Acute hemolytic transfusion reaction associated with anti-Mta : case report and review of the literature.
CONCLUSION: To our knowledge, this is the first case report of an HTR associated with anti-Mta . PMID: 31503331 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 10, 2019 Category: Hematology Authors: Claes V, Peyrard T, Deleers M, El Kenz H Tags: Transfusion Source Type: research

Effect of storage of platelet concentrates in PAS-B, PAS-C, or plasma on transfusion reactions.
CONCLUSIONS: In plasma platelets, longer storage time was not associated with a higher incidence of transfusion reactions. In PAS platelets, longer storage time was associated with higher transfusion reaction incidences, in particular for allergic reactions with both PAS fluids and febrile reactions with PAS-B. This indicates that the effect of storage time is different for different reaction types and depends on the storage fluid. PMID: 31503334 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 10, 2019 Category: Hematology Authors: van Hout FMA, Middelburg RA, van der Meer PF, Pors A, Wiersum-Osselton JC, Schipperus MR, Kerkhoffs JL, van der Bom JG Tags: Transfusion Source Type: research

Expanded feasibility of ferritin testing: stability of ferritin stored as whole blood and validation of plastic tubes.
Abstract BACKGROUND: Ferritin testing is a recommended strategy to mitigate iron depletion in blood donors. A barrier for some testing platforms is a requirement to complete sample management and testing within a temporal window incompatible with the logistics of many blood collectors. The ability to delay separation of plasma/serum from red cells and subsequent testing would enhance the feasibility of ferritin testing on a broader scale. STUDY DESIGN AND METHODS: Thirty blood donors provided a research donation of 12, 4-mL sample tubes of whole blood. Six pairs of serum and K2 -EDTA-plasma tubes were centrif...
Source: Transfusion - September 10, 2019 Category: Hematology Authors: Spencer BR, Brodsky JP, Holley GC, Foster GA, Winton C, Stramer SL Tags: Transfusion Source Type: research

Characterization of reemergent anti-B red blood cell antibodies in a patient with recurrent acute myeloid leukemia with ABO-incompatible allogeneic peripheral blood stem cell transplantation.
CONCLUSION: To our knowledge, this is the first report investigating the characteristic changes of isohemagglutinins between the pre- and post-HSCT sera in a patient with recurrent acute myeloid leukemia. The present study suggests that the plasma cells producing anti-donor B RBCs in the patient have been selectively eliminated or induced into an anergic state by the post-HSCT immunologic reconstruction. PMID: 31503348 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 10, 2019 Category: Hematology Authors: Tajima K, Takizawa K, Yasuda T, Tsumanuma R, Okuyama S, Kumagai H, Omoto E, Okumura W Tags: Transfusion Source Type: research

Characterization of RHD locus polymorphism in D negative and D variant donors from Northwestern Argentina.
CONCLUSIONS: A RHD genotyping strategy for patients and donors from Northwestern Argentina must consider the detection of the frequently found RHD*01N.75, RHD*DEL43, and RHD*weak D type 93 variants. Taking into account that RHD*DEL43 has scarcely been found in North Americans and Europeans whereas RHD*01N.75 and RHD*weak D type 93 have never been described in populations other than Argentineans, these RHD variants could be attributed to Native Amerindian genetic influence. PMID: 31503349 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 10, 2019 Category: Hematology Authors: Trucco Boggione C, Nogués N, González-Santesteban C, Mufarrege N, Luján Brajovich M, Mattaloni SM, Leri M, Biondi C, Muñiz-Diaz E, Castilho L, Cotorruelo C Tags: Transfusion Source Type: research

