Productivity of Young Experts in Hemostasis and Thrombosis before and during the SARS-CoV-2 Pandemic-A Special Issue.
PMID: 32726820 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Scharf RE Tags: Hamostaseologie Source Type: research

The Millennial Generation of Thrombosis and Hemostasis.
PMID: 32726821 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Barco S Tags: Hamostaseologie Source Type: research

Screening for Occult Cancer in Patients with Venous Thromboembolism: Past, Present, and Future.
Abstract A strong link between cancer and thrombosis has been well recognized. The occurrence of venous thromboembolism (VTE) can be the first clinical sign of an undiagnosed (i.e., occult) cancer. Cancer is more often diagnosed after unprovoked compared with provoked VTE events, with a reported risk in recent studies of around 5%. Extensive, imaging-based screening strategies to detect occult cancer after unprovoked VTE do not appear to have a clear clinical benefit compared with a more limited cancer screening. To identify patients with unprovoked VTE at high risk of occult cancer, risk factors have been explore...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: van Es N, Ay C, Jara-Palomares L Tags: Hamostaseologie Source Type: research

How to Differentiate Recurrent Deep Vein Thrombosis from Postthrombotic Syndrome.
Abstract Venous thromboembolism (VTE) is associated with significant morbidity and mortality. Accuracy of diagnosis is thus of vital importance. Failure to diagnose VTE increases the risk of progression and complications. Conversely, anticoagulation as a result of an incorrect diagnosis exposes patients to the associated hazards of bleeding. The diagnostic management of recurrent deep vein thrombosis (DVT) and postthrombotic syndrome (PTS) is especially challenging due to the lack of well-established diagnostic standards. Particularly, the differentiation between the two is notoriously difficult as symptoms, clini...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Gautam G, Sebastian T, Klok FA Tags: Hamostaseologie Source Type: research

Management of Anticoagulant Treatment and Anticoagulation-Related Complications in Nonagenarians.
Abstract Given the aging population, the burden of age-dependent diseases is growing. Despite this, elderly patients are often underrepresented in clinical trials and little data are available on current anticoagulant management and outcomes in this unique population, especially those aged 90 years or older. There is uncertainty, and a fear of "doing harm," that often leads to de-prescription of antithrombotic agents in nonagenarian patients. Decision-making concerning the use of anticoagulant treatment needs to balance the risk of thrombotic events against the risk of major bleeding, especially intracra...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Giustozzi M, Castellucci LA, Barnes GD Tags: Hamostaseologie Source Type: research

Head, Neck, and Abdominopelvic Septic Thrombophlebitis: Current Evidence and Challenges in Diagnosis and Treatment.
Abstract Septic thrombophlebitis (STP) is a complex, cross-disciplinary clinical condition that combines a localized infection with a neighboring venous thrombosis. STP can occur at several possible anatomic sites, such as dural sinuses, jugular vein (Lemierre syndrome), portal vein (pylephlebitis), and pelvic veins. Its high mortality in the preantibiotic era improved considerably with the introduction of modern antibiotics. However, little evidence exists to date to guide its clinical management. The incidence of STP or its risk factors may be increasing, and its mortality may still be considerable. These trends...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Valerio L, Riva N Tags: Hamostaseologie Source Type: research

The Evolution of Hemophilia Care: Clinical and Laboratory Advances, Opportunities, and Challenges.
Abstract Hemophilia A (HA) and B (HB) are X-linked bleeding disorders caused by mutations in the F8 or F9 gene that result in the absence, or reduced activity, of the corresponding clotting factor. The severity of bleeding and related complications is proportional to the amount of residual circulating functional factor. The development of a safe and effective hemophilia treatment lasted several decades and has been mainly based on clotting factor replacement. Advances in the engineering and manufacturing of clotting concentrates have led to the widespread availability of extended half-life products that reduced th...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Trinchero A, Sholzberg M, Matino D Tags: Hamostaseologie Source Type: research

