Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making
Leukemia, Published online: 09 March 2020; doi:10.1038/s41375-020-0791-3Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making (Source: Leukemia)
Source: Leukemia - March 9, 2020 Category: Hematology Authors: Si-Ye Chen Yong Yang Shu-Nan Qi Ying Wang Chen Hu Xia He Li-Ling Zhang Gang Wu Bao-Lin Qu Li-Ting Qian Xiao-Rong Hou Fu-Quan Zhang Xue-Ying Qiao Hua Wang Gao-Feng Li Yu-Jing Zhang Yuan Zhu Jian-Zhong Cao Sheng-Min Lan Jun-Xin Wu Tao Wu Su-Yu Zhu Mei Shi L Source Type: research

UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy
Leukemia, Published online: 09 March 2020; doi:10.1038/s41375-020-0784-2UGT1A1 genotype influences clinical outcome in patients with intermediate-risk acute myeloid leukemia treated with cytarabine-based chemotherapy (Source: Leukemia)
Source: Leukemia - March 9, 2020 Category: Hematology Authors: Johana D íaz-Santa Roc ío Rodríguez-Romanos Gemma Osca Marta Pratcorona Ana Garrido Rosa Coll Carla Moret Lourdes Escoda Mar Tormo Inma Heras Montse Arnan Susanna Vives Olga Salamero Nat àlia Lloveras Joan Bargay Ant ònia Sampol David Cruz Antoni Gar Source Type: research

Selective targeting of α4β1 integrin attenuates murine graft versus host disease
Leukemia, Published online: 09 March 2020; doi:10.1038/s41375-020-0786-0Selective targeting of α4β1 integrin attenuates murine graft versus host disease (Source: Leukemia)
Source: Leukemia - March 9, 2020 Category: Hematology Authors: Bader Alahmari Matthew L. Cooper Kiran Vij Julie Ritchey Peter Ruminski Feng Gao Jaebok Choi John F. DiPersio Source Type: research

Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids
Leukemia, Published online: 09 March 2020; doi:10.1038/s41375-020-0790-4Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids (Source: Leukemia)
Source: Leukemia - March 9, 2020 Category: Hematology Authors: Daniela Hernandez Laura Palau Kelly Norsworthy Nicole M. Anders Salvador Alonso Meng Su Martin Petkovich Rosh Chandraratna Michelle A. Rudek B. Douglas Smith Richard J. Jones Gabriel Ghiaur Source Type: research

Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia
Leukemia, Published online: 06 March 2020; doi:10.1038/s41375-020-0782-4Correction: Evaluation of ERK as a therapeutic target in acute myelogenous leukemia (Source: Leukemia)
Source: Leukemia - March 6, 2020 Category: Hematology Authors: Ellen Weisberg Chengcheng Meng Abigail Case Martin Sattler Hong L. Tiv Prafulla C. Gokhale Sara Buhrlage Jinhua Wang Nathanael Gray Richard Stone Suiyang Liu Shripad V. Bhagwat Ramon V. Tiu Sophia Adamia James D. Griffin Source Type: research

Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL
Leukemia, Published online: 05 March 2020; doi:10.1038/s41375-020-0766-4Targeting of inflammatory pathways with R2CHOP in high-risk DLBCL (Source: Leukemia)
Source: Leukemia - March 5, 2020 Category: Hematology Authors: Keenan T. Hartert Kerstin Wenzl Jordan E. Krull Michelle Manske Vivekananda Sarangi Yan Asmann Melissa C. Larson Matthew J. Maurer Susan Slager William R. Macon Rebecca L. King Andrew L. Feldman Anita K. Gandhi Brian K. Link Thomas M. Habermann Zhi-Zhang Source Type: research

Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study
Leukemia, Published online: 04 March 2020; doi:10.1038/s41375-020-0783-3Management of hyperleukocytosis and impact of leukapheresis among patients with acute myeloid leukemia (AML) on short- and long-term clinical outcomes: a large, retrospective, multicenter, international study (Source: Leukemia)
Source: Leukemia - March 4, 2020 Category: Hematology Authors: Maximilian Stahl Rory M. Shallis Wei Wei Pau Montesinos Etienne Lengline Judith Neukirchen Vijaya R. Bhatt Mikkael A. Sekeres Amir T. Fathi Heiko Konig Selina Luger Irum Khan Gail J. Roboz Thomas Cluzeau David Mart ínez-Cuadron Emmanuel Raffoux Ulrich Ge Source Type: research