Blood transfusion for deep space exploration.
CONCLUSION: Medical planning for space exploration should consider the possibility of acute blood loss. A model for "floating" blood banks based on terrestrial walking blood bank protocols from austere environments is presented, with suggestions for future development. Constraints on volume, mass, storage, and crew, present challenges to blood transfusion in space and must be weighed against the benefits of expanding medical capabilities. PMID: 31490558 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 6, 2019 Category: Hematology Authors: Nowak ES, Reyes DP, Bryant BJ, Cap AP, Kerstman EL, Antonsen EL Tags: Transfusion Source Type: research

c.426G > C mutation in ABO*A1.02 allele was associated with Aw phenotype.
c.426G>C mutation in ABO*A1.02 allele was associated with Aw phenotype. Transfusion. 2019 Sep 05;: Authors: Chen S, Hong X, Xu X, Ma K, He J, Zhu F PMID: 31487040 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 5, 2019 Category: Hematology Authors: Chen S, Hong X, Xu X, Ma K, He J, Zhu F Tags: Transfusion Source Type: research

The emperor and the blood center.
PMID: 31487053 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 5, 2019 Category: Hematology Authors: Rahimi-Levene N, Levene D, Sandler SG Tags: Transfusion Source Type: research

A retrospective study of the added value of parallel titers compared with serial titers.
CONCLUSION: This study questions the value of parallel titers on every prenatal titer performed. When no increase in serial titers was observed, parallel titers added no new information. PMID: 31483503 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 4, 2019 Category: Hematology Authors: Lin Y, Cohen R, Buckstein J, Callum J, Lieberman L Tags: Transfusion Source Type: research

Analyses of sphingosine-1-phosphate in the context of transfusion: how much is in stored blood products and in patient blood?
CONCLUSION: S1P concentrations in blood products are significantly higher compared to human plasma S1P levels, even though plasma S1P levels decreased after RBC transfusion in critically ill patients and reached pretransfusion values within 24 hours. PMID: 31483505 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 4, 2019 Category: Hematology Authors: Poppe A, Moritz E, Geffken M, Schreiber J, Greiwe G, Amschler K, Wruck ML, Schwedhelm E, Daum G, Kluge S, Peine S, Winkler MS Tags: Transfusion Source Type: research

Implementation and 2-year outcomes of the first FDA-approved implantable apheresis vascular access device.
CONCLUSION: The PowerFlow Implantable Apheresis IV Port can achieve flow rates necessary for all apheresis therapies and is a promising alternative vascular access device for patients undergoing apheresis. PMID: 31483876 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - September 4, 2019 Category: Hematology Authors: Gray KL, Steidley IG, Benson HL, Pearce CL, Bachman AM, Adamski J Tags: Transfusion Source Type: research

Evaluating emergency-release blood transfusion of newborn infants at the Intermountain Healthcare hospitals.
Abstract BACKGROUND: An emergency-release blood transfusion (ERBT) protocol (uncrossmatched type O-negative red blood cells, AB plasma, AB platelets) is critical for neonatology practice. However, few reports of emergency transfusions are available. We conducted an ERBT quality improvement project as a basis for progress. STUDY DESIGN AND METHODS: For each ERBT in the past 8 years, we logged indications, products, locations and timing of the transfusions, and outcomes. RESULTS: One hundred forty-nine ERBTs were administered; 42% involved a single blood product, and 58% involved two or more. The incidence...
Source: Transfusion - September 3, 2019 Category: Hematology Authors: Bahr TM, DuPont TL, Christensen TR, Rees T, O'Brien EA, Ilstrup SJ, Christensen RD Tags: Transfusion Source Type: research

Cryopreserved platelets: the thaw begins … (Article, p. 2794).
Cryopreserved platelets: the thaw begins … (Article, p. 2794). Transfusion. 2019 Sep;59(9):2759-2762 Authors: Cohn CS, Williams S PMID: 31483878 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - September 1, 2019 Category: Hematology Authors: Cohn CS, Williams S Tags: Transfusion Source Type: research

Sero-positive blood donors to Trypanosoma cruzi: focus on the diagnostic.
es RV PMID: 31483879 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - September 1, 2019 Category: Hematology Authors: Novaes RD, Gonçalves RV Tags: Transfusion Source Type: research

