IIG Seminar - Type I interferon induction and exhaustion upon viral infection

Dr. Zuniga ’ s laboratory discovered that, in response to a viral infection, systemic type I interferons (IFN-I) are initially elevated but are subsequently and rapidly silenced despite continuous pathogen replication. They showed that there is an IFN-I refractory (or exhaustion) phase, during which the infected host fails to elevate IFN-I upon secondary unrelated infections, explaining delayed viral control and enhanced susceptibility to opportunistic infections. Dr. Zuniga will present their recent work on the mechanisms underlying the initial IFN-I elevation and its subsequent, rapid, suppression after viral infection.For more information go tohttps://www.niaid.nih.gov/research/immunology-interest-groupAir date: 9/23/2020 4:15:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video