Use of a rapid electronic survey methodology to estimate blood donors' potential exposure to emerging infectious diseases: Application of a statistically representative sampling methodology to assess risk in US blood centers.
CONCLUSION: The structured donor demographic sample-based data provided an assessment of blood donors' potential exposure to an emerging pathogen that was 63% larger than the U.S. population-based estimate. This illustrates the need for tailored blood donor-based EID risk assessments that provide more specific demographic risk intelligence and can inform appropriate regulatory decision making. PMID: 32743798 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 3, 2020 Category: Hematology Authors: Whitaker BI, Walderhaug M, Hinkins S, Steele WR, Custer B, Kessler D, Leparc G, Gottschall JL, Bialkowski W, Stramer SL, Dodd RY, Crowder L, Vahidnia F, Shaz BH, Kamel H, Rebosa M, Stern M, Anderson SA Tags: Transfusion Source Type: research

Performance profile of an updated safety measure rapid assay for bacteria in platelets.
CONCLUSION: The PGD test has been successfully updated to PGDprime with an innovative sequential assay format to deliver a robust simplified workflow and improved specificity and sensitivity. PMID: 32743810 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 3, 2020 Category: Hematology Authors: Vallejo RP, Shinefeld L, LaVerda D, Best N, Lawrence G, Lousararian A, Hornbaker N, Rasmusson P, Mintz PD Tags: Transfusion Source Type: research

Red blood cell and platelet transfusion support in the first 30 and 100  days after allogeneic hematopoietic cell transplant.
CONCLUSIONS: This study provided for the first time quantitative and comparative transfusion data on a large contemporary cohort of HSCT recipients, including haploidentical and cord graft recipients, and identified factors predictive of increased transfusions. PMID: 32743866 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 3, 2020 Category: Hematology Authors: Yuan S, Yang D, Nakamura R, Zhuang L, Al Malki MM, Karanes C, Wang S Tags: Transfusion Source Type: research

Sepsis from an apheresis platelet contaminated with Acinetobacter calcoaceticus/baumannii complex bacteria and Staphylococcus saprophyticus after pathogen reduction.
CONCLUSION: CC sterility, PR studies, residual S-59 photoproducts, and mtDNA amplification inhibition suggest successful PR. Unidentified environmental sources and inherent or acquired bag defects may have contributed to postmanufacturing pathogen-reduced PLT contamination. PMID: 32738079 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - August 1, 2020 Category: Hematology Authors: Fridey JL, Stramer SL, Nambiar A, Moayeri M, Bakkour S, Langelier C, Crawford E, Lu T, Lanteri MC, Kamm J, Miller S, Wagner SJ, Benjamin RJ, Busch MP Tags: Transfusion Source Type: research

Preliminary characterization of the properties of cold-stored apheresis platelets suspended in PAS-III with and without an 8-hour room temperature hold.
Abstract BACKGROUND: Use of extended cold storage of platelets promises to increase PLT availability and the bacterial safety of bleeding patients. No information is currently available on the preservation of apheresis PLT in vitro quality parameters when PLTs are held at room temperature early in the storage period prior to transfer to cold storage. STUDY DESIGN AND METHODS: Double units of platelets suspended in 35% plasma/65% PAS-III were collected from normal consenting research donors and rested at room temperature for 1-2 hours. One of the units was then stored at 1-6°C while the other unit was plac...
Source: Transfusion - July 31, 2020 Category: Hematology Authors: Wagner SJ, Getz TM, Thompson-Montgomery D, Turgeon A Tags: Transfusion Source Type: research

Vaso-occlusive crisis in a sickle cell patient after transfusion-transmitted dengue infection.
CONCLUSION: This is the first description of TT-DENV in a SCD patient. A presumed high viral load in the transfused RBC unit probably determined the early clinical manifestation. In endemic regions dengue fever should be considered as differential diagnosis in SCD patients with fever and acute pain crisis, mainly during DENV outbreaks. PMID: 32735379 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 31, 2020 Category: Hematology Authors: Santos FLS, Slavov SN, Bezerra RS, Santos EV, Silva-Pinto AC, Morais ALL, Sá MB, Ubiali EMA, De Santis GC, Covas DT, Kashima S Tags: Transfusion Source Type: research

