITK to this process. ITK is a Tec family tyrosine kinase known to modulate ‘ TCR signal strength ’ ; biochemically, ITK phosphorylates and activates the enzyme phospholipaseC- γ 1. Using a combination of transcription factor activation assays, genomi...
Source: Videocast - All Events - October 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
NIDCR Clinical Research Fellowship Grand Round: The temporomandibular Joint (TMJ)
The temporomandibular joint (TMJ) is the synovial joint of craniofacial complex and is critical for dental occlusion, mastication, and speech. TMJ trauma and diseases, such as osteoarthritis, are debilitating and compromise quality of life. Current TMJ treatments are two-fold, involving either palliative care or invasive total joint replacement surgeries. There are no minimally invasive, regenerative TMJ therapies. We have identified TMJ-specific fibrocartilage stem cells that self-organize and regenerate cartilage, fat and vascularized bone. Here we define heterogeneous populations of TMJ fibrocartilage stem cells and the...
Source: Videocast - All Events - October 9, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - October 2020
The 5th Virtual Meeting of the Frederick National Laboratory Advisory CommitteeAir date: 10/14/2020 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - September 29, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Type I interferon induction and exhaustion upon viral infection
Dr. Zuniga ’ s laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection...
Source: Videocast - All Events - September 15, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Human antibody responses to SARS-CoViD-2
NIH Director's Wednesday Afternoon Lecture Series
Annual William E. Paul Lecture – – Dr. Nussenzweig ’ s laboratory studies the molecular aspects of the immune system ’ s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses.For more information go tohttps://oir.nih.gov/wals/about-walsAir date: 1...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Translating Thought into Blood Flow in the Brain: Capillaries as Sensors of Neural Activity
NIH Director's Wednesday Afternoon Lecture Series
The Nelson laboratory ’ s research interests include elucidating the mechanisms by which cerebral blood flow is controlled to meet the diverse and ever-changing demands of active neurons and how these mechanisms are disrupted in small vessel disease (SVD) — a major cause of stroke and dementia. Dr. Nelson and colleagues have unraveled many of the major mechanisms that control cerebrovascular function, including the discovery of local calcium signals ( “ sparks ” ), which counter-intuitively oppose vasoconstriction. They have recently shown that brain capillaries ac...
Source: Videocast - All Events - September 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
The Whole Woman Seminar Series: Work, Life, and COVID: The Balancing Act of Women in Science
Meet four NIH Scientist. Learn their roles at the NIH, ways they balance work/life, How do they maintain self-care/wellness, How has COVID affected this balance. Effects of being parent or caretaker and scientist during COVID.
The panel discussion will focus on the challenges and joys of being a woman in science, and the importance of maintaining work life balance and self-care.
Moderator: Erika L. Barr, PhD Director: NIH Community College Programs& SOAR Office of Intramural Training& Education The panelists: Audrey Thurm Ph.D. Director, Neurodevelopmental and Behavioral Phenotyping Service Office of the Clinical Directo...
Source: Videocast - All Events - September 3, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Buckeye butterfly with selectively bred blue coloring
A buckeye butterfly (Junonia coenia) selectively bred to shift wing color from the typical brown coloring to blue.
[Research supported by a U.S. National Science Foundation grants DEB 1601815 and DGE 1106400.]
Learn more in the Marine Biological Laboratory news story (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 24, 2020 Category: Science Source Type: video
Buckeye butterfly (Junonia coenia)
A buckeye butterfly (Junonia coenia) with typical brown wing coloration.
[Research supported by a U.S. National Science Foundation grants DEB 1601815 and DGE 1106400.]
Learn more in the Marine Biological Laboratory news story (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 24, 2020 Category: Science Source Type: video
Underside of artificially selected blue buckeye butterfly wing scales
The underside of artificially selected blue buckeye butterfly (Junonia coenia) wing scales showing their iridescent lamina.
[Research supported by a U.S. National Science Foundation grants DEB 1601815 and DGE 1106400.]
Learn more in the Marine Biological Laboratory news story (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - July 24, 2020 Category: Science Source Type: video
Frederick National Laboratory Advisory Committee - July 2020
The 4th Virtual Meeting of the Frederick National Laboratory Advisory CommitteeAir date: 7/13/2020 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - June 19, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Sailing Close to the Breeze: Hospital Epidemiology in the COVID-19 Pandemic
NIH COVID-19 SIG Lecture Series
Dr. Palmore will discuss infection control related to COVID-19. Dr. Palmore began her career at the NIH as a staff clinician in the NIAID Laboratory of Clinical Infectious Diseases. She became deputy hospital epidemiologist in the NIH Clinical Center in 2007 and became hospital epidemiologist in 2014. As hospital epidemiologist, Dr. Palmore aims to optimize patient safety through prevention of hospital-acquired infections. Her research interests include modes of nosocomial transmission of multidrug-resistant bacteria, Clostridium difficile and antimicrobial stewardship.Air date: 5/20/2020 3:...
Source: Videocast - All Events - May 14, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee - May 2020
The 3rd Virtual Meeting of the Frederick National Laboratory Advisory CommitteeAir date: 5/21/2020 1:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 7, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
New shoes powered by Artificial Intelligence unlock the secrets of your sole.
Researchers at Stevens Institute of Technology have developed an AI-powered, smart insole that instantly turns any shoe into a portable gait-analysis laboratory. The work could benefit clinical researchers by providing a new way to precisely measure walking function in patients with movement ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - April 1, 2020 Category: Science Source Type: video
The Case for BK Polyomavirus as a Cause of Bladder Cancer
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Buck ’ s lab studies polyomaviruses. A great majority of healthy adults chronically shed
polyomavirus virions in their urine and from the surface of their skin. Although these lifelong infections generally aren't known to cause symptoms in healthy individuals, under conditions of immune impairment polyomaviruses can cause disease. For example, BK polyomavirus (BKV) causes kidney and bladder damage in organ transplant patients, while its close relative JCV causes a lethal brain disease in patients on immunosuppressive therapies and in individuals suffering from ...
Source: Videocast - All Events - March 2, 2020 Category: General Medicine Tags: Upcoming Events Source Type: video
