Management of Deep Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Apr;44(2):97-110. doi: 10.1055/a-2178-6574. Epub 2024 Apr 30.ABSTRACTDeep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term. Only recently, the AWMF S2k guidelines on Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism have been rev...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Jan Beyer-Westendorf Christine Espinola-Klein Katja S M ühlberg Oliver J M üller Robert Klamroth Source Type: research
Current Topics from the Revised German S2k Guideline on Diagnosis and Treatment of Venous Thromboembolism
Hamostaseologie. 2024 Apr;44(2):90-92. doi: 10.1055/a-2239-0770. Epub 2024 Apr 30.ABSTRACTIt is an honor and a great pleasure for us to be guest editors for this special issue of Hämostaseologie - Progress in Haemostasis, which addresses important issues surrounding the complex of venous thromboembolism (VTE). In February 2023, the revised guideline on "Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism" has been published on the website of the Association of the Scientific Medical Societies in Germany (AWMF)1. This guideline was drawn up under the leadership of the German Society of Angiology (DGA), and ...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Robert Klamroth Source Type: research
Thrombozyten: Blutstillung ohne Gerinnselbildung
Hamostaseologie. 2024 Apr;44(2):94. doi: 10.1055/a-2280-1098. Epub 2024 Apr 30.ABSTRACTIM VORLIEGENDEN REVIEW FASSEN R. KAISER UND KOLLEGEN BEREITS ANERKANNTE UND NEUERE STUDIEN ZUSAMMEN, DIE ERLäUTERN, WIE ES DEN KLEINEN, KERNLOSEN THROMBOZYTEN GELINGT, DIE VASKULäRE INTEGRITäT AUFRECHTZUERHALTEN, WENN SIE MIT HERAUSFORDERUNGEN WIE INFEKTIONEN, STERILEN ENTZüNDUNGEN UND SOGAR MALIGNITäT KONFRONTIERT WERDEN.PMID:38688266 | DOI:10.1055/a-2280-1098 (Source: Hamostaseologie)
Source: Hamostaseologie - April 30, 2024 Category: Hematology Source Type: research
Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy
CONCLUSION: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.PMID:38685733 | PMC:PMC11058424 | DOI:10.3348/kjr.2023.0985 (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - April 30, 2024 Category: Radiology Authors: Yubo Guo Xiao Li Yajuan Gao Kaini Shen Lu Lin Jian Wang Jian Cao Zhuoli Zhang Ke Wan Xi Yang Zhou Yucheng Chen Long Jiang Zhang Jian Li Yining Wang Source Type: research
Impact of sub-chronic polystyrene nanoplastics exposure on hematology, histology, and endoplasmic reticulum stress-related protein expression in Nile tilapia (Oreochromis niloticus)
Comp Biochem Physiol B Biochem Mol Biol. 2024 Apr 28:110982. doi: 10.1016/j.cbpb.2024.110982. Online ahead of print.ABSTRACTNanoplastics (NPs) are one of the most hazardous marine litters, having the potential to cause far-reaching impacts on the environment and humankind. The effect of NPs on fish health has been studied, but their impact on the subcellular organelles remains unexplored. The present investigation studied the possible implications of polystyrene-nanoplastics (PS-NPs) on the hematology, tissue organization, and endoplasmic reticulum (ER) stress-related proteins in Nile tilapia (Oreochromis niloticus). Fish ...
Source: Comparative biochemistry and physiology. Part B, Biochemistry and molecular biology. - April 30, 2024 Category: Biochemistry Authors: Vadavanath Prabhakaran Vineetha Kummari Suresh Devika Pillai Source Type: research
The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Hematology. 2024 Dec;29(1):2346401. doi: 10.1080/16078454.2024.2346401. Epub 2024 Apr 30.ABSTRACTAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of t...
Source: Hematology - April 30, 2024 Category: Hematology Authors: Mariana G Meade Javier Bola ños-Meade Source Type: research
Genetic mutations and immune microenvironment: unveiling the connection to AML prognosis
CONCLUSION: This results implies that distinct genetic mutations may play a role not only in tumor initiation but also in shaping the tumor microenvironment, consequently impacting prognosis.PMID:38687637 | DOI:10.1080/16078454.2024.2346965 (Source: Hematology)
Source: Hematology - April 30, 2024 Category: Hematology Authors: ZhongLi Hu YanLi Yang JiaJia Li ZhongTing Hu Source Type: research
The long-term outcomes and safety of severe aplastic anemia treated with porcine antilymphocyte globulin plus cyclosporine, with or without thrombopoietin receptor agonists: a double-center retrospective study
CONCLUSIONS: p-ALG along with CsA is an effective choice for patients with SAA. p-ALG combined with TPO-RA may contribute to the early restoration of hematopoiesis.PMID:38687471 | DOI:10.1080/17474086.2024.2350527 (Source: Expert Review of Hematology)
Source: Expert Review of Hematology - April 30, 2024 Category: Hematology Authors: Shan Xu Yue Xiao Xingquan Liang Yan Lu Mingyang Deng Source Type: research
Current Topics from the Revised German S2k Guideline on Diagnosis and Treatment of Venous Thromboembolism
