Poly-Aneuploid Cancer Cells: Actuators of Cancer Resistance

NCI ’ s Center for Cancer Research (CCR) Grand Rounds Dr. Pienta is a Professor of Urology, Oncology, Pharmacology and Molecular Sciences and Chemical and Biomolecular Engineering as well an American Cancer Society Clinical Research Professor. Between 1995 and 2013, Dr. Pienta served as the Director of the Prostate Specialized Program of Research Excellence (SPORE) at the University of Michigan and has served as co-PI of the Johns Hopkins Prostate SPORE from 2013-2018. He has a proven, peer-reviewed track record in organizing and administering a translational research program that successfully incorporates bench research, agent development and clinical application. Dr. Pienta has made major contributions in understanding prostate cancer biology and metastasis as well as improving diagnosis and treatment, including: (i) applying cooperation and ecologic theories to understanding cancer biology; (ii) understanding that metastatic prostate cancer cells mimic hematopoietic stems cells to establish in the bone marrow ’ (iii) developing one of the first successful therapies for castrate-resistant prostate cancer with estramustine and etoposide; (iv) developing circulating tumor cells as an FDA – approved test for monitoring prostate cancer therapy; (v) developing the FACT-P, the most widely used quality of life instrument for prostate cancer clinical trials; and (vi) contributing to the development of the clinical application of integrated sequencing for individualized cancer...
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