Comparison of the platelet activation status of single-donor platelets obtained with two different cell separator technologies.
This study assessed the impact of apheresis technology and other factors on the activation status (MP%) of single-donor apheresis platelets. STUDY DESIGN AND METHODS: Data from six US hospitals that screened platelets by measuring MP% through dynamic light scattering (ThromboLUX) were retrospectively analyzed. Relative risks (RRs) were derived from univariate and multivariable regression models, with activation rate (MP% ≥15% for plasma-stored platelets; ≥10% for platelet additive solution [PAS]-stored platelets) and MP% as outcomes. Apheresis platform (Trima Accel vs Amicus), storage medium (plasma vs PAS), pat...
Source: Transfusion - July 29, 2020 Category: Hematology Authors: Millar D, Hayes C, Jones J, Klapper E, Kniep JN, Luu HS, Noland DK, Petitti L, Poisson JL, Spaepen E, Ye Z, Maurer-Spurej E Tags: Transfusion Source Type: research

Thawed solvent/detergent-treated plasma demonstrates comparable clinical efficacy to thawed plasma.
CONCLUSION: T-S/D was as efficacious as TP for the treatment of coagulopathies and the reversal of coagulation laboratory values. PMID: 32720432 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 27, 2020 Category: Hematology Authors: Racine-Brzostek SE, Canver MC, DeSimone RA, Zdravkova M, Lo DT, Crowley KM, Hsu YS, Vasovic LV, Hill SS, Cushing MM Tags: Transfusion Source Type: research

Effect of repeat transfusion exposure on plasma cytokine and markers of endothelial activation in the extremely preterm neonate.
Abstract BACKGROUND: Very preterm newborns receive up to three to five red blood cell (RBC) transfusions, often early, after birth. Despite awareness of the association of transfusion with increases in cytokines and markers of endothelial activation, research has focused on single transfusions weeks after birth. With pathophysiologic processes contributing to the development of morbidities starting soon after delivery, we investigated the response to early, repeated transfusion exposure. STUDY DESIGN AND METHODS: Three consecutive transfusion exposures were studied in transfusion-naive infants less than 30&th...
Source: Transfusion - July 25, 2020 Category: Hematology Authors: Crawford TM, Andersen CC, Stark MJ Tags: Transfusion Source Type: research

Frequency of allotype "b" in human platelet antigen 1 to 29 systems among blood donors in Japan estimated using high-resolution melt analysis.
CONCLUSION: Nine HPA systems are of primary importance in Japan in potentially triggering thrombocytopenia via the HPA antibodies. Similar studies in other countries or races, together with ours, could provide basic information for clinicians in multiethnic societies. PMID: 32710598 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 25, 2020 Category: Hematology Authors: Hayashi T, Aminaka R, Ishii H, Tani Y, Fujimura Y, Takihara Y, Hirayama F Tags: Transfusion Source Type: research

Corrigendum.
CORRIGENDUM. Transfusion. 2020 Jul 23;: Authors: PMID: 32700340 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 23, 2020 Category: Hematology Tags: Transfusion Source Type: research

Electronic clinical decision support to facilitate a change in clinical practice: Small details can make or break success.
Abstract BACKGROUND: The use of electronic clinical decision support (CDS) is becoming common to change historically common clinical practices considered outdated by current guidelines. Preimplementation design of CDS tools is key to their success in changing clinical behaviors. Unfortunately, there are no established protocols for CDS tool development, and CDS failure can result from even small design flaws. This paper describes an example of a design oversight and how correction resulted in CDS success. STUDY DESIGN AND METHODS: We performed a retrospective review of compliance with a CDS tool to encourage ...
Source: Transfusion - July 23, 2020 Category: Hematology Authors: Connor JP, Medow JE, Ehlenfeldt BD, Rose AE, Raife T Tags: Transfusion Source Type: research

Therapeutic plasma exchange taper does not decrease exacerbations in immune thrombotic thrombocytopenic purpura patients.
CONCLUSION: Since TPE taper did not reduce exacerbations in our TTP patients, we no longer advocate for TPE taper and have reverted to our original standard of care. PMID: 32696551 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 21, 2020 Category: Hematology Authors: Raval JS, Mazepa MA, Rollins-Raval MA, Kasthuri RS, Park YA Tags: Transfusion Source Type: research