The ice recrystallization inhibitor polyvinyl alcohol does not improve platelet cryopreservation.
PMID: 31483880 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - September 1, 2019 Category: Hematology Authors: Six KR, Lyssens S, Devloo R, Compernolle V, Feys HB Tags: Transfusion Source Type: research

The pillars of patient blood management: key to successful implementation (Article, p. 2840).
PMID: 31483881 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - September 1, 2019 Category: Hematology Authors: Sullivan HC, Roback JD Tags: Transfusion Source Type: research

A Supplement to TRANSFUSION Abstract Presentations from the AABB Annual Meeting San Antonio, TX, October 19-22, 2019.
Authors: PMID: 31486521 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - September 1, 2019 Category: Hematology Tags: Transfusion Source Type: research

The pipeline of antiviral T-cell therapy: what's in the clinic and undergoing development.
Abstract Virus-specific T cells allow targeting of multiple pathogens in patients after hematopoietic stem cell transplantation and have demonstrated potential efficacy for cytomegalovirus, Epstein-Barr Virus, and adenovirus. Novel targets may include BK virus, JC virus, varicella zoster virus, human herpesvirus 6, Aspergillus, human parainfluenza virus-3, herpes simplex virus Type I, Zika virus, and mycobacteria. Generation of patient-specific products and third-party products may expand feasibility of therapy. PMID: 31469438 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 30, 2019 Category: Hematology Authors: Fatic A, Zhang N, Keller MD, Hanley PJ Tags: Transfusion Source Type: research

First report of using low-titer cold-stored type O whole blood in massive postpartum hemorrhage.
CONCLUSIONS: This is the first report of which we are aware of massive postpartum hemorrhage treated using LTOWB. Our positive experience leads us to speculate that this approach could have a role in massive obstetric hemorrhage. PMID: 31469450 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 30, 2019 Category: Hematology Authors: Bahr TM, DuPont TL, Morris DS, Pierson SE, Esplin MS, Brown SM, O'Brien EA, Ilstrup SJ, Christensen RD Tags: Transfusion Source Type: research

A monthly roundup of key articles in other journals.
PMID: 31453641 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 27, 2019 Category: Hematology Authors: McOmish C Tags: Transfusion Source Type: research

Blood group genotyping of blood donors: validation of a highly accurate routine method.
CONCLUSION: We have established a robust and highly accurate blood group genotyping system with a very high capacity for screening blood donors. The system represents a significant improvement over the former serotyping-only procedure. Almost all new technology in medicine incurs increased costs, but the presented efficient genotyping system is a rare example of a significant qualitative and quantitative technologic progress that is also more cost-efficient than previous technologies. PMID: 31415105 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 15, 2019 Category: Hematology Authors: Krog GR, Rieneck K, Clausen FB, Steffensen R, Dziegiel MH Tags: Transfusion Source Type: research

Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy.
Gaps in the knowledge of human platelet lysate as a cell culture supplement for cell therapy: a joint publication from the AABB and the International Society for Cell & Gene Therapy. Transfusion. 2019 Aug 14;: Authors: Bieback K, Fernandez-Muñoz B, Pati S, Schäfer R PMID: 31412158 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 14, 2019 Category: Hematology Authors: Bieback K, Fernandez-Muñoz B, Pati S, Schäfer R Tags: Transfusion Source Type: research

Acute Zika virus infection in an asymptomatic blood donor at the onset of the Puerto Rico epidemic.
CONCLUSION: This study identified an asymptomatic ZIKV infection in a blood donor occurring before those previously recognized by blood donation screening. NAT and PR continue to be used as acceptable strategies to prevent transfusion-transmitted arboviral infections worldwide; however, repeated arboviral outbreaks warrant consideration of PR as a more proactive approach. PMID: 31407817 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 13, 2019 Category: Hematology Authors: Saa P, Chiu C, Grimm K, Yu G, Benjamin RJ, Corash L, Stramer SL Tags: Transfusion Source Type: research