Hamostaseologie. 2024 Apr;44(2):90-92. doi: 10.1055/a-2239-0770. Epub 2024 Apr 30.ABSTRACTIt is an honor and a great pleasure for us to be guest editors for this special issue of Hämostaseologie - Progress in Haemostasis, which addresses important issues surrounding the complex of venous thromboembolism (VTE). In February 2023, the revised guideline on "Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism" has been published on the website of the Association of the Scientific Medical Societies in Germany (AWMF)1. This guideline was drawn up under the leadership of the German Society of Angiology (DGA), and ...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Robert Klamroth Source Type: research
Thrombozyten: Blutstillung ohne Gerinnselbildung
Hamostaseologie. 2024 Apr;44(2):94. doi: 10.1055/a-2280-1098. Epub 2024 Apr 30.ABSTRACTIM VORLIEGENDEN REVIEW FASSEN R. KAISER UND KOLLEGEN BEREITS ANERKANNTE UND NEUERE STUDIEN ZUSAMMEN, DIE ERLäUTERN, WIE ES DEN KLEINEN, KERNLOSEN THROMBOZYTEN GELINGT, DIE VASKULäRE INTEGRITäT AUFRECHTZUERHALTEN, WENN SIE MIT HERAUSFORDERUNGEN WIE INFEKTIONEN, STERILEN ENTZüNDUNGEN UND SOGAR MALIGNITäT KONFRONTIERT WERDEN.PMID:38688266 | DOI:10.1055/a-2280-1098 (Source: Hamostaseologie)
Source: Hamostaseologie - April 30, 2024 Category: Hematology Source Type: research
Efgartigimod hilft bei Immunthrombozytopenie
Hamostaseologie. 2024 Apr;44(2):96. doi: 10.1055/a-2280-1083. Epub 2024 Apr 30.ABSTRACTDIE PRIMäRE IMMUNTHROMBOZYTOPENIE (ITP) IST EINE ERWORBENE AUTOIMMUNERKRANKUNG DURCH AUTOANTIKöRPER GEGEN THROMBOZYTäRE ANTIGENE UND GEKENNZEICHNET DURCH EINE ISOLIERTE THROMBOZYTOPENIE. EFGARTIGIMOD BINDET DEN FC-REZEPTOR KOMPETITIV UND BEWIRKT EINEN ABBAU UND DIE REDUKTION ZIRKULIERENDER IGG-AUTOANTIKöRPER. IN DER PHASE-3-ADVANCE-IV-STUDIE PROFITIERTEN VORBEHANDELTE ERKRANKTE MIT CHRONISCHER UND PERSISTIERENDER ITP.PMID:38688267 | DOI:10.1055/a-2280-1083 (Source: Hamostaseologie)
Source: Hamostaseologie - April 30, 2024 Category: Hematology Source Type: research
Management of Deep Vein Thrombosis: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Apr;44(2):97-110. doi: 10.1055/a-2178-6574. Epub 2024 Apr 30.ABSTRACTDeep vein thrombosis (DVT) and pulmonary embolism (PE) are the most common manifestations of venous thromboembolism (VTE). Most DVTs affect the lower-extremity veins. Since the symptoms of DVT are non-specific, a prompt and standardised diagnostic work-up is essential to minimise the risk of PE in the acute phase and to prevent thrombosis progression, post-thrombotic syndrome and VTE recurrence in the long-term. Only recently, the AWMF S2k guidelines on Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism have been rev...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Birgit Linnemann Jan Beyer-Westendorf Christine Espinola-Klein Katja S M ühlberg Oliver J M üller Robert Klamroth Source Type: research
Pulmonary Embolism: An Update Based on the Revised AWMF-S2k Guideline
Hamostaseologie. 2024 Apr;44(2):111-118. doi: 10.1055/s-0044-1779011. Epub 2024 Apr 30.ABSTRACTPulmonary embolism (PE) is the third most common acute cardiovascular disease. The risk of PE increases with age and mortality is high. Patients are stratified into hemodynamically stable versus unstable patients, as this has important implications for diagnosis and therapy. Since clinical signs and symptoms of acute PE are nonspecific, the clinical likelihood of PE is estimated to guide diagnostic pathways. D-dimer testing is performed in hemodynamically stable patients with low or intermediate probability of PE and the visualiz...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Christian F Opitz F Joachim Meyer Source Type: research
Recurrent Venous Thromboembolism in Patients on Anticoagulation: An Update Based on the Revised AWMF S2k Guideline
Hamostaseologie. 2024 Apr;44(2):150-154. doi: 10.1055/a-2173-7729. Epub 2024 Apr 30.ABSTRACTIn the recently updated German S2k Guideline "Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism," a new chapter was incorporated about recurrent venous thromboembolism (VTE) in patients on anticoagulation treatment. Despite the high efficacy of anticoagulation in most patients, approximately 2% experience a recurrent VTE event while receiving anticoagulant drugs. The proper diagnosis of the recurrent VTE is important and possible only with the knowledge of localization and thrombus burden of the primary VTE event. ...
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: Robert Klamroth Hanno Riess Jan Beyer-Westendorf Birgit Linnemann Source Type: research
Aktueller Bericht der BDDH über die aktuellen gesundheitspolitischen Entwicklungen mit politischer Einordnung
Hamostaseologie. 2024 Apr;44(2):156-157. doi: 10.1055/a-2239-5959. Epub 2024 Apr 30.NO ABSTRACTPMID:38688271 | DOI:10.1055/a-2239-5959 (Source: Hamostaseologie)
Source: Hamostaseologie - April 30, 2024 Category: Hematology Authors: J ürgen Koscielny G ünther Kappert Christoph Sucker Source Type: research