Prolonged (post-thaw) shelf life of -80 °C frozen AB apheresis plasma.
CONCLUSION: AB DFP quality was unaffected by almost 7 years of frozen storage. Quality of thawed 14-day stored AB DFP met, with exception of Protein S, all minimal guidelines which implies that its quality is sufficient for use in the (pre)-hospital (military) environment for treatment of major hemorrhage. PMID: 32692441 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 21, 2020 Category: Hematology Authors: Rijnhout TWH, Noorman F, Zoodsma M, De Kort B, Hoencamp R Tags: Transfusion Source Type: research

Prevalence of natural and acquired antibodies to amustaline/glutathione pathogen reduced red blood cells.
CONCLUSION: Standardized RRC screening panels are sensitive for the detection of natural and acquired S-303-specific antibodies. Natural low titer antibodies to amustaline/GSH RBC are present in 0.15% of naïve patients. The clinical relevance of these antibodies appears minimal but is under further investigation. PMID: 32692456 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 21, 2020 Category: Hematology Authors: Geisen C, North A, Becker L, Brixner V, von Goetz M, Corash L, Benjamin RJ, Mufti N, Seifried E Tags: Transfusion Source Type: research

Improved long-term time-series predictions of total blood use data from England.
CONCLUSION: This paradigm allows short- and long-term prediction of RBC use and could provide reliable and precise prediction up to 52 weeks ahead to improve the efficiency of blood services and sufficiency of blood supply with reduced costs. PMID: 32691487 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 20, 2020 Category: Hematology Authors: Nandi AK, Roberts DJ, Nandi AK Tags: Transfusion Source Type: research

Targeted exome sequencing designed for blood group, platelet, and neutrophil antigen investigations: Proof-of-principle study for a customized single-test system.
CONCLUSION: This single-test system demonstrates high coverage and quality, allowing for the detection of previously overlooked variants and increased sample throughput. This system has the potential to integrate genomic testing across laboratories within hematologic reference settings. PMID: 32687227 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 20, 2020 Category: Hematology Authors: Roulis E, Schoeman E, Hobbs M, Jones G, Burton M, Pahn G, Liew YW, Flower R, Hyland C Tags: Transfusion Source Type: research

Early recognition of possible transfusion reactions using an electronic automatic notification system for changes in vital signs in patients undergoing blood transfusions.
Abstract BACKGROUND: The study was designed to evaluate the ability of a novel electronic automatic notification system (EANS) to detect significant changes in transfusion-associated vital signs (VSs) during transfusion and to determine whether the EANS improved acute transfusion reaction (ATR) detection rates and suspected ATR reporting rates. STUDY DESIGN AND METHODS: VSs were measured three times per unit or batch product transfused:-before, 15 minutes after commencement, and at the completion of the transfusion-and recorded on the EANS. Significant changes in VSs were defined as increased temperatu...
Source: Transfusion - July 20, 2020 Category: Hematology Authors: Lim YA, Kim J, Park C Tags: Transfusion Source Type: research

Preoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study.
Abstract BACKGROUND: In orthopedic surgery, a patient blood management program (PBM) has been proposed to reduce blood transfusion. The aim of this observational study was to assess, within a PBM, the specific efficacy of preoperative erythropoietin (EPO). STUDY DESIGN AND METHODS: In a single hospital, 723 patients undergoing elective primary hip or knee arthroplasty were prospectively studied. The PBM included EPO if preoperative hemoglobin was lower than 13 g/dL, intraoperative administration of tranexamic acid, use of recommended transfusion thresholds, and postoperative infusion of iron. Blood tra...
Source: Transfusion - July 18, 2020 Category: Hematology Authors: Biboulet P, Motais C, Pencole M, Karam O, Dangelser G, Smilevitch P, Maissiat G, Capdevila X, Bringuier S Tags: Transfusion Source Type: research

Emotional mechanisms and format effects of motivational questions for blood donation.
CONCLUSION: These studies expand our understanding of the association between particular motivational questions and donation intentions and provide preliminary support for the notion that specific questions may influence donation intention by increasing anticipated positive and negative emotional reactions to the thought of giving or not giving, respectively. PMID: 32678484 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 17, 2020 Category: Hematology Authors: France CR, France JL, Himawan LK, Jeitani A, Williams LA Tags: Transfusion Source Type: research

