Navigating the challenges: a case report on managing a complicated postpartum course in type 3 von Willebrand disease with alloantibodies
CONCLUSION: The current case emphasizes the postpartum clinical challenges of patients with type 3 VWD and alloantibodies. It underscores the potential role of emicizumab in maintaining hemostatic control.PMID:38689620 | PMC:PMC11058073 | DOI:10.1016/j.rpth.2024.102399 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 1, 2024 Category: Hematology Authors: Konrad van der Zwet Karin P M van Galen Annemiek C C Evers Kathelijn Fischer Roger E G Schutgens Lize F D van Vulpen Source Type: research
Predictive performance of pharmacokinetic-guided prophylactic dosing of factor concentrates in hemophilia A and B
CONCLUSION: PK-guided dosing was reliable according to post hoc analyses, based on low absolute errors that were regarded as clinically irrelevant in most cases. The predefined predictive performance was achieved in mid and peak factor levels but not in trough factor levels due to measurement inaccuracy. PK guidance also seemed feasible.PMID:38689619 | PMC:PMC11058079 | DOI:10.1016/j.rpth.2024.102397 (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - May 1, 2024 Category: Hematology Authors: Tine M H J Goedhart Laura H Bukkems Anne-Fleur Zwagemaker Michiel Coppens Karin Fijnvandraat Saskia E M Schols Roger E G Schutgens Jeroen Eikenboom Floor C J I Heubel-Moenen Paula F Ypma Laurens Nieuwenhuizen Karina Meijer Frank W G Leebeek Ron A A Math à Source Type: research
Protection from bleeds during physical activity in people with haemophilia: the role of factor levels: a response to Nogami et al. (2023)
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03785-1. Online ahead of print.NO ABSTRACTPMID:38691311 | DOI:10.1007/s12185-024-03785-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Olav Versloot J van der Net K Fischer Source Type: research
Positive anti-nuclear antibody in patients with polyclonal hypergammaglobulinemia suggests the presence of multiple distinct comorbidities
Conclusion These results establish a previously underappreciated unique immunological state of multimorbidity in PHGG and indicate that the gamma-globulin levels and ANAs could serve as markers for the clinical assessment of comorbidities in PHGG.PMID:38692914 | DOI:10.2169/internalmedicine.3594-24 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yasutaka Masuda Ken Morita Mineo Kurokawa Source Type: research
Publisher Correction: Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis
Pediatr Res. 2024 Apr 30. doi: 10.1038/s41390-024-03176-6. Online ahead of print.NO ABSTRACTPMID:38693279 | DOI:10.1038/s41390-024-03176-6 (Source: Pediatric Research)
Source: Pediatric Research - May 1, 2024 Category: Pediatrics Authors: Qingqi Chong Zhiru Wang Ting Guo Liaoran Zhang Li Lu Cheng Cai Xiaohui Gong Zhibao Lv Qingfeng Sheng Source Type: research
Evolution of natural killer cell-targeted therapy for acute myeloid leukemia
Int J Hematol. 2024 May 1. doi: 10.1007/s12185-024-03778-0. Online ahead of print.ABSTRACTIn hematologic oncology, acute myeloid leukemia (AML) presents a significant challenge due to its complex genetic landscape and resistance to conventional therapies. Despite advances in treatment, including intensive chemotherapy and hematopoietic stem cell transplantation (HSCT), the prognosis for many patients with AML remains poor. Recently, immunotherapy has emerged as a promising approach to improve outcomes by augmenting existing treatments. Natural killer (NK) cells, a subset of innate lymphoid cells, have garnered attention fo...
Source: International Journal of Hematology - May 1, 2024 Category: Hematology Authors: Yuta Kaito Yoichi Imai Source Type: research
High CD34-positive cell dose in matched unrelated donor allogeneic hematopoietic stem cell transplant is not associated with graft-versus-host disease or mortality
DISCUSSION: We found no difference in survival, relapse, or GVHD incidence or severity in patients receiving CD34+ doses above prior cutoffs reported in the literature. These data do not support the routine use of graft CD34+ dose reduction.PMID:38693089 | DOI:10.1111/trf.17864 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Zachary M Avigan Ajoy L Dias Laura E Dodge Jon E Arnason Robin M Joyce Jessica Liegel Jacalyn Rosenblatt Matthew J Weinstock David E Avigan Richard L Haspel Source Type: research
The Effect of Glycyrrhizin on the Viability and Proliferation of Dental Pulp Stem Cells Compared to Intracanal Medicaments
CONCLUSION: Based upon the potential of GA on DPSCs proliferation compared with Ca(OH)2 and TAP, It is conceivable to acknowledge that GA could be used as an intracanal medicaments for revascularization process of necrotic immature teeth.CLINICAL SIGNIFICANCE: This study emphasizes the significance of assessing alternative root canal medicaments and their impact on the proliferation and viability of DPSCs. The results regarding GA, specifically its impact on the viability and growth of DPSCs, provide essential understanding for its potential application as an intracanal medicine. This study adds to the continuous endeavors...