Diversity of RH and transfusion support in Brazilian sickle cell disease patients with unexplained Rh antibodies.
CONCLUSION: RHD variation in this SCD cohort differs from that reported for African Americans, with increased prevalence of RHD*DAR and underrepresentation of the DAU cluster. Many unexplained Rh antibodies were found in patients with conventional RH allele(s) only. RH genotyping was useful to guide transfusion to determine which patients could potentially benefit from receiving RH genotyped donor units. PMID: 31408202 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 13, 2019 Category: Hematology Authors: Dinardo CL, Kelly S, Dezan MR, Ribeiro IH, Castilho SL, Schimidt LC, Valgueiro MDC, Preiss LR, Custer B, Sabino EC, Westhoff CM, NHLBI Recipient Epidemiology and Donor Evaluation Study (REDS)-III Tags: Transfusion Source Type: research

Phased implementation of pathogen-reduced platelets in a health system facilitates increased manufacturing at the blood center.
CONCLUSION: Phased implementation is a practical and ethical way to introduce PR PLTs in a health system and facilitates scalability at the blood center. Widespread availability of PR products may require collective action and can be increased by optimization strategies during manufacturing. PMID: 31408203 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 13, 2019 Category: Hematology Authors: Allen ES, Vincent C, Reeve DA, Kopko PM Tags: Transfusion Source Type: research

Improved in vitro quality of stored red blood cells upon oxygen reduction prior to riboflavin/UV light treatment of whole blood.
This study evaluated the impact of deoxygenation of WB prior to riboflavin/UV light treatment versus deoxygenation of RBC concentrates after PI treatment by monitoring RBC in vitro quality parameters. STUDY DESIGN AND METHODS: Six ABO-matched WB units were pooled and split. Within three pairs, one unit was treated with riboflavin/UV light while the other was kept as an untreated control prior to manufacture into red cell concentrates (RCCs). The first pair (Cntr; Cntr-PI) served as the normoxic controls. Deoxygenation was performed at the RCC level for the second pair (RCCdeox; PI-RCCdeox), and at the WB level of the ...
Source: Transfusion - August 13, 2019 Category: Hematology Authors: Schubert P, Culibrk B, Chen D, Serrano K, Levin E, Chen Z, Zoescher P, Goodrich RP, Yoshida T, Devine DV Tags: Transfusion Source Type: research

Trends in return behavior after an adverse event in Australian whole blood and plasma donors.
CONCLUSION: This study highlights the detrimental effects of DAEs on plasma return, in particular VVRs, and the differences in factors associated with return compared to WB donors. Further research is required to understand the mechanisms underlying the decision to return following a DAE. PMID: 31403178 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 12, 2019 Category: Hematology Authors: Thijsen A, Masser B, Gemelli CN, Davison TE Tags: Transfusion Source Type: research

Mass casualty drill with paper blood products.
PMID: 31403181 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 12, 2019 Category: Hematology Authors: Tuott EE, Tadina EC, Monoski TJ, Natividad LM, Riveira MC, Hess JR Tags: Transfusion Source Type: research

Type 1 IFN signaling critically regulates influenza-induced alloimmunization to transfused KEL RBCs in a murine model.
CONCLUSION: These and other data suggest that Type 1 IFN responses to toll-like receptor agonists or infections regulate RBC alloantibody responses. Studies investigating whether such a correlation exists in humans may be informative. PMID: 31403208 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 12, 2019 Category: Hematology Authors: Liu D, Gibb DR, Escamilla-Rivera V, Liu J, Santhanakrishnan M, Shi Z, Xu L, Eisenbarth SC, Hendrickson JE Tags: Transfusion Source Type: research

Evaluation of a routine hematology analyzer for quality control of leukoreduced plasma.
CONCLUSION: For quality control purposes of leukoreduced plasma, the Sysmex XN-10 analyzer is suitable for the enumeration of residual RBCs but not of residual WBCs. PMID: 31400008 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 9, 2019 Category: Hematology Authors: Petersson A, Ekblom K Tags: Transfusion Source Type: research