Blood stewardship: Conservation and supply of blood components during the SARS-CoV-2 pandemic.
PMID: 32672371 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 16, 2020 Category: Hematology Authors: Vossoughi S, Fischkoff K, DeSimone RA, Schwartz J Tags: Transfusion Source Type: research

A novel B variant allele with c.586T > C (p.Cys196Arg) mutation identified at the ABO locus.
A novel B variant allele with c.586T>C (p.Cys196Arg) mutation identified at the ABO locus. Transfusion. 2020 Jul 15;: Authors: Chi X, Liu L, Feng Z, Zhang S PMID: 32671839 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 15, 2020 Category: Hematology Authors: Chi X, Liu L, Feng Z, Zhang S Tags: Transfusion Source Type: research

Platelet transfusion refractoriness and thrombophagocytosis in an HIV/AIDS patient with hemophagocytic lymphohistiocytosis.
PMID: 32666517 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 14, 2020 Category: Hematology Authors: Ma T, Hudgins JP, Vergara-Lluri M, Pham H, Brynes R, Shulman IA Tags: Transfusion Source Type: research

No evidence of SARS-CoV-2 RNA among blood donors: A multicenter study in Hubei, China.
CONCLUSION: Nucleic acid test screening of SARS-CoV-2 on blood donations is suitable in blood establishments using the commercial real-time PCR detection kit based on available instruments. The negative result indicated that SARS-CoV-2 appears to be no direct threat to blood safety but raises some serious issues for general blood supply. PMID: 32666556 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 14, 2020 Category: Hematology Authors: Chang L, Yan Y, Zhao L, Hu G, Deng L, Su D, Peng D, Nie X, Wang S, Li Y, Wang J, Ruan Z, Gao S, Yang H, Guo F, Wang L Tags: Transfusion Source Type: research

How do I develop a process to effectively treat parturients with iron deficiency anemia?
Abstract Anemia is common in pregnant women and is associated with increased morbidity for the mother and the fetus, including increased risk of allogeneic blood transfusion. Iron deficiency is the most common etiology for anemia during pregnancy. Oral iron therapy remains the standard treatment but is often poorly tolerated due to its gastrointestinal side effects. Intravenous iron has been shown to be a safe and effective way to treat iron deficiency anemia but may be challenging to do in the outpatient setting given the need for an indwelling venous catheter and a small risk of infusion reactions. To improve ou...
Source: Transfusion - July 13, 2020 Category: Hematology Authors: Guinn NR, Cooter ML, Maisonave Y, Grimsley A, Cellura C, Grotegut CA, Lamon A, Aronson S, Duke Perioperative Enhancement Team (POET) Tags: Transfusion Source Type: research

A multicenter evaluation of heterogeneity in cellular therapy processing laboratory procedure times to assess workload capacity.
Abstract BACKGROUND: Growth in size and complexity of clinical hematopoietic progenitor cell (HPC) transplant programs necessitates parallel increases in cellular therapy laboratory (CTL) workload. Typically individually developed, HPC product processing is labor and time intensive. Variation in procedure type and numbers across CTLs complicates direct comparisons, and benchmark data are not readily available. STUDY DESIGN AND METHODS: Studies were undertaken at seven CTLs. Transplant volume and staff numbers were determined. Staff recorded time performing tasks broken down into steps: paperwork, product acce...
Source: Transfusion - July 12, 2020 Category: Hematology Authors: Thibodeaux SR, McKenna DH, Szczepiorkowski ZM, Fontaine MJ, Kelley L, Reems JA, Young PP, Biomedical Excellence for Safer Transfusion (BEST) Collaborative Tags: Transfusion Source Type: research

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902.
CONCLUSIONS: These studies demonstrate that ECP/pentostatin/TBI is well tolerated and associated with adequate engraftment of neutrophils and platelets in patients with lymphomas and MDS. PMID: 32654201 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 12, 2020 Category: Hematology Authors: Foss FM, Wang XV, Luger SM, Jegede O, Miller KB, Stadtmauer EA, Whiteside TL, Avigan DE, Gascoyne RD, Arber D, Wagner H, Strair RK, Hogan WJ, Sprague KA, Lazarus HM, Litzow MR, Tallman MS, Horning SJ Tags: Transfusion Source Type: research

