Clinical Center Grand Rounds: How Nucleic Acid Structure and Chromatin Environment Influence Gene Transcription
How Nucleic Acid Structure and Chromatin Environment Influence Gene Transcription
Jason Watts, MD, PhD
Earl Stadtman Investigator
Epigenetics& Stem Cell Biology Laboratory
Transcriptional Responses in Disease Group
National Institute of Environmental Health Sciences, NIEHSFor more information go tohttps://clinicalcenter.nih.gov/about/news/grcurrent.htmlAir date: 2/22/2023 12:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - February 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds - Personalized Cellular Therapy for Cancer
CCR Grand Rounds
Antoni Ribas, M.D., Ph.D. is Professor of Medicine, Professor of Surgery, and Professor of Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA), Director of the Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC), Director of the Parker Inst itute for Cancer Immunotherapy (PICI) Center at UCLA. Dr Ribas is a physician-scientist who conducts laboratory and clinical research in malignant melanoma, focusing on gene engineered T cells, PD-1 blockade and BRAF targeted therapies.
His National Cancer Institute (NCI), State of California and fo undation-sup...
Source: Videocast - All Events - February 2, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG: The diversity of neutrophils
Dr. Hidalgo is interested in the cellular and molecular mechanisms by which innate immune cells and their hematopoietic precursors contribute to organismal physiology and pathology. As a postdoctoral trainee he developed and used live imaging modalities to study acute inflammatory disease and discovered the receptors that mediate early neutrophil recruitment, and the signals that cause acute vascular injury. As an independent researcher at CNIC (Spain), his laboratory further developed tools to study thrombo-inflammation and the dramatic consequences in several organs, including the lung, brain and heart. The Hidalgo lab d...
Source: Videocast - All Events - January 27, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
CCR Grand Rounds
“ Personalized Celular Therapy for Cancer ”
Antoni Ribas, M.D., Ph.D.
PROFESSOR OF MEDICINE WITH TENURE
PROFESSOR OF SURGERY
PROFESSOR OF MOLECULAR AND MEDICAL PHARMACOLOGY
UNIVERSITY OF CALIFORNIA LOS ANGELES (UCLA)
Friday, February 3, 2023
12:00 – 1:00 p.m.
Lipsett Amphitheater
(Masks required)
Also available to view via NIH Videocast.
Antoni Ribas, M.D., Ph.D. is Professor of Medicine, Professor of Surgery, and Professor of Molecular and Medical Pharmacology at the University of California Los Angeles (UCLA), Director of the Tumor Immunology Program at the Jonsson Com prehensive Cancer Center (JCCC), D...
Source: Videocast - All Events - January 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Modeling Vaccine Responses and Tumor Immunity Using Lymph Nodes and Microfluidics
Predicting the response of the immune system to a new vaccine, immunotherapy, or infection remains a grand challenge of biomedical science. Current models of immunity largely rely
on in vivo animal studies that are difficult to control and analyze over time, or simple in vitro cultures that lack the spatial organization and cell-cell interactions of the body. Here, I will
share our laboratory ’ s development of technology to model immunity outside the body. By combining intact, live cultures of ex vivo lymph node tissue with microfluidic devices, we can
test the impact of localized drug delivery or the effect of cocul...
Source: Videocast - All Events - January 13, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The diversity of neutrophils.
Dr. Hidalgo is interested in the cellular and molecular mechanisms by which innate immune cells and their hematopoietic precursors contribute to organismal physiology and pathology. As a postdoctoral trainee he developed and used live imaging modalities to study acute inflammatory disease and discovered the receptors that mediate early neutrophil recruitment, and the signals that cause acute vascular injury. As an independent researcher at CNIC (Spain), his laboratory further developed tools to study thrombo-inflammation and the dramatic consequences in several organs, including the lung, brain and heart. The Hidalgo lab d...
Source: Videocast - All Events - January 10, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
IIG Seminar - Tissue-Resident Memory T cells in cancer.
The Mami-Choua ï b laboratory has identified several constitutive elements of the tumor environment (TME) involved in the regulation of antitumor T-cell response. In particular: the influence of TGF- β on the expression and signaling of CD103 in CD8+ resident memory T cells (TRM), and the role of this integrin to sustain specific cytotoxicity and to promote T-cell recruitment within epithelial tumor regions; the role of hypoxia, epithelial-mesenchymal transition (EMT) and p53 in controlling tumor cell susceptibility to T-cell-mediated killing; and the effect of Von Hippel-Lindau (VHL) gene mutations in promoting PD-L1 ex...
