Erratum to: Treatment of sepsis-induced coagulopathy. Results of a  Germany-wide survey in intensive care units
Anaesthesist. 2021 Apr 13. doi: 10.1007/s00101-021-00951-6. Online ahead of print.NO ABSTRACTPMID:33847764 | DOI:10.1007/s00101-021-00951-6 (Source: Hamostaseologie)
Source: Hamostaseologie - April 13, 2021 Category: Hematology Authors: Thomas Schmoch Thorsten Brenner Andrea Becker-Pennrich Ludwig Christian Hinske Markus A Weigand Josef Briegel Patrick M öhnle SepNet Study Group Source Type: research

Erratum to: Treatment of sepsis-induced coagulopathy. Results of a  Germany-wide survey in intensive care units
Anaesthesist. 2021 Apr 13. doi: 10.1007/s00101-021-00951-6. Online ahead of print.NO ABSTRACTPMID:33847764 | DOI:10.1007/s00101-021-00951-6 (Source: Hamostaseologie)
Source: Hamostaseologie - April 13, 2021 Category: Hematology Authors: Thomas Schmoch Thorsten Brenner Andrea Becker-Pennrich Ludwig Christian Hinske Markus A Weigand Josef Briegel Patrick M öhnle SepNet Study Group Source Type: research

Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders
DISCUSSION: The medical care of patients with inherited bleeding disorders, who need a continuous supply of essential drugs, is a particular challenge in times of pandemics. Therefore, worries and fears of IBD patients should be taken seriously and innovative communication channels established to maintain therapy standards and quality of care.PMID:33831972 | DOI:10.1055/a-1399-9166 (Source: Hamostaseologie)
Source: Hamostaseologie - April 8, 2021 Category: Hematology Authors: Martin Olivieri Susan Halimeh Cornelia Wermes Wolf Hassenpflug Katharina Holstein Sylvia von Mackensen Source Type: research

Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders
DISCUSSION: The medical care of patients with inherited bleeding disorders, who need a continuous supply of essential drugs, is a particular challenge in times of pandemics. Therefore, worries and fears of IBD patients should be taken seriously and innovative communication channels established to maintain therapy standards and quality of care.PMID:33831972 | DOI:10.1055/a-1399-9166 (Source: Hamostaseologie)
Source: Hamostaseologie - April 8, 2021 Category: Hematology Authors: Martin Olivieri Susan Halimeh Cornelia Wermes Wolf Hassenpflug Katharina Holstein Sylvia von Mackensen Source Type: research

Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders
DISCUSSION: The medical care of patients with inherited bleeding disorders, who need a continuous supply of essential drugs, is a particular challenge in times of pandemics. Therefore, worries and fears of IBD patients should be taken seriously and innovative communication channels established to maintain therapy standards and quality of care.PMID:33831972 | DOI:10.1055/a-1399-9166 (Source: Hamostaseologie)
Source: Hamostaseologie - April 8, 2021 Category: Hematology Authors: Martin Olivieri Susan Halimeh Cornelia Wermes Wolf Hassenpflug Katharina Holstein Sylvia von Mackensen Source Type: research

Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders
DISCUSSION: The medical care of patients with inherited bleeding disorders, who need a continuous supply of essential drugs, is a particular challenge in times of pandemics. Therefore, worries and fears of IBD patients should be taken seriously and innovative communication channels established to maintain therapy standards and quality of care.PMID:33831972 | DOI:10.1055/a-1399-9166 (Source: Hamostaseologie)
Source: Hamostaseologie - April 8, 2021 Category: Hematology Authors: Martin Olivieri Susan Halimeh Cornelia Wermes Wolf Hassenpflug Katharina Holstein Sylvia von Mackensen Source Type: research

Impact of COVID-19 Pandemic on Medical Care of Patients with Inherited Bleeding Disorders
DISCUSSION: The medical care of patients with inherited bleeding disorders, who need a continuous supply of essential drugs, is a particular challenge in times of pandemics. Therefore, worries and fears of IBD patients should be taken seriously and innovative communication channels established to maintain therapy standards and quality of care.PMID:33831972 | DOI:10.1055/a-1399-9166 (Source: Hamostaseologie)
Source: Hamostaseologie - April 8, 2021 Category: Hematology Authors: Martin Olivieri Susan Halimeh Cornelia Wermes Wolf Hassenpflug Katharina Holstein Sylvia von Mackensen Source Type: research

Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH
Hamostaseologie. 2021 Apr 1. doi: 10.1055/a-1469-7481. Online ahead of print.ABSTRACTThe COVID-19 pandemic is an ongoing global healthcare crisis. Based on reports of atypically located thromboses following vaccination with the AstraZeneca COVID-19 vaccine, the Society of Thrombosis and Haemostasis Research (GTH) has issued guidance statements on the recognition, diagnosis, and treatment of this rare complication. It shares pathophysiological features with heparin-induced thrombocytopenia (HIT) and is referred to as vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).PMID:33822348 | DOI:10.1055/a-1469-7481 (Source: Hamostaseologie)
Source: Hamostaseologie - April 6, 2021 Category: Hematology Authors: Johannes Oldenburg Robert Klamroth Florian Langer Manuela Albisetti Charis von Auer Cihan Ay Wolfgang Korte R üdiger E Scharf Bernd P ötzsch Andreas Greinacher Source Type: research

Diagnosis and Management of Vaccine-Related Thrombosis following AstraZeneca COVID-19 Vaccination: Guidance Statement from the GTH
Hamostaseologie. 2021 Apr 1. doi: 10.1055/a-1469-7481. Online ahead of print.ABSTRACTThe COVID-19 pandemic is an ongoing global healthcare crisis. Based on reports of atypically located thromboses following vaccination with the AstraZeneca COVID-19 vaccine, the Society of Thrombosis and Haemostasis Research (GTH) has issued guidance statements on the recognition, diagnosis, and treatment of this rare complication. It shares pathophysiological features with heparin-induced thrombocytopenia (HIT) and is referred to as vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).PMID:33822348 | DOI:10.1055/a-1469-7481 (Source: Hamostaseologie)
Source: Hamostaseologie - April 6, 2021 Category: Hematology Authors: Johannes Oldenburg Robert Klamroth Florian Langer Manuela Albisetti Charis von Auer Cihan Ay Wolfgang Korte R üdiger E Scharf Bernd P ötzsch Andreas Greinacher Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Diagnosis and Therapy of aplastic anemia - update 2021
This article briefly summarizes developments of the last few years with potential clinical impact and puts it into perspective. Focus is given to the growing list of inherited BMFS and the need to e. g. screen patients at all ages for telomeropathies before initiation of treatment as part of routine evaluation of AA. The usage of next generation sequencing (NGS) to differentiate between AA and malignancies such as myelodysplatic syndrome (MDS) and the need to watch out for potential clonal evolution during and after treatment is also briefly discussed. Recent data on combinations of immunosuppressive therapy (IST) with thr...
Source: Hamostaseologie - March 29, 2021 Category: Hematology Authors: Jens Panse Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Unclear massive hemorrhage with obstruction of the airways
HNO. 2021 Mar 15. doi: 10.1007/s00106-021-01025-0. Online ahead of print.NO ABSTRACTPMID:33723671 | DOI:10.1007/s00106-021-01025-0 (Source: Hamostaseologie)
Source: Hamostaseologie - March 16, 2021 Category: Hematology Authors: T Brunner P M öhnle F Probst C Welz M Ehrenfeld L Ney Source Type: research

Effects and Side Effects of Platelet Transfusion
Hamostaseologie. 2021 Mar 12. doi: 10.1055/a-1347-6551. Online ahead of print.ABSTRACTAside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and ...
Source: Hamostaseologie - March 12, 2021 Category: Hematology Authors: Fabrice Cognasse Kathryn Hally Sebastien Fauteux-Daniel Marie-Ange Eyraud Charles-Antoine Arthaud Jocelyne Fagan Patrick Mismetti Hind Hamzeh-Cognasse Sandrine Laradi Olivier Garraud Peter Larsen Source Type: research