Current and Future Perspectives on ADAMTS13 and Thrombotic Thrombocytopenic Purpura.
Abstract Thrombotic thrombocytopenic purpura (TTP) is a rare, relapsing, and life-threatening disorder with an annual incidence of 10 cases per million people. TTP is a thrombotic microangiopathy characterized by severe thrombocytopenia, microangiopathic hemolytic anemia, and organ ischemia. The disease is caused by a severe deficiency of the enzyme ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13), which can either be acquired, mainly by autoantibodies targeting ADAMTS13, or congenital due to mutations in the ADAMTS13 gene. Thanks to the establishment of national registrie...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Roose E, Joly BS Tags: Hamostaseologie Source Type: research

Role of Platelet Cytoskeleton in Platelet Biomechanics: Current and Emerging Methodologies and Their Potential Relevance for the Investigation of Inherited Platelet Disorders.
Abstract Cytoskeleton is composed of more than 100 proteins and represents a dynamic network of the cellular cytoplasm. Cytoskeletal functions include spatial organization of cellular components, structural connection of the cell with external environment, and biomechanical force generation. Cytoskeleton takes part, at different levels, in all phases of platelet biogenesis: megakaryocyte (MK) differentiation, MK maturation, and platelet formation. In addition, it also plays a major role in each stage of platelet function. Inherited platelet disorders (IPDs) are a group of rare diseases featured by low platelet cou...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Zaninetti C, Sachs L, Palankar R Tags: Hamostaseologie Source Type: research

Use of Anticoagulants in Patients with Pulmonary Hypertension.
Abstract Since the earliest works on the understanding of different forms of pulmonary hypertension, thrombosis has been involved in the pathophysiology of the disease, both in pulmonary arterial hypertension (PAH) and in chronic thromboembolic pulmonary hypertension (CTEPH). Autopsy and then pathophysiological data paved the way for the use of anticoagulants as a treatment for PAH and CTEPH. In PAH their role has diminished with the advent of specific targeted therapies, but they are still prescribed in more than half of PAH patients, because of concomitant venous thromboembolism or atrial fibrillation. In CTEPH ...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Bertoletti L, Mismetti V, Giannakoulas G Tags: Hamostaseologie Source Type: research

Understanding and Preventing Placenta-Mediated Pregnancy Complications.
cute;inle F Abstract Placenta-mediated pregnancy complications are clinically important conditions and include preeclampsia, placental abruption, intrauterine growth restriction, and late fetal loss. Pathophysiology is complex, and may be linked to prothrombotic disorders such as antiphospholipid syndrome, whose understanding is still evolving. In this narrative review, we will present the latest evidence to better understand hemostatic mechanisms of preeclampsia, as well as in women with placenta-mediated pregnancy complications and inherited thrombophilia or antiphospholipid antibodies. Using four clinical scena...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Skeith L, Blondon M, Ní Áinle F Tags: Hamostaseologie Source Type: research

Can We Measure the Individual Prothrombotic or Prohemorrhagic Tendency by Global Coagulation Tests?
l H Abstract Hemostasis is a complex process in which abnormalities can cause shifts toward prothrombotic or prohemorrhagic states resulting in thrombosis or bleeding, respectively. Several coagulation tests may be required to characterize these defects but may yet not always reflect a patient's true hemostatic capacity. Thus, global coagulation tests aiming to simulate the coagulation process in vitro instead of measuring single components thereof are certainly of interest to assess prothrombotic or prohemorrhagic tendencies. This review describes the development and application of global coagulation tests, conce...
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Reda S, Morimont L, Douxfils J, Rühl H Tags: Hamostaseologie Source Type: research

About mentees and mentors: what kind of advanced training should young scientists receive? - A personal reflection.
Abstract Comprehensive training of talented MD or PhD students and postdoctoral fellows is one of the essential requirements for a future career as an established investigator or even an outstanding scientist. Here, from personal experience, several relevant aspects are summarized including the high responsibility of the academic mentor. Specifically, the interaction of the mentor with fellows, the choice of the research project, and the impact of the mentor's personality on mentees are discussed. PMID: 32726832 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Scharf RE Tags: Hamostaseologie Source Type: research

Erfolgreicher Launch der GTH Mediathek im Juni.
Authors: PMID: 32726833 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 30, 2020 Category: Hematology Tags: Hamostaseologie Source Type: research

