Economic evaluation of anti-CD19 CAR T-cell pathway for large B-cell lymphomas in the real-life setting: the experience of an Italian hub center in the first three years of activity
AbstractPoor literature report actual and detailed costs of chimeric antigen receptor (CAR) T-cell pathway in a real-life setting. We retrospectively collect data for all patients with relapsed/refractory aggressive large B-cell lymphoma who underwent leukapheresis between August 2019 and August 2022. All costs and medical resource consumption accountability were calculated on an intention-to-treat (ITT) basis, starting from leukapheresis to the time when the patient (infused or not) exited the CAR T-cell pathway for any reason. Eighty patients were addressed to leukapheresis and 59 were finally infused. After excluding CA...
Source: Annals of Hematology - May 2, 2024 Category: Hematology Source Type: research
Management options for pediatric venous thromboembolic disease: Beyond anticoagulation with endovascular therapies
Venous thromboembolism (VTE) in pediatric patients is an uncommon but serious diagnosis that has an array of therapeutic options and challenges. An assessment of the existing literature on management of pediatric patients with VTE was conducted. The interventions reviewed include anticoagulation, thrombolysis, thrombectomy, inferior vena cava (IVC) filters, and venous stenting. For each intervention, a discussion of mechanism of action, indications, contraindications, and potential complications was performed. (Source: Thrombosis Research)
Source: Thrombosis Research - May 2, 2024 Category: Hematology Authors: Priyanka Mitta, Jake DiFatta, Chase Mahler, Junjian Huang, Rachel Oser, Andrew John Gunn, Hope Wilson, Junaid Raja Tags: Review Article Source Type: research
Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients
Blood Cancer Journal, Published online: 02 May 2024; doi:10.1038/s41408-024-01060-4Continuously improving outcome over time after second allogeneic stem cell transplantation in relapsed acute myeloid leukemia: an EBMT registry analysis of 1540 patients (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - May 2, 2024 Category: Hematology Authors: Ann-Kristin Schm älter Maud Ngoya Jacques-Emmanuel Galimard Ali Bazarbachi J ürgen Finke Nicolaus Kr öger Martin Bornh äuser Matthias Stelljes Friedrich St ölzel Johanna Tischer Thomas Schroeder Peter Dreger Igor-Wolfgang Blau Bipin Savani Sebastian Source Type: research
Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target
Blood Cancer Journal, Published online: 02 May 2024; doi:10.1038/s41408-024-01041-7Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - May 2, 2024 Category: Hematology Authors: C èlia Dobaño-López Juan Garc Ãa Valero Ferran Araujo-Ayala Ferran Nadeu Fabien Gava Carla Faria Marine Norlund Renaud Morin Pascale Bernes-Lasserre Fabian Arenas Marta Grau Cristina L ópez Irene L ópez-Oreja Neus Serrat Ares Mart Ãnez-Farran Llu à Source Type: research
Similar efficacy of ibrutinib arms across ALPINE and ELEVATE-RR trials in relapsed/refractory chronic lymphocytic leukemia: a matching-adjusted indirect comparison
Blood Cancer Journal, Published online: 02 May 2024; doi:10.1038/s41408-024-01044-4Similar efficacy of ibrutinib arms across ALPINE and ELEVATE-RR trials in relapsed/refractory chronic lymphocytic leukemia: a matching-adjusted indirect comparison (Source: Blood Cancer Journal)
Source: Blood Cancer Journal - May 2, 2024 Category: Hematology Authors: Mazyar Shadman Alessandra Tedeschi Leyla Mohseninejad Keri Yang Nicole Lamanna Sheng Xu Aileen Cohen Swetha Challagulla Mei Xue Rhys Williams Susan M. O ’Brien Jennifer R. Brown Constantine Tam Source Type: research
AAV mediated genome engineering with a bypass coagulation factor alleviates the bleeding phenotype in a murine model of hemophilia B
It is crucial to develop a long-term therapy that targets hemophilia A and B, including inhibitor-positive patients. We have developed an Adeno-associated virus (AAV) based strategy to integrate the bypass coagulation factor FVIIa (murine, mFVIIa) gene into the Rosa26 locus using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 mediated gene editing. AAV vectors designed for expression of guide RNA (AAV8-gRNA), Cas9 (AAV2 neddylation mutant-Cas9), and mFVIIa (AAV8-mFVIIa) flanked by homology arms of the target locus were validated in vitro. (Source: Thrombosis Research)
Source: Thrombosis Research - May 2, 2024 Category: Hematology Authors: Pratiksha Sarangi, Narendra Kumar, Ramkumar Sambasivan, Sivaprakash Ramalingam, Sonal Amit, Dinesh Chandra, Giridhara R. Jayandharan Tags: Full Length Article Source Type: research
A Novel 165  Kb Duplication Involving the α-Globin Gene Cluster Is Identified by Low-Pass Whole Genome Sequencing in a Chinese Thalassemia Intermedia Patient
. (Source: Hemoglobin)
Source: Hemoglobin - May 2, 2024 Category: Hematology Authors: Xiaohong HePeirun TianLijuan ZhongShanshan PengShiping ChenLei PanYutao DuRui Zhanga Department of Medical Genetics and Prenatal Diagnosis, Baoan Women ’s and Children’s Hospital, Jinan University, Shenzhen, Chinab BGI-Shenzhen, Shenzhen, Chinac Hebei Source Type: research
First report of validation of the prognostic nutritional index in patients with subarachnoid hemorrhage undergoing endovascular occlusion or surgical clipping
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - May 2, 2024 Category: Neuroscience Authors: Mehmet Selim GelIskender Samet DaltabanNesibe Taser KanatAyhan Kanata Department of Neurosurgery, Kanuni Research and Training Hospital, Trabzon, Turkeyb Medical Faculty, Department of Internal Medicine, Division of Hematology, Erciyes University, Kayseri Source Type: research
Targeted therapies prime oncogene-driven lung cancers for macrophage-mediated destruction
Macrophage immune checkpoint inhibitors, such as anti-CD47 antibodies, show promise in clinical trials for solid and hematologic malignancies. However, the best strategies to use these therapies remain unknown, and ongoing studies suggest they may be most effective when used in combination with other anticancer agents. Here, we developed an unbiased, high-throughput screening platform to identify drugs that render lung cancer cells more vulnerable to macrophage attack, and we found that therapeutic synergy exists between genotype-directed therapies and anti-CD47 antibodies. In validation studies, we found that the combinat...
Source: Journal of Clinical Investigation - May 1, 2024 Category: Biomedical Science Authors: Kyle Vaccaro, Juliet Allen, Troy W. Whitfield, Asaf Maoz, Sarah Reeves, José Velarde, Dian Yang, Anna Meglan, Juliano Ribeiro, Jasmine Blandin, Nicole Phan, George W. Bell, Aaron N. Hata, Kipp Weiskopf Source Type: research
Positive anti-nuclear antibody in patients with polyclonal hypergammaglobulinemia suggests the presence of multiple distinct comorbidities
Conclusion These results establish a previously underappreciated unique immunological state of multimorbidity in PHGG and indicate that the gamma-globulin levels and ANAs could serve as markers for the clinical assessment of comorbidities in PHGG.PMID:38692914 | DOI:10.2169/internalmedicine.3594-24 (Source: Internal Medicine)
Source: Internal Medicine - May 1, 2024 Category: Internal Medicine Authors: Yasutaka Masuda Ken Morita Mineo Kurokawa Source Type: research
Publisher Correction: Gestational age-specific hematological features in preterm infants with necrotizing enterocolitis
Pediatr Res. 2024 Apr 30. doi: 10.1038/s41390-024-03176-6. Online ahead of print.NO ABSTRACTPMID:38693279 | DOI:10.1038/s41390-024-03176-6 (Source: Pediatric Research)
Source: Pediatric Research - May 1, 2024 Category: Pediatrics Authors: Qingqi Chong Zhiru Wang Ting Guo Liaoran Zhang Li Lu Cheng Cai Xiaohui Gong Zhibao Lv Qingfeng Sheng Source Type: research
Why are we donating less?
Transfusion. 2024 May 1. doi: 10.1111/trf.17861. Online ahead of print.NO ABSTRACTPMID:38693100 | DOI:10.1111/trf.17861 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Minh-Ha Tran ChenChen Niu Walter Kelley Source Type: research
In memoriam: Dr. Dirk de Korte: June 10, 1955 to March 22, 2024
Transfusion. 2024 May 1. doi: 10.1111/trf.17834. Online ahead of print.NO ABSTRACTPMID:38693467 | DOI:10.1111/trf.17834 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Raymond P Goodrich Source Type: research
Severe neonatal thrombocytopenia due to anti-HPA-4b alloantibodies: Third report described in a Caucasian mother
CONCLUSION: We described the third case of anti-HPA-4b alloantibody discovered in a Caucasian mother. This case strengthens the need for reference laboratory to genotype a panel of HPA alleles reflecting local genetic population diversity and for crossmatch of maternal serum with fresh paternal platelets in clinical suspected cases of neonatal alloimmune thrombocytopenia.PMID:38693097 | DOI:10.1111/trf.17863 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Rachel Petermann Fr édéric Bianchi Loubna Saib Nicolas Ferr é Nathalie Francelle Olivier Oudin Christophe Chenet Yasmine Mammasse Vincent Jallu Am élie Chaussade Antonin Cornu Laureline Dubray Agn ès Mailloux Source Type: research
Measuring the effectiveness of online search ads on blood donor recruitment and donation
CONCLUSION: We developed a method for determining the effectiveness of online search ads on donation outcomes. Rewards/promotions messaging was most effective at recruiting first-time donors. Our methodology is generalizable to different blood centers to explore messaging effectiveness among their unique communities.PMID:38693096 | DOI:10.1111/trf.17850 (Source: Transfusion)
Source: Transfusion - May 1, 2024 Category: Hematology Authors: Duncan C McElfresh Jennifer Bennet Kay Enriquez Tho D Pham Source Type: research