How do we use electronic clinical decision support and feedback to promote good transfusion practice.
This report describes the evolution of the electronic clinical decision support system (CDSS) and feedback methods at our center and the challenges and lessons learned. The electronic blood product order with integrated CDSS ensures collection of data regarding the patient's clinical condition and the justification for the blood product order. An alert is generated in real time if the order is placed outside agreed guidelines. We have provided feedback in several ways. We began with monthly review meetings with the junior hematology clinicians responsible for ordering blood. This was successful in reducing unjustified tran...
Source: Transfusion - July 9, 2020 Category: Hematology Authors: Staples S, Salisbury RA, King AJ, Polzella P, Bakhishli G, Staves J, Murphy MF Tags: Transfusion Source Type: research

How do I manage long-term blood component shortages in a hospital transfusion service?
PMID: 32643156 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 8, 2020 Category: Hematology Authors: Cohn CS, Pagano MB, Allen ES, Frey KP, Gniadek T, Lokhandwala PM, Murphy CH, Raval JS, Dunbar NM Tags: Transfusion Source Type: research

Factors that influence flow through intravascular catheters: the clinical relevance of Poiseuille's law.
CONCLUSION: Catheter and tubing choice, adjuncts, and fluid viscosity influence flow rates. Our results will help inform adequate vascular access planning in the perioperative environment. PMID: 32643172 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 8, 2020 Category: Hematology Authors: Berman DJ, Schiavi A, Frank SM, Duarte S, Schwengel DA, Miller CR Tags: Transfusion Source Type: research

How do we design and report a high-quality survey?
Abstract Every day, new surveys are planned, distributed, or reported by health care professionals. Surveys are an inexpensive and convenient research tool used with increasing frequency as an approach to gather and collate information on attitudes and behaviors for a specific topic. However, surveys can squander the valuable time of respondents who may derive little, if any, benefit from participation. Similar to any other research methodology, a careful design is needed to avoid introducing bias and to obtain meaningful information. A recent study evaluating the quality of surveys addressing clinical topics in t...
Source: Transfusion - July 8, 2020 Category: Hematology Authors: Pagano MB, Dunbar NM, Stanworth S, BEST Collaborative and the Clinical Studies Group Tags: Transfusion Source Type: research

The comparative safety of bacterial risk control strategies for platelet components: a simulation study.
CONCLUSION: Two-step policies that used secondary culture were generally safer than single-step policies. Performance of two-step policies that used rapid testing depended on the CFU per milliter threshold of exposure used. PMID: 32632927 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 6, 2020 Category: Hematology Authors: Walker BS, Schmidt RL, Fisher MA, White SK, Blaylock RC, Metcalf RA Tags: Transfusion Source Type: research

Daudi cell stroma: An alternative to dithiothreitol to resolve daratumumab interference in pretransfusion testing.
CONCLUSIONS: Daudi cell stroma is inexpensive, easy to prepare in large batches, and can be used as an off-the-shelf reagent. Incubation of plasma from DARA-treated patients with Daudi cell stroma can efficiently overcome DARA interference in serologic testing without affecting DTT- or trypsin-sensitive antigens. PMID: 32632934 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 6, 2020 Category: Hematology Authors: Tremblay T, Branch DR, Loubaki L Tags: Transfusion Source Type: research

Novel multiple swab method enables high efficiency in SARS-CoV-2 screenings without loss of sensitivity for screening of a complete population.
CONCLUSIONS: The new method enables countries to increase the total number of testing significantly. The multiple swab method is able to screen system relevant groups of employees frequently. Secondly the example in Germany shows that blood transfusion services can support general health systems with their experience in NAT and their high throughput instruments. Screening of a huge number of inhabitants is currently the only option to prevent a second infection wave and enable exit strategies in many countries. This article is protected by copyright. All rights reserved. PMID: 32627200 [PubMed - as supplied by publish...
Source: Transfusion - July 6, 2020 Category: Hematology Authors: Schmidt M, Hoehl S, Berger A, Zeichhardt H, Hourfar K, Ciesek S, Seifried E Tags: Transfusion Source Type: research