EBM-Reform zum 01.04.2020.
PMID: 32726834 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 30, 2020 Category: Hematology Authors: Sucker C, Kappert G, Koscielny J Tags: Hamostaseologie Source Type: research

In Vitro Closure Times (PFA-100) Are Different Between Peritoneal Dialysis and Hemodialysis.
a M Abstract INTRODUCTION:  Platelet dysfunction is not uncommon in patients with end-stage renal disease (ESRD). Type of renal replacement therapy may have an effect on platelet functions, which has not been well investigated. We evaluated in vitro closure time (CT) differences between peritoneal dialysis (PD) and hemodialysis (HD) patients using platelet function analyzer (PFA-100)and observed a significant difference between these renal replacement therapies. METHODS:  Patients with ESRD undergoing PD (n = 24) or HD (n = 23) for more than 6 months were included. Blood ...
Source: Hamostaseologie - July 27, 2020 Category: Hematology Authors: Gokalp C, Karadag FK, Braunisch MC, Schmaderer C, Gunay E, Kiper HD, Tobu M, Ustün C, Demirci MS, Ozkahya M Tags: Hamostaseologie Source Type: research

Origins, Development, Current Challenges and Future Directions with Activated Prothrombin Complex Concentrate for the Treatment of Patients with Congenital Haemophilia with Inhibitors.
ier C Abstract Congenital haemophilia A (HA) is caused by deficiency of coagulation factor VIII (FVIII) activity, leading to spontaneous or traumatic bleeding events. While FVIII replacement therapy can treat and prevent bleeds, approximately 30% of patients with severe HA develop inhibitor antibodies that render FVIII replacement therapy ineffective. The bypassing agents (BPAs), activated prothrombin complex concentrate (aPCC) and recombinant activated FVII, first approved in 1977 and 1996, respectively, act to generate thrombin independent of pathways that involve factors IX and VIII. Both may be used in patient...
Source: Hamostaseologie - July 27, 2020 Category: Hematology Authors: Brackmann HH, Schramm W, Oldenburg J, Cano V, Turecek PL, Négrier C Tags: Hamostaseologie Source Type: research

Correction: Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study.
idel FH Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper. PMID: 32651539 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - July 10, 2020 Category: Hematology Authors: Crodel CC, Jentsch-Ullrich K, Koschmieder S, Kämpfe D, Griesshammer M, Döhner K, Jost PJ, Wolleschak D, Isfort S, Stegelmann F, Jilg S, Hofmann V, Auteri G, Rachow T, Ernst P, Brioli A, von Lilienfeld-Toal M, Hochhaus A, Palandri F, Heidel FH Tags: Leukemia Source Type: research

From Routine to Research Laboratory: Strategies for the Diagnosis of Congenital Fibrinogen Disorders.
Abstract Congenital fibrinogen disorders (CFDs) encompass a heterogeneous group of fibrinogen defects with a wide spectrum of biological and clinical features. An accurate diagnosis is thus essential to assure the optimal management for the patient. Diagnosis involves a multistep approach starting with routine coagulation assays and assessment of functional and antigenic fibrinogen followed by identification of the molecular anomaly. However, the diagnosis of CFD can be challenging as the sensitivity and specificity of coagulation assays depend on the fibrinogen level as well as on the fibrinogen variant. In addit...
Source: Hamostaseologie - July 9, 2020 Category: Hematology Authors: Casini A Tags: Hamostaseologie Source Type: research

Navigating the Myriad of von Willebrand Factor Assays.
Abstract von Willebrand factor (VWF) represents a large and complex adhesive plasma protein whose main function is to provide a bridge between blood platelets and damaged endothelium, and thus facilitate primary hemostasis. VWF also binds to FVIII, preventing early proteolysis, and delivers this cargo to sites of vascular injury, thereby promoting clot formation and secondary hemostasis. An absence, deficiency, or defect in VWF can lead to a bleeding diathesis called von Willebrand disease (VWD), considered the most common inherited bleeding disorder. Contemporary laboratory assays used in VWD diagnosis/exclusion ...
Source: Hamostaseologie - June 26, 2020 Category: Hematology Authors: Favaloro EJ Tags: Hamostaseologie Source Type: research

