Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
J Leukoc Biol. 2024 May 3:qiae100. doi: 10.1093/jleuko/qiae100. Online ahead of print.ABSTRACTEosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinophils are now known for their role in adipocyte beiging, adipokine secretion, and adipose tissue inflammation. This intricate interaction involves complex immune and metabolic processes, carrying significant implications for systemic metabolic health. Importantly, the interplay between eosinophils ...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Nana-Fatima Haruna Sergejs Berdnikovs Zhenying Nie Source Type: research
The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils
J Leukoc Biol. 2024 May 3:qiae105. doi: 10.1093/jleuko/qiae105. Online ahead of print.ABSTRACTIntestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-activated transcription factor that responds to dietary or environmental ligands. AHR regulates tissue adaptation, survival, adhesion, and immune functions in intestinal eosinophils. The AHR repressor (AHRR) is itself induced by AHR and believed to limit AHR activity in a negative feedback loop. We analysed gene expression in intestinal eosinophils from WT and AHRR-KO mice and found that AHRR did not suppress most AHR-dependent g...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Heike Weighardt Michael Shapiro Michelle Mayer Irmgard F örster Brigitta Stockinger Nicola Laura Diny Source Type: research
Validation of a Simplified Model for Subarachnoid Hemorrhage in Mice
CONCLUSIONS: This simplified model of SAH elicits pathological changes consistent with those described for more complex models in the literature. Therefore, it can be used in future preclinical studies examining the pathophysiology of SAH and novel treatment options.PMID:38701138 | DOI:10.3233/CH-231997 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 3, 2024 Category: Hematology Authors: Sophie Tanner Juan Zhou Bashir Bietar Christian Lehmann Source Type: research
The first Japanese case with familial combined hypolipidemia without any complications caused by loss-of function variants in < em > ANGPTL3 < /em > : Case report
Heliyon. 2024 Apr 21;10(8):e29924. doi: 10.1016/j.heliyon.2024.e29924. eCollection 2024 Apr 30.ABSTRACTFamilial combined hypolipidemia, previously known as Familial hypobetalipoproteinemia 2 (FHBL2) is considered as an extremely rare recessive disease. Here, we present the case of familial combined hypolipidemia with homozygous loss-of function (LOF) variants in angiopoietin-like protein 3 (ANGPTL3) ((NM_014495.4) c.439_442del (p.Thr146_Asn147insTer)) using panel sequencing (46 yr male whose LDL cholesterol = 34 mg/dL). The serum level of ANGPTL3 was quite low (undetectable). Despite of extreme decreasing LDL cholesterol, ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Hayato Tada Nobuko Kojima Masa-Aki Kawashiri Masayuki Takamura Source Type: research
Cancer stem-like cells in uveal melanoma: Novel insights and therapeutic implications
Biochim Biophys Acta Rev Cancer. 2024 May 1:189104. doi: 10.1016/j.bbcan.2024.189104. Online ahead of print.ABSTRACTUveal melanoma (UM) is the most common primary ocular tumor in the adult population. Even though these primary tumors are successfully treated in 90% of cases, almost 50% of patients ultimately develop metastasis, mainly in the liver, via hematological dissemination, with a median survival spanning from 6 to 12 months after diagnosis. In this context, chemotherapy regimens and molecular targeted therapies have demonstrated poor response rates and failed to improve survival. Among the multiple reasons for ther...
Source: Biochimica et Biophysica Acta - May 3, 2024 Category: Biochemistry Authors: Alessandra Loda Francesco Semeraro Silvia Parolini Roberto Ronca Sara Rezzola Source Type: research
Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina
Res Pract Thromb Haemost. 2024 Apr 3;8(3):102395. doi: 10.1016/j.rpth.2024.102395. eCollection 2024 Mar.ABSTRACTThe University of North Carolina Symposia on Hemostasis began in 2002, with The First Symposium on Hemostasis with a Special Focus on FVIIa and Tissue Factor. They have occurred biannually since and have maintained the primary goal of establishing a forum for the sharing of outstanding advances made in the basic sciences of hemostasis. The 2024 11th Symposium on Hemostasis will bring together leading scientists from around the globe to present and discuss the latest research related to coagulation factors and pla...