Automated typing of red blood cell and platelet antigens from whole exome sequences.
CONCLUSION: The automated bloodTyper software was modified for WES biases to allow for accurate RBC and PLT antigen typing. Such analysis could become a routing part of future WES efforts. PMID: 31392742 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 8, 2019 Category: Hematology Authors: Lane WJ, Vege S, Mah HH, Lomas-Francis C, Aguad M, Smeland-Wagman R, Koch C, Killian JM, Gardner CL, De Castro M, Lebo MS, Kaufman RM, Green RC, Westhoff CM, MilSeq Project Tags: Transfusion Source Type: research

Full annotation of serum virome in Chinese blood donors with elevated alanine aminotransferase levels.
CONCLUSION: Viral etiology is not responsible for elevated ALT levels in Chinese blood donors. The ALT test, if not abandoned, should be adjusted for its cutoff in response to donor shortage in China. PMID: 31393615 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 8, 2019 Category: Hematology Authors: Li G, Zhou Z, Yao L, Xu Y, Wang L, Fan X Tags: Transfusion Source Type: research

Transfusion-associated circulatory overload risk mitigation: survey on hospital policies for compliance with AABB Standard 5.9.17.
CONCLUSIONS: Many but not all AABB accredited institutions have policies to comply with the TACO risk mitigation Standard. However, the vast majority conduct activities that could mitigate risk for TACO. PMID: 31393616 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 8, 2019 Category: Hematology Authors: Yazer MH, Dunbar NM, Thomas J, Nunes E, Murphy MF, Biomedical Excellence for Safer Transfusion (BEST) Collaborative Tags: Transfusion Source Type: research

Prevalence of Babesia in Canadian blood donors: June-October 2018.
CONCLUSIONS: This is the largest B. microti prevalence study performed in Canada. The results indicate very low prevalence, with only one TMA-confirmed-positive donation of 50,752 tested. This donor was from the only region in Canada where autochthonous infection has been reported. Seropositive donations in southwestern Ontario suggest low prevalence; travel should not be ruled out given the proximity to the US border. PMID: 31385317 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 5, 2019 Category: Hematology Authors: Tonnetti L, O'Brien SF, Grégoire Y, Proctor MC, Drews SJ, Delage G, Fearon MA, Brès V, Linnen JM, Stramer SL Tags: Transfusion Source Type: research

Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.
CONCLUSION: Transfusion of PIPA-treated RBCs further increases the metabolic benefits of RCE to patients with SCA, significantly reducing the levels of post-transfusion plasticizers. PMID: 31385330 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 5, 2019 Category: Hematology Authors: Gehrke S, Shah N, Gamboni F, Kamyszek R, Srinivasan AJ, Gray A, Landrigan M, Welsby I, D'Alessandro A Tags: Transfusion Source Type: research

Rapid review: next generation of cord blood banks; transplantation and beyond.
Abstract Cord blood (CB) is a medicinal product of human origin with unique cellular properties such as the presence of multipotent stem cells, naive immune cells, and fetal blood components. CB transplantation provides high rate of donor chimerism, and a good balance of graft-versus-host (GVH) and graft-versus-leukemia (GVL) effects. Use of CB for transplantation has decreased in recent years as haplo-identical stem cell transplants have achieved similar short-term clinical outcomes. For most patients, however, the optimal stem cell source remains unclear. CB inventories can be used as a starting material to deve...
Source: Transfusion - August 2, 2019 Category: Hematology Authors: Querol S, Samarkanova D Tags: Transfusion Source Type: research

Personalizing transfusion in sickle cell disease: where is the canary in the mine?
PMID: 31374145 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Fields ME Tags: Transfusion Source Type: research

Falsely low ADAMTS13 activity caused by levofloxacin.
PMID: 31374146 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Nixon CP, Guertin C, Sweeney JD Tags: Transfusion Source Type: research

Intravenous vitamin K as a cause of bright yellow plasma discoloration.
PMID: 31374147 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Karp JK, Piacentino M, Gould JM, Peedin AR Tags: Transfusion Source Type: research