Prevention of Venous Thromboembolism during Pregnancy and the Puerperium with a Special Focus on Women with Hereditary Thrombophilia or Prior VTE-Position Paper of the Working Group in Women's Health of the Society of Thrombosis and Haemostasis (GTH).
Abstract Venous thromboembolism (VTE) is a major cause of maternal morbidity during pregnancy and the postpartum period. Because there is a lack of adequate study data, management strategies for the prevention of VTE during pregnancy have mainly been deduced from case-control and observational studies and extrapolated from recommendations for non-pregnant patients. The decision for or against pharmacologic thromboprophylaxis must be made on an individual basis weighing the risk of VTE against the risk of adverse side effects such as severe bleeding complications. A comprehensive, multidisciplinary approach is ofte...
Source: Hamostaseologie - June 26, 2020 Category: Hematology Authors: Hart C, Bauersachs R, Scholz U, Zotz R, Bergmann F, Rott H, Linnemann B Tags: Hamostaseologie Source Type: research

Practical Guidance of the GTH Haemophilia Board on the Use of Emicizumab in Patients with Haemophilia A.
In conclusion, this study is designed to support haemophilia physicians using Emicizumab in physicians treating hemophilia and using (PWHAs). With further post-marketing experience and trials, regular updates are necessary. PMID: 32588417 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - June 25, 2020 Category: Hematology Authors: Holstein K, Albisetti M, Bidlingmaier C, Halimeh S, Heine S, Klamroth R, Königs C, Kurnik K, Male C, Oldenburg J, Streif W, Wermes C, Escuriola-Ettingshausen C, ‘Ständige Kommission Hämophilie’ (Haemophilia board) of the German, Swiss Austrian Soci Tags: Hamostaseologie Source Type: research

Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis.
Abstract The novel coronavirus, SARS-CoV-2, is causing a global pandemic of life-threatening multiorgan disease, called COVID-19. Accumulating evidence indicates that patients with COVID-19 are at significant risk of thromboembolic complications, mainly affecting the venous, but also the arterial vascular system. While the risk of venous thromboembolism (VTE) appears to be higher in patients requiring intensive care unit support compared to those admitted to general wards, recent autopsy findings and data on the timing of VTE diagnosis relative to hospitalization clearly suggest that thromboembolic events also con...
Source: Hamostaseologie - June 4, 2020 Category: Hematology Authors: Langer F, Kluge S, Klamroth R, Oldenburg J Tags: Hamostaseologie Source Type: research

Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke.
t B Abstract Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical involvement of platelets in inflammatory processes including acute ischemic stroke (AIS), which is one of the leading causes of death and disability worldwide. Recanalization of the occluded brain artery to reconstitute cerebral blood flow is the primary goal in the treatment of stroke patients. However, despite successful reperfusion many patients show progression of infarct sizes, a phenomenon referred...
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Burkard P, Vögtle T, Nieswandt B Tags: Hamostaseologie Source Type: research

Prevention of Pregnancy Complications in Antiphospholipid Syndrome.
Abstract Despite a lot of research on antiphospholipid antibodies (aPL), standardization of test systems, and better definition of its clinical symptoms, the pathomechanism of this acquired autoimmune disease is not yet fully explained. Progress in treatment increased the live birth rate in 70 to 80% of women suffering from obstetric antiphospholipid syndrome (OAPS). However, still 20 to 30% will develop adverse pregnancy outcome. Lack of awareness of this disorder as the cause for pregnancy complications is very harmful to mothers and to their newborns. Complications can be avoided or minimized by proper treatmen...
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Czwalinna A, Bergmann F Tags: Hamostaseologie Source Type: research

Does One Dose Really Fit All? On the Monitoring of Direct Oral Anticoagulants: A Review of the Literature.
CONCLUSION:  There is a likely benefit to monitor DOACs in order to improve their safety and efficacy but randomized controlled trials are required to determine the therapeutic range of these drugs and evaluate whether DOAC monitoring can improve outcomes in a clinical setting. PMID: 32455459 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Moner-Banet T, Alberio L, Bart PA Tags: Hamostaseologie Source Type: research

