NIH Director's Seminar - Phantoms in the transcriptome: post-transcriptional mRNA regulation through DNA and RNA modifications

NIH Director's Seminar Series Research in Dr. Oberdoerffer ’ s laboratory broadly examines how DNA and RNA epigenetics dynamically regulate gene expression. They ask how methylation of cytidine in DNA affects pre-mRNA splicing decisions, and how subsequent acetylation of cytidine in processed mRNA affects translation. They use a variety of tools to investigate the enzymatic regulation of cytidine modifications and the net impact at target genes and genome-wide. Current efforts in the laboratory are focused on developing methods to achieve base-resolution analysis of the modification landscape in single cells.Air date: 2/28/2020 12:00:00 PM
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