Effects and Side Effects of Platelet Transfusion
Hamostaseologie. 2021 Mar 12. doi: 10.1055/a-1347-6551. Online ahead of print.ABSTRACTAside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and ...
Source: Hamostaseologie - March 12, 2021 Category: Hematology Authors: Fabrice Cognasse Kathryn Hally Sebastien Fauteux-Daniel Marie-Ange Eyraud Charles-Antoine Arthaud Jocelyne Fagan Patrick Mismetti Hind Hamzeh-Cognasse Sandrine Laradi Olivier Garraud Peter Larsen Source Type: research

Effects and Side Effects of Platelet Transfusion
Hamostaseologie. 2021 Mar 12. doi: 10.1055/a-1347-6551. Online ahead of print.ABSTRACTAside from their canonical role in hemostasis, it is increasingly recognized that platelets have inflammatory functions and can regulate both adaptive and innate immune responses. The main topic this review aims to cover is the proinflammatory effects and side effects of platelet transfusion. Platelets prepared for transfusion are subject to stress injury upon collection, preparation, and storage. With these types of stress, they undergo morphologic, metabolic, and functional modulations which are likely to induce platelet activation and ...
Source: Hamostaseologie - March 12, 2021 Category: Hematology Authors: Fabrice Cognasse Kathryn Hally Sebastien Fauteux-Daniel Marie-Ange Eyraud Charles-Antoine Arthaud Jocelyne Fagan Patrick Mismetti Hind Hamzeh-Cognasse Sandrine Laradi Olivier Garraud Peter Larsen Source Type: research

The Genomic Landscape of Myeloid Malignancies: Options for Pan-myeloid Therapies?
PMID: 33604515 [PubMed] (Source: Hamostaseologie)
Source: Hamostaseologie - February 21, 2021 Category: Hematology Authors: Heidel FH, Platzbecker U Tags: Hemasphere Source Type: research

Thrombotic Thrombocytopenic Purpura: When Basic Science Meets Clinical Research.
We report here the most recent therapeutic findings that allowed progressively improving the prognostic of TTP, both at the acute phase and through long-term outcome. PMID: 33607665 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - February 19, 2021 Category: Hematology Authors: Bécel G, Faict S, Picod A, Bouzid R, Veyradier A, Coppo P Tags: Hamostaseologie Source Type: research

[Cancer patients in the intensive care unit].
Abstract Over the past 20 years, demographic changes and a longer life expectancy of cancer patients has significantly increased the prevalence of this patient group in the intensive care unit (ICU). A fundamental finding is that acute organ dysfunction, rather than the underlying malignancy, determines the prognosis of ICU patients. While hematologic patients often suffer from a more severe disease course, patients with solid tumors do not present an increased hospital mortality compared to the normal population. As with other indications, the decision to transfer a cancer patient to an ICU should be made as soon...
Source: Hamostaseologie - February 16, 2021 Category: Hematology Authors: Lueck C, Beutel G Tags: Med Klin Intensivmed Notfmed Source Type: research

[Treatment-refractory anaemia in a  35-year-old heart transplant recipient on chronic hemodialysis].
This article presents a case of pure red cell aplasia in a 35-year-old heart transplant recipient on chronic hemodialysis. Elevated parvovirus B19 immunoglobulin M blood levels were detected along with a high viral load of 80 billion IU/ml quantified by polymerase chain reaction. Bone marrow examination revealed giant proerythroblasts confirming parvovirus B19 infection. High-dose intravenous immunoglobulin was used for treatment. Anaemia had significantly improved 4 weeks later. Parvovirus B19 infection should be excluded in organ transplant recipients with anaemia due to ineffective erythrop...
Source: Hamostaseologie - February 12, 2021 Category: Hematology Authors: Schröder C, Roeles J, Schwarzer A, Heuser M, Retzlaff J, Hiß M Tags: Internist (Berl) Source Type: research