How Do I Reverse Oral and Parenteral Anticoagulants?
Abstract An understanding of reversal strategies alone is important to safely and effectively care for patients in cases of bleeding or invasive procedures. The recent diversification in the number of licensed anticoagulants makes an understanding of drug-specific reversal strategies essential. Intravenous or oral vitamin K can reverse the effect of vitamin K antagonists (VKAs) within 12 to 48 hours and is indicated for any bleeding or an international normalized ratio>10 or 4.5 to 10 in patients with additional risk factors for bleeding. Furthermore, an additional administration of prothrombin complex c...
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Koscielny J, Rutkauskaite E, Sucker C, von Heymann C Tags: Hamostaseologie Source Type: research

Diagnosis and Treatment of Postthrombotic Syndrome.
Abstract After acute treatment of deep vein thrombosis, not only the risk but also associated side effects of postthrombotic syndrome (PTS) are often underestimated.There are essentially two main types of PTS.1. Obstructive type-no sufficient recanalization of the deep vein.2. Refluctive type-sufficient recanalization of the deep vein, but insufficient venous valves in conjunction with venous reflux.A statement regarding deep vein recanalization and venous valve function can be made at the earliest after 6 months.PTS is often diagnosed without appropriate medical history. However, the assessment of the degree of r...
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Bruning G, Woitalla-Bruning J, Queisser AC, Buhr JK Tags: Hamostaseologie Source Type: research

Acquired von Willebrand Syndrome and Platelet Function Defects during Extracorporeal Life Support (Mechanical Circulatory Support).
Abstract Patients with ventricular assist devices (VADs) and extracorporeal membrane oxygenation (ECMO) suffer from an increased risk for thromboembolic events as well as for hemorrhages. High shear stress in the mechanical device results in acquired von Willebrand syndrome (AVWS), characterized by a loss of high-molecular-weight multimers of von Willebrand factor (VWF) leading to an increased bleeding risk. Onset of AVWS occurs within hours, persists during the whole period of mechanical support, and subsides rapidly after explantation. Patients with the older HeartMate II exhibit more severe AVWS than those with...
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Schlagenhauf A, Kalbhenn J, Geisen U, Beyersdorf F, Zieger B Tags: Hamostaseologie Source Type: research

SARS-CoV-2 Ausbruchssituation: Appell an den Bundesgesundheitsminister und die Gesundheitsbeh örden der Bundesländer zur Verschiebung der Umsetzung des Vertriebsweges von Gerinnungsfaktorenzubereitungen.
SARS-CoV-2 Ausbruchssituation: Appell an den Bundesgesundheitsminister und die Gesundheitsbehörden der Bundesländer zur Verschiebung der Umsetzung des Vertriebsweges von Gerinnungsfaktorenzubereitungen. Hamostaseologie. 2020 Jun;40(2):245 Authors: Koscielny J, Kappert G, Sucker C PMID: 32455463 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - May 29, 2020 Category: Hematology Authors: Koscielny J, Kappert G, Sucker C Tags: Hamostaseologie Source Type: research

Phenotypic and Genotypic Analysis of a Hereditary Antithrombin Deficiency Pedigree Due to a Novel SERPINC1 Mutation (p.Met281Thr).
PMID: 32450575 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - May 25, 2020 Category: Hematology Authors: Liu S, Luo S, Yang L, Wang M, Jin Y, Li X, Xu Q Tags: Hamostaseologie Source Type: research

Pathophysiology of the Venous Thromboembolism Risk in Preeclampsia.
F, Kevane B Abstract Haemostatic derangements are a hallmark of preeclampsia and appear to favour an increased risk of venous thromboembolism. However, haemorrhagic complications have also been reported. The mechanisms underlying these competing risks remain to be fully elucidated although recent work has highlighted the role of placental factors, such as extra-cellular vesicles and inflammatory mediators, in modulating these haemostatic derangements as well as driving progression of preeclampsia. Identifying affected women at risk of thrombosis and managing the competing thrombotic and haemorrhagic risks continue...
Source: Hamostaseologie - May 25, 2020 Category: Hematology Authors: Kelliher S, Maguire PB, Szklanna PB, Weiss L, Ewins K, O'Doherty R, Angelov D, Ní Áinle F, Kevane B Tags: Hamostaseologie Source Type: research