Source: Videocast - All Events - January 9, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH-FDA Immunology Interest Group Seminar
All immune system cells develop from a common hematopoietic stem cell (HSC) whose differentiation pathway is controlled in part by the activation and repression of lineage specific gene programs. Our laboratory is interested in understanding how these transcriptional programs are wired and how alterations in these pathways lead to disease such as autoimmunity, asthma and acute leukemia. ID2 and ID3 control the development and effector fate of innate lymphoid cells including NK cells, ILCs and NKT cells. Our laboratory has focused on understanding how ID protein expression is regulated in innate lymphoid cells and how the t...
Source: Videocast - All Events - December 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Combination Immunotherapy in HPV Associated Malignancies and Other Solid Tumors
CCR Grand Rounds
Dr. Strauss received his M.D. from Stony Brook University Medical Center School of Medicine in 2010 and completed his internal medicine residency at Montefiore Medical Center in 2013. He joined the NCI Medical Oncology Service as a Medical Oncology Fellow in 2013. Dr. Strauss was the Co-Director o f the Clinical Trials Group of the Laboratory of Tumor Immunology and Biology, NCI. He is currently the Clinical Director of CIO Combination Immunotherapy Group. He is board certified in medical oncology and internal medicine. Dr. Strauss was part of the larger effort of the Laboratory of Tumor Immu nology and B...
Source: Videocast - All Events - November 17, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Sex-specific in vitro models of aortic valve stenosis
Cardiovascular disease is the leading cause of death in both men and women, yet our mechanistic knowledge of the sex-specific molecular and cellular mechanisms that guide cardiovascular disease progression, particularly in women, remain poorly characterized. Studies evaluating disease mechanisms rarely state the sex of cells used for in vitro studies or are performed primarily in male animal models, causing our gap in knowledge. My laboratory uses precision biomaterials as in vitro and in vivo tools to dissect mechanisms that contribute to sexual dimorphisms in cardiovascular diseases, specifically aortic valve stenosis. I...
Source: Videocast - All Events - November 8, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
2022 Stephen E. Straus Lecture: From the Mouths of Babes: What Can Research on Babies, Moms, Stress, and Substance Use Tell Us About Resilience?
Stress and adversity experienced during early development can exert a profound and persistent imprint on our physiology, brain, and health across the lifespan. This imprint can lead to long-term health outcomes ranging from substance use and depression to obesity and cardiovascular disease. There is also emerging evidence that stress and adversity may be transmitted from one generation to the next. However, protective experiences may prevent or mitigate these effects.
This lecture will provide examples of findings from Dr. Laura Stroud ’ s laboratory focused on revealing the earliest intergenerational transmission of mat...
Source: Videocast - All Events - October 12, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
FDA Investigational Device Exemptions (IDE): Overview and Application to Research Involving Magnetic Resonance Imaging
On October 6, 2022, the Office of Human Subjects Research Protections (OHSRP) Education Series will present “ FDA Investigational Device Exemptions (IDE): Overview and Application to Research Involving Magnetic Resonance Imaging. ” Our speakers will be Drs. Alan Koretsky, William Pritchard, and Laura Reoma. Dr. Koretsky is the NINDS Chief of the Laboratory of Functional and Molecular Imaging and Director of the NIH MRI Research Facility. Dr. Pritchard works in the NIH Center for Interventional Oncology and formerly served as a medical officer in FDA ’ s CDRH. Dr. Reoma is the Director of the NINDS Clinical Trials Un...
Source: Videocast - All Events - October 4, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC) - October 2022
This is an NCI advisory board meetingAir date: 10/12/2022 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - September 21, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Frederick National Laboratory Advisory Committee (FNLAC)
This is an NCI advisory board meetingAir date: 10/12/2022 11:00:00 AM (Source: Videocast - All Events)
Source: Videocast - All Events - September 20, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases
NIH Director ’ s Wednesday Afternoon Lecture Series
Astute Clinician Lecture
Dr. Holland received his M.D. from the Johns Hopkins University School of Medicine in 1983, where he stayed as a resident in internal medicine, assistant chief of service in medicine, and fellow in infectious diseases. He came to the National Institutes of Health in 1989 as a National Research Cou ncil fellow in the Laboratory of Molecular Microbiology, working on transcriptional regulation of HIV. In 1991, Dr. Holland joined the Laboratory of Host Defenses, shifting his research to the host side, with a focus on phagocyte defects and their ass...
Source: Videocast - All Events - August 29, 2022 Category: General Medicine Tags: Upcoming Events Source Type: video