Source: J Contemp Dent Pract - May 1, 2024 Category: Dentistry Authors: Mohammad A Alrashidi Manal F Badawi Mohamed G Elbeltagy Amany E Badr Source Type: research
The roles of epigenetic regulation in graft-versus-host disease
Biomed Pharmacother. 2024 Apr 30;175:116652. doi: 10.1016/j.biopha.2024.116652. Online ahead of print.ABSTRACTAllogeneic hematopoietic stem cell transplantation (aHSCT) is utilized as a potential curative treatment for various hematologic malignancies. However, graft-versus-host disease (GVHD) post-aHSCT is a severe complication that significantly impacts patients' quality of life and overall survival, becoming a major cause of non-relapse mortality. In recent years, the association between epigenetics and GVHD has garnered increasing attention. Epigenetics focuses on studying mechanisms that affect gene expression without...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2024 Category: Drugs & Pharmacology Authors: Yimin Wang Qi Liu Lei Deng Xiting Ma Yuling Gong Yifei Wang Fang Zhou Source Type: research
Brentuximab Vedotin Plus Ibrutinib in Relapsed and Refractory Hodgkin Lymphoma
DISCUSSION: The combination of BV and ibrutinib was active in r/r HL; however, given significant toxicity, it cannot be recommended for future development.PMID:38693037 | DOI:10.1016/j.clml.2024.03.013 (Source: Clinical Lymphoma and Myeloma)
Source: Clinical Lymphoma and Myeloma - May 1, 2024 Category: Cancer & Oncology Authors: Matthew Mei Ni-Chun Tsai Joycelynne Palmer Saro Armenian Robert Chen Steven Rosen Stephen Forman Leslie Popplewell Larry Kwak Peter Martin Kami Maddocks David Bond Alex F Herrera Source Type: research
The PI3K signaling pathway; from normal lymphopoiesis to lymphoid malignancies
Expert Rev Anticancer Ther. 2024 May 1. doi: 10.1080/14737140.2024.2350629. Online ahead of print.ABSTRACTINTRODUCTION: As a vital mechanism of survival, lymphopoiesis requires the collaboration of different signaling molecules to orchestrate each step of cell development and maturation. The PI3K pathway is considerably involved in the maturation of lymphatic cells and therefore, its dysregulation can immensely affect human well-being and cause some of the most prevalent malignancies. As a result, studies that investigate this pathway could pave the way for a better understanding of the lymphopoiesis mechanisms, the undesi...
Source: Expert Review of Anticancer Therapy - May 1, 2024 Category: Cancer & Oncology Authors: Bahareh Kashani Zahra Zandi Atieh Pourbagheri-Sigaroodi Amir-Mohammad Yousefi Seyed H Ghaffari Davood Bashash Source Type: research
Comparative impact of replacing fish meal with azolla on growth, water quality, and physiology of red tilapia fingerlings at varying salinities
In conclusion, this study recommends the utilization of azolla at inclusion levels ranging from 20 to 40%, as it has the potential to nota bly enhance the immune system and elevate the survival rate of RTF. (Source: Journal of Animal Physiology and Animal Nutrition)
Source: Journal of Animal Physiology and Animal Nutrition - May 1, 2024 Category: Zoology Authors: Ghada R. Sallam,
Amr M. Helal,
Hafez A. H. Mabrouk,
Andrew H. F. G. Hermina,
Yusuf J. Habib,
Walied M. Fayed,
Serge Dossou,
Mohammed F. El Basuini,
Akram I. Shehata Tags: ORIGINAL ARTICLE Source Type: research
The potential and promise for clinical application of adoptive T cell therapy in cancer
Adoptive cell therapy has revolutionized cancer treatment, especially for hematologic malignancies. T cells are the most extensively utilized cells in adoptive cell therapy. Currently, tumor-infiltrating lymph... (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - May 1, 2024 Category: Research Authors: Yinqi Li, Yeteng Zheng, Taiqing Liu, Chuanyun Liao, Guobo Shen and Zhiyao He Tags: Review Source Type: research
ChatGPT ’s ability to generate realistic experimental images poses a new challenge to academic integrity
The rapid advancements in large language models (LLMs) such as ChatGPT have raised concerns about their potential impact on academic integrity. While initial concerns focused on ChatGPT ’s writing capabilities,... (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - May 1, 2024 Category: Hematology Authors: Lingxuan Zhu, Yancheng Lai, Weiming Mou, Haoran Zhang, Anqi Lin, Chang Qi, Tao Yang, Liling Xu, Jian Zhang and Peng Luo Tags: Correspondence Source Type: research
The Comparative Effect of Plasma Exosomes of Young and Old People on the Expression of BCL-2 and BAX Genes in Hematopoietic Stem Cells
AbstractApoptosis may disrupt differentiation of hematopoietic stem cells (HSCs), which can affect aging. Thus, the main goal of this study was to compare the effect of plasma exosomes from young and old people on the expression of Bcl-2-associated X (BAX) and B-cell lymphoma 2 (BCL-2) genes in the HSCs. Plasma samples were acquired from four elderly adults and four younger adults, referring to Blood Transfusion Organization of Tehran-Iran during August 2022 – September 2022.Then, the exosomes of the samples were extracted and analyzed using DLS, TEM, and CD63 surface marker. HSCs were isolated from umbilical cord blood ...
Source: Indian Journal of Hematology and Blood Transfusion - May 1, 2024 Category: Hematology Source Type: research