Health-Related Quality of Life, Treatment Satisfaction and Adherence Outcomes of Haemophilia Patients Living in a German Rural Region.
Abstract In the context of the 'Mobile Haemophilia Outpatient Care (MHOC)' project we aimed to gather insights into the health-related quality of life (HRQoL), treatment satisfaction (TS) and adherence of persons with haemophilia (PWHs) who get treated at the Saarland University Hospital Haemophilia Treatment Centre (HTC). PWHs were visited at home at least twice (baseline, follow-up) by trained medical staff. Individual interviews were performed to measure patients' HRQoL and TS with validated questionnaires (Haem-A-QoL/Haemo-QoL and Hemo-SatA/Hemo-SatP). Socio-demographic and clinical data were collected. In tot...
Source: Hamostaseologie - May 4, 2020 Category: Hematology Authors: von Mackensen S, Schleicher C, Heine S, Graf N, Eichler H Tags: Hamostaseologie Source Type: research

Factors Influencing the Choice between DOACs and LMWHs: A Survey of German Physicians on the Treatment of Cancer-Associated Venous Thromboembolism.
Abstract Recently direct-acting oral anticoagulants (DOACs) have become a new therapeutic option besides parenteral anticoagulants to treat cancer-associated venous thromboembolism (VTE). With this survey we wanted to identify factors influencing the choice between low-molecular-weight heparin and DOACs among physicians treating cancer patients. A questionnaire was presented at several medical educational activities on cancer care and VTE management between August 2018 and January 2019. One hundred fifteen physicians returned their surveys. The two most compelling arguments pro DOAC were when the patient had no ch...
Source: Hamostaseologie - April 30, 2020 Category: Hematology Authors: Matzdorff A, Langer F Tags: Hamostaseologie Source Type: research

[Side effects of novel cancer immunotherapies].
This article summarizes the broad spectrum of currently known renal and more frequently occuring non-renal forms of irAEs and aims to prime the reader on diagnostic and therapeutic options. PMID: 32351619 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - April 29, 2020 Category: Hematology Authors: Braun GS, Kirschner M, Rübben A, Wahl RU, Amann K, Benesova K, Leipe J Tags: Nephrologe Source Type: research

Potential Drug Interactions between Recombinant Interleukin-2 and Direct Oral Anticoagulants: Indirect Evidence from In Vivo Animal Studies.
Abstract Recombinant interleukin-2 (rIL-2) is indicated for metastatic renal cell carcinoma and melanoma. Over recent years low-dose rIL-2 has been studied for the treatment of autoimmune diseases and acute coronary syndrome because of its ability to expand and activate T regulatory (Treg) cells. However, several medical conditions potentially benefiting from rIL-2 administrations are characterized by an intrinsic prothrombotic risk, thus requiring concurrent anticoagulation. In our systematic review of the literature, we investigated the potential for drug interactions between oral anticoagulants and rIL-2 by ass...
Source: Hamostaseologie - April 23, 2020 Category: Hematology Authors: Mahmoudpour SH, Valerio L, Douxfils J, Mahan CE, Jankowski M, Quitzau K, Konstantinides SV, Barco S Tags: Hamostaseologie Source Type: research

Childhood Arterial Ischaemic Stroke: Clinical Presentation, Risk Factors and Management.
Abstract Childhood arterial ischaemic stroke (AIS) is a rare, but potentially life-threatening event which requires early diagnosis and adequate treatment. The reported significant time delay to childhood AIS diagnosis may be associated with low awareness, the more nonspecific clinical presentation as well as difficult clinical differentiation to more common "stroke mimics" and a less established "acute care structure" with delayed access to proper neuroimaging. Compared with adult stroke care, experiences with acute reperfusion therapies like thrombolysis and mechanical thrombectomy are promis...
Source: Hamostaseologie - April 23, 2020 Category: Hematology Authors: Gerstl L, Bonfert MV, Heinen F, Olivieri M, Schroeder AS, Tacke M, Kurnik K, Bidlingmaier C, Reiter K, Borggraefe I Tags: Hamostaseologie Source Type: research