Blood Donor Recruitment in Guangzhou, China, during the 2019 Novel Coronavirus (COVID-19) Epidemic.
CONCLUSION: Various measures could ease blood shortage during the COVID-19 epidemic. Administration of Questionnaire 1 could increase blood donations during the epidemic. This article is protected by copyright. All rights reserved. PMID: 32627205 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 6, 2020 Category: Hematology Authors: Ou-Yang J, Li SJ, Bei CH, He B, Chen JY, Liang HQ, Fu YS Tags: Transfusion Source Type: research

Characteristics and serological patterns of COVID-19 convalescent plasma donors: optimal donors and timing of donation.
CONCLUSION: This study indicates that the S-RBD-specific IgG antibody reaches higher levels after 4 weeks from the onset of COVID-19 symptoms. We recommend the following selection criteria for optimal donation of COVID-19 convalescent plasma: 28 days after the onset of symptoms and with a disease presentation of fever lasting longer than 3 days or a body temperature exceeding 38.5°C. Selection based on these criteria can ensure a high likelihood of achieving sufficiently high S-RBD-specific IgG titers. PMID: 32627216 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 6, 2020 Category: Hematology Authors: Li L, Tong X, Chen H, He R, Lv Q, Yang R, Zhao L, Wang J, Xu H, Liu C, Chen G, Chen S, Li C, Qiao J, Yang J, Wu Y, Liu Z Tags: Transfusion Source Type: research

Evaluation of donor informed consents and associated predonation educational materials in the United States and Canada: variability in elements of consent and measures of readability and reading burden.
CONCLUSIONS: Donor consent documents and associated materials vary widely, are written at challenging grade levels, present considerable reading burden, contain substantial jargon, and are missing key elements of consent. The authors recommend an organized effort, including blood donors, legal experts, and blood collection experts, to reach consensus on the minimal requirements for standardized clear and concise consent documents in an optimized format. PMID: 32621545 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 4, 2020 Category: Hematology Authors: Townsend M, Buccino T, Katz L Tags: Transfusion Source Type: research

Identification of a novel A allele with a c.731T > C mutation on the ABO*A1.02 allele.
Identification of a novel A allele with a c.731T>C mutation on the ABO*A1.02 allele. Transfusion. 2020 Jul 03;: Authors: Hong X, Ying Y, Ma K, Xu X, He J, Zhu F PMID: 32619045 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 3, 2020 Category: Hematology Authors: Hong X, Ying Y, Ma K, Xu X, He J, Zhu F Tags: Transfusion Source Type: research

Pathogen reduction of double-dose platelet concentrates from pools of eight buffy coats: Product quality, safety, and economic aspects.
CONCLUSION: A new production method resulting in two PR-PCs made from pools of 8 BCs with use of one PR set was successfully introduced, and our experience of nearly 3 years demonstrated the high efficacy and in vitro quality of the PR-PCs obtained. PMID: 32619068 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 3, 2020 Category: Hematology Authors: Rosskopf K, Helmberg W, Schlenke P Tags: Transfusion Source Type: research

A typology of blood donor motivations.
CONCLUSION: We present the most comprehensive account of blood donor motivations to-date. This work also offers a structure for coding free-text responses, developing motivational measures, and identifying tangible interventions. Thus, we feel that this is a valuable resource for blood donor researchers, marketers, and policy makers. PMID: 32618010 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 2, 2020 Category: Hematology Authors: Ferguson E, Hill A, Lam M, Reynolds C, Davison K, Lawrence C, Brailsford SR Tags: Transfusion Source Type: research

RHCE*02 (c.148G > A, p.Val50Ile) allele with silenced RHCE*Ce expression.
RHCE*02 (c.148G>A, p.Val50Ile) allele with silenced RHCE*Ce expression. Transfusion. 2020 Jul 01;: Authors: Anderson R, Vege S, Aeschlimann J, Westhoff C, Banerjee S, Yang J PMID: 32608521 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 1, 2020 Category: Hematology Authors: Anderson R, Vege S, Aeschlimann J, Westhoff C, Banerjee S, Yang J Tags: Transfusion Source Type: research

