Dynamic Organelle Shape and Function During Herpesvirus Infection
" The research of our laboratory is at the interface between virology and proteomics. We are studying cellular mechanisms used in defense against viruses, as well as mechanisms used by viruses to inhibit or hijack host cell processes. For these studies, we use multidisciplinary approaches, integrating molecular virology, microscopy, mass spectrometry-based proteomics, and bioinformatics. We have developed a series of proteomics-based approaches for characterizing cellular processes occurring during the progression of viral infections, and we are exploring several areas of interest. "For more information go tohttps://oir.ni...
Source: Videocast - All Events - November 29, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Genomic Basis of Breast Cancer Progression in Blacks
This is the annual Marshall W. Nirenberg Lecture. Speaker Olufunmilayo I. Olopade the consummate physician-scientist with sustained and impactful translational research in genetics that spans more than two decades. She is a pioneer in cancer genetics whose body of work has focused on the molecular genetics of breast cancer progression. Her seminal contributions have provided an understanding of the root causes of aggressive breast cancer in young women, especially young women of African ancestry across the Diaspora. Her laboratory was the first to describe recurrent BRCA1 mutations in extended African American families wit...
Source: Videocast - All Events - November 27, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Toward Personalizing HIV Treatment and Prevention
This is the annual Rolla E. Dyer Lecture. Speaker Namandje Bumpus's laboratory uses mass spectrometry and molecular pharmacology based approaches to investigate the biotransformation of clinically used drugs by the cytochromes P450s. The cytochromes P450 are responsible for the metabolism of an estimated 75 percent of currently marketed drugs. Cytochrome P450-mediated biotransformation of drugs most often results in the production of hydrophilic metabolites that can be readily excreted from the body; however, in certain instances toxic metabolites are formed that can stimulate cell death and organ failure.For more informat...
Source: Videocast - All Events - November 26, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Tiny Technologies and Medicine: From Hepatic Tissue Engineering to Cancer Nanotechnology
This is a special Tuesday WALS Lecture, part of Demystifying Medicine. The speaker is Sangeeta Bhatia: " Our laboratory conducts research at the intersection of engineering, medicine, and biology to develop novel platforms for understanding, diagnosing and treating human disease. Our long-term goals are to improve cellular therapies for liver disease and to develop nanotechnology for the diagnosis and treatment of cancer. "For more information go tohttps://oir.nih.gov/walsAir date: 3/22/2022 3:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - November 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Evolving Adaptive Reproductive Capacity: A Systems Approach Using Drosophila Models
The Extavour laboratory is interested in understanding early embryonic development, the genes that control this development, the evolutionary origins of these genes and how their functions have changed over evolutionary time. The lab is particularly interested in the development and evolution of reproductive systems, including both germ cells, which are cells that make eggs and sperm in sexually reproducing animals, and somatic gonad cells, which create the structures to house and protect the germ cells, and regulate egg and sperm production.For more information go tohttps://oir.nih.gov/walsAir date: 2/16/2022 3:00:00 PM (...
Source: Videocast - All Events - November 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
RNA Splicing, Chromatin Modification, and the Coordinated Control of Gene Expression
This is an NIH Director's Lecture. Speaker Tracy Johnson ’ s research program is focused on understanding the mechanisms of gene regulation, particularly RNA processing and chromatin modification. She developed the University of California, Los Angeles/Howard Hughes Medical Institute Pathways to Success program, a comprehensive strategy to provide students with an authentic research experience early in their academic careers while creating a rigorous, but supportive learning community. Johnson ’ s program has three key components: a research-based laboratory course called The Collaborative Undergraduate Research Lab (C...
Source: Videocast - All Events - November 24, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Molecular Medicine in the War on Cancer: Success or Failure?
Office of NIH History Lecture Series
A virologist is among the luckiest of biologists because he can see into his chosen pet down to the details of all of its molecules. ” --David Baltimore, 1975. Accepting his Nobel Prize for his part in the identification of reverse transcriptase, David Baltimore reflected on the “ luck ” that virologists enjoyed in their ability to see into problems with molecular precision. Although this vision seems inspiring and compelling today, Baltimore spoke at a time of fierce debate among biologists, legislators, and clinicians as to what, if anything, this molecular approach to disease o...
Source: Videocast - All Events - November 22, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
The History of Cancer Virus Research
This is a continuation of the Office of NIH History Lecture Series.
Speaker Robin Wolfe Scheffler, Associate Professor in the Science, Technology, and Society Program, is an historian of the modern biological and biomedical sciences and their intersections with developments in American history. He is currently working on a project that follows the history of cancer virus research in the twentieth century from legislature to laboratory, documenting its origins and impact on the modern biological sciences. His other projects include the history of the biotechnology industry and a chemical biography of dioxins. The common g...