[Diagnosis and therapy of tumors with NTRK gene fusion].
macher P, Wörmann B, Bielack S, Seufferlein TTW Abstract NTRK gene fusions are sporadic genetic alterations that can occur across tumor entities. Whereas they are quite rare in most solid tumors they are present at much higher frequencies in certain rare tumors such as infantile fibrosarcoma, congenital mesoblastic nephroma, secretory breast, or salivary gland carcinoma. NTRK gene fusions or TRK fusion proteins are considered strong oncogenic drivers. If NTRK gene fusions are detected, TRK inhibitors such as entrectinib and larotrectinib can be used regardless of the tumor entity. So far only larotrectinib is...
Source: Hamostaseologie - February 1, 2021 Category: Hematology Authors: Stenzinger A, van Tilburg CM, Tabatabai G, Länger F, Graf N, Griesinger F, Heukamp LC, Hummel M, Klingebiel T, Hettmer S, Vokuhl C, Merkelbach-Bruse S, Overkamp F, Reichardt P, Scheer M, Weichert W, Westphalen CB, Bokemeyer C, Ivanyi P, Loges S, Schirmac Tags: Pathologe Source Type: research

[Should children of cancer patients attend daycare centers or schools during the COVID-19 pandemic?]
TH PMID: 33519099 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - January 25, 2021 Category: Hematology Authors: Bremen R, Petermann-Meyer A, Ernstmann N, Jost E, Panse J, Brümmendorf TH Tags: Onkologe (Berl) Source Type: research

Decitabine treatment in 311 patients with acute myeloid leukemia: outcome and impact of TP53 mutations - a registry based analysis.
erdel WE, Sockel K, Stölzel F, Platzbecker U, Ehninger G, Bornhäuser M, Schetelig J, Thiede C, Study Alliance Leukemia (SAL) Abstract We performed a registry-based analysis of 311 AML patients treated with decitabine in a standard of care setting to assess response and survival data with a distinct focus on the impact of the TP53 mutation status. Median age was 73 years. 172 patients received decitabine first-line and 139 in r/r disease. The ORR (whole cohort) was 30% with a median overall survival of 4.7 months. First-line patients achieved better responses than r/r-patients (ORR: 38% vs. ...
Source: Hamostaseologie - January 5, 2021 Category: Hematology Authors: Middeke JM, Teipel R, Röllig C, Stasik S, Zebisch A, Sill H, Kramer M, Scholl S, Hochhaus A, Jost E, Brümmendorf TH, Naumann R, Steffen B, Serve H, Altmann H, Kunzmann V, Einsele H, Parmentier S, Schaich M, Burchert A, Neubauer A, Schliemann C, Berdel W Tags: Leuk Lymphoma Source Type: research

New Developments in the Pathophysiology and Management of Primary Immune Thrombocytopenia.
Abstract Immune thrombocytopenia (ITP) is an autoimmune disease that is characterized by a significant reduction in the number of circulating platelets and frequently associated with bleeding. Although the pathogenesis of ITP is still not completely elucidated, it is largely recognized that the low platelet count observed in ITP patients is due to multiple alterations of the immune system leading to increased platelet destruction as well as impaired thrombopoiesis. The clinical manifestations and patients' response to different treatments are very heterogeneous suggesting that ITP is a group of disorders sharing c...
Source: Hamostaseologie - December 21, 2020 Category: Hematology Authors: Althaus K, Faul C, Bakchoul T Tags: Hamostaseologie Source Type: research

Ovarian Vein Thrombosis: A Narrative Review.
Abstract Ovarian vein thrombosis (OVT) is a rare type of venous thromboembolism. The most common risk factors for OVT include pregnancy, oral contraceptives, malignancies, recent surgery, and pelvic infections; however, in 4 to 16% of cases, it can be classified as idiopathic. Most of the available information regards pregnancy-related OVT, which has been reported to complicate 0.01 to 0.18% of pregnancies and to peak around 2 to 6 days after delivery or miscarriage/abortion. The right ovarian vein is more frequently involved (70-80% of cases). Clinical features of OVT include abdominal pain and tenderness, fever,...
Source: Hamostaseologie - December 21, 2020 Category: Hematology Authors: Riva N, Calleja-Agius J Tags: Hamostaseologie Source Type: research

Persistent inhibitor in acquired haemophilia A: A case for emicizumab?
e P PMID: 33314498 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - December 13, 2020 Category: Hematology Authors: Ganslmeier M, Pekrul I, Heinrich DA, Angstwurm M, Spannagl M, Möhnle P Tags: Haemophilia Source Type: research