Flat line in the blood bank: code H (hyperfibrinolysis)?
PMID: 32609379 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 1, 2020 Category: Hematology Authors: Dillard A, DeSimone RA, Hsu YM, Ma L, Vasovic L, Racine-Brzostek S, Ivascu N, Haas T, Cushing MM Tags: Transfusion Source Type: research

A combined effect of anti-HPA-1a and anti-HLA Class I in pregnancy?
CONCLUSIONS: Unadjusted neonatal platelet counts and the frequency of neonatal thrombocytopenia was not significantly affected by the presence of anti-HLA Class I alongside anti-HPA-1a, but results from regression analyses revealed a possible increased risk when the mother was nulliparous. These results warrant further investigation. PMID: 32608103 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 30, 2020 Category: Hematology Authors: Dahl J, Skogen B, Kjaer M, Husebekk A, Kjeldsen-Kragh J, Tiller H Tags: Transfusion Source Type: research

Efficacy and safety of high-dose intravenous iron as the first-choice therapy in outpatients with severe iron deficiency anemia.
CONCLUSIONS: In chronic very severe sideropenic anemias, third-generation IVI is effective and safe for quick correction and avoidance of red blood cell transfusion. These results suggest that more specific guidelines for this clinical setting are warranted. PMID: 32597514 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 29, 2020 Category: Hematology Authors: Jericó C, Beverina I, Quintana-Diaz M, Salvadori U, Melli C, Rondinelli MB, Recasens V, Brando B, Garcia-Erce JA Tags: Transfusion Source Type: research

Identification of a novel null allele of the KEL gene in a Korean patient with the Kell null phenotype.
PMID: 32598050 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 29, 2020 Category: Hematology Authors: Kim TY, Kim H, Hong YJ, Park KU Tags: Transfusion Source Type: research

Machine learning-based prediction of transfusion.
CONCLUSION: This study demonstrates that the necessity for intrahospital transfusion can be forecasted reliably, however the amount of RBC units transfused during a hospital stay is more difficult to predict. PMID: 32596877 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 28, 2020 Category: Hematology Authors: Mitterecker A, Hofmann A, Trentino KM, Lloyd A, Leahy MF, Schwarzbauer K, Tschoellitsch T, Böck C, Hochreiter S, Meier J Tags: Transfusion Source Type: research

The use of cryopreserved platelets in a trauma-induced hemorrhage model.
Abstract BACKGROUND: Cryopreserved platelet products can be stored for years and are mainly used in military settings. Following thawing, cryopreserved platelets are activated, resulting in faster clot formation but reduced aggregation in vitro, rendering their efficacy in bleeding unknown. Also, concerns remain on the safety of these products. The aim was to investigate the efficacy and safety of cryopreserved platelets in a rat model of traumatic hemorrhage. STUDY DESIGN AND METHODS: After 1 hour of shock, rats (n = 13/group) were randomized to receive a balanced transfusion pack (1:1:1 red blood cel...
Source: Transfusion - June 27, 2020 Category: Hematology Authors: Kleinveld DJB, Sloos PH, Noorman F, Maas MAW, Kers J, Rijnhout TWH, Zoodsma M, Hoencamp R, Hollmann MW, Juffermans NP Tags: Transfusion Source Type: research

Validation of PLASMIC score: an academic medical center case series (2012-present).
Abstract BACKGROUND: The PLASMIC score is a rapid and inexpensive tool for predicting severe ADAMTS13 deficiency (activity
Source: Transfusion - June 26, 2020 Category: Hematology Authors: Moosavi H, Ma Y, Miller MJ, Duncan A Tags: Transfusion Source Type: research

Tan-White amorphous material in an apheresis cassette reservoir.
PMID: 32589260 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 26, 2020 Category: Hematology Authors: Ellis A, Ahmed I, Deol R, Hermelin D, Blackall D Tags: Transfusion Source Type: research

KDAS, a new blood group antigen in the Knops blood group system antithetical to KCAM.
t P PMID: 32589271 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - June 26, 2020 Category: Hematology Authors: Scharberg EA, Rink G, Schulz D, Rothenberger S, Stürtzel A, Gillhuber N, Seyboth S, Bugert P Tags: Transfusion Source Type: research