A cold case of hemolytic disease of the fetus and newborn resolved by genomic sequencing and population studies to define a new antigen in the Rh system
CONCLUSION: This antibody was of clinical significance, resulting in a mild to moderate hemolytic disease of the fetus and newborn (HDFN). In the past, the cause of such HDFN cases may have remained unresolved. Genomic sequencing combined with population studies now assists in resolving such cases. Further population studies have potential to inform the need to design population-specific red cell antibody typing panels for antibody screening in the Australian population.PMID:38686705 | DOI:10.1111/trf.17205 (Source: Transfusion)
Source: Transfusion - April 30, 2024 Category: Hematology Authors: Brett Wilson Candice L Davison Genghis H Lopez Glenda M Millard Yew-Wah Liew Tanya Powley Tamika Campbell Sudhir S Jadhao Shivashankar H Nagaraj Maree Perry Eileen V Roulis Maree Toombs David O Irving Robert L Flower Catherine A Hyland Source Type: research
Clinical features of immature leukemias in children
Int J Hematol. 2024 Apr 30. doi: 10.1007/s12185-024-03771-7. Online ahead of print.ABSTRACTEarly T-cell precursor acute lymphoblastic leukemia (ETP-ALL), mixed phenotypic acute leukemia (MPAL), and acute myeloid leukemia with minimal differentiation (AML-M0) all originate from immature hematopoietic progenitor cells and have a poor prognosis. We investigated the clinical characteristics of these immature leukemias in 17 children (ETP-ALL: 8, MPAL: 5, AML-M0: 4) at seven institutions. Clinical and laboratory findings were comparable across disease types. Eleven and six patients received ALL- and AML-oriented induction chemo...
Source: International Journal of Hematology - April 30, 2024 Category: Hematology Authors: Daichi Sajiki Nao Yoshida Hideki Muramatsu Kimiyoshi Sakaguchi Naoko Maeda Norifumi Yokoyama Yuji Miyajima Makito Tanaka Yoshiyuki Takahashi Asahito Hama Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy
CONCLUSION: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.PMID:38685733 | DOI:10.3348/kjr.2023.0985 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Yubo Guo Xiao Li Yajuan Gao Kaini Shen Lu Lin Jian Wang Jian Cao Zhuoli Zhang Ke Wan Xi Yang Zhou Yucheng Chen Long Jiang Zhang Jian Li Yining Wang Source Type: research
Predicting Amputation Rates in Acute Limb Ischemia: Is the Neutrophil-Lymphocyte Ratio a Reliable Indicator?
Conclusions Based on our findings, the main factor affecting the need for amputation in ALI patients was the symptom-to-door time. Biochemical and hematological parameters had no effect on amputation in ALI.PMID:38686104 | PMC:PMC11057397 | DOI:10.7759/cureus.59253 (Source: Atherosclerosis)
Source: Atherosclerosis - April 30, 2024 Category: Cardiology Authors: Mehmet Emir Erol İsa Civelek Sertan Ozyalcin Deniz Sarp Beyazp ınar Ozer Kandemir Source Type: research
Hepatic artery infusion chemotherapy with systemic capecitabine and camrelizumab for treating unresectable hilar cholangiocarcinoma: An initial investigation of efficacy and safety
CONCLUSION: HAIC sequentially combined with systemic capecitabine chemotherapy and a programmed death-1 inhibitor displayed favorable effects for unresectable HCCA, with controllable adverse reactions.PMID:38687927 | DOI:10.4103/jcrt.jcrt_1549_23 (Source: Cancer Control)
Source: Cancer Control - April 30, 2024 Category: Cancer & Oncology Authors: Long Li Song Liu Qingdong Wang Yanhua Wang Guangji Yu Source Type: research
Letermovir primary cytomegalovirus prophylaxis in allogeneic hematopoietic cell transplant recipients: could infection and disease no longer be a significant problem?
Conclusions: LET primary prophylaxis proved effective in preventing cs-CMVi and CMVd and reducing hospitalizations in allo-HCT adults. Blips can occur during prophylaxis and do not require LET discontinuation.Keywords: letermovir; cytomegalovirus; hematopoietic cell transplantation. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Fabian Herrera Source Type: research
Beyond silence: evolving ultrasound strategies in the battle against cardiovascular thrombotic challenges
AbstractCardiovascular thrombotic events have long been a perplexing factor in clinical settings, influencing patient prognoses significantly. Ultrasound-mediated acoustic therapy, an innovative thrombolytic treatment method known for its high efficiency, non-invasiveness, safety, and convenience, has demonstrated promising potential for clinical applications and has gradually become a focal point in cardiovascular thrombotic disease research. The current challenge lies in the technical complexities of preparing ultrasound-responsive carriers with thrombus-targeting capabilities and high thrombolytic efficiency. Additional...
Source: Journal of Thrombosis and Thrombolysis - April 30, 2024 Category: Hematology Source Type: research
Limb Ischemic Necrosis Secondary to Microvascular Thrombosis: A Brief Historical Review
Semin Thromb Hemost DOI: 10.1055/s-0044-1786356Ischemic limb injury can be broadly classified into arterial (absent pulses) and venous/microvascular (detectable pulses); the latter can be divided into two overlapping disorders—venous limb gangrene (VLG) and symmetrical peripheral gangrene (SPG). Both VLG and SPG feature predominant acral (distal) extremity ischemic necrosis, although in some instances, concomitant nonacral ischemia/skin necrosis occurs. Historically, for coagulopathic disorders with prominent nonacral ischemic necrosis, clinician-scientists implicated depletion of natural anticoagulants, especially invol...
Source: Seminars in Thrombosis and Hemostasis - April 30, 2024 Category: Hematology Authors: Warkentin, Theodore E. Tags: Review Article Source Type: research
Blood Rheology and Hemodynamics: Still Illuminating after 20 Years
Semin Thromb Hemost DOI: 10.1055/s-0044-1786357 Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents | Full text (Source: Seminars in Thrombosis and Hemostasis)
Source: Seminars in Thrombosis and Hemostasis - April 30, 2024 Category: Hematology Authors: Simmonds, Michael J. Meiselman, Herbert J. Detterich, Jon A. Tags: Commentary Source Type: research
Oral anticoagulants and cognitive impairment in patients with atrial fibrillation: A systematic review with meta-analysis and trial sequential analysis
This systematic review assesses the likelihood of developing dementia and cognitive impairment in patients with atrial fibrillation (AF) receiving non-vitamin K antagonist oral anticoagulants (NOACs) as opposed to vitamin K antagonists (VKAs). (Source: Thrombosis Research)
Source: Thrombosis Research - April 30, 2024 Category: Hematology Authors: Kun-Han Lee, Jiunn-Tyng Yeh, Meng-Lun Wu, Wan-Yu Yeh, Gregory Y.H. Lip, Chern-En Chiang, Chen-Huan Chen, Hao-Min Cheng Source Type: research
Targeting myeloma essential genes using NOT Gated CAR T-cells, a computational approach
Leukemia, Published online: 30 April 2024; doi:10.1038/s41375-024-02247-1Targeting myeloma essential genes using NOT Gated CAR T-cells, a computational approach (Source: Leukemia)
Source: Leukemia - April 30, 2024 Category: Hematology Authors: Ieuan G. Walker James P. Roy Georgina S. F. Anderson Jose Guerrero Lopez Michael A. Chapman Source Type: research
Evaluation of VTE-PREDICT risk score in patients receiving low-dose DOACs for venous thromboembolism (VTE) secondary prophylaxis
(Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Alessandro Lagan à, Giovanni Manfredi Assanto, Mauro Passucci, Cristina Santoro, Antonio Chistolini Source Type: research
Ebv-related lymphoproliferative diseases: a review in light of new classifications
This article summarizes the current evidence for EBV-associated LPDs in the light of the upcoming World Health Organization classification and the 2022 ICC classification.Keywords: Epstein Barr Virus: EBV, Lymphoma; Lymphoproliferative Diseases.WHO Classification. (Source: Mediterranean Journal of Hematology and Infectious Diseases)
Source: Mediterranean Journal of Hematology and Infectious Diseases - April 30, 2024 Category: Hematology Authors: Pietro Tralongo, Arianna Bakacs, Luigi Maria Larocca Source Type: research
Impact of Early Cytomegalovirus Reactivation after Allogeneic Hematopoietic Stem Cell Transplantation on Relapse in Patients with Myelodysplastic Syndrome: A Nationwide Retrospective Study from Adult Myelodysplastic Syndrome Working Group of the JSTCT
Cytomegalovirus (CMV) reactivation is a well-recognized major complication associated with morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).1-5 Although different prophylactic and pre-emptive approaches have been developed to manage CMV reactivation in allogeneic HSCT recipients, several studies still emphasized the negative association between CMV reactivation and various post-transplant outcomes, including non-relapse mortality caused by infectious complications or graft-versus-host disease (GVHD) and overall survival. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - April 30, 2024 Category: Hematology Authors: Tatsuya Konishi, Kensuke Matsuda, Hidehiro Itonaga, Noriko Doki, Tetsuya Nishida, Ken-ichi Matsuoka, Takashi Ikeda, Yoshinobu Kanda, Takahiro Fukuda, Junya Kanda, Hirohisa Nakamae, Kazunori Imada, Yasunori Ueda, Tatsuo Ichinohe, Yoshiko Atsuta, Ken Ishiya Source Type: research