Source: Videocast - All Events - November 12, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NEI AGI Seminar: Human iPSC-derived 3D retinal tissue for stem cell-based therapies for retinal degenerative diseases
Dr. Canto-Soler completed her Ph.D. in Biomedical Sciences at Austral University in Argentina and a postdoctoral fellowship at the Wilmer Eye Institute, Johns Hopkins University. She joined the Wilmer faculty as a research associate in 2006 and was promoted to assistant professor in 2008. In July 2017 she joined the Department of Ophthalmology at the University of Colorado School of Medicine as the Doni Solich Family Chair in Ocular Stem Cell Research and the Director of CellSight – the Ocular Stem Cell and Regeneration Research Program. Over the years she has received several national and international awards including ...
Source: Videocast - All Events - November 10, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Psoriasis as a Model to Study Inflammation and Cardiometabolic Diseases in Humans
NIH Director's Seminar Series
Inflammation is critical to atherosclerosis initiation, progression and complications. The goal of The Laboratory of Inflammation and Cardiometabolic Diseases, NHLBI, is to understand how chronic systemic inflammation drives development of cardiometabolic diseases in humans. Dr. Mehta ’ s research program has utilized psoriasis, a chronic inflammatory skin disease, as a model to probe inflammatory, lipid and metabolic pathways associated with atherosclerosis progression. In 2012, Dr. Mehta founded the Psoriasis Atherosclerosis Cardiometabolic Initiative (PACI) at the NHLBI Intramural Program...
Source: Videocast - All Events - October 19, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Dynamic Organelle Shape and Function During Herpesvirus Infection
Speaker Ileana M. Cristea's research of our laboratory is at the interface between virology and proteomics. We are studying cellular mechanisms used in defense against viruses, as well as mechanisms used by viruses to inhibit or hijack host cell processes. For these studies, we use multidisciplinary approaches, integrating molecular virology, microscopy, mass spectrometry-based proteomics, and bioinformatics. We have developed a series of proteomics-based approaches for characterizing cellular processes occurring during the progression of viral infections, and we are exploring several areas of interest.For more information...
Source: Videocast - All Events - October 15, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: Psoriasis as a Model to Study Inflammation and Cardiometabolic Diseases in Humans
Inflammation is critical to atherosclerosis initiation, progression and complications. The goal of The Laboratory of Inflammation and Cardiometabolic Diseases, NHLBI, is to understand how chronic systemic inflammation drives development of cardiometabolic diseases in humans. Dr. Mehta ’ s research program has utilized psoriasis, a chronic inflammatory skin disease, as a model to probe inflammatory, lipid and metabolic pathways associated with atherosclerosis progression. In 2012, Dr. Mehta founded the Psoriasis Atherosclerosis Cardiometabolic Initiative (PACI) at the NHLBI Intramural Program when he was awarded the Inaug...
Source: Videocast - All Events - October 7, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Engineering Human Tissues for Medical Impact
The newly established Biomedical Engineering Scientific Interest Group (BMESIG) is launching a seminar series, to start on Tuesday, Oct. 12 at 1 p.m. with a lecture by Dr. Gordana Vunjak-Novakovic, director of the Laboratory for Stem Cells and Tissue Engineering at Columbia University.
The inaugural speaker Vunjak-Novakovic has pioneered the use of stem cell engineering to grow tissue. Working primarily in the field of temporomandibular joint (TMJ) disorders, Vunjak-Novakovic ’ s lab has successfully grown bone grafts that match a patient ’ s original jawbone for facial reconstruction surgery to repair injuries, disea...
Source: Videocast - All Events - October 4, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
COVID-19 Scientific Interest Group: Human Antibody Response to SARS-CoV-2 Infection and Vaccination
COVID-19 Scientific Interest Group
Michel C. Nussenzweig is the Zanvil A. Cohn and Ralph M. Steinman Professor and Investigator, Howard Hughes Medical Institute. The Nussenzweig ’ s laboratory studies the molecular aspects of the immune system ’ s innate and adaptive responses using a combination of biochemistry, molecular biology, and genetics. For work on adaptive immunity, he focuses on B lymphocytes and antibodies to HIV-1, while his studies of innate immunity focus on dendritic cells. His work is leading to new antibody-based therapies for infections by HIV and the novel SARS-CoV-2 coronavirus, among other viruses...
Source: Videocast - All Events - September 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
Acute Severe COVID-19 and Multisystem Inflammatory Syndrome in U.S. Children and Adolescents
Speaker Adrienne G. Randolph is Senior Associate, Critical Care Medicine at Boston Children's Hospital and Professor of Anaesthesia and Pediatrics, Harvard Medical School. The Randolph Lab studies the immunobiology of critical illness in children with a focus on life-threatening and fatal infections and acute lung injury. Her long-term goal is to identify new diagnostic tests and therapies that could restore health more rapidly and decrease morbidity and mortality. Her laboratory focuses on clinical-translational research in the areas of the immune response of pediatric patients with acute respiratory distress syndrome and...
Source: Videocast - All Events - September 23, 2021 Category: General Medicine Tags: Upcoming Events Source Type: video