Erratum: Critical Bleeding in Acquired Hemophilia A: Bypassing Agents or Recombinant Porcine Factor VIII?
PMID: 33307578 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - December 11, 2020 Category: Hematology Authors: Tiede A Tags: Hamostaseologie Source Type: research

Melphalan 200  mg/m2 does not increase toxicity and improves survival in comparison to reduced doses of melphalan in multiple myeloma patients.
Melphalan 200 mg/m2 does not increase toxicity and improves survival in comparison to reduced doses of melphalan in multiple myeloma patients. Bone Marrow Transplant. 2020 Dec 09;: Authors: Brioli A, Vom Hofe F, Rucci P, Ernst T, Yomade O, Hilgendorf I, Scholl S, Sayer H, Mügge LO, Hochhaus A, von Lilienfeld-Toal M Abstract Autologous stem cell transplantation (ASCT) conditioned with melphalan 200 mg/m2 (Mel200) is standard of care for young multiple myeloma (MM) patients. Lower doses of melphalan (MelRed) have been used to reduce toxicity, although data regarding their efficacy are not co...
Source: Hamostaseologie - December 9, 2020 Category: Hematology Authors: Brioli A, Vom Hofe F, Rucci P, Ernst T, Yomade O, Hilgendorf I, Scholl S, Sayer H, Mügge LO, Hochhaus A, von Lilienfeld-Toal M Tags: Bone Marrow Transplant Source Type: research

[Thromboembolic Complications in COVID-19].
f J Abstract COVID-19 represents a clinical situation that lacks precedence and clinical experience. It introduces a number of pitfalls in well-established clinical routines and poses unique challenges to diagnostic pathways. This review discusses the current evidence on the thromboembolic risk of COVID-19 patients, the recommendations for thromboprophylaxis and the relevance of abnormal coagulation tests. Pathophysiological concepts are discussed and practical solutions and current guidance recommendations are presented. PMID: 33254245 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - December 1, 2020 Category: Hematology Authors: Müller S, Beyer-Westendorf J Tags: Dtsch Med Wochenschr Source Type: research

[Prevalence of SARS-CoV-2 in children from a cohort of 2192  patients].
Conclusion: We can confirm the first data showing that children and adolescents often have an asymptomatic or mild clinical course of infection or disease. We found no evidence of a high grey area of SARS-CoV‑2 infections in this regional pediatric cohort. PMID: 33235395 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - November 19, 2020 Category: Hematology Authors: Meyer M, Rübsteck E, Lehmann C, Klein F, Gruell H, Hünseler C, Weber LT Tags: Monatsschr Kinderheilkd Source Type: research

Insights from the Hereditary Thrombotic Thrombocytopenic Purpura Registry: Discussion of Key Findings Based on Individual Cases from Switzerland.
Discussion of Key Findings Based on Individual Cases from Switzerland. Hamostaseologie. 2020 Nov;40(S 01):S5-S14 Authors: Kremer Hovinga JA, Braschler TR, Buchkremer F, Farese S, Hengartner H, Lovey PY, Largiadèr CR, Mansouri Taleghani B, Tarasco E Abstract The Hereditary TTP Registry is an international cohort study for patients with a confirmed or suspected diagnosis of hereditary thrombotic thrombocytopenic purpura (hTTP) and their family members. Hereditary TTP is an ultra-rare blood disorder (prevalence of ∼1-2 cases per million), the result of autosomal-recessively inherited congenita...
Source: Hamostaseologie - November 1, 2020 Category: Hematology Authors: Kremer Hovinga JA, Braschler TR, Buchkremer F, Farese S, Hengartner H, Lovey PY, Largiadèr CR, Mansouri Taleghani B, Tarasco E Tags: Hamostaseologie Source Type: research