Should persons with acute myeloid leukemia (AML) in 1st histological complete remission who are measurable residual disease (MRD) test positive receive an allotransplant?
Leukemia, Published online: 04 March 2020; doi:10.1038/s41375-020-0780-6Should persons with acute myeloid leukemia (AML) in 1st histological complete remission who are measurable residual disease (MRD) test positive receive an allotransplant? (Source: Leukemia)
Source: Leukemia - March 4, 2020 Category: Hematology Authors: Adriano Venditti Robert Peter Gale Francesco Buccisano Gert Ossenkoppele Source Type: research

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia
Leukemia, Published online: 03 March 2020; doi:10.1038/s41375-020-0776-2European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia (Source: Leukemia)
Source: Leukemia - March 3, 2020 Category: Hematology Authors: A. Hochhaus M. Baccarani R. T. Silver C. Schiffer J. F. Apperley F. Cervantes R. E. Clark J. E. Cortes M. W. Deininger F. Guilhot H. Hjorth-Hansen T. P. Hughes J. J. W. M. Janssen H. M. Kantarjian D. W. Kim R. A. Larson J. H. Lipton F. X. Mahon J. Mayer F Source Type: research

Pharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment
Leukemia, Published online: 03 March 2020; doi:10.1038/s41375-020-0787-zPharmacological activation of nitric oxide signaling promotes human hematopoietic stem cell homing and engraftment (Source: Leukemia)
Source: Leukemia - March 3, 2020 Category: Hematology Authors: Danhua Xu Min Yang Maegan Capitano Bin Guo Sheng Liu Jun Wan Hal E. Broxmeyer Xinxin Huang Source Type: research

Correction: Role of growth arrest-specific gene 6-mer axis in multiple myeloma
Leukemia, Published online: 03 March 2020; doi:10.1038/s41375-020-0781-5Correction: Role of growth arrest-specific gene 6-mer axis in multiple myeloma (Source: Leukemia)
Source: Leukemia - March 3, 2020 Category: Hematology Authors: J. S. Waizenegger I. Ben-Batalla N. Weinhold T. Meissner M. Wroblewski M. Janning K. Riecken M. Binder D. Atanackovic H. Taipaleenmaeki D. Schewe S. Sawall V. Gensch M. Cubas-Cordova A. Seckinger W. Fiedler E. Hesse N. Kr öger B. Fehse D. Hose B. Klein M Source Type: research

Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing
Leukemia, Published online: 03 March 2020; doi:10.1038/s41375-020-0762-8Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing (Source: Leukemia)
Source: Leukemia - March 3, 2020 Category: Hematology Authors: Wibowo Arindrarto Daniel M. Borr às Ruben A. L. de Groen Redmar R. van den Berg Irene J. Locher Saskia A. M. E. van Diessen Rosalie van der Holst Edith D. van der Meijden M. Willy Honders Rick H. de Leeuw Wina Verlaat Inge Jedema Wilma G. M. Kroes Jeroen Source Type: research

Comprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia
Leukemia, Published online: 03 March 2020; doi:10.1038/s41375-020-0779-zComprehensive genomic characterization of gene therapy-induced T-cell acute lymphoblastic leukemia (Source: Leukemia)
Source: Leukemia - March 3, 2020 Category: Hematology Authors: Peter Horak Sebastian Uhrig Maximilian Witzel Irene Gil-Farina Barbara Hutter Tim Rath Laura Gieldon Gnana Prakash Balasubramanian Xavier Pastor Christoph E. Heilig Daniela Richter Evelin Schr öck Claudia R. Ball Benedikt Brors Christian J. Braun Michael Source Type: research

Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis
Leukemia, Published online: 02 March 2020; doi:10.1038/s41375-020-0785-1Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis (Source: Leukemia)
Source: Leukemia - March 2, 2020 Category: Hematology Authors: Vishesh Sarin Katharine Yu Ian D. Ferguson Olivia Gugliemini Matthew A. Nix Byron Hann Marina Sirota Arun P. Wiita Source Type: research

