CCR Eminent Lecture: The Multifaceted Function of the PD-1 Pathway

NCI Center for Cancer Research Eminent Lecture Arlene Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women ’ s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women ’ s Hospital. Dr. Sharpe earned her A.B. from Harvard University and her M.D. and Ph.D. degrees from Harvard Medical School. She completed residency training in Pathology at Brigham and Women ’ s Hospital and is board certified in Anatomic Pathology. Dr. Sharpe has served as a member and chair of the NIH Hypersensitivity, Autoimmunity and Immune-mediated diseases (HAI) study section and is currently a member of NIAID Council. She also served as President of the American Association of Immunologists from 2016-2017. Dr. Sharpe is a leader in the field of T-cell costimulation. Her laboratory has discovered and elucidated the functions of T-cell costimulatory pathways, including the immunoinhibitory functions of the CTLA-4 and PD-1 pathways, which have become exceptionally promising targets for cancer immunotherapy. Her laboratory currently focuses on the roles of T-cell costimulatory pathway...
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