Source: Thrombosis and Haemostasis - May 3, 2024 Category: Hematology Authors: Maria Aleman Gowthami M Arepally Trevor Baglin Lorena Buitrago Pavel Davizon-Castillo Sanjana Dayal Matthew J Flick Gloria Gerber Yohei Hisada Krasimir Kolev Ana O'Loghlen Alireza R Rezaie Erica M Sparkenbaugh Evi X Stavrou Bet ül Ünlü Gregory M Vercel Source Type: research
Validation of a Simplified Model for Subarachnoid Hemorrhage in Mice
CONCLUSIONS: This simplified model of SAH elicits pathological changes consistent with those described for more complex models in the literature. Therefore, it can be used in future preclinical studies examining the pathophysiology of SAH and novel treatment options.PMID:38701138 | DOI:10.3233/CH-231997 (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - May 3, 2024 Category: Hematology Authors: Sophie Tanner Juan Zhou Bashir Bietar Christian Lehmann Source Type: research
The aryl hydrocarbon receptor (AHR) repressor limits expression of antimicrobial genes but not AHR-dependent genes in intestinal eosinophils
J Leukoc Biol. 2024 May 3:qiae105. doi: 10.1093/jleuko/qiae105. Online ahead of print.ABSTRACTIntestinal eosinophils express the aryl hydrocarbon receptor (AHR), an environmental sensor and ligand-activated transcription factor that responds to dietary or environmental ligands. AHR regulates tissue adaptation, survival, adhesion, and immune functions in intestinal eosinophils. The AHR repressor (AHRR) is itself induced by AHR and believed to limit AHR activity in a negative feedback loop. We analysed gene expression in intestinal eosinophils from WT and AHRR-KO mice and found that AHRR did not suppress most AHR-dependent g...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Heike Weighardt Michael Shapiro Michelle Mayer Irmgard F örster Brigitta Stockinger Nicola Laura Diny Source Type: research
Eosinophil biology from the standpoint of metabolism: implications for metabolic disorders and asthma
J Leukoc Biol. 2024 May 3:qiae100. doi: 10.1093/jleuko/qiae100. Online ahead of print.ABSTRACTEosinophils, recognized for their immune and remodeling functions and participation in allergic inflammation, have recently garnered attention due to their impact on host metabolism, especially in the regulation of adipose tissue. Eosinophils are now known for their role in adipocyte beiging, adipokine secretion, and adipose tissue inflammation. This intricate interaction involves complex immune and metabolic processes, carrying significant implications for systemic metabolic health. Importantly, the interplay between eosinophils ...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Nana-Fatima Haruna Sergejs Berdnikovs Zhenying Nie Source Type: research
Emerging evidence of context-dependent synapse elimination by phagocytes in the CNS
J Leukoc Biol. 2024 May 3:qiae098. doi: 10.1093/jleuko/qiae098. Online ahead of print.ABSTRACTPrecise synapse elimination is essential for the establishment of a fully developed neural circuit during brain development and higher function in adult brain. Beyond immune and nutrition support, recent groundbreaking studies have revealed that phagocytic microglia and astrocytes can actively and selectively eliminate synapses in normal and diseased brains, thereby mediating synapse loss and maintaining circuit homeostasis. Multiple lines of evidence indicate that the mechanisms of synapse elimination by phagocytic glia are not u...
Source: Journal of Leukocyte Biology - May 3, 2024 Category: Hematology Authors: Fang-Shuai Shen Cui Liu Hui-Zhe Sun Xin-Yi Chen Yan Xue Lei Chen Source Type: research
Highly sensitive detection of Epstein-Barr virus-infected cells by EBER flow FISH
Int J Hematol. 2024 May 3. doi: 10.1007/s12185-024-03786-0. Online ahead of print.ABSTRACTWhen Epstein-Barr virus (EBV) infection is suspected, identification of infected cells is important to understand the pathogenesis, determinine the treatment strategy, and predict the prognosis. We used the PrimeFlow™ RNA Assay Kit with a probe to detect EBV-encoded small RNAs (EBERs) and multiple surface markers, to identify EBV-infected cells by flow cytometry. We analyzed a total of 24 patients [11 with chronic active EBV disease (CAEBV), 3 with hydroa vacciniforme lymphoproliferative disorder, 2 with X-linked lymphoproliferative...
Source: International Journal of Hematology - May 3, 2024 Category: Hematology Authors: Dan Tomomasa Kay Tanita Yuriko Hiruma Akihiro Hoshino Ko Kudo Shohei Azumi Mitsutaka Shiota Masayoshi Yamaoka Katsuhide Eguchi Masataka Ishimura Yuka Tanaka Keiji Iwatsuki Keisuke Okuno Asahito Hama Ken-Ichi Sakamoto Takashi Taga Kimitoshi Goto Haruka Ota Source Type: research
The first Japanese case with familial combined hypolipidemia without any complications caused by loss-of function variants in < em > ANGPTL3 < /em > : Case report
Heliyon. 2024 Apr 21;10(8):e29924. doi: 10.1016/j.heliyon.2024.e29924. eCollection 2024 Apr 30.ABSTRACTFamilial combined hypolipidemia, previously known as Familial hypobetalipoproteinemia 2 (FHBL2) is considered as an extremely rare recessive disease. Here, we present the case of familial combined hypolipidemia with homozygous loss-of function (LOF) variants in angiopoietin-like protein 3 (ANGPTL3) ((NM_014495.4) c.439_442del (p.Thr146_Asn147insTer)) using panel sequencing (46 yr male whose LDL cholesterol = 34 mg/dL). The serum level of ANGPTL3 was quite low (undetectable). Despite of extreme decreasing LDL cholesterol, ...
Source: Atherosclerosis - May 3, 2024 Category: Cardiology Authors: Hayato Tada Nobuko Kojima Masa-Aki Kawashiri Masayuki Takamura Source Type: research
Malignancies of the Upper Gastrointestinal Tract
HEMATOLOGY/ONCOLOGY CLINICS OF NORTH AMERICA (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - May 3, 2024 Category: Cancer & Oncology Authors: David H. Ilson Source Type: research
Copyright
ELSEVIER (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - May 3, 2024 Category: Cancer & Oncology Source Type: research
Contributors
GEORGE P. CANELLOS, MD (Source: Hematology/Oncology Clinics of North America)
Source: Hematology/Oncology Clinics of North America - May 3, 2024 Category: Cancer & Oncology Source Type: research