Molecular Profiling of Liver Sinusoidal Endothelial Cells in Comparison to Hepatocytes: Reflection on Which Cell Type Should Be the Target for Gene Therapy.
Abstract Human factor VIII (FVIII), which deficiency leads to hemophilia A, is largely synthesized and secreted by the liver sinusoidal endothelial cells (LSECs). However, the characteristics of these cells that secrete FVIII are not well known. We have previously reported that based on genome-wide expression and CpG methylation profiling, LSECs have a distinct molecular profile that distinguishes them from other endothelial cells. Hepatocytes are targeted by gene therapy protocols to treat hemophilia A. However, the hepatocyte is not the natural site for FVIII synthesis and current gene therapy protocols are elic...
Source: Hamostaseologie - November 1, 2020 Category: Hematology Authors: El-Maarri O, Jamil MA, Oldenburg J Tags: Hamostaseologie Source Type: research

Extended Half-Life Factor VIII/Factor IX Products: Assay Discrepancies and Implications for Hemophilia Management.
nburg J Abstract Due to structural differences between extended half-life (EHL) factor VIII (FVIII) or FIX products and equivalent plasma wild-type molecules used for assay calibration, reagent-dependent discrepancies during monitoring of FVIII- and FIX-replacement therapies with EHL products have been described. To assess the performance of available one-stage clotting and chromogenic substrate assays on the Siemens Atellica COAG 360 analyzer, an in vitro study using spiked plasma samples was performed. The described results confirm previously described findings and allowed allocation of each EHL product to an ap...
Source: Hamostaseologie - November 1, 2020 Category: Hematology Authors: Müller J, Goldmann G, Marquardt N, Pötzsch B, Oldenburg J Tags: Hamostaseologie Source Type: research

Flow Cytometric Assessment of AKT Signaling in Platelet Activation: An Alternative Diagnostic Tool for Small Volumes of Blood.
CONCLUSION:  An activation of the AKT-signal pathway by different agonists can clearly be detected on the flow cytometer, indicating that the visualization of signaling in platelets by flow cytometry might be an efficient alternative for light transmission aggregometry to test platelet function in children. PMID: 33187007 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - November 1, 2020 Category: Hematology Authors: Althaus K, Wagner M, Marini I, Bakchoul T, Pelzl L Tags: Hamostaseologie Source Type: research

A Collection of Jewels.
Abstract The authors of this issue of Hämostaseologie-Progress in Haemostasis on "PROGRESS AND PITFALLS IN LABORATORY HEMOSTASIS DIAGNOSIS: " were asked to write conceptual reviews, enucleating the quintessence of their subjects in order to share it with a wide audience. All performed a masterful job and you can now enjoy a collection of jewels, each with its peculiar character, which are presented in five "invisible" sections. PMID: 33091946 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - October 24, 2020 Category: Hematology Authors: Alberio L Tags: Hamostaseologie Source Type: research

Hemostasis Laboratory Diagnostics: Characteristics, Communication Issues, and Current Challenges Resulting from Centralization of Laboratory Medicine.
Abstract Laboratory diagnostics of patients with bleeding and thrombotic disorders can be a delicate task, which requires special skills and expertise. In this article, characteristic features of hemostasis testing are reviewed, including staged protocols and synoptic assessment of the patient history, clinical symptoms, and laboratory findings. Despite major progress in the diagnostic and therapeutic management, centralized testing of hemostasis can be associated with substantial challenges, resulting from the current dissociation between the clinical and laboratory world. To address some of these challenges, pos...
Source: Hamostaseologie - October 24, 2020 Category: Hematology Authors: Scharf RE Tags: Hamostaseologie Source Type: research

Challenges in Detecting Clinically Relevant Heparin-Induced Thrombocytopenia Antibodies.
Abstract Heparin-induced thrombocytopenia (HIT) is an antibody-mediated hypercoagulable state featuring high thrombosis risk and distinct pathogenesis involving immunoglobulin G-mediated platelet activation. The target of the immune response is a cationic "self" protein, platelet factor 4 (PF4), rendered antigenic by heparin. A key problem is that only a minority of anti-PF4/polyanion antibodies induced by heparin are pathogenic, i.e., capable of causing platelet activation and thereby clinical HIT. Since thrombocytopenia occurs frequently in hospitalized, heparin-treated patients, testing for "HIT ...
Source: Hamostaseologie - October 24, 2020 Category: Hematology Authors: Warkentin TE Tags: Hamostaseologie Source Type: research