Laboratory testing in hemophilia: impact of factor and non-factor replacement therapy on coagulation assays.
Abstract The advent of extended half-life (EHL) recombinant clotting factors and innovative non-factor replacement therapeutics, such as emicizumab, offers several advantages over existing products for the prophylactic treatment of people living with hemophilia (PwH). These include low annual bleeding rates with less frequent dosing, higher trough plasma concentrations, and a more convenient route of administration. However, increasing use of these therapies poses challenges to clinicians and coagulation laboratories due to the lack of standardized assays for monitoring of hemostatic parameters, and the potential ...
Source: Hamostaseologie - March 1, 2020 Category: Hematology Authors: Peyvandi F, Kenet G, Pekrul I, Pruthi RK, Ramge P, Spannagl M Tags: J Thromb Haemost Source Type: research

Hemophagocytic lymphohistiocytosis in adults: collaborative analysis of 137 cases of a nationwide German registry.
acute;e P Abstract PURPOSE: Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome emerging from a deregulated immune response due to various triggers. In adults, systematic data are sparse, which is why recommendations on diagnosis and management have been adopted from pediatric guidelines. A nationwide clinical registry with associated consulting service as collaborative initiative of HLH-specialized pediatricians and hematologists was initiated to better characterize HLH in adults. METHODS: Patients with proven or suspected HLH were registered by 44 institutions. Both HLH-2004 diag...
Source: Hamostaseologie - February 20, 2020 Category: Hematology Authors: Birndt S, Schenk T, Heinevetter B, Brunkhorst FM, Maschmeyer G, Rothmann F, Weber T, Müller M, Panse J, Penack O, Schroers R, Braess J, Frickhofen N, Ehl S, Janka G, Lehmberg K, Pletz MW, Hochhaus A, Ernst T, La Rosée P Tags: J Cancer Res Clin Oncol Source Type: research

Baseline and interim PET-based outcome prediction in peripheral T-cell lymphoma: A subgroup analysis of the PETAL trial.
, Brenner W, Giagounidis A, Moeller R, Runde V, Sandmann M, Hautzel H, Wilop S, Krohn T, Dürk H, Heike M, Alashkar F, Brinkmann M, Trenn G, Wacker D, Kreisel-Büstgens C, Bernhard H, Heil G, Larisch R, Kurch L, Jöckel KH, Hoelzer D, Klapper W, Boellaard R, Dührsen U, Hüttmann A Abstract The prospective randomized Positron Emission Tomography (PET)-Guided Therapy of Aggressive Non-Hodgkin Lymphomas (PETAL) trial was designed to test the ability of interim PET (iPET) to direct therapy. As reported previously, outcome remained unaffected by iPET-based treatment changes. In this subgroup analys...
Source: Hamostaseologie - February 18, 2020 Category: Hematology Authors: Schmitz C, Rekowski J, Müller SP, Hertenstein B, Franzius C, Ganser A, Bengel FM, Kroschinsky F, Kotzerke J, La Rosée P, Freesmeyer M, Hoeffkes HG, Hertel A, Behringer D, Mesters R, Weckesser M, Mahlmann S, Haberkorn U, Martens U, Prange-Krex G, Brenner Tags: Hematol Oncol Source Type: research

40 Years of H ämostaseologie - Progress in Haemostasis.
40 Years of Hämostaseologie - Progress in Haemostasis. Hamostaseologie. 2020 Feb;40(1):7-8 Authors: Scharf RE PMID: 32050288 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Scharf RE Tags: Hamostaseologie Source Type: research

64th Annual Congress of the Gesellschaft f ür Thrombose- und Hämostaseforschung e.V. in Bremen.
64th Annual Congress of the Gesellschaft für Thrombose- und Hämostaseforschung e.V. in Bremen. Hamostaseologie. 2020 Feb;40(1):9-11 Authors: Langer F, Renné T PMID: 32050289 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Langer F, Renné T Tags: Hamostaseologie Source Type: research

How I Manage Thrombotic/Thromboembolic Complications in Myeloproliferative Neoplasms.
Abstract Patients with myeloproliferative neoplasms (MPNs), such as polycythemia vera, essential thrombocythemia, and primary myelofibrosis, are at increased risk for arterial and venous thrombosis/thromboembolism. In particular, the risk of splanchnic venous thrombosis, such as portal vein thrombosis or Budd-Chiari syndrome, is significantly higher in patients with MPN than in the normal population. At the same time, MPN patients are at increased risk for severe bleeding. Therefore, the treatment of patients with MPN must be based on their suspected probability of thrombosis/thromboembolism and bleeding. For this...
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Koschmieder S Tags: Hamostaseologie Source Type: research

Use of Direct Oral Anticoagulants in Children and Adolescents.
Abstract While the need for anticoagulation in children has increased over the last decades, dose regimens of currently used anticoagulants, including low-molecular-weight heparin (LMWH) and vitamin K antagonist (VKA), are still extrapolated from adult guidelines because well-designed clinical trials were never performed in children. This approach is not optimal due to specific pediatric features of the hemostatic system and pathophysiology of thrombosis. These anticoagulants also present several disadvantages that further hamper optimal anticoagulation of pediatric patients, especially newborns and infants. The n...
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Albisetti M Tags: Hamostaseologie Source Type: research

Diagnostic Challenges in Newborns and Infants with Coagulation Disorders.
Abstract Laboratory diagnostics in children and adolescents, especially in newborns and very small children, differ considerably compared with laboratory diagnostics in adults. This applies to all individual steps of the examination (i.e., the indication, the preanalytical phase, the analysis itself, and interpretation of the findings). This is particularly true in the diagnostics of hemostasis, in which small sample volumes and relatively error prone coagulation tests are posing particular challenges to the strategy, performance, and evaluation of the tests. Differences in the individual steps are illustrated bel...
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Eberl W Tags: Hamostaseologie Source Type: research

GTH News.
Authors: PMID: 32050293 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - February 1, 2020 Category: Hematology Tags: Hamostaseologie Source Type: research

Laborreform der Stufe 2 in Berlin.
PMID: 32050294 [PubMed - in process] (Source: Hamostaseologie)
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Sucker C, Kappert G Tags: Hamostaseologie Source Type: research

[Current diagnostic and therapeutic standards in aggressive B-cell  lymphomas].
[Current diagnostic and therapeutic standards in aggressive B-cell lymphomas]. Dtsch Med Wochenschr. 2020 Feb;145(3):151-154 Authors: Friedrichs B, Schmitz N, Lenz G Abstract In this review, we focus on new advances regarding diagnostic and therapeutic standards of aggressive B-cell lymphomas. This includes the introduction of the so-called "cell of origin" classification which differentiates diffuse large B-cell lymphomas (DLBCL) into the ABC and GCB subtypes and became part of the revised WHO classification of 2017. While 6-8 cycles of R-CHOP remain the standard of first-line treatmen...
Source: Hamostaseologie - February 1, 2020 Category: Hematology Authors: Friedrichs B, Schmitz N, Lenz G Tags: Dtsch Med Wochenschr Source Type: research

Oral Anticoagulation in the Elderly and Frail.
In conclusion, elderly and frail patients requiring anticoagulation for AF or VTE are at higher risk of adverse outcomes, but also have a higher absolute benefit from OAC. Important practical aspects to improve efficacy and safety in this challenging population are summarized in this overview. PMID: 32000266 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - January 30, 2020 Category: Hematology Authors: Bauersachs RM, Herold J Tags: Hamostaseologie Source Type: research

Health Care Transition of Adolescents and Young Adults with Haemophilia: the Situation in Germany and the Munich experience.
We describe the situation in Germany, discuss our experience in Munich and review some of the available guidance; we conclude that transition programmes should become a standard of care in haemophilia. PMID: 31994160 [PubMed - as supplied by publisher] (Source: Hamostaseologie)
Source: Hamostaseologie - January 28, 2020 Category: Hematology Authors: Bidlingmaier C, Olivieri M, Schilling FH, Kurnik K, Pekrul I Tags: Hamostaseologie Source Type: research