NEI Audacious Goals: Cytoplasmic material exchange between sensory neurons in vivo

Dr. Wallace is Director of Vision Sciences and Chair of the Vision Science Research Program at the Toronto Western Research Institute/University Health Network. She holds appointments in the Departments of Ophthalmology and Vision Sciences and Laboratory Medicine and Pathobiology, University of Toronto. A molecular and developmental biologist by training, she is recognized for her work on the role of Hedgehog signaling in neural progenitor proliferation in the central nervous system. Her lab is now applying this knowledge towards investigating the role of morphogen signaling in tumorigenesis and the development of cell-based approaches for the treatment of blinding eye diseases. Her talk is titled " Cytoplasmic material exchange between sensory neurons in vivo " . The National Eye Institute's Audacious Goals Initiative (AGI)for Regenerative Medicine in Vision is stimulating the development of new therapies for vision loss and blindness. With continued support and guidance through the National Eye Institute, it aims to regenerate the light-sensitive retina and its connections to the brain. Dr. Valerie Wallace will present her soon to be published work that will discuss new strategies for reversing vision loss.Air date: 3/3/2020 10:00:00 AM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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Conclusions: We have reported three new cases with pathogenic variants in PEX6 presenting with milder forms of the Zellweger spectrum disorders (ZSD). The three cases showed distinct clinical features. Thus, expanding the phenotypic spectrum of PBDs and ascertaining exome sequencing is an effective strategy for an accurate diagnosis of clinically overlapping and genetically heterogeneous disorders such as deafness-blindness association. PMID: 32214787 [PubMed - in process]
Source: Molecular Vision - Category: Molecular Biology Tags: Mol Vis Source Type: research
This study investigated the effects of human umbilical-cord mesenchymal stem cells (HUMSCs) injection on diabetic rat model. The results show that the level of MIAT is significantly decreased in the diabetic retina after the injection of HUMSCs. Moreover, HUMSCs can significantly decrease the expression of IL-1β and IL-6 mRNA; alleviate microvascular permeability, and upregulate Occludin expression. Studies have shown that MIAT knockdown could alleviate diabetes-induced inflammation responses and vascular leakage. Furthermore, our findings also showed that the expression of MIAT was positively correlated with the expr...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
ConclusionUse of these recommendations may yield more effective DR screening programs that reduce the risk of vision loss worldwide.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
ConclusionsPhysical and mental health components contribute  equally to the HRQOL of rehabilitated soldiers with permanent limb disabilty. Their poorer HRQOL was determined by certain person- and injury-related factors. These need to be addressed during re-integration and post-rehabilitation services.
Source: Quality of Life Research - Category: Health Management Source Type: research
The transient receptor potential vanilloid member 1 (TRPV1) in the central nervous system may contribute to homeostatic plasticity by regulating intracellular Ca2+, which becomes unbalanced in age-related neurodegenerative diseases, including Alzheimer’s and Huntington’s. Glaucomatous optic neuropathy – the world’s leading cause of irreversible blindness – involves progressive degeneration of retinal ganglion cell (RGC) axons in the optic nerve through sensitivity to stress related to intraocular pressure (IOP). In models of glaucoma, genetic deletion of TRPV1 (Trpv1–/–) accelerate...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusions: Here we report the first autosomal dominant congenital cataract variant p.(R130C) in LIM2, causing a non-syndromic pulverulent and nuclear phenotype in European families. PMID: 32202185 [PubMed - as supplied by publisher]
Source: Ophthalmic Genetics - Category: Opthalmology Tags: Ophthalmic Genet Source Type: research
Horm Metab Res 2020; 52: 142-148 DOI: 10.1055/a-1107-2943Diabetic retinopathy (DR), a serious microvascular complication of diabetes, is a leading cause of blindness in adults. The pathogenesis of DR involves a variety of tissues and complex mechanisms, such as inflammation, oxidative stress, optic neurodegeneration, and autophagy. Nowadays, microRNAs (miRNAs), a novel group of non-coding small RNAs, have been extensively studied and recognized to play a key role in the pathogenesis of DR through aforementioned pathways. Furthermore, some miRNAs have been proposed as biomarkers tha...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Review Source Type: research
Juvenile idiopathic arthritis-associated uveitis (JIA-U) is a serious condition associated with the risk of blindness. However, pediatric rheumatologists rarely encounter cases of blindness, because most patie...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Case Report Source Type: research
Abstract Retinoblastomas represent 6% of all malignant tumors in children under 5 years old, which untreated lead to blindness in the affected eye and death due to metastases. The main symptoms are leukocoria and strabismus, which if possible, always necessitate a clarification within 1 week for exclusion of a retinoblastoma. The most frequent differential diagnoses are Coats' disease and persistent fetal vasculature (PFV) as well as other intraocular tumors, in particular astrocytomas. Systemic chemotherapy, if necessary in combination with laser hyperthermia, local chemotherapy and brachytherapy are the most imp...
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
Authors: Yamamoto-Rodríguez L, Zarbin MA, Casaroli-Marano RP Abstract Age-related macular degeneration (AMD) involves progressive degeneration of the central retina, termed the macula, which provides high-acuity vision needed to recognize faces, drive, etc. AMD is the leading cause of blindness in the aging population. A plethora of paradigm-shifting perspectives regarding AMD's multifaceted pathophysiology is emerging. This review will endeavor to gather novel insights and attempts to identify translational implications and new areas of research. The concept of aberrant inflammation being at the center of a...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
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