TRIX with treats: the considerable safety benefits of a transfusion medicine registry.
PMID: 31374148 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Hauser RG, Hendrickson JE, Tormey CA Tags: Transfusion Source Type: research

Intradonor reproducibility and changes in hemolytic variables during RBC storage: a common mistake in reproducibility analysis.
PMID: 31374149 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Naderi M, Sabour S Tags: Transfusion Source Type: research

Manual polybrene method for pretransfusion test could overcome the interference of daratumumab therapy in myeloma.
PMID: 31374150 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Yeh TJ, Yeh CJ, Liu YC, Hsiao HH Tags: Transfusion Source Type: research

Blood donor component-recipient linkages: is there fire where there is smoke?
PMID: 31374151 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Roubinian NH, Kanias T Tags: Transfusion Source Type: research

In response.
PMID: 31374152 [PubMed - in process] (Source: Transfusion)
Source: Transfusion - August 1, 2019 Category: Hematology Authors: Page GP, Brambilla DJ Tags: Transfusion Source Type: research

Increase in Google search interest for paid plasma donation in the United States during and after the great recession.
PMID: 31355947 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 29, 2019 Category: Hematology Authors: Vasovic LV, DeSimone RA Tags: Transfusion Source Type: research

Red blood cell alloimmunization is associated with lower expression of Fc γR1 on monocyte subsets in patients with sickle cell disease.
CONCLUSIONS: Monocytes and the inflammatory milieu increasingly are being appreciated to play a role in some complications of SCD. The differences in FcγR1 expression on monocyte subsets noted between responders and non-responders, which cannot be directly explained by the serum cytokines evaluated, warrant further investigation. PMID: 31355970 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 29, 2019 Category: Hematology Authors: Balbuena-Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE Tags: Transfusion Source Type: research

RHD del28Phe (DMW) encoded by a novel in-frame deletion resulting in reduced D antigen expression.
M, Wagner T PMID: 31334863 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 23, 2019 Category: Hematology Authors: Matzhold EM, Polin H, Körmöczi GF, Macher S, Schönbacher M, Wagner T Tags: Transfusion Source Type: research

A novel single-nucleotide substitution in the proximal ABO promoter gives rise to the B3 phenotype.
n ML PMID: 31329303 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 22, 2019 Category: Hematology Authors: Hellberg Å, Hult AK, Moser I, Tomaz B, Rodrigues M, Olsson ML Tags: Transfusion Source Type: research

Fast and low-cost direct ELISA for high-throughput serological HPA-1a typing.
Abstract BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by maternal alloantibodies against fetal human platelet antigens (HPAs), mostly caused by anti-HPA-1a. Population-based screening for FNAIT is still a topic of debate. Logistically and financially, the major challenge for implementation is the typing of pregnant women to recognize the 2% HPA-1a-negative women. Therefore, there is need for a high-throughput and low-cost HPA-1a-typing assay. STUDY DESIGN AND METHODS: A sandwich ELISA was developed, using a monoclonal anti-GPIIIa as coating antibody and horseradish-peroxidase-c...
Source: Transfusion - July 22, 2019 Category: Hematology Authors: Winkelhorst D, Porcelijn L, Muizelaar E, Oldert G, Huiskes E, van der Schoot CE Tags: Transfusion Source Type: research

Transfusion-related immune modulation: functional consequence of extracellular vesicles?
Abstract Extracellular vesicles (EVs) are small, subcellular vesicles that are released from a variety of cells and play important roles in cell-to-cell communication. Transfused blood products, including red blood cell, platelet, and plasma products contain EVs that are capable of interacting with and altering immune cell function. The extent to which EVs may contribute to clinically meaningful immunomodulatory effects of transfusion remains unclear and deserving of further study. PMID: 31322730 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 19, 2019 Category: Hematology Authors: Menocha S, Muszynski JA Tags: Transfusion Source Type: research