The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK− anaplastic large cell lymphoma by regulating the DNA helicase HELLS
Leukemia, Published online: 02 March 2020; doi:10.1038/s41375-020-0754-8The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK− anaplastic large cell lymphoma by regulating the DNA helicase HELLS (Source: Leukemia)
Source: Leukemia - March 2, 2020 Category: Hematology Authors: Valentina Fragliasso Akanksha Verma Gloria Manzotti Annalisa Tameni Rohan Bareja Tayla B. Heavican Javeed Iqbal Rui Wang Danilo Fiore Valentina Mularoni Wing C. Chan Priscillia Lhoumaud Jane Skok Eleonora Zanetti Francesco Merli Alessia Ciarrocchi Oliver Source Type: research

CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm
Leukemia, Published online: 28 February 2020; doi:10.1038/s41375-020-0777-1CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm (Source: Leukemia)
Source: Leukemia - February 28, 2020 Category: Hematology Authors: Elodie B ôle-Richard Maxime Fredon Sabeha Biichl é Fran çois Anna Jean-Marie Certoux Florian Renosi Fr édéric Tsé Chlo é Molimard S éverine Valmary-Degano Aliz ée Jenvrin Walid Warda Jean-Ren é Pallandre Francis Bonnefoy Margaux Poussard Marina Source Type: research

miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk
Leukemia, Published online: 27 February 2020; doi:10.1038/s41375-020-0767-3miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk (Source: Leukemia)
Source: Leukemia - February 27, 2020 Category: Hematology Authors: F. Ferrer-Mar ín A. B. Arroyo B. Bellosillo E. J. Cuenca L. Zamora J. M. Hern ández-Rivas J. C. Hern ández-Boluda C. Fernandez-Rodriguez E. Lu ño C. Garc ía Hernandez A. Kerguelen D. V. Fiallo-Su árez M. T. G ómez-Casares R. Ayala P. V élez C. Boq Source Type: research

Serial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy
Leukemia, Published online: 26 February 2020; doi:10.1038/s41375-020-0760-xSerial evaluation of CD19 surface expression in pediatric B-cell malignancies following CD19-targeted therapy (Source: Leukemia)
Source: Leukemia - February 26, 2020 Category: Hematology Authors: Diane Libert Constance M. Yuan Katherine E. Masih Pallavi Galera Dalia Salem Haneen Shalabi Bonnie Yates Cindy Delbrook Jack F. Shern Terry J. Fry Javed Khan Maryalice Stetler-Stevenson Nirali N. Shah Source Type: research

T(6;14)(q25;q32) involves BCL11B and is highly associated with mixed-phenotype acute leukemia, T/myeloid
Leukemia, Published online: 25 February 2020; doi:10.1038/s41375-020-0761-9T(6;14)(q25;q32) involves BCL11B and is highly associated with mixed-phenotype acute leukemia, T/myeloid (Source: Leukemia)
Source: Leukemia - February 25, 2020 Category: Hematology Authors: Wei Wang Hannah Beird Caleb Jonathan Kroll Shimin Hu Carlos E. Bueso-Ramos Hong Fang Guilin Tang Zhenya Tang Feng Wang Koichi Takahashi M. James You Joseph D. Khoury L. Jeffrey Medeiros P. Andrew Futreal Source Type: research

A phase 1/2 study of ruxolitinib and decitabine in patients with post-myeloproliferative neoplasm acute myeloid leukemia
Leukemia, Published online: 25 February 2020; doi:10.1038/s41375-020-0778-0A phase 1/2 study of ruxolitinib and decitabine in patients with post-myeloproliferative neoplasm acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 25, 2020 Category: Hematology Authors: Prithviraj Bose Srdan Verstovsek Jorge E. Cortes Susan Tse Yvonne Gasior Nitin Jain Elias J. Jabbour Zeev Estrov Yesid Alvarado Courtney D. DiNardo Naveen Pemmaraju Steven M. Kornblau Tapan M. Kadia Naval G. Daver Kiran Naqvi Nicholas J. Short Lucia Masar Source Type: research

Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine
Leukemia, Published online: 25 February 2020; doi:10.1038/s41375-020-0772-6Reinstated p53 response and high anti-T-cell leukemia activity by the novel alkylating deacetylase inhibitor tinostamustine (Source: Leukemia)
Source: Leukemia - February 25, 2020 Category: Hematology Authors: S. P ützer L. Varghese J. von Jan T. Braun A. K. Giri P. Mayer N. Riet S. Timonen S. Oberbeck H. Kuusanm äki S. Mustjoki M.-H. Stern T. Aittokallio S. Newrzela A. Schrader M. Herling Source Type: research

Inhibition of LSD1 in MDS progenitors restores differentiation of CD141Hi conventional dendritic cells
Leukemia, Published online: 25 February 2020; doi:10.1038/s41375-020-0765-5Inhibition of LSD1 in MDS progenitors restores differentiation of CD141Hi conventional dendritic cells (Source: Leukemia)
Source: Leukemia - February 25, 2020 Category: Hematology Authors: Pragya Srivastava Stephanie L. Tzetzo Eduardo Cortes Gomez Kevin H. Eng Sheila N. Jani Sait Joseph B. Kuechle Prashant K. Singh Kitty De Jong Kyle R. Wiatrowski Jennifer Peresie Ava Dimitroff Miranda L. Lynch Jianmin Wang Scott I. Abrams Elizabeth A. Grif Source Type: research

Identifying IGH disease clones for MRD monitoring in childhood B-cell acute lymphoblastic leukemia using RNA-Seq
Leukemia, Published online: 25 February 2020; doi:10.1038/s41375-020-0774-4Identifying IGH disease clones for MRD monitoring in childhood B-cell acute lymphoblastic leukemia using RNA-Seq (Source: Leukemia)
Source: Leukemia - February 25, 2020 Category: Hematology Authors: Zhenhua Li Nan Jiang Evelyn Huizi Lim Winnie Hui Ni Chin Yi Lu Kean Hui Chiew Shirley Kow Yin Kham Wentao Yang Thuan Chong Quah Hai Peng Lin Ah Moy Tan Hany Ariffin Jun J. Yang Allen Eng-Juh Yeoh Source Type: research

Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0764-6Simultaneous kinase inhibition with ibrutinib and BCL2 inhibition with venetoclax offers a therapeutic strategy for acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Christopher A. Eide Stephen E. Kurtz Andy Kaempf Nicola Long Anupriya Agarwal Cristina E. Tognon Motomi Mori Brian J. Druker Bill H. Chang Alexey V. Danilov Jeffrey W. Tyner Source Type: research

Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0769-1Chromosome 21 gain is dispensable for transient myeloproliferative disorder driven by a novel GATA1 mutation (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Julius Lukes Jr. Petr Danek Oriol Alejo-Valle Eliska Potuckova Ondrej Gahura Dirk Heckl Julia Starkova Jan Stary Ester Mejstrikova Meritxell Alberich-Jorda Jan Zuna Jan Trka Jan-Henning Klusmann Marketa Zaliova Source Type: research

Blinatumomab versus historical standard therapy in pediatric patients with relapsed/refractory Ph-negative B-cell precursor acute lymphoblastic leukemia
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0770-8Blinatumomab versus historical standard therapy in pediatric patients with relapsed/refractory Ph-negative B-cell precursor acute lymphoblastic leukemia (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Franco Locatelli James A. Whitlock Christina Peters Christiane Chen-Santel Victoria Chia Robyn M. Dennis Kenneth M. Heym Aaron J. Katz Michael A. Kelsh Richard Sposto Huakang Tu Catherine A. Tuglus Anupam Verma Luciana Vinti Jennifer J. Wilkes Nathalya Zu Source Type: research

Decreased cell stiffness enhances leukemia development and progression
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0763-7Decreased cell stiffness enhances leukemia development and progression (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Linping Hu Fang Ni Xinyi Wang Meredith E. Fay Katherine M. Young Wilbur A. Lam Todd A. Sulchek Cheng-Kui Qu Source Type: research

Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0775-3Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Chengxiang Xia Tongjie Wang Hui Cheng Yong Dong Qitong Weng Guohuan Sun Peiqing Zhou Kaitao Wang Xiaofei Liu Yang Geng Shihui Ma Sha Hao Ling Xu Yuxian Guan Juan Du Xin Du Yangqiu Li Xiaofan Zhu Yufang Shi Sheng Xu Demin Wang Tao Cheng Jinyong Wang Source Type: research

Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0756-6Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Maria Gavriatopoulou Ajai Chari Christine Chen Nizar Bahlis Dan T. Vogl Andrzej Jakubowiak David Dingli Robert F. Cornell Craig C. Hofmeister David Siegel Jesus G. Berdeja Donna Reece Darrell White Suzanne Lentzsch Cristina Gasparetto Carol Ann Huff Sunda Source Type: research

Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0768-2Restoration of microRNA function impairs MYC-dependent maintenance of MLL leukemia (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Shouhai Zhu Xiaoyan Cheng Ruiheng Wang Yuting Tan Maolin Ge Dan Li Qiongyu Xu Yan Sun Chunjun Zhao Saijuan Chen Han Liu Source Type: research

PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma
Leukemia, Published online: 24 February 2020; doi:10.1038/s41375-020-0737-9PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma (Source: Leukemia)
Source: Leukemia - February 24, 2020 Category: Hematology Authors: Masaharu Kawashima Joaquim Carreras Hiroshi Higuchi Ryutaro Kotaki Takahiro Hoshina Kazuki Okuyama Naoto Suzuki Masatoshi Kakizaki Yuji Miyatake Kiyoshi Ando Masafumi Nakayama Shinjiro Umezu Ryouichi Horie Yuriko Higuchi Koko Katagiri Susumu Goyama Toshio Source Type: research

TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia
Leukemia, Published online: 21 February 2020; doi:10.1038/s41375-020-0759-3TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia (Source: Leukemia)
Source: Leukemia - February 21, 2020 Category: Hematology Authors: Eva Szenes Andrea H ärzschel Sarah Decker Erika Tissino Justine Pischeli Julia Christine Gutjahr Sandra Kissel Sandra Pennisi Jan Philip H öpner Alexander Egle Nadja Zaborsky Christine Dierks Marie Follo Alexandre Chigaev Antonella Zucchetto Richard Gre Source Type: research

The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index
Leukemia, Published online: 21 February 2020; doi:10.1038/s41375-020-0746-8The IPSS-R more accurately captures fatigue severity of newly diagnosed patients with myelodysplastic syndromes compared with the IPSS index (Source: Leukemia)
Source: Leukemia - February 21, 2020 Category: Hematology Authors: Fabio Efficace Francesco Cottone Laura B. Oswald David Cella Andrea Patriarca Pasquale Niscola Massimo Breccia Uwe Platzbecker Giuseppe A. Palumbo Giovanni Caocci Reinhard Stauder Alessandra Ricco Duska Petranovic Jo Caers Mario Luppi Luana Fianchi Chiara Source Type: research

A gene-expression-based signature predicts survival in adults with T-cell lymphoblastic lymphoma: a multicenter study
Leukemia, Published online: 20 February 2020; doi:10.1038/s41375-020-0757-5A gene-expression-based signature predicts survival in adults with T-cell lymphoblastic lymphoma: a multicenter study (Source: Leukemia)
Source: Leukemia - February 20, 2020 Category: Hematology Authors: Xiao-Peng Tian Dan Xie Wei-Juan Huang Shu-Yun Ma Liang Wang Yan-Hui Liu Xi Zhang Hui-Qiang Huang Tong-Yu Lin Hui-Lan Rao Mei Li Fang Liu Fen Zhang Li-Ye Zhong Li Liang Xiao-Liang Lan Juan Li Bing Liao Zhi-Hua Li Qiong-Lan Tang Qiong Liang Chun-Kui Shao Qi Source Type: research

Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia
Leukemia, Published online: 20 February 2020; doi:10.1038/s41375-020-0771-7Investigating the role of the innate immune response in relapse or blast crisis in chronic myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 20, 2020 Category: Hematology Authors: Weiqi Huang Bin Liu Elizabeth A. Eklund Source Type: research

SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
Leukemia, Published online: 19 February 2020; doi:10.1038/s41375-020-0753-9SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications (Source: Leukemia)
Source: Leukemia - February 19, 2020 Category: Hematology Authors: Shalini Singh Doaa Ahmed Hamid Dolatshad Dharamveer Tatwavedi Ulrike Schulze Andrea Sanchi Sarah Ryley Ashish Dhir Lee Carpenter Suzanne M. Watt David J. Roberts Amal M. Abdel-Aal Sohair K. Sayed Somaia A. Mohamed Anna Schuh Paresh Vyas Sally Killick Andr Source Type: research

Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative Study
Leukemia, Published online: 19 February 2020; doi:10.1038/s41375-020-0758-4Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide—an International Collaborative Study (Source: Leukemia)
Source: Leukemia - February 19, 2020 Category: Hematology Authors: Sabine Kayser Ramy Rahm é David Mart ínez-Cuadrón Gabriel Ghiaur Xavier Thomas Marta Sobas Agnes Guerci-Bresler Ana Garrido Arnaud Pigneux Cristina Gil Emmanuel Raffoux Mar Tormo Norbert Vey Javier de la Serna Olga Salamero Eva Lengfelder Mark J. Levis Source Type: research

Aberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia
Leukemia, Published online: 19 February 2020; doi:10.1038/s41375-020-0751-yAberrant RAG-mediated recombination contributes to multiple structural rearrangements in lymphoid blast crisis of chronic myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 19, 2020 Category: Hematology Authors: Daniel W. Thomson Nur Hezrin Shahrin Paul P. S. Wang Carol Wadham Naranie Shanmuganathan Hamish S. Scott Marcel E. Dinger Timothy P. Hughes Andreas W. Schreiber Susan Branford Source Type: research

Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial
Leukemia, Published online: 18 February 2020; doi:10.1038/s41375-020-0747-7Early treatment with FCR versus watch and wait in patients with stage Binet A high-risk chronic lymphocytic leukemia (CLL): a randomized phase 3 trial (Source: Leukemia)
Source: Leukemia - February 18, 2020 Category: Hematology Authors: Carmen D. Herling Florence Cymbalista Carolin Gro ß-Ophoff-Müller Jasmin Bahlo Sandra Robrecht Petra Langerbeins Anna-Maria Fink Othman Al-Sawaf Raymonde Busch Raphael Porcher Bruno Cazin Brigitte Dreyfus Stefan Ibach St éphane Leprêtre Kirsten Fische Source Type: research

Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy
Leukemia, Published online: 18 February 2020; doi:10.1038/s41375-020-0749-5Ibrutinib plus CIT for R/R mature B-NHL in children (SPARKLE trial): initial safety, pharmacokinetics, and efficacy (Source: Leukemia)
Source: Leukemia - February 18, 2020 Category: Hematology Authors: G. A. Amos Burke Auke Beishuizen Deepa Bhojwani Birgit Burkhardt V éronique Minard-Colin Robin E. Norris Edita Kabickova F. Guclu Pinarli Nurdan Tacyildiz Angela Howes Jan de Jong Grace Liu Kerri Nottage Mariya Salman Xavier Woot de Trixhe Mitchell Cairo Source Type: research

The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia
Leukemia, Published online: 18 February 2020; doi:10.1038/s41375-020-0755-7The CD33 splice isoform lacking exon 2 as therapeutic target in human acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 18, 2020 Category: Hematology Authors: Colin D. Godwin George S. Laszlo Brent L. Wood Colin E. Correnti Olivia M. Bates Eliotte E. Garling Zhengwei J. Mao Mary E. Beddoe Margaret C. Lunn Olivier Humbert Hans-Peter Kiem Roland B. Walter Source Type: research

A proposal for a new staging system for extranodal natural killer T-cell lymphoma: a multicenter study from China and Asia Lymphoma Study Group
Leukemia, Published online: 17 February 2020; doi:10.1038/s41375-020-0740-1A proposal for a new staging system for extranodal natural killer T-cell lymphoma: a multicenter study from China and Asia Lymphoma Study Group (Source: Leukemia)
Source: Leukemia - February 17, 2020 Category: Hematology Authors: Huangming Hong Yexiong Li Soon Thye Lim Chaoyong Liang He Huang Pingyong Yi Tao Wu Xin Du Mingzhi Zhang Jinghua Wang Jun Zhu Ting Liu Fanyi Meng Gang Wu Ye Guo Yuan Zhu Weili Zhao Jie Jin Juan Li Yanming Deng Kangsheng Gu Xiangyuan Wu Xiaoyan Ke Derong Xi Source Type: research

Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia
Leukemia, Published online: 17 February 2020; doi:10.1038/s41375-020-0748-6Loss of glucocorticoid receptor expression mediates in vivo dexamethasone resistance in T-cell acute lymphoblastic leukemia (Source: Leukemia)
Source: Leukemia - February 17, 2020 Category: Hematology Authors: Anica M. Wandler Benjamin J. Huang Jeffrey W. Craig Kathryn Hayes Hannah Yan Lauren K. Meyer Alessandro Scacchetti Gabriela Monsalve Monique Dail Qing Li Jasmine C. Wong Olga Weinberg Robert P. Hasserjian Scott C. Kogan Philip Jonsson Keith Yamamoto Deepa Source Type: research

Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7
Leukemia, Published online: 17 February 2020; doi:10.1038/s41375-020-0728-xImpact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7 (Source: Leukemia)
Source: Leukemia - February 17, 2020 Category: Hematology Authors: Elena Cris à Austin G. Kulasekararaj Vera Adema Esperanza Such Julie Schanz Detlef Haase Katayoon Shirneshan Steven Best Syed A Mian Aytug Kizilors Jos é Cervera Nicholas Lea Dario Ferrero Ulrich Germing Barbara Hildebrandt Ana Bel én Valencia Martíne Source Type: research

Archived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0744-xArchived bone marrow smears are an excellent source for NGS-based mutation detection in acute myeloid leukemia (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Adil S. A. Al Hinai Tim Grob Fran çois G. Kavelaars Melissa Rijken Annelieke Zeilemaker Claudia A. J. Erpelinck-Verschueren Kirsten J. Gussinklo Mathijs A. Sanders Kirsten van Lom Peter J. M. Valk Source Type: research

A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0745-9A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Lijie Xing Liang Lin Tengteng Yu Yuyin Li Shih-Feng Cho Jiye Liu Kenneth Wen Phillip A. Hsieh Krista Kinneer Nikhil Munshi Kenneth C. Anderson Yu-Tzu Tai Source Type: research

Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0741-0Significance of minimal residual disease in pediatric mixed phenotype acute leukemia: a multicenter cohort study (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Matthew J. Oberley Sunil S. Raikar Gerald B. Wertheim Jemily Malvar Richard Sposto Karen R. Rabin Jyotinder N. Punia Alix E. Seif Viviane C. Cahen Reuven J. Schore Dragos C. Luca Terri Guinipero William G. Woods Maurice R. G. O ’Gorman Etan Orgel Source Type: research

Single-agent activity of phosphatidylinositol 3-kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell lymphoma
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0743-ySingle-agent activity of phosphatidylinositol 3-kinase inhibition with copanlisib in patients with molecularly defined relapsed or refractory diffuse large B-cell lymphoma (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Georg Lenz Eliza Hawkes Gregor Verhoef Corinne Haioun Soon Thye Lim Dae Seog Heo Kirit Ardeshna Geoffrey Chong Jacob Haaber Wei Shi Igor Gorbatchevsky Susanne Lippert Florian Hiemeyer Paolo Piraino Georg Beckmann Carol Pe ña Viktoriya Buvaylo Barrett H. Source Type: research

Spectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative analysis with somatic RUNX1 mutations in MDS/MPN overlap neoplasms
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0752-xSpectrum of abnormalities and clonal transformation in germline RUNX1 familial platelet disorder and a genomic comparative analysis with somatic RUNX1 mutations in MDS/MPN overlap neoplasms (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Emma C. DiFilippo Giacomo Coltro Ryan M. Carr Abhishek A. Mangaonkar Moritz Binder Shakila P. Khan Vilmarie Rodriguez Naseema Gangat Alexandra Wolanskyj Rajiv K. Pruthi Dong Chen Rong He David S. Viswanatha Terra Lasho Christy Finke Ayalew Tefferi Animesh Source Type: research

Multiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease
Leukemia, Published online: 14 February 2020; doi:10.1038/s41375-020-0742-zMultiple Myeloma DREAM Challenge reveals epigenetic regulator PHF19 as marker of aggressive disease (Source: Leukemia)
Source: Leukemia - February 14, 2020 Category: Hematology Authors: Mike J. Mason Carolina Schinke Christine L. P. Eng Fadi Towfic Fred Gruber Andrew Dervan Brian S. White Aditya Pratapa Yuanfang Guan Hongjie Chen Yi Cui Bailiang Li Thomas Yu Elias Chaibub Neto Konstantinos Mavrommatis Maria Ortiz Valeriy Lyzogubov Kamles